What is Norvir
RitonavirThe Generic name of this drug
Treatment SummaryRitonavir is an antiviral medicine used to treat HIV, and is often used in combination with other medications. It is also used to boost the effects of other protease inhibitors. Ritonavir is available in liquid form and as capsules. It is usually combined with other medications to treat hepatitis C virus (HCV), and is found in fixed-dose combination products such as Viekira Pak and Technivie. In Canada, it is also available in Holkira Pak. Ritonavir can cause HIV-1 protease inhibitor resistance if used with HCV/HIV-1 co-infected patients
Kaletrais the brand name
Norvir Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kaletra
Ritonavir
2000
50
Approved as Treatment by the FDA
Ritonavir, also called Kaletra, is approved by the FDA for 1 uses which include HIV .HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with null
Effectiveness
How Norvir Affects PatientsRitonavir is a drug used to treat HIV-1 by blocking a specific enzyme (protease) that the virus needs to survive. By doing this, it prevents the virus from being able to form infectious particles. It is usually taken in combination with other anti-HIV drugs, and a low dose of ritonavir is often added to increase the effectiveness of the other drugs.
How Norvir works in the bodyRitonavic works by blocking the cleavage of two important proteins in the HIV virus, *gag* and *pol*. This prevents the virus from maturing and forming infectious particles. Ritonavir also works by preventing the cytochrome P450 enzyme from breaking down other protease inhibitors, as well as blocking cellular transport of these inhibitors.
When to interrupt dosage
The measure of Norvir is contingent upon the identified illness, such as weight 40 kg or more, HIV (Human Immunodeficiency Virus) and Mild to Moderate COVID-19. The dosage amount fluctuates as per the administration strategy (e.g. Oral or Tablet, film coated - Oral) presented in the table below.Condition
Dosage
Administration
weight 40 kg or more
20.0 mg/mL, 50.0 mg, , 100.0 mg, 33.33 mg, 100.0 mg/mL, 25.0 mg, 80.0 mg/mL, 33.3 mg
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
SARS-CoV-2 Positive Patients
20.0 mg/mL, 50.0 mg, , 100.0 mg, 33.33 mg, 100.0 mg/mL, 25.0 mg, 80.0 mg/mL, 33.3 mg
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
HIV
20.0 mg/mL, 50.0 mg, , 100.0 mg, 33.33 mg, 100.0 mg/mL, 25.0 mg, 80.0 mg/mL, 33.3 mg
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Mild to Moderate COVID-19
20.0 mg/mL, 50.0 mg, , 100.0 mg, 33.33 mg, 100.0 mg/mL, 25.0 mg, 80.0 mg/mL, 33.3 mg
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Chronic hepatitis C genotype 1a
20.0 mg/mL, 50.0 mg, , 100.0 mg, 33.33 mg, 100.0 mg/mL, 25.0 mg, 80.0 mg/mL, 33.3 mg
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Chronic hepatitis C genotype 1b
20.0 mg/mL, 50.0 mg, , 100.0 mg, 33.33 mg, 100.0 mg/mL, 25.0 mg, 80.0 mg/mL, 33.3 mg
Oral, Tablet, film coated - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, , Tablet, film coated, Capsule - Oral, Capsule, Solution - Oral, Kit; Tablet, film coated, Solution, Kit; Tablet; Tablet, film coated, Kit; Tablet; Tablet, film coated - Oral, Powder - Oral, Powder, Tablet - Oral, Kit; Tablet, film coated - Oral, Capsule, liquid filled, Powder, for suspension, Tablet, extended release - Oral, Capsule, liquid filled - Oral, Powder, for suspension - Oral, Tablet, extended release
Warnings
Norvir ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Pulmonary Arterial Hypertension
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Common Norvir Drug Interactions
Drug Name
Risk Level
Description
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Ritonavir.
Alfuzosin
Major
The serum concentration of Alfuzosin can be increased when it is combined with Ritonavir.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ritonavir.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Ritonavir.
Anagrelide
Major
The metabolism of Anagrelide can be increased when combined with Ritonavir.
Norvir Toxicity & Overdose RiskRitonavir overdose is not common, but one patient reported tingling sensations after taking too much of the drug. Additionally, one case of kidney failure has been reported. Doses of ritonavir that are more than twenty times the normal amount for humans are thought to be fatal for rats, and ten times the normal amount for humans is thought to be fatal for mice. Taking too much ritonavir may also lead to liver damage, pancreatitis, and allergic reactions.
Norvir Novel Uses: Which Conditions Have a Clinical Trial Featuring Norvir?
43 active studies are currently being conducted to assess the utility of Norvir in treating Chronic hepatitis C genotype 1a, weight 40 kg or more and Human Immunodeficiency Virus (HIV).Condition
Clinical Trials
Trial Phases
weight 40 kg or more
0 Actively Recruiting
Chronic hepatitis C genotype 1a
0 Actively Recruiting
HIV
45 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Phase 1, Phase 4, Not Applicable
Mild to Moderate COVID-19
0 Actively Recruiting
Chronic hepatitis C genotype 1b
0 Actively Recruiting
SARS-CoV-2 Positive Patients
0 Actively Recruiting
Norvir Reviews: What are patients saying about Norvir?
5Patient Review
5/15/2009 I highly recommend this medication. I missed a few days (3) due to a pharmacy error and felt awful as a result - tired, sick, and lethargic. So please don't skip any doses!
5Patient Review
11/3/20075Patient Review
6/17/2008 I started sweating within an hour of taking the medication, and I also experienced some withdrawal symptoms.
5Patient Review
5/17/2014 I'm wondering if Norviera has affected my heart and cholesterol levels. I've never had issues with cholesterol before, but now I do.
Patient Q&A Section about norvir
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What drug class is Norvir?
"Protease inhibitors interfere with an HIV enzyme called protease which is needed for the HIV virus to multiply.
Protease inhibitors are a class of drugs that prevent the HIV virus from multiplying. This class of drugs includes indinavir (Crixivan), nelfinavir (Viracept), emtricitabine (Emtriva) and saquinavir (Invirase, Fortovase). When a person is infected with HIV, the virus multiplies within the body's cells. Protease inhibitors work by interfering with an HIV enzyme called protease, which is necessary for the virus to multiply."
Answered by AI
What is the brand Name for Norvir?
"Ritonavir is a prescription medication approved by the FDA for the treatment of HIV infection in adults and children. It is always used in combination with other HIV medications."
Answered by AI
What are the side effects of Norvir?
"If you experience any of the following effects for an extended period of time, you should speak with a doctor: diarrhea, nausea, vomiting, heartburn, stomach pain, dizziness, tiredness, weakness, changes in taste, or tingling/numbness of the mouth area."
Answered by AI
What is Norvir used for?
"The oral powder form of NORVIR is a prescription medicine used in conjunction with other antiviral medications to treat children with HIV-1 infection. HIV-1 is the virus that causes AIDS."
Answered by AI