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What is Norethindrone And Ethinyl Estradiol
NorethisteroneThe Generic name of this drug
Treatment SummaryNorethisterone (also known as norethindrone) is a hormone medication used to treat menstrual irregularity and endometriosis. It is a synthetic version of the hormone progesterone and is more powerful than the natural hormone. Norethisterone is also used in combination with other hormones for contraception and hormone replacement therapy. It was first developed in 1951 and approved for use as a contraceptive in 1962.
Neconis the brand name
Norethindrone And Ethinyl Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Necon
Norethisterone
1967
347
Effectiveness
How Norethindrone And Ethinyl Estradiol Affects PatientsNorethisterone is a type of medicine taken by mouth that is used for birth control or to treat other hormone-related conditions. It is a much stronger version of the hormone progesterone, and works by changing the cervical and endometrial function, as well as blocking hormones that are linked to ovulation. Taking this medicine may slightly increase the risk of developing breast cancer, so patients should be aware of this risk and do regular self-examinations to check for any lumps or masses.
How Norethindrone And Ethinyl Estradiol works in the bodyNorethisterone works by changing the environment of the reproductive tract to make it harder for sperm to move around, and making the endometrium inhospitable for implantation. It also suppresses the release of hormones that help with ovulation, preventing eggs from being released. When used in hormone replacement therapy, it suppresses the growth of the endometrium, reducing the risk of cancer. Finally, it has a low affinity for other hormone receptors, but can still cause some adverse effects like acne and changes in lipids.
When to interrupt dosage
The measure of Norethindrone And Ethinyl Estradiol is dependent on the determined illness, including Atrophic, Fracture and Hormone Replacement Therapy. The amount of dosage is contingent upon the method of administration (e.g. Oral or Tablet) as specified in the table below.Condition
Dosage
Administration
Hot flashes
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormone Replacement Therapy
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Atrophic
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
female castration
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Low Testosterone
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
hypoestrogenism
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Therapeutic procedure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Fracture
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Ovarian Failure
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Postmenopausal Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Vasomotor System
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Oral Contraceptives
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Hormonal Contraception
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Estrogen Deprivation Symptoms
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Menopause
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Birth Control
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Osteoporosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Endometriosis
0.014 mg/hour, , 0.025 mg/hour, 0.5 mg, 0.1 mg, 5.0 mg, 1.0 mg, 0.35 mg, 1.5 mg, 0.8 mg, 2.7 mg, 4.8 mg, 0.75 mg, 0.4 mg, 2.25 mg, 30.0 mg, 3.0 mg
Transdermal, Patch, extended release, , Patch, extended release - Transdermal, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit - Oral, Patch, Patch - Transdermal, Tablet, chewable, Tablet, chewable - Oral, Capsule - Oral, Capsule, Intramuscular; Oral; Topical
Warnings
Norethindrone And Ethinyl Estradiol has eight counterindications. It should not be administered if any of the conditions in the subsequent table are present.Norethindrone And Ethinyl Estradiol ContraindicationsCondition
Risk Level
Notes
active liver disease
Do Not Combine
Thrombophilia
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Malignant Neoplasms
Do Not Combine
Benign hepatic neoplasm
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Norethisterone may interact with Pulse Frequency
Common Norethindrone And Ethinyl Estradiol Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Norethisterone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norethisterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Norethisterone.
Clomipramine
Major
The metabolism of Clomipramine can be increased when combined with Norethisterone.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Norethisterone.
Norethindrone And Ethinyl Estradiol Toxicity & Overdose RiskThe lowest toxic dose of oral contraceptives in mice is 6g/kg, and in women is 42mg/kg. No serious side effects have been reported after overdose, but nausea and/or vomiting are likely to occur.
Norethindrone And Ethinyl Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Norethindrone And Ethinyl Estradiol?
160 active studies are currently underway to examine the potential of Norethindrone And Ethinyl Estradiol in providing Birth Control, Atrophic Uterine Conditions and Low Testosterone Levels.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Estrogen Deprivation Symptoms
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Endometriosis
32 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Oral Contraceptives
2 Actively Recruiting
Not Applicable
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Therapeutic procedure
0 Actively Recruiting
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Menopause
0 Actively Recruiting
Hormone Replacement Therapy
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Fracture
0 Actively Recruiting
female castration
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Vasomotor System
0 Actively Recruiting
Endometriosis
1 Actively Recruiting
Phase 4
Ovarian Failure
2 Actively Recruiting
Not Applicable, Phase 1
Hormonal Contraception
0 Actively Recruiting
Norethindrone And Ethinyl Estradiol Reviews: What are patients saying about Norethindrone And Ethinyl Estradiol?
5Patient Review
8/10/2020 This medication has been wonderful for me. It's helped regulate my periods and made them much shorter and less painful. It's also an effective form of birth control. The only issue I had was some spotting when I first started taking the pills, but that resolved after a couple of months as my body adjusted to the hormones.
5Patient Review
3/15/2022 I was originally hesitant to try this medication, but I'm so glad I did. It's been incredibly effective in preventing ovarian cysts and hasn't had any negative side effects that I've noticed.
5Patient Review
8/10/2020 This medication has been great for both my heavy, painful periods and as a form of birth control. My periods are now only one or two days long, which is such a relief. The spotting I experienced in the first few months stopped once my body adjusted to the new hormones.
5Patient Review
3/15/2022 I was initially hesitant to try this medication because I had been doing so well with my IUD, but it turns out this is the best birth control pill I've ever been on. No weight changes or emotional symptoms that I could tell. I did have to switch OBGYNs though, which wasn't ideal.
5Patient Review
3/21/2022 I started taking this medication for bad premenstrual nausea and it has been really effective. I've had no nausea and it's also good at preventing pregnancy.
5Patient Review
3/21/2022 I started taking this medication for nausea related to my period, and it worked great! I haven't had any issues with nausea since starting the 21 day dosage, and it's also been effective in preventing pregnancy.
4.7Patient Review
2/20/2017 I've been taking this medication for over a year now with no issues. I have had unprotected sex during this time period and have not gotten pregnant, so I can attest to its reliability. The only downside is that I think it's made it harder for me to lose weight and I get nauseous more easily.
4.7Patient Review
2/20/2017 I've been taking this medication for over a year now, and it has prevented pregnancy effectively. I have noticed that it's harder to lose weight while on the medication, and I get nauseous more easily. Additionally, I get migraines more often; however, I'm not sure if these things are due to the medication or not.
3.7Patient Review
6/8/2021 I've been taking it for a month and it has eased my mental perimenopause symptoms like moodiness and hot flashes. My appetite has decreased marginally because of bloat but I have more energy and the ability to control mood swings.
3.7Patient Review
6/8/2021 I've been taking it for a month and it has eased my mental perimenopause symptoms like moodiness and hot flashes. My appetite has decreased marginally because of bloat but I have more energy and the ability to control mood swings.
3.3Patient Review
12/14/2009 I experienced dizziness, some nausea, increased moodiness (anxiety), depression, and bloating while taking this medication.
3.3Patient Review
12/14/2009 The main side effects I experienced were dizziness and nausea, though I also felt more anxious and down. Additionally, my stomach became bloated.
2Patient Review
8/8/2020 I was on a regular schedule with my periods until I switched to this pill at the suggestion of my doctor. However, since switching, I've been dealing with breakthrough bleeding. It's been really frustrating and disappointing.
2Patient Review
7/18/2018 I have experienced a lot of negative side effects since taking this medication, including nausea, bloating, migraines, headaches, breakthrough bleeding, and a heavy feeling in my chest. Most of these are listed as possible adverse reactions on the medication's packaging.
2Patient Review
7/18/2018 The adverse reactions I experienced on this medication were really severe, including migraines, daily headaches, breakthrough bleeding, and bloating. I stopped taking the meds because I just couldn't handle it anymore.
2Patient Review
8/8/2020 I was on a regular schedule with my periods until I switched to this pill at the recommendation of my doctor. However, since starting this medication, I have been experiencing breakthrough bleeding. This has been really frustrating and disappointing.
1.7Patient Review
11/13/2020 I got very sick after my first pack-- dizzy, with a headache and horrible bleeding. I stopped taking it and felt much better within a week. From what I can tell from research, this is a common reaction to the medication.
1.7Patient Review
11/4/2022 I was on this pill for two weeks and it was the worst experience of my life. I was constantly dizzy and nauseous, and experienced massive cramps, bleeding, and blood clots. I've used other pills before and this one was by far the worst.
1.7Patient Review
11/13/2020 I got my first pack done. I came down very sick dizzy, bad headache, horrible bleeding and blood cloths, pressure in my chest for a hole week.I stopped taking it and within a week I felt 100x better. From what I can tell after doing some research, this is a pretty common reaction to the treatment.
1.7Patient Review
11/4/2022 I lasted two weeks on this pill before throwing in the towel. I experienced dizziness, nausea, and MASSIVE CRAMPS, as well as bleeding and blood clots. I've used other pills before and these were by far the worst.
1Patient Review
12/25/2017 The packaging is very misleading and makes it difficult to know which pills to take and when. Additionally, all the pills are the same color so it's easy to get confused. I looked up the recall information and it seems like this batch was mis-packaged.
1Patient Review
12/25/2017 I was very disappointed with this product. The packaging was confusing and the pills were all the same color, making it difficult to tell which one I was supposed to take first. Additionally, the lot number on the recall information didn't match up with the lot number on the actual packaging.
Patient Q&A Section about norethindrone and ethinyl estradiol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How effective is norethindrone and ethinyl estradiol?
"Other norethindrone/ethinyl estradiol pills have a success rate of more than 99% when used as directed."
Answered by AI
Does ethinyl estradiol stop your period?
"The birth control pill contains 2 hormones: levonorgestrel (a progestin) and ethinyl estradiol (an estrogen). Besides preventing pregnancy, birth control pills may also make your periods more regular, decrease blood loss and painful periods, decrease your risk of ovarian cysts, and treat acne."
Answered by AI
What is the brand name for norethindrone ethinyl estradiol?
"This is a description of the drug Loestrin, which is used to treat conditions like birth control and acne. Some of the possible side effects of this drug include weight gain, headaches, and breast tenderness."
Answered by AI
What kind of birth control is norethindrone acetate and ethinyl estradiol?
"Norethindrone acetate and ethinyl estradiol is an oral contraceptive that combines two types of female hormones, an estrogen and a progestin. These products prevent ovulation and pregnancy."
Answered by AI