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What is Norpace
DisopyramideThe Generic name of this drug
Treatment SummaryProcainamide is a heart medication used to treat abnormal heart rhythms. It works by stabilizing the electrical activity in the heart, slowing down the heartbeat. It also has anticholinergic and numbing properties.
Norpaceis the brand name
Norpace Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norpace
Disopyramide
1977
30
Approved as Treatment by the FDA
Disopyramide, otherwise known as Norpace, is approved by the FDA for 1 uses which include Ventricular Arrhythmia .Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia
Effectiveness
How Norpace Affects PatientsDisopyramide is a drug used to treat dangerous heart rhythms, such as sustained ventricular tachycardia. Disopyramide helps to regulate the heartbeat and reduce the risk of life-threatening arrhythmias. It slightly increases the time it takes for the heart's natural pacemaker (sinus node) to reset, and it makes the heart's upper chambers (atria) less likely to develop arrhythmias. Disopyramide has no significant effect on the time it takes for electrical signals to travel through the heart's lower chambers (AV node) or other pathways, but it does slightly lengthen the
How Norpace works in the bodyDisopyramide is a medicine used to treat irregular heartbeats. It works by blocking sodium channels in the heart muscle, which helps to regulate the heart rate. Studies in animals have shown that disopyramide can reduce the speed of diastolic depolarization, decrease the speed at which the heart muscle contracts, and even help protect against damage to the heart muscle due to lack of oxygen. It does not affect alpha or beta receptors.
When to interrupt dosage
The approved dosage of Norpace is contingent upon the diagnosed condition. The measure of dosage also varies in accordance with the technique of delivery (e.g. Tablet, extended release - Oral or Oral) shown in the table beneath.Condition
Dosage
Administration
Ventricular Arrhythmia
, 100.0 mg, 150.0 mg, 250.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral
Warnings
Norpace has three contraindications, and it must not be taken together with the conditions outlined in the following table.Norpace ContraindicationsCondition
Risk Level
Notes
Prolonged QT interval
Do Not Combine
Shock, Cardiogenic
Do Not Combine
third degree AV block
Do Not Combine
Common Norpace Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Major
Disopyramide may increase the bradycardic activities of Acebutolol.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Disopyramide is combined with Aclidinium.
Alprenolol
Major
Disopyramide may increase the bradycardic activities of Alprenolol.
Anisodamine
Major
Disopyramide may increase the bradycardic activities of Anisodamine.
Arotinolol
Major
Disopyramide may increase the bradycardic activities of Arotinolol.
Norpace Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 580mg/kg.
Norpace Novel Uses: Which Conditions Have a Clinical Trial Featuring Norpace?
Four active clinical trials are presently underway to assess the potential of Norpace for Ventricular Arrhythmia management.Condition
Clinical Trials
Trial Phases
Ventricular Arrhythmia
2 Actively Recruiting
Not Applicable
Norpace Reviews: What are patients saying about Norpace?
4.7Patient Review
10/7/2013 Norpace has effectively stopped my heart palpitations. The only change I've noticed is that my blood pressure seems to be higher now, which is strange.
4.3Patient Review
8/19/2011 So far, this has been working well. No complaints!
4.3Patient Review
2/27/2013 I've had several issues with atrial fibrillation and have needed to go to the ER on three occasions. I find that Norpace is about 80-90% effective, which is great. However, I have slowly started experiencing erectile dysfunction over the 2-3 years of using this medication, and only recently realized that it could be a side effect of Norpace.
4Patient Review
1/13/2015 So far, so good! This medication has helped me immensely by curbing my irregular heartbeats. The gastrointestinal side effects are a bit of a nuisance, but overall I'm very pleased with the results.
1.7Patient Review
3/30/2009Patient Q&A Section about norpace
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of drug is Norpace?
"The drug Disopyramide is classified as a Class Ia antiarrhythmic drug, meaning it works on the sodium channels in the heart. Other Class Ia antiarrhythmics include procainamide and quinidine."
Answered by AI
Does Norpace cause weight gain?
"The following are symptoms of congestive heart failure: shortness of breath (even with mild exertion), swelling, rapid weight gain, or low blood sugar (headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery)."
Answered by AI
Is there a generic for Norpace?
"There is no cheaper generic version of Norpace CR available in the United States as of August 10th, 2022. Be wary of online pharmacies trying to sell you the medication, as it is likely counterfeit and dangerous."
Answered by AI
What is Norpace used to treat?
"This drug is used to treat some serious irregular heartbeats, which could be fatal. It is used to make the heart beat regularly again and at a steady pace. Disopyramide is anti-arrhythmic drug."
Answered by AI