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What is Nucynta Er
TapentadolThe Generic name of this drug
Treatment SummaryAn opioid medication used to treat moderate to severe pain. This drug was approved by the FDA in 2008 and is used to help manage pain.
Nucyntais the brand name
Nucynta Er Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nucynta
Tapentadol
2009
46
Effectiveness
How Nucynta Er Affects PatientsTapentadol is a synthetic painkiller that is 18 times weaker than morphine. It works by increasing the amount of a type of brain chemical (norepinephrine) and can be blocked by special antagonists like naloxone. Tapentadol does not affect the heart rate or rhythm.
How Nucynta Er works in the bodyTapendadol works by increasing the amount of the chemical norepinephrine in the body. It does this by binding to mu opioid receptors and blocking the reuptake of noradrenaline.
When to interrupt dosage
The suggested amount of Nucynta Er is contingent upon the identified condition, including intense, moderate Pain, Pain and Pain. The measure of dosage relies upon the method of administration (e.g. Tablet, extended release or Tablet, film coated, extended release - Oral) listed in the table beneath.Condition
Dosage
Administration
Diabetic Neuralgia
100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Pain
100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Pain
100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
acute, moderate Pain
100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Pain
100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Solution, Solution - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Warnings
Nucynta Er ContraindicationsCondition
Risk Level
Notes
Bronchial Asthma
Do Not Combine
Paralytic Ileus
Do Not Combine
Hypercapnia
Do Not Combine
Pulse Frequency
Do Not Combine
Respiratory Function Impaired
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Mental Depression
Do Not Combine
Common Nucynta Er Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Tapentadol is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Azelastine
Major
Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Benmoxin
Major
The risk or severity of adverse effects can be increased when Tapentadol is combined with Benmoxin.
Brofaromine
Major
The risk or severity of adverse effects can be increased when Tapentadol is combined with Brofaromine.
Caroxazone
Major
The risk or severity of adverse effects can be increased when Tapentadol is combined with Caroxazone.
Nucynta Er Toxicity & Overdose RiskTests in rabbits, mice, and rats have shown the toxic dose of this drug to be 3200mg/kg, 300mg/kg, and 980mg/kg respectively. The most common side effects reported in patients taking this drug are dizziness, nausea, vomiting, drowsiness, and headaches.
Nucynta Er Novel Uses: Which Conditions Have a Clinical Trial Featuring Nucynta Er?
Presently, one clinical trial is assessing the viability of Nucynta Er in providing relief from acute, moderate Pain and Pain.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Diabetic Neuralgia
3 Actively Recruiting
Phase 2, Phase 1
acute, moderate Pain
0 Actively Recruiting
Pain
0 Actively Recruiting
Nucynta Er Reviews: What are patients saying about Nucynta Er?
5Patient Review
6/29/2017 Cymbalta on its own didn't quite cut it for my fibromyalgia pain, but adding this medication to the mix finally allowed me to get relief and function normally again. I'm really thankful that I found this treatment; it's been a life-changer.
5Patient Review
8/11/2017 I've been struggling with chronic pain for years now, and I've tried a lot of different medications. Nucynta ER is definitely the best in terms of providing relief without making me feel out of it. It's also easy on my stomach, which is a big plus since I have IBS.
5Patient Review
11/1/2017 I have fibromyalgia and three cysts in my lower left sacrum. I had an operation to remove them, but the nerves were too close to the cysts so they may have caused a spinal fluid leak. They did a laminectomy, but there was no relief. I was on two 50 mg iron tabs and I would wake up every night in pain. Now I am on 100mg er and it really does work for 12 hours. I've been walking a lot since I started
5Patient Review
8/11/2017 Nucynta ER has been the best pain medication I've tried in years. Not only does it relieve my chronic neck and back pain, but it doesn't make me feel high or fuzzy-headed. Additionally, it's easy on my stomach compared to other medications I've taken for my IBS.
5Patient Review
11/1/2017 This treatment has been a godsend for me. I have fibromyalgia and three cysts in my lower left sacrum, which caused me a lot of pain. I had an operation to remove them, but it didn't provide any relief. I was taking two 50 mg iron tablets every night, but I would still wake up in pain. Now that I'm on the 100 mg extended release version, I don't have any pain at all and I can walk around without any problem.
5Patient Review
6/29/2017 Cymbalta on its own did not provide me with enough pain relief to get through my day-to-day life. However, once I added this medication, I found that my pain was much more manageable and tolerable. This has been a huge help in being able to keep my job and maintain some semblance of a normal life.
4.3Patient Review
8/11/2017 I have chronic pain from degenerative disk disease in my neck, right shoulder, right arm and hand. I used to take Oxycodone but hated the high feeling. Nucynta ER is much better for me.
4.3Patient Review
8/11/2017 I suffer from chronic pain from degenerative disk disease in my neck, right shoulder, right arm and hand. I use to take Oxycodone but hated the high feeling. I've taken Nucynta ER
4Patient Review
10/25/2016 Spinal Stenosis due to scar tissue from previous surgery at L5/S1. Worked better for my chronic pain at higher doses 200 to 300mg 2X/day. I been on it for just over a year, but a doctor recommended taking me off as it is still an opoid narcotic and not recommended for longer-term use (if a non-narcotic substitute can be helpful). Glad to have received the pain relief when I needed it most.
4Patient Review
10/25/2016 Spinal Stenosis due to scar tissue from previous surgery at L5/S1. Worked better for my chronic pain at higher doses 200 to 300mg 2X/day. I been on it for just over a year, but a doctor recommended taking me off as it is still an opoid narcotic and not recommended for longer-term use (if a non-narcotic substitute can be helpful). Glad to have received the pain relief when I needed it most.
3.3Patient Review
10/27/2022 I was in a car accident and Nucynta has helped with the pain, though I sweat terribly as a result. Has anyone else had this problem?
3.3Patient Review
9/6/2016 I've just started taking this medication, but thus far I haven't experienced any negative side effects.
3.3Patient Review
10/27/2022 Nucynta has been helpful for my pain management following a car accident, though I have experienced some extreme sweating as a side effect. If anyone has suggestions of other medications that might work better for me, please let me know.
3.3Patient Review
9/6/2016 I've just started taking this medication, but thus far I haven't experienced any negative side effects.
2.7Patient Review
1/2/2019 The 200mg slow release was difficult for me to break down, and I had to take it on an empty stomach to feel any pain relief. It also didn't last 12 hours like advertised; more like 10 hours.
2.7Patient Review
1/2/2019 The 200mg slow release is hard to breakdown after they changed the composition, and I have to take it on an empty stomach to feel any pain relief. It doesn't last 12 hours; more like 10. And my digestion is really fragile and slow despite my healthy efforts.
1Patient Review
6/28/2017 Not only was this medication over-priced, but the pharmacy never had it in stock. This made it very difficult to get a hold of and ended up being quite frustrating. On top of that, it actually increased my foot pain rather than helping it.
1Patient Review
5/5/2019 Despite being on 50mg of Nucynta for three days, I have yet to experience any pain relief from the nerve damage in my SI joints. From what I can tell, it looks like I'll need at least 100mg for this medication to be effective. This is my fifth attempt at finding a pain med that works, and so far nothing has been successful.
1Patient Review
4/28/2018 I have chronic pain and have had two failed back surgeries. I'm currently herniated in my disc and need another surgery. This drug did not work for me at all and I experienced terrible withdrawal symptoms. My advice is to never take it.
1Patient Review
6/28/2017 Not only was this medication overpriced, but the pharmacy never had it in stock. It would take up to four days to get, and actually increased my foot pain. The drug has serotonin to help with depression which always had a negative effect on me. In short: I do not recommend this drug for chronic pain sufferers.
1Patient Review
5/5/2019 So far, no luck with this medication in terms of pain relief for nerve damage in my SI joints. I may need to increase the dosage, but we'll see.
1Patient Review
4/28/2018 I have chronic pain and have had two failed back surgeries. I'm currently herniated in my lower back and need another surgery. This drug hasn't been working for me as intended, so I'll be contacting the doctor soon. I've also had severe withdrawal from Duragesic Fentanyl patches. So all in all, I would advise against taking this medication.
Patient Q&A Section about nucynta er
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for Nucynta ER to start working?
"When will I start to feel better?
You should notice some pain relief within 3-6 hours of taking extended release tapentadol. With continued twice daily dosing, a steady amount of drug will be present in the blood supply and help achieve continuous pain relief."
Answered by AI
What are the side effects of Nucynta ER?
"The following side effects may occur: nausea, vomiting, constipation, dizziness, drowsiness, dry mouth, increased sweating, or tiredness. To prevent constipation, eat dietary fiber, drink enough water, and exercise. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position."
Answered by AI
How often can you take nucynta ER?
"The recommended starting dose for patients who are not opioid tolerant is NUCYNTA ER 50 mg orally twice daily. Use of higher starting doses in patients who are not opioid tolerant can cause fatal respiratory depression."
Answered by AI
How does nucynta ER make you feel?
"Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders. Nucynta ER may cause common side effects including: constipation, nausea, vomiting, stomach pain; headache, feeling tired; or."
Answered by AI