Nexavar

Hemangiosarcoma, Gastrointestinal Stromal Tumors, leiomyosarcoma + 4 more
Treatment
20 Active Studies for Nexavar

What is Nexavar

SorafenibThe Generic name of this drug
Treatment SummarySorafenib (also known as Nexavar) is a medication approved to treat advanced kidney cancer. It has been given FDA "Fast Track" status for the treatment of advanced liver cancer and has been successful in clinical trials. It works by blocking multiple pathways in cancer cells, including the Raf/Mek/Erk pathway. Sorafenib is unique in that it targets multiple pathways at once, which makes it more effective than other drugs that only target one pathway.
Nexavaris the brand name
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Nexavar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexavar
Sorafenib
2005
8

Effectiveness

How Nexavar Affects PatientsTaking this drug did not cause any major changes in the QTc interval. After one month of treatment, the highest average QTc interval change was 8.5 milliseconds at 6 hours after taking the drug on the first day of the second cycle.
How Nexavar works in the bodySorafenib works by blocking certain enzymes that help tumors grow and spread. It does this by targeting kinases, which are enzymes that control cell growth and angiogenesis, which is the process of forming new blood vessels. By blocking these enzymes, Sorafenib reduces the blood flow to the tumor and prevents it from growing. It also blocks genetic transcription, which helps to prevent cell proliferation and further growth of the tumor.

When to interrupt dosage

The recommended dose of Nexavar is contingent upon the diagnosed circumstance, including Advanced Renal Cell Carcinoma (aRCC), Gastrointestinal Stromal Tumors and progressive, locally recurrent radioactive iodine-refractory Differentiated Thyroid Carcinoma (DTC). The amount of dosage is distinct, in accordance with the manner of administration outlined in the table below.
Condition
Dosage
Administration
Hemangiosarcoma
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Gastrointestinal Stromal Tumors
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
leiomyosarcoma
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Liver Neoplasms
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Thyroid Neoplasms
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Thyroid Neoplasms
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Kidney Neoplasms
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

Nexavar Contraindications
Condition
Risk Level
Notes
Squamous cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
There are 20 known major drug interactions with Nexavar.
Common Nexavar Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Sorafenib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Sorafenib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Sorafenib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Sorafenib is combined with Abetimus.
Abrocitinib
Major
The metabolism of Abrocitinib can be decreased when combined with Sorafenib.
Nexavar Toxicity & Overdose RiskThe maximum recommended dose of sorafenib is 800 mg twice a day. Common side effects associated with this dose are diarrhea and skin reactions. It is not known what symptoms an animal may experience if they overdose, as absorption is maxed out during oral acute toxicity studies.
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Nexavar Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexavar?

There are currently 48 active trials investigating the potential of Nexavar in treating Gastrointestinal Stromal Tumors, Advanced Renal Cell Carcinoma (aRCC) and refractory Differentiated Thyroid Carcinoma (DTC) that has progressed locally and is resistant to radioactive iodine.
Condition
Clinical Trials
Trial Phases
Kidney Neoplasms
16 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1
leiomyosarcoma
1 Actively Recruiting
Phase 2
Gastrointestinal Stromal Tumors
3 Actively Recruiting
Phase 2, Phase 1
Thyroid Neoplasms
0 Actively Recruiting
Thyroid Neoplasms
0 Actively Recruiting
Liver Neoplasms
16 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable
Hemangiosarcoma
8 Actively Recruiting
Phase 2, Phase 1

Nexavar Reviews: What are patients saying about Nexavar?

5Patient Review
2/23/2013
Nexavar for Liver Cell Cancer
My husband was recently diagnosed with stage IV liver cancer and has been on Nexavar for two weeks. So far, he's only had mild itchiness as a side-effect. The 800mg dosage seems to be quite effective in terms of managing his pain, nausea, and fatigue. We're hopeful that the tumors will shrink by May.
5Patient Review
5/29/2021
Nexavar for Thyroid Cancer
I've only been taking nexavar for a short time, but I've already experienced some soreness in my feet and legs. Additionally, I've had three headaches since starting the medication. However, I am hopeful that this medication will be effective for me.
5Patient Review
1/19/2012
Nexavar for Liver Cell Cancer
Sadly, my husband passed away after only a year of treatment. He experienced a lot of pain due to side effects like colostomy, bleeding, leg swelling, and back pain.
4Patient Review
12/25/2015
Nexavar for Thyroid Cancer that has Spread to Another Part of Body
I have been taking Nexavar for 10 months to treat my thyroid cancer, and it has been effective in preventing the growth of tumors. Side effects have been minimal, but it is important to monitor blood pressure and potassium levels.
2.7Patient Review
1/8/2017
Nexavar for Liver Cell Cancer
After my liver transplant, I started taking nex. After 8 weeks, I developed painful calouses on my feet. Compression socks and skin cream help; however, the foot pain is physically and emotionally disturbing. It's difficult to imagine taking 800mil.
View All Reviews
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Patient Q&A Section about nexavar

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How effective is Nexavar for liver cancer?

"Patients who were administered Nexavar showed a 41% reduction in the risk of progression or death, compared to those who were given placebo. The median PFS (progression-free survival) for patients treated with Nexavar was 10.8 months, compared to 5.8 months for those receiving placebo."

Answered by AI

How much does Nexavar cost per month?

"Nexavar is a drug used to treat kidney, liver and thyroid cancers. It has a list price of about $18,670 per month."

Answered by AI

What kind of drug is Nexavar?

"Nexavar is a chemotherapeutic medication used to treat kidney and liver cancer."

Answered by AI

What is the drug Nexavar used for?

"Sorafenib is a drug that is used to treat kidney, liver, and thyroid cancer by slowing or stopping the growth of cancer cells."

Answered by AI

Does Nexavar cure cancer?

"NEXAVAR will not cure your cancer, but it can help to slow down or temporarily stop the growth or spread of certain cancer cells. This is called 'stable disease'."

Answered by AI

Clinical Trials for Nexavar

Have you considered Nexavar clinical trials? We made a collection of clinical trials featuring Nexavar, we think they might fit your search criteria.
Have you considered Nexavar clinical trials? We made a collection of clinical trials featuring Nexavar, we think they might fit your search criteria.
Have you considered Nexavar clinical trials? We made a collection of clinical trials featuring Nexavar, we think they might fit your search criteria.
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