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What is Nitro-Dur
NitroglycerinThe Generic name of this drug
Treatment SummaryNitroglycerin is a drug used to relax the blood vessels and reduce chest pain and high blood pressure. It was approved in 2000 and is made by Pfizer in different forms, including a spray, tablets placed under the tongue, intravenous injections, extended-release tablets, and a patch applied to the skin. Not many people know that nitroglycerin can also be used as an ointment to relieve the pain of anal fissures. The rectal ointment form was approved by the FDA in 1955.
Nitroglycerinis the brand name
Nitro-Dur Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nitroglycerin
Nitroglycerin
1981
182
Effectiveness
How Nitro-Dur Affects PatientsNitroglycerin helps to relax the blood vessels, increasing blood flow to the heart, reducing the pressure in the arteries and veins, and decreasing the strain on the heart. Over time, taking nitroglycerin can make it less effective as it may reduce the body's response to it. This can be caused by an enzyme (aldehyde dehydrogenase) being blocked, which can also lead to pro-oxidant effects, a decrease in the health of the cells lining the inside of blood vessels, and increased sensitivity to other drugs that cause narrowing of the blood vessels.
How Nitro-Dur works in the bodyNitroglycerin works by releasing nitric oxide in smooth muscle cells. Nitric oxide then activates an enzyme which produces a chemical called cGMP. The cGMP causes the muscle cells to relax, allowing more blood to flow and decreasing the pressure in the veins and arteries. This relaxation of the muscle cells also helps reduce the pressure in the heart, which is important for people with heart conditions. Nitric oxide may also target a specific receptor to help the body get rid of extra sodium, which helps reduce blood pressure.
When to interrupt dosage
The measure of Nitro-Dur is dependent upon the recognized illness, like Coronary Artery Spasm, induction of Uterine relaxation and Anal Fissure. The dosage fluctuates as per the technique of delivery (e.g. Tablet or Tablet - Oral) featured in the table beneath.Condition
Dosage
Administration
Chest Pain
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
prophylaxis of Angina pectoris
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Congestive Heart Failure
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Coronary Artery Disease (CAD)
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Hypotension
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Anal Fissure
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Hypertensive disease
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Myocardial Infarction
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
induction of Intraoperative Hypotension
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
insufficient response to beta-blockers
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
nitroglycerin
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Pain
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Angina Attacks
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Warnings
Nitro-Dur has eleven contraindications and should not be used in the presence of any of the conditions enumerated in the following table.Nitro-Dur ContraindicationsCondition
Risk Level
Notes
pericardial tamponade
Do Not Combine
Pulse Frequency
Do Not Combine
Hypovolemic Shock
Do Not Combine
Anemia
Do Not Combine
Pick Disease of Heart
Do Not Combine
Pulse Frequency
Do Not Combine
Acute Circulatory Failure
Do Not Combine
Intracranial Hypertension
Do Not Combine
Cardiomyopathy, Restrictive
Do Not Combine
Myocardial Infarction
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Nitroglycerin may interact with Pulse Frequency
Common Nitro-Dur Drug Interactions
Drug Name
Risk Level
Description
Amediplase
Major
The therapeutic efficacy of Amediplase can be decreased when used in combination with Nitroglycerin.
Amifostine
Major
Nitroglycerin may increase the hypotensive activities of Amifostine.
Desmoteplase
Major
The therapeutic efficacy of Desmoteplase can be decreased when used in combination with Nitroglycerin.
Reteplase
Major
The therapeutic efficacy of Reteplase can be decreased when used in combination with Nitroglycerin.
Riociguat
Major
Nitroglycerin may increase the hypotensive activities of Riociguat.
Nitro-Dur Toxicity & Overdose RiskAn overdose of nitroglycerin can cause low blood pressure, a headache that won't go away, dizziness, heart palpitations, blurred vision, red and sweaty skin that later turns pale and blue, nausea, diarrhea (possibly with blood), fainting (especially when standing up), abnormally high levels of methemoglobin in the blood (causing cyanosis and loss of appetite), shallow breathing, and a slow pulse. Severe cases may lead to confusion, fever, paralysis, seizures, and even death due to circulatory collapse. Methemoglobinemia is a rare side effect which can occur at normal
Nitro-Dur Novel Uses: Which Conditions Have a Clinical Trial Featuring Nitro-Dur?
At present, 38 active investigations are looking into the efficacy of Nitro-Dur in providing Gastroesophageal variceal hemorrhage prophylaxis, Hypotension and Congestive Heart Failure alleviation.Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Myocardial Infarction
0 Actively Recruiting
Anal Fissure
0 Actively Recruiting
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
insufficient response to beta-blockers
0 Actively Recruiting
Hypotension
1 Actively Recruiting
Early Phase 1
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
induction of Intraoperative Hypotension
0 Actively Recruiting
prophylaxis of Angina pectoris
0 Actively Recruiting
nitroglycerin
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Angina Attacks
0 Actively Recruiting
Pain
0 Actively Recruiting
Nitro-Dur Reviews: What are patients saying about Nitro-Dur?
5Patient Review
4/30/2016Patient Q&A Section about nitro-dur
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long do you leave Nitro-Dur on?
"Apply one patch on an adult once a day in the morning, and leave the patch in place for a total of 12 to 14 hours."
Answered by AI
Is Nitro-Dur transdermal?
"The organic nitrates are vasodilators, which means they widen blood vessels. The NITRO-DUR Transdermal Infusion System is a flat unit that releases a continuous, controlled amount of nitroglycerin through the skin."
Answered by AI
What is Nitro-Dur used for?
"This drug works by relaxing and widening the blood vessels so that blood can flow more easily to the heart.
This medication is used to prevent chest pain (angina) in people with a certain heart condition (coronary artery disease) by relaxing and widening the blood vessels so that blood can flow more easily to the heart."
Answered by AI
What is the generic name for Nitro-Dur?
"This medicine is a patch used to treat or prevent attacks of chest pain (angina).
The medicine is a patch that is used to treat or prevent episodes of chest pain that are caused by angina."
Answered by AI