Nexium 24Hr

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 14 more
Treatment
3 FDA approvals
20 Active Studies for Nexium 24Hr

What is Nexium 24Hr

EsomeprazoleThe Generic name of this drug
Treatment SummaryEsomeprazole, sold under the brand name Nexium, is a medication used to reduce stomach acid production in people with gastroesophageal reflux disease (GERD), ulcers, or other hypersecretory conditions. It is part of a class of drugs known as proton pump inhibitors (PPIs) and is similar to other PPIs like omeprazole and lansoprazole. Esomeprazole works by attaching to the enzyme (H+, K+)-ATPase in the stomach and blocking acid production. It has been shown to be effective and safe for both children and adults.
Nexiumis the brand name
image of different drug pills on a surface
Nexium 24Hr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexium
Esomeprazole
2001
347

Approved as Treatment by the FDA

Esomeprazole, otherwise called Nexium, is approved by the FDA for 3 uses including Heartburn and Heartburn .
Heartburn
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Effectiveness

How Nexium 24Hr Affects PatientsEsomeprazole helps to reduce the amount of acid in your stomach, and is used to treat acid reflux, heal esophagus damage, and prevent ulcers. This drug works by stopping a special enzyme (H+/K+ ATPase) that helps to produce stomach acid. Esomeprazole is similar to another antacid called [DB00338] but does not have any anticholinergic or H2 histamine side effects. Taking esomeprazole can reduce your risk of cardiovascular events, however long-term use may lead to bacterial infections, reduced absorption of certain vitamins and minerals, and
How Nexium 24Hr works in the bodyEsomeprazole stops the production of stomach acid by binding to proteins in the stomach lining. This prevents the acid from being made, regardless of what has caused it. The binding is permanent, meaning that it takes a long time for the acid to start being produced again. As a result, esomeprazole's effects last for more than 24 hours.

When to interrupt dosage

The suggested measure of Nexium 24Hr is contingent upon the diagnosed ailment, including Curling Ulcer, Hemorrhage and Critical Illness. The dosage amount may vary in accordance with the technique of delivery (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) noted in the following table.
Condition
Dosage
Administration
antibacterial therapy
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
previous gastric or duodenal ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
maintenance of healing Erosive esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Critical Illness
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Helicobacter Pylori Infection
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
develop NSAID-induced gastric ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Erosive Esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Gastric ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
prophylaxis of Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Zollinger-Ellison Syndrome
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Curling Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated

Warnings

Nexium 24Hr Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Nexium 24Hr.
Common Nexium 24Hr Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.
Atazanavir
Major
Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Esomeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.
Nexium 24Hr Toxicity & Overdose RiskTaking too much of this drug may cause blurry vision, confusion, sleepiness, dryness in the mouth, feeling hot, headaches, vomiting, a faster heartbeat, and sweating.
image of a doctor in a lab doing drug, clinical research

Nexium 24Hr Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexium 24Hr?

Currently, there are 26 active clinical trials investigating the potential of Nexium 24Hr to manage previous gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer.
Condition
Clinical Trials
Trial Phases
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Helicobacter Pylori Infection
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
previous gastric or duodenal ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
develop NSAID-induced gastric ulcers
0 Actively Recruiting
Peptic Ulcer
2 Actively Recruiting
Not Applicable, Phase 4
Hemorrhage
1 Actively Recruiting
Phase 4
Gastric ulcer
0 Actively Recruiting
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
maintenance of healing Erosive esophagitis
0 Actively Recruiting
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Hemorrhage
0 Actively Recruiting
prophylaxis of Stress Ulcers
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
Critical Illness
0 Actively Recruiting

Nexium 24Hr Reviews: What are patients saying about Nexium 24Hr?

4.3Patient Review
2/2/2015
Nexium 24Hr for Excessive Production of Stomach Acid
This medication really helped me with my GERD.
4Patient Review
4/25/2015
Nexium 24Hr for Condition in which Stomach Acid is Pushed Into the Esophagus
This medication has been a life-saver for me. After trying other medications and struggling with ulcers and acidity, this one finally healed my ulcers and got everything under control. The only downside is that it affected my B12 levels, so I had to get injections and then take oral supplements for a while. But overall, this med has renewed my life after months of agony.
4Patient Review
11/25/2014
Nexium 24Hr for Condition in which Stomach Acid is Pushed Into the Esophagus
Even though this medicine has alleviated my stomach acid problem, I have experienced some unfortunate side effects after taking it for more than 3 months. These include uncontrollable diarrhea and severe abdominal cramping.
2Patient Review
4/2/2015
Nexium 24Hr for Condition in which Stomach Acid is Pushed Into the Esophagus
I had to switch from the 40 mg prescription Nexium to the over-the-counter 20 mg version due to insurance, and it was a terrible decision. The OTC medication did nothing for me, and actually made my symptoms worse. I tried it for over a month before giving up and going back to the RX version. Within one hour of taking the RX version, my symptoms were gone. The next day when I went back to the OTC stuff, I started feeling burning in my throat within 30 minutes. There is a big difference between the two versions of this drug!
2Patient Review
6/2/2021
Nexium 24Hr for Increased Stomach Acid from Systemic Mastocytosis
I'm no longer a customer because you changed your product, and I refer a lot of people to your store.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nexium 24hr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Nexium 24 hour good for acid reflux?

"This medication decreases the amount of acid your stomach makes and relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication also helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus."

Answered by AI

What is Nexium 24 hours used for?

"Do not take for more than 14 days or more often than every 4 months unless directed by a doctor.

Nexium 24HR is indicated for adults with frequent heartburn, defined as heartburn occurring two or more days per week. Prescription Nexium is indicated for a variety of other acid-related conditions. It is possible to experience relief from heartburn while taking Nexium 24HR as directed for 14 days. Do not take Nexium for more than 14 days or more often than every 4 months unless directed by a doctor."

Answered by AI

How long can you take Nexium 24HR?

"You should not take Nexium® 24HR for longer than 14 days unless your healthcare professional tells you to. You can repeat a 14-day regimen every four months."

Answered by AI

Can I take Nexium 24HR at night?

"It is better to take Nexium before eating because the medication is absorbed better on an empty stomach. If you would prefer to take it at night before bed, make sure you haven't eatenWithin an hour or two of taking the medication."

Answered by AI

Clinical Trials for Nexium 24Hr

Have you considered Nexium 24Hr clinical trials? We made a collection of clinical trials featuring Nexium 24Hr, we think they might fit your search criteria.
Have you considered Nexium 24Hr clinical trials? We made a collection of clinical trials featuring Nexium 24Hr, we think they might fit your search criteria.
Have you considered Nexium 24Hr clinical trials? We made a collection of clinical trials featuring Nexium 24Hr, we think they might fit your search criteria.