Ofev

Pulmonary Fibrosis, Systemic Scleroderma, Respiratory Function Impaired

Treatment

1 Active Study for Ofev

Treatment for

Pulmonary Fibrosis

What is Ofev

Nintedanib

The Generic name of this drug

Treatment Summary

Nintedanib is a medication used to treat lung diseases such as pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC). It was approved by the FDA in 2014 and is used as the first treatment option for idiopathic pulmonary fibrosis. For NSCLC it is used in combination with Docetaxel to treat patients who have already tried other chemotherapy treatments.

Ofev

is the brand name

image of different drug pills on a surface

Ofev Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ofev

Nintedanib

2014

Effectiveness

How Ofev Affects Patients

Nintedanib is a drug that blocks certain enzymes, helping to stop the growth of fibroblasts and cells in tumours. Taking this drug carries a risk of liver damage, so liver function tests must be done before starting the drug and regularly during the first three months. People with existing liver problems should not take Nintedanib.

How Ofev works in the body

Nintedanib is a medicine used to treat diseases such as lung fibrosis, non-small cell lung cancer, and systemic sclerosis-associated interstitial lung disease. It works by blocking certain proteins that help cells grow and spread. These proteins are known as receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Nintedanib binds to the ATP-binding pocket of these proteins and stops them from working. This action stops the growth and spread of cells, including those in tumour tissue. It also inhibits signalling pathways in the cells, which

When to interrupt dosage

The measure of Ofev is dependent on the diagnosed affliction, including Adenocarcinoma, Respiratory Function Impaired and Systemic Scleroderma. The amount of dosage fluctuates as per the technique of delivery (e.g. Capsule - Oral or Capsule) outlined in the table beneath.

Condition

Dosage

Administration

Pulmonary Fibrosis

100.0 mg, , 150.0 mg

, Capsule, Oral, Capsule - Oral

Systemic Scleroderma

100.0 mg, , 150.0 mg

, Capsule, Oral, Capsule - Oral

Respiratory Function Impaired

100.0 mg, , 150.0 mg

, Capsule, Oral, Capsule - Oral

Warnings

Ofev Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Nintedanib may interact with Pulse Frequency

There are 20 known major drug interactions with Ofev.

Common Ofev Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Nintedanib is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Nintedanib is combined with (S)-Warfarin.

3,5-Diiodotyrosine

Moderate

The therapeutic efficacy of 3,5-Diiodotyrosine can be decreased when used in combination with Nintedanib.

3,5-diiodothyropropionic acid

Moderate

The therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Nintedanib.

4-hydroxycoumarin

Moderate

The risk or severity of bleeding can be increased when Nintedanib is combined with 4-hydroxycoumarin.

Ofev Toxicity & Overdose Risk

People who have taken too much nintedanib may experience elevated liver enzymes and digestive problems, which are known side effects. No specific treatments exist for nintedanib overdose, so it is important to stop taking the drug and get supportive care if needed.

image of a doctor in a lab doing drug, clinical research

Ofev Novel Uses: Which Conditions Have a Clinical Trial Featuring Ofev?

Two active studies are presently assessing the utility of Ofev in alleviating Adenocarcinoma, Pulmonary Fibrosis and Impaired Respiratory Function.

Condition

Clinical Trials

Trial Phases

Respiratory Function Impaired

1 Actively Recruiting

Not Applicable

Systemic Scleroderma

0 Actively Recruiting

Pulmonary Fibrosis

0 Actively Recruiting

Ofev Reviews: What are patients saying about Ofev?

Patient Review

6/10/2019

Ofev for idiopathic pulmonary fibrosis

I was diagnosed with IPF in August of 2018 and after taking prednisone for a bit my Dr switched me Ofev. I've been on this therapy for a while now and according to my pulmonary Dr my lungs have not worsened although they are stable for now.

Patient Review

5/17/2017

Ofev for Lung Fibrosis

I was diagnosed with IPF and started taking Esbriet, but it made me so incredibly tired. My pulmonologist switched me to OFEV and I feel SO much better. There are barely any side effects and my lung functions have been stable for six months now.

4.3

Patient Review

8/2/2022

Ofev for idiopathic pulmonary fibrosis

I've only been on the medication for three weeks, but I already have much more energy. My cough is also almost entirely gone. The diarrhea is a bit of an issue, but it's manageable. Napping has become a regular part of my afternoon routine since starting this drug, but I know it's still early days yet.

Patient Review

9/6/2021

Ofev for idiopathic pulmonary fibrosis

After taking this medication for five months, I started having severe diarrhea. However, Imodium in the morning and a banana with each dose of the medication, as well as a daily probiotic, really helped. I would recommend this to anyone else experiencing similar problems.

3.3

Patient Review

5/30/2016

Ofev for Lung Fibrosis

I was diagnosed 12/2015 and have been taking Ofev for 4 months. I'm not sure how effective it is, but I might get a better idea from a CT scan. Fatigue and mild diarrhea are the only side effects I've experienced so far.

3.3

Patient Review

9/9/2016

Ofev for Lung Fibrosis

I was diagnosed in 2016 and started this treatment a few months ago. I'm working and haven't experienced any side effects yet, which may have something to do with my age/weight/general health.

2.3

Patient Review

8/16/2016

Ofev for Lung Fibrosis

I began taking Esbriet as part of a clinical trial in 2014. However, by 2016 my doctor switched me to OFEV after noticing that my IPF had progressed significantly. OFEV is only 2 pills at 150mg each, while Esbriet was 9 pills at 267mg each. Additionally, Esbriet would make me drowsy and I'd fall asleep within 30 minutes of taking it; however, the only side effect I've experienced with OFEV is a rash which can be treated with Benedryl. It's hard to say if either medication works better than the other, but we do what we can and hope

Patient Review

2/8/2022

Ofev for progressive fibrosing interstitial lung disease

About three weeks into treatment, I started noticing that I was more tired than usual and having trouble catching my breath. This got progressively worse over the next few months to the point where even simple tasks like getting dressed for work would leave me out of breath. I stopped taking the medication in hopes of returning to my previous level of fitness, but so far it hasn't made much difference.

1.7

Patient Review

8/15/2016

Ofev for Lung Fibrosis

I was placed on this drug by a lung specialist, but had to stop taking it after just three weeks due to its constant side effects of bathroom trips, dizziness, and weakness. Blue Cross also reversed the charge for the second prescription because of its ineffectiveness.

1.3

Patient Review

12/29/2020

Ofev for Lung Fibrosis

I was on this medication for eight months and saw very slow progress. However, once I started taking Ofev, my symptoms got much worse. I constantly felt nauseous and had a hard time breathing. This drug did not help me at all, so I stopped taking it.

1.3

Patient Review

3/1/2022

Ofev for idiopathic pulmonary fibrosis

After taking ofev for three months, I developed congestive heart failure and had to be taken off the medication. Additionally, I lost my sense of taste while taking this drug.

1.3

Patient Review

12/17/2019

Ofev for Lung Fibrosis

I took Ofev for seven weeks to try and treat my pulmonary fibrosis, but unfortunately saw zero benefit. On the contrary, I felt generally horrible the entire time I was on it--back pain, stomach pains, diarrhea. It's possible that I'm too far gone for this medication to be effective.

Patient Review

12/29/2020

Ofev for idiopathic pulmonary fibrosis

My pulmonary fibrosis had been progressing very slowly over years, but when I was put on Ofev, all of my symptoms got worse. Now I'm constantly coughing and feeling short of breath, on top of the nausea I already felt most of the time. This drug doesn't seem to be helping at all and so I've decided to stop taking it.

Patient Review

1/4/2020

Ofev for idiopathic pulmonary fibrosis

I have had pulmonary fibrosis for a number of years and tried OFEV for two months. There were terrible side effects with no benefits that I could see. It made me feel nauseous, gave me diarrhea, and caused sharp pains in my sides. discontinuing use was the best decision I ever made regarding this drug.

Patient Review

9/6/2021

Ofev for idiopathic pulmonary fibrosis

I stopped using this product on May 20th and I'm still experiencing diarrhea today, September 6th. Not happy with the results, to say the least.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ofev

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does OFEV do for the lungs?

"Preclinical studies indicate that OFEV has the potential to significantly inhibit the development of fibrosis.

OFEV is a drug that is used to treat a rare lung disease called idiopathic pulmonary fibrosis (IPF). IPF is a serious and progressive condition in which the lungs become scarred and damaged, making it increasingly difficult to breathe. There is currently no cure for IPF.

OFEV is a medication that is used to treat idiopathic pulmonary fibrosis, a rare lung disease where the lungs become scarred and damaged over time, making it difficult to breathe. OFEV works by blocking some of the activity in the cells that cause this scarring."

Answered by AI

What does Ofev do for the lungs?

"OFEV is a medication that is used to block the activity of cells that cause scarring in the lungs. OFEV is a type of targeted therapy known as a tyrosine kinase inhibitor (TKI), which works by disrupting the activity of specific cell proteins (tyrosine kinases) that are responsible for making scar tissue."

Answered by AI

Is Ofev a form of chemotherapy?

"What is Nintedanib?

Nintedanib is a drug that was approved by the U.S. Food and Drug Administration (FDA) in 2014 as a treatment for progressive lung scarring. In Europe, a version of the drug named Vargatef was also approved for use in chemotherapy for lung cancer."

Answered by AI

How long does Ofev increase life expectancy?

"2 recent studies have found that Esbriet (pirfenidone) and Ofev (nintedanib) can help improve the prognosis for patients with IPF by reducing the rate of decline in lung function and increasing life expectancy by a few years."

Answered by AI

What side effects does Ofev have?

"The most common side effects of OFEV are:

-Diarrhea -Nausea -Stomach pain -Vomiting -Liver problems -Decreased appetite -Headache -Weight loss -High blood pressure"

Answered by AI

What side effects does OFEV have?

"The side effects most commonly associated with OFEV are diarrhea, nausea, stomach pain, vomiting, liver problems, decreased appetite, headache, weight loss, and high blood pressure."

Answered by AI

How long does OFEV increase life expectancy?

"Two recent studies found that drugs like pirfenidone and nintedanib can prolong life expectancy and prevent decline in lung function for patients with IPF."

Answered by AI

Is OFEV a form of chemotherapy?

"Nintedanib is a drug that was first approved by the FDA in 2014 as a treatment for progressive lung scarring. In Europe, a version of the drug named Vargatef was approved for use in chemotherapy for lung cancer."

Answered by AI