What is Neggram
Nalidixic acidThe Generic name of this drug
Treatment SummaryNalidixic acid is an artificial antibiotic used to kill a limited range of bacteria. It works by blocking the action of the A subunit of bacterial DNA gyrase, an enzyme that helps bacteria to replicate.
NegGramis the brand name
Neggram Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
NegGram
Nalidixic acid
1964
1
Effectiveness
How Neggram Affects PatientsNalidixic acid is an antibiotic that is taken orally to treat infections caused by certain types of bacteria, such as Enterobacter, Escherichia coli, Morganella Morganii, Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. This drug is effective against most urinary pH levels and kills the bacteria it targets. In some cases, bacteria can become resistant to nalidixic acid, but this resistance cannot be passed on.
How Neggram works in the bodyNalidixic acid works by attaching itself to DNA. This blocks the production of RNA and proteins, which stops bacteria from growing and multiplying.
When to interrupt dosage
The prescribed dosage of Neggram is contingent upon the diagnosed condition. The dosage likewise fluctuates based on the method of delivery (e.g. Tablet - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
Urinary Tract Infection
, 500.0 mg
Tablet - Oral, Oral, , Tablet
Warnings
Neggram has four contraindications and should not be taken when suffering from any of the disorders detailed in the following table.Neggram ContraindicationsCondition
Risk Level
Notes
Porphyria
Do Not Combine
known hypersensitivity to the drug or any of the ingredients
Do Not Combine
Seizures
Do Not Combine
Toxoplasma Infections
Do Not Combine
Common Neggram Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Amiodarone.
Amitriptyline
Major
Nalidixic acid may increase the QTc-prolonging activities of Amitriptyline.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Artemether.
Neggram Toxicity & Overdose RiskThe toxic dose of this drug for rats is 1160 mg/kg, and for mice it is 572 mg/kg. Taking too much of this drug may cause mental confusion, seizures, increased brain pressure, and an acid buildup in the body. People may also experience vomiting, nausea, and extreme tiredness.
Neggram Novel Uses: Which Conditions Have a Clinical Trial Featuring Neggram?
There are currently 10 active trials assessing the potential of Neggram to manage Urinary Tract Infection.Condition
Clinical Trials
Trial Phases
Urinary Tract Infection
10 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Neggram Reviews: What are patients saying about Neggram?
1Patient Review
9/26/2009 I had an incredibly severe allergic reaction to this medication when I was 10 years old. I spent over a month hospitalized and my joints were so swollen it was excruciating to even move. In my opinion, this drug should be taken off the market entirely.
Patient Q&A Section about neggram
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of nalidixic acid?
"blurred vision
The person experiences drowsiness, weakness, headache, dizziness, a spinning sensation, abdominal pain, nausea, vomiting, and blurred vision."
Answered by AI
What is negram used for?
"Nalidixic acid (Negram - Bayer) is a new antibacterial drug that can be used to treat acute and chronic urinary tract infections. The recommended dose is 1 gram taken six hours apart. The drug is a naphthyridine derivative and is chemically unrelated to any of the established antibacterial substances."
Answered by AI
What does nalidixic acid do to bacteria?
"In 1963, nalidixic acid, the first quinolone antibiotic, was approved. Later derivatives of quinolones, such as fluoroquinolones, block DNA replication and repair by inhibiting DNA gyrase. They are active against both Gram-positive and Gram-negative pathogens."
Answered by AI
What is nalidixic acid used for?
"Nalidixic acid is a drug that is only effective against a small number of types of enteric bacteria. It is used to treat uncomplicated urinary tract infections."
Answered by AI