Oleptro

Insomnia, Schizophrenia, Alzheimer's Disease + 8 more
Treatment
1 FDA approval
20 Active Studies for Oleptro

What is Oleptro

TrazodoneThe Generic name of this drug
Treatment SummaryTrazodone is an antidepressant medication that is used to treat depression in adults. It is similar in efficacy to other antidepressants like tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors. Unlike other antidepressant drugs, Trazodone does not cause anxiety, sexual symptoms, or insomnia. Trazodone works on different receptors than other antidepressants, and was approved by the FDA in 1981.
Trazodone Hydrochlorideis the brand name
Oleptro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trazodone Hydrochloride
Trazodone
1987
344

Approved as Treatment by the FDA

Trazodone, otherwise called Trazodone Hydrochloride, is approved by the FDA for 1 uses which include Depression .
Depression

Effectiveness

How Oleptro Affects PatientsTrazodone is used to treat depression and can help with insomnia due to its sedative effects. Taking it may make you feel drowsy or forgetful, especially if you are elderly. However, it can also be dangerous as it can cause priapism, which is a long-lasting and painful erection that can cause permanent damage to the nerves if not treated. If you experience this, you should seek medical attention right away.
How Oleptro works in the bodyThe exact way that trazodone works is not known, but it is thought to block the reuptake of serotonin in the brain. This prevents serotonin from being broken down and allows it to stay in the brain longer, which can help reduce symptoms of depression. Trazodone also blocks histamine and alpha-1-adrenergic receptors, which helps prevent further serotonin breakdown. Lastly, trazodone inhibits serotonin transporters, which helps keep serotonin in the brain longer. All of these processes help reduce symptoms of depression.

When to interrupt dosage

The suggested measure of Oleptro is contingent upon the diagnosed condition, for example, Insomnia, Schizophrenia and Pain. The measure of dosage also differs as per the technique of delivery (e.g. Tablet, extended release - Oral or Tablet - Oral) outlined in the given table.
Condition
Dosage
Administration
Insomnia
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Generalized Anxiety Disorder
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Alzheimer's Disease
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Eating Disorders
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Depression
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Fibromyalgia
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Alcoholism
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Pain
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Pain
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Schizophrenia
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Alzheimer's Disease
, 50.0 mg, 100.0 mg, 150.0 mg, 300.0 mg, 68.25 mg, 75.0 mg, 0.5 mg, 1.0 mg
Oral, Tablet, Tablet - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit

Warnings

Oleptro Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Oleptro.
Common Oleptro Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Trazodone.
Abexinostat
Major
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Abexinostat.
Acebutolol
Major
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Acebutolol.
Acepromazine
Major
Trazodone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Trazodone is combined with Aceprometazine.
Oleptro Toxicity & Overdose RiskThe toxic dose of trazodone for rats is 690mg/kg. An overdose of trazodone can cause difficulty breathing, slow heartbeat, low blood pressure, confusion, lack of coordination, and even coma. It can also lead to a persistent and unrelievable erection of the penis that may be permanent if not treated quickly. There is no specific antidote for a trazodone overdose. If an overdose occurs, it is possible that trazodone was mixed with other drugs, so contact a poison control center for guidance. Dialysis will not help remove trazodone from the body.
image of a doctor in a lab doing drug, clinical research

Oleptro Novel Uses: Which Conditions Have a Clinical Trial Featuring Oleptro?

A formidable number of 948 active trials are presently analyzing the potential of Oleptro to ameliorate Schizophrenia, Alzheimer's Disease and Pain.
Condition
Clinical Trials
Trial Phases
Fibromyalgia
0 Actively Recruiting
Eating Disorders
0 Actively Recruiting
Alzheimer's Disease
252 Actively Recruiting
Phase 1, Phase 4, Phase 2, Phase 3, Not Applicable, Early Phase 1
Alcoholism
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Insomnia
89 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Pain
1 Actively Recruiting
Phase 1
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Alzheimer's Disease
41 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Depression
200 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Generalized Anxiety Disorder
245 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Pain
0 Actively Recruiting

Oleptro Reviews: What are patients saying about Oleptro?

5Patient Review
12/7/2010
Oleptro for Major Depressive Disorder
I strongly recommend avoiding this treatment. I had terrible dreams and felt like I had a hangover the next day.
5Patient Review
2/5/2012
Oleptro for Major Depressive Disorder
It was tough to fall asleep after taking this medication, and I also experienced some discomfort with my muscles. However, I didn't gain any weight, which is great.
5Patient Review
2/7/2011
Oleptro for Major Depressive Disorder
I experienced vertigo, loss of focus and concentration, slurred speech (like being drunk), and extreme difficulty waking up in the morning. I was also very tired.
5Patient Review
10/7/2010
Oleptro for Major Depressive Disorder
4.7Patient Review
10/13/2011
Oleptro for Major Depressive Disorder
I've been taking Oleptro for four months now and it's done wonders for my mood, restless legs, sleep quality, and even some of my ADHD symptoms. The only downside is that insurance doesn't cover it so I have to rely on samples from my doctor.
4.7Patient Review
5/6/2011
Oleptro for Major Depressive Disorder
I had to stop taking Lexapro because I started putting on weight. However, Oleptro has worked great for me so far. Not only was I able to fall asleep, but I stayed asleep through the night--a problem Lunesta couldn't address. My doctor is now treating my depression and sleep problems with a single 300mg dose of Oleptro taken at bedtime.
4.7Patient Review
3/9/2011
Oleptro for Major Depressive Disorder
I unfortunately had to discontinue this medication because it caused me intense night sweats and muscle aches. However, while I was taking it I did notice a significant improvement in my depression.
2.7Patient Review
2/8/2011
Oleptro for Major Depressive Disorder
So far, I'm really liking this. I've tried Lexapro and Pristiq in the past, but both came with a range of unpleasant side effects. This medication has helped me sleep better than ever before, and I haven't experienced any weight gain or sexual side effects.
2.3Patient Review
10/29/2010
Oleptro for Major Depressive Disorder
I don't have any trouble sleeping at night or gaining weight while taking this medication, which is great.
2Patient Review
2/27/2011
Oleptro for Major Depressive Disorder
I experienced some really unpleasant side effects while taking this medication, including dizziness, sexual dysfunction, and tingling/numbness in my extremities. It also didn't help me sleep any better as was intended, so I stopped taking it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about oleptro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Oleptro still available?

"The Oleptro brand name has been discontinued and there are no generic equivalents available in the U.S. as of May 23, 2022."

Answered by AI

Is trazodone a sleeping pill?

"The medication trazodone was originally designed to treat depression and anxiety disorders, but is now also commonly prescribed as a sleep aid for those who suffer from acute insomnia."

Answered by AI

What is Oleptro used for?

"Oleptro is an antidepressant medication used to treat major depressive disorder. It specifically works to balance chemicals in the brain that may be unbalanced in people who suffer from depression. In addition to treating major depressive disorder, Oleptro may also be used for other purposes not listed in the medication guide."

Answered by AI

Is Oleptro the same as trazodone?

"Trazodone hydrochloride extended-release tablets are a prescription medicine used to treat the symptoms of depression."

Answered by AI

Clinical Trials for Oleptro

Have you considered Oleptro clinical trials? We made a collection of clinical trials featuring Oleptro, we think they might fit your search criteria.
Have you considered Oleptro clinical trials? We made a collection of clinical trials featuring Oleptro, we think they might fit your search criteria.
Have you considered Oleptro clinical trials? We made a collection of clinical trials featuring Oleptro, we think they might fit your search criteria.
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