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What is Nexavar
SorafenibThe Generic name of this drug
Treatment SummarySorafenib (also known as Nexavar) is a medication approved to treat advanced kidney cancer. It has been given FDA "Fast Track" status for the treatment of advanced liver cancer and has been successful in clinical trials. It works by blocking multiple pathways in cancer cells, including the Raf/Mek/Erk pathway. Sorafenib is unique in that it targets multiple pathways at once, which makes it more effective than other drugs that only target one pathway.
Nexavaris the brand name
Nexavar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexavar
Sorafenib
2005
8
Effectiveness
How Nexavar Affects PatientsTaking this drug did not cause any major changes in the QTc interval. After one month of treatment, the highest average QTc interval change was 8.5 milliseconds at 6 hours after taking the drug on the first day of the second cycle.
How Nexavar works in the bodySorafenib works by blocking certain enzymes that help tumors grow and spread. It does this by targeting kinases, which are enzymes that control cell growth and angiogenesis, which is the process of forming new blood vessels. By blocking these enzymes, Sorafenib reduces the blood flow to the tumor and prevents it from growing. It also blocks genetic transcription, which helps to prevent cell proliferation and further growth of the tumor.
When to interrupt dosage
The recommended dose of Nexavar is contingent upon the diagnosed circumstance, including Advanced Renal Cell Carcinoma (aRCC), Gastrointestinal Stromal Tumors and progressive, locally recurrent radioactive iodine-refractory Differentiated Thyroid Carcinoma (DTC). The amount of dosage is distinct, in accordance with the manner of administration outlined in the table below.Condition
Dosage
Administration
progressive, metastatic radioactive iodine-refractory Differentiated Thyroid Carcinoma (DTC)
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Unresectable Hepatocellular Carcinoma (HCC)
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hemangiosarcoma
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Gastrointestinal Stromal Tumors
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Advanced Renal Cell Carcinoma (aRCC)
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
progressive, locally recurrent radioactive iodine-refractory Differentiated Thyroid Carcinoma (DTC)
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
leiomyosarcoma
200.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Nexavar ContraindicationsCondition
Risk Level
Notes
Squamous cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
Common Nexavar Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Sorafenib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Sorafenib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Sorafenib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Sorafenib is combined with Abetimus.
Abrocitinib
Major
The metabolism of Abrocitinib can be decreased when combined with Sorafenib.
Nexavar Toxicity & Overdose RiskThe maximum recommended dose of sorafenib is 800 mg twice a day. Common side effects associated with this dose are diarrhea and skin reactions. It is not known what symptoms an animal may experience if they overdose, as absorption is maxed out during oral acute toxicity studies.
Nexavar Novel Uses: Which Conditions Have a Clinical Trial Featuring Nexavar?
There are currently 48 active trials investigating the potential of Nexavar in treating Gastrointestinal Stromal Tumors, Advanced Renal Cell Carcinoma (aRCC) and refractory Differentiated Thyroid Carcinoma (DTC) that has progressed locally and is resistant to radioactive iodine.Condition
Clinical Trials
Trial Phases
leiomyosarcoma
1 Actively Recruiting
Phase 2
Gastrointestinal Stromal Tumors
6 Actively Recruiting
Phase 2, Not Applicable, Phase 1
progressive, locally recurrent radioactive iodine-refractory Differentiated Thyroid Carcinoma (DTC)
0 Actively Recruiting
Advanced Renal Cell Carcinoma (aRCC)
17 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
progressive, metastatic radioactive iodine-refractory Differentiated Thyroid Carcinoma (DTC)
0 Actively Recruiting
Unresectable Hepatocellular Carcinoma (HCC)
14 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hemangiosarcoma
11 Actively Recruiting
Phase 2, Phase 1
Nexavar Reviews: What are patients saying about Nexavar?
5Patient Review
2/23/2013 My husband was recently diagnosed with stage IV liver cancer and has been on Nexavar for two weeks. So far, he's only had mild itchiness as a side-effect. The 800mg dosage seems to be quite effective in terms of managing his pain, nausea, and fatigue. We're hopeful that the tumors will shrink by May.
5Patient Review
5/29/2021 I've only been taking nexavar for a short time, but I've already experienced some soreness in my feet and legs. Additionally, I've had three headaches since starting the medication. However, I am hopeful that this medication will be effective for me.
5Patient Review
1/19/2012 Sadly, my husband passed away after only a year of treatment. He experienced a lot of pain due to side effects like colostomy, bleeding, leg swelling, and back pain.
4Patient Review
12/25/2015 I have been taking Nexavar for 10 months to treat my thyroid cancer, and it has been effective in preventing the growth of tumors. Side effects have been minimal, but it is important to monitor blood pressure and potassium levels.
2.7Patient Review
1/8/2017 After my liver transplant, I started taking nex. After 8 weeks, I developed painful calouses on my feet. Compression socks and skin cream help; however, the foot pain is physically and emotionally disturbing. It's difficult to imagine taking 800mil.
2.7Patient Review
1/28/20112Patient Review
9/8/2014 My husband passed away from liver cancer two years ago. Nexavar only prolonged his life for three months before the liver got worse again. It's so frustrating that there's no cure for cancer, despite all the money spent on research.
2Patient Review
3/31/2014 My husband has liver cancer and is taking nexavar. It's been tough on him, like most cancer treatments, but it hasn't caused the tumor to shrink. We're hopeful that it will at least stabilize his condition.
2Patient Review
9/14/2022 I had a transplant for HCC Liver cancer, and have been taking nexavar since they discovered cancer in my adrenal gland (6 mos after transplant). Now it's in my arm where it caused a hole in my humerus. 9 mos after transplant. All I know is that it makes going to the bathroom all the time fun. This drug sucks for me.
1.7Patient Review
3/10/2017 I've been on this medication for a while now and I've developed new problems. I'm covered in what look like little tumors, plus there's pain on my right side and moderate headaches. My doctor isn't giving me much information about the cancer or my prognosis. It's hard to stay positive when things seem so uncertain.
1.7Patient Review
1/13/2018 I had a lot of negative side effects while using this drug.
1.7Patient Review
1/28/2011 Vomiting and diarrhea constantly. Could not control the bowels
1Patient Review
8/8/2014 I had a terrible reaction to this medication 10 days after starting the treatment. I was covered in hives and red spots from head to toe. I spent two days in the hospital as a result. Do not take this drug if you're allergic to it!
1Patient Review
7/15/2016 Unfortunately, this medication didn't work for me. Not only that, but it also caused some nasty side effects.
1Patient Review
11/15/2021 The tumor continued to grow and spread despite this treatment. It was a slow, agonizing process that took five months before she finally passed away.
1Patient Review
8/15/2011 Nausea, vomiting and diarrhea
1Patient Review
11/10/2015 I was only on this pill for three days when I experienced a side effect that landed me in the emergency room. I was diagnosed with pancreatitis and ended up staying in the hospital for seven days. This pill is incredibly dangerous and not worth it.
Patient Q&A Section about nexavar
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How effective is Nexavar for liver cancer?
"Patients who were administered Nexavar showed a 41% reduction in the risk of progression or death, compared to those who were given placebo. The median PFS (progression-free survival) for patients treated with Nexavar was 10.8 months, compared to 5.8 months for those receiving placebo."
Answered by AI
What kind of drug is Nexavar?
"Nexavar is a chemotherapeutic medication used to treat kidney and liver cancer."
Answered by AI
What is the drug Nexavar used for?
"Sorafenib is a drug that is used to treat kidney, liver, and thyroid cancer by slowing or stopping the growth of cancer cells."
Answered by AI