Nexium 24Hr

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 14 more

Treatment

5 FDA approvals

18 Active Studies for Nexium 24Hr

What is Nexium 24Hr

Esomeprazole

The Generic name of this drug

Treatment Summary

Esomeprazole, sold under the brand name Nexium, is a medication used to reduce stomach acid production in people with gastroesophageal reflux disease (GERD), ulcers, or other hypersecretory conditions. It is part of a class of drugs known as proton pump inhibitors (PPIs) and is similar to other PPIs like omeprazole and lansoprazole. Esomeprazole works by attaching to the enzyme (H+, K+)-ATPase in the stomach and blocking acid production. It has been shown to be effective and safe for both children and adults.

Nexium

is the brand name

image of different drug pills on a surface

Nexium 24Hr Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nexium

Esomeprazole

2001

347

Approved as Treatment by the FDA

Esomeprazole, otherwise called Nexium, is approved by the FDA for 5 uses including Heartburn and Heartburn .

Heartburn

Heartburn

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Gastro-esophageal Reflux Disease (GERD)

Helps manage Gastro-esophageal Reflux Disease (GERD)

Heartburn

Helps manage Gastro-esophageal Reflux Disease (GERD)

Effectiveness

How Nexium 24Hr Affects Patients

Esomeprazole helps to reduce the amount of acid in your stomach, and is used to treat acid reflux, heal esophagus damage, and prevent ulcers. This drug works by stopping a special enzyme (H+/K+ ATPase) that helps to produce stomach acid. Esomeprazole is similar to another antacid called [DB00338] but does not have any anticholinergic or H2 histamine side effects. Taking esomeprazole can reduce your risk of cardiovascular events, however long-term use may lead to bacterial infections, reduced absorption of certain vitamins and minerals, and

How Nexium 24Hr works in the body

Esomeprazole stops the production of stomach acid by binding to proteins in the stomach lining. This prevents the acid from being made, regardless of what has caused it. The binding is permanent, meaning that it takes a long time for the acid to start being produced again. As a result, esomeprazole's effects last for more than 24 hours.

When to interrupt dosage

The suggested measure of Nexium 24Hr is contingent upon the diagnosed ailment, including Curling Ulcer, Hemorrhage and Critical Illness. The dosage amount may vary in accordance with the technique of delivery (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) noted in the following table.

Condition

Dosage

Administration

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Hemorrhage

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Stomach Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

antibacterial therapy

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Zollinger-Ellison Syndrome

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Curling Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

maintenance of healing Erosive esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Gastric ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Peptic Ulcer

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Erosive Esophagitis

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Critical Illness

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Helicobacter Pylori Infection

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

prophylaxis of Stress Ulcers

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Heartburn

20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg

, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release - Oral, Tablet, delayed release, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Tablet - Oral, Tablet, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Capsule - Oral, Capsule, For suspension - Oral, Granule, for suspension, extended release, Granule, for suspension, extended release - Oral, For suspension, Kit - Oral, Capsule, coated pellets, Capsule, coated pellets - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Nexium 24Hr Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Nexium 24Hr.

Common Nexium 24Hr Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.

Atazanavir

Major

Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Esomeprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.

Infigratinib

Major

The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.

Nexium 24Hr Toxicity & Overdose Risk

Taking too much of this drug may cause blurry vision, confusion, sleepiness, dryness in the mouth, feeling hot, headaches, vomiting, a faster heartbeat, and sweating.

image of a doctor in a lab doing drug, clinical research

Nexium 24Hr Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexium 24Hr?

Currently, there are 26 active clinical trials investigating the potential of Nexium 24Hr to manage previous gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer.

Condition

Clinical Trials

Trial Phases

Hemorrhage

0 Actively Recruiting

Curling Ulcer

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Erosive Esophagitis

2 Actively Recruiting

Phase 2, Phase 3

Gastric ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

2 Actively Recruiting

Not Applicable, Phase 4

Stomach Ulcer

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Stress Ulcers

0 Actively Recruiting

maintenance of healing Erosive esophagitis

0 Actively Recruiting

Peptic Ulcer

0 Actively Recruiting

Critical Illness

0 Actively Recruiting

Hemorrhage

0 Actively Recruiting

Heartburn

12 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Peptic Ulcer

0 Actively Recruiting

prophylaxis of Stress Ulcers

0 Actively Recruiting

Nexium 24Hr Reviews: What are patients saying about Nexium 24Hr?

4.3

Patient Review

2/2/2015

Nexium 24Hr for Excessive Production of Stomach Acid

This medication really helped me with my GERD.

4

Patient Review

4/25/2015

Nexium 24Hr for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication has been a life-saver for me. After trying other medications and struggling with ulcers and acidity, this one finally healed my ulcers and got everything under control. The only downside is that it affected my B12 levels, so I had to get injections and then take oral supplements for a while. But overall, this med has renewed my life after months of agony.

4

Patient Review

11/25/2014

Nexium 24Hr for Condition in which Stomach Acid is Pushed Into the Esophagus

Even though this medicine has alleviated my stomach acid problem, I have experienced some unfortunate side effects after taking it for more than 3 months. These include uncontrollable diarrhea and severe abdominal cramping.

2

Patient Review

4/2/2015

Nexium 24Hr for Condition in which Stomach Acid is Pushed Into the Esophagus

I had to switch from the 40 mg prescription Nexium to the over-the-counter 20 mg version due to insurance, and it was a terrible decision. The OTC medication did nothing for me, and actually made my symptoms worse. I tried it for over a month before giving up and going back to the RX version. Within one hour of taking the RX version, my symptoms were gone. The next day when I went back to the OTC stuff, I started feeling burning in my throat within 30 minutes. There is a big difference between the two versions of this drug!

2

Patient Review

6/2/2021

Nexium 24Hr for Increased Stomach Acid from Systemic Mastocytosis

I'm no longer a customer because you changed your product, and I refer a lot of people to your store.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nexium 24hr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Nexium 24 hour good for acid reflux?

"This medication decreases the amount of acid your stomach makes and relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication also helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus."

Answered by AI

What is Nexium 24 hours used for?

"Do not take for more than 14 days or more often than every 4 months unless directed by a doctor.

Nexium 24HR is indicated for adults with frequent heartburn, defined as heartburn occurring two or more days per week. Prescription Nexium is indicated for a variety of other acid-related conditions. It is possible to experience relief from heartburn while taking Nexium 24HR as directed for 14 days. Do not take Nexium for more than 14 days or more often than every 4 months unless directed by a doctor."

Answered by AI

How long can you take Nexium 24HR?

"You should not take Nexium® 24HR for longer than 14 days unless your healthcare professional tells you to. You can repeat a 14-day regimen every four months."

Answered by AI

Can I take Nexium 24HR at night?

"It is better to take Nexium before eating because the medication is absorbed better on an empty stomach. If you would prefer to take it at night before bed, make sure you haven't eatenWithin an hour or two of taking the medication."

Answered by AI

Clinical Trials for Nexium 24Hr

Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA

Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.

Waitlist Available
Has No Placebo

University of California, Irvine - UCI Medical Center

Jason Samarasena, MD, MBA

Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ

The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences

Phase 3
Waitlist Available

Del Sol Research Management, LLC (+24 Sites)

Cinclus Pharma Holding AB

Have you considered Nexium 24Hr clinical trials?

We made a collection of clinical trials featuring Nexium 24Hr, we think they might fit your search criteria.
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Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting
Has No Placebo

Brigham and Women's Hospital

Christopher C Thompson, MD

Erbe Elektromedizin GmbH

Image of Cleveland Clinic Center for Abdominal Core Health in Cleveland, United States.

Mesh vs Pledgets for Hernia Repair

18+
All Sexes
Cleveland, OH

The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms

Recruiting
Has No Placebo

Cleveland Clinic Center for Abdominal Core Health

David M Krpata, MD

Have you considered Nexium 24Hr clinical trials?

We made a collection of clinical trials featuring Nexium 24Hr, we think they might fit your search criteria.
Go to Trials

Have you considered Nexium 24Hr clinical trials?

We made a collection of clinical trials featuring Nexium 24Hr, we think they might fit your search criteria.
Go to Trials