Norvir

Hepatitis C, Chronic, Hepatitis C, Chronic, Obesity + 3 more
Treatment
1 FDA approval
20 Active Studies for Norvir

What is Norvir

RitonavirThe Generic name of this drug
Treatment SummaryRitonavir is an antiviral medicine used to treat HIV, and is often used in combination with other medications. It is also used to boost the effects of other protease inhibitors. Ritonavir is available in liquid form and as capsules. It is usually combined with other medications to treat hepatitis C virus (HCV), and is found in fixed-dose combination products such as Viekira Pak and Technivie. In Canada, it is also available in Holkira Pak. Ritonavir can cause HIV-1 protease inhibitor resistance if used with HCV/HIV-1 co-infected patients
Kaletrais the brand name
image of different drug pills on a surface
Norvir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kaletra
Ritonavir
2000
50

Approved as Treatment by the FDA

Ritonavir, also called Kaletra, is approved by the FDA for 1 uses which include HIV .
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null

Effectiveness

How Norvir Affects PatientsRitonavir is a drug used to treat HIV-1 by blocking a specific enzyme (protease) that the virus needs to survive. By doing this, it prevents the virus from being able to form infectious particles. It is usually taken in combination with other anti-HIV drugs, and a low dose of ritonavir is often added to increase the effectiveness of the other drugs.
How Norvir works in the bodyRitonavic works by blocking the cleavage of two important proteins in the HIV virus, *gag* and *pol*. This prevents the virus from maturing and forming infectious particles. Ritonavir also works by preventing the cytochrome P450 enzyme from breaking down other protease inhibitors, as well as blocking cellular transport of these inhibitors.

When to interrupt dosage

The measure of Norvir is contingent upon the identified illness, such as weight 40 kg or more, HIV (Human Immunodeficiency Virus) and Mild to Moderate COVID-19. The dosage amount fluctuates as per the administration strategy (e.g. Oral or Tablet, film coated - Oral) presented in the table below.
Condition
Dosage
Administration
Hepatitis C, Chronic
, 50.0 mg, 100.0 mg, 25.0 mg, 20.0 mg/mL, 80.0 mg/mL, 33.3 mg, 33.33 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Kit; Tablet, Kit; Tablet - Oral, Powder, Powder - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, liquid filled, Capsule, liquid filled - Oral, Powder, for suspension, Powder, for suspension - Oral
COVID-19
, 50.0 mg, 100.0 mg, 25.0 mg, 20.0 mg/mL, 80.0 mg/mL, 33.3 mg, 33.33 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Kit; Tablet, Kit; Tablet - Oral, Powder, Powder - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, liquid filled, Capsule, liquid filled - Oral, Powder, for suspension, Powder, for suspension - Oral
Hepatitis C, Chronic
, 50.0 mg, 100.0 mg, 25.0 mg, 20.0 mg/mL, 80.0 mg/mL, 33.3 mg, 33.33 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Kit; Tablet, Kit; Tablet - Oral, Powder, Powder - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, liquid filled, Capsule, liquid filled - Oral, Powder, for suspension, Powder, for suspension - Oral
HIV
, 50.0 mg, 100.0 mg, 25.0 mg, 20.0 mg/mL, 80.0 mg/mL, 33.3 mg, 33.33 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Kit; Tablet, Kit; Tablet - Oral, Powder, Powder - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, liquid filled, Capsule, liquid filled - Oral, Powder, for suspension, Powder, for suspension - Oral
Obesity
, 50.0 mg, 100.0 mg, 25.0 mg, 20.0 mg/mL, 80.0 mg/mL, 33.3 mg, 33.33 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Kit; Tablet, Kit; Tablet - Oral, Powder, Powder - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, liquid filled, Capsule, liquid filled - Oral, Powder, for suspension, Powder, for suspension - Oral
SARS-CoV-2 Positive Patients
, 50.0 mg, 100.0 mg, 25.0 mg, 20.0 mg/mL, 80.0 mg/mL, 33.3 mg, 33.33 mg, 100.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Kit; Tablet, Kit; Tablet - Oral, Powder, Powder - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, liquid filled, Capsule, liquid filled - Oral, Powder, for suspension, Powder, for suspension - Oral

Warnings

Norvir Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulmonary Arterial Hypertension
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Norvir.
Common Norvir Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ritonavir.
Alfuzosin
Major
The serum concentration of Alfuzosin can be increased when it is combined with Ritonavir.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ritonavir.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Ritonavir.
Anagrelide
Major
The metabolism of Anagrelide can be increased when combined with Ritonavir.
Norvir Toxicity & Overdose RiskRitonavir overdose is not common, but one patient reported tingling sensations after taking too much of the drug. Additionally, one case of kidney failure has been reported. Doses of ritonavir that are more than twenty times the normal amount for humans are thought to be fatal for rats, and ten times the normal amount for humans is thought to be fatal for mice. Taking too much ritonavir may also lead to liver damage, pancreatitis, and allergic reactions.
image of a doctor in a lab doing drug, clinical research

Norvir Novel Uses: Which Conditions Have a Clinical Trial Featuring Norvir?

43 active studies are currently being conducted to assess the utility of Norvir in treating Chronic hepatitis C genotype 1a, weight 40 kg or more and Human Immunodeficiency Virus (HIV).
Condition
Clinical Trials
Trial Phases
COVID-19
0 Actively Recruiting
Obesity
0 Actively Recruiting
HIV
38 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Not Applicable, Phase 1, Phase 4
Hepatitis C, Chronic
0 Actively Recruiting
Hepatitis C, Chronic
0 Actively Recruiting
SARS-CoV-2 Positive Patients
0 Actively Recruiting

Norvir Reviews: What are patients saying about Norvir?

5Patient Review
5/15/2009
Norvir for HIV
I highly recommend this medication. I missed a few days (3) due to a pharmacy error and felt awful as a result - tired, sick, and lethargic. So please don't skip any doses!
5Patient Review
11/3/2007
Norvir for HIV
5Patient Review
6/17/2008
Norvir for HIV
I started sweating within an hour of taking the medication, and I also experienced some withdrawal symptoms.
5Patient Review
5/17/2014
Norvir for HIV
I'm wondering if Norviera has affected my heart and cholesterol levels. I've never had issues with cholesterol before, but now I do.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about norvir

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is Norvir?

"Protease inhibitors interfere with an HIV enzyme called protease which is needed for the HIV virus to multiply.

Protease inhibitors are a class of drugs that prevent the HIV virus from multiplying. This class of drugs includes indinavir (Crixivan), nelfinavir (Viracept), emtricitabine (Emtriva) and saquinavir (Invirase, Fortovase). When a person is infected with HIV, the virus multiplies within the body's cells. Protease inhibitors work by interfering with an HIV enzyme called protease, which is necessary for the virus to multiply."

Answered by AI

What is the brand Name for Norvir?

"Ritonavir is a prescription medication approved by the FDA for the treatment of HIV infection in adults and children. It is always used in combination with other HIV medications."

Answered by AI

What are the side effects of Norvir?

"If you experience any of the following effects for an extended period of time, you should speak with a doctor: diarrhea, nausea, vomiting, heartburn, stomach pain, dizziness, tiredness, weakness, changes in taste, or tingling/numbness of the mouth area."

Answered by AI

What is Norvir used for?

"The oral powder form of NORVIR is a prescription medicine used in conjunction with other antiviral medications to treat children with HIV-1 infection. HIV-1 is the virus that causes AIDS."

Answered by AI

Clinical Trials for Norvir

Have you considered Norvir clinical trials? We made a collection of clinical trials featuring Norvir, we think they might fit your search criteria.
Have you considered Norvir clinical trials? We made a collection of clinical trials featuring Norvir, we think they might fit your search criteria.
Have you considered Norvir clinical trials? We made a collection of clinical trials featuring Norvir, we think they might fit your search criteria.
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