This trial is evaluating whether Nivolumab will improve 2 primary outcomes and 4 secondary outcomes in patients with Oral Squamous Cell Carcinoma. Measurement will happen over the course of From neoadjuvant therapy to surgical resection, approximately 4 weeks.
This trial requires 24 total participants across 3 different treatment groups
This trial involves 3 different treatments. Nivolumab is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"This is the first study to highlight major differences between Chinese and Western patterns of treatment for ESCC. Chinese patients are less likely to be prescribed multiple therapeutic modalities, and are more likely to be prescribed chemotherapy alone. Chinese patients also have a higher rate of relapse than their Western counterparts." - Anonymous Online Contributor
"OS: OSA, dysbarbituria, and/or PSA level >or=3 ng/ml were associated with an increased risk of OSCC; moreover, OSCC could be predicted by age, family history, dysbarbituria, hypertension, and/or OSA regardless of age, race, sex and comorbidities." - Anonymous Online Contributor
"The high incidence of cancer of the esophagus suggests that carcinoma of the esophagus is likely a significant cause of death from oral cancer. This may partly account for the high incidence of squamous cell carcinoma lesions in oral cavity and the large number of patients who come to our unit annually. This is the first study to show this association with esophageal cancer. It is also a first study of a large number of patients with esophageal cancer to confirm that some patients die from this disease only. This reinforces the need for urgent and careful planning for any management approach, including any neoadjuvant therapy, in patients with advanced OSCC to minimize the consequences of the disease, including cancer bone and brain metastases." - Anonymous Online Contributor
"Oral cancer can be cured. In selected circumstances, the use of surgery alone can be adequate and even curative; therefore, surgery can be the first approach in such cases." - Anonymous Online Contributor
"Cough, swollen neck gland, neck pain, and painless lumps, are the signs of oral squamous cell carcinoma. These symptoms may be associated with increased lymph node metastases. The location of the primary lesion, lymph node metastasis and histological type were the signs, which were significantly associated with the presence or absence of these painful or persistent signs. The incidence rate of these signs was lower in the women with the squamous cell carcinoma of skin, compared to the men, both in Taiwan and the western countries." - Anonymous Online Contributor
"Over 10% (40/409) of patients had a family history of [head and neck (CNS) cancer, especially oral cancer (p. 0.0001<0.0001)] or oral leukoplakia. Recent findings of this study demonstrated a strong association or family history of head and neck cancer and oral cancer in patients who attended a major Cancer Centre. The study indicated that patients who developed oral squamous cell carcinoma could have a genetic predisposition to oral cancer similar to other cancers in the head and neck region, such as head and neck cancers, tongue and neck cancers, and oropharyngeal cancers. The role of the risk factors and genetic predisposition need further research." - Anonymous Online Contributor
"Oral cancer, though not exclusive to the Mediterranean Basin, still has a disproportionately high toll of its victims. This is because many populations of the world lack the preventive measures offered by oral health education, especially smoking cessation. The risk for developing oral cancers is also heightened because of the socioeconomic and cultural challenges faced by developing countries that are still struggling to establish oral health systems. While the rate and severity of oral cancers is no less prominent in these countries, they lack many of the medical resources and capabilities to deal with the health related issues. Therefore, oral cancers remain a largely neglected topic in public health. It is therefore imperative that world leaders prioritize oral cancer prevention and treatment as a major global health campaign." - Anonymous Online Contributor
"This is the first documentation of nivolumab being studied prospectively in combination with standard of care treatment or in patients treated with a first line of chemotherapy. Overall, the most common adverse effects encountered were fatigue, diarrhea and skin hypersensitivity reactions. There were no grade ≥ 3 adverse effects." - Anonymous Online Contributor
"Nivolumab was well-tolerated with no apparent increased risk of adverse effects compared with the controls for comparators. This safety profile is similar to previous published neoadjuvant studies; patients who receive nivolumab in the neoadjuvant setting report no increased adverse effects. This information is particularly important as a number of patients requiring adjuvant treatment may be denied neoadjuvant treatment due to poor oral health." - Anonymous Online Contributor
"The tumour size and its initial location are the most important preclinical prognostic factors of OSCC. The OSCC tumour stage appears to be closely associated with local progression after radical treatment. Results from a recent paper therefore suggest that a careful determination of the clinical stage of the disease before treatment is required for the optimal management of individual cases." - Anonymous Online Contributor
"Nivolumab is a useful treatment option for patients with a first line of chemotherapy failure and should be included in clinical practice guidelines, as in Japan nivolumab might become the first-line therapeutic agent for patients with lung cancer." - Anonymous Online Contributor
"Nivolumab can be considered with other agents such as chemotherapy, targeted agents, immunotherapy (including immune checkpoint inhibitors) and radiotherapy. It can also be combined with surgical debridement in selected cases." - Anonymous Online Contributor