Neggram

Urinary Tract Infections

Treatment

4 Active Studies for Neggram

Treatment for

Urinary Tract Infections

What is Neggram

Nalidixic acidThe Generic name of this drug

Treatment SummaryNalidixic acid is an artificial antibiotic used to kill a limited range of bacteria. It works by blocking the action of the A subunit of bacterial DNA gyrase, an enzyme that helps bacteria to replicate.

NegGramis the brand name

image of different drug pills on a surface

Neggram Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

NegGram

Nalidixic acid

1964

Effectiveness

How Neggram Affects PatientsNalidixic acid is an antibiotic that is taken orally to treat infections caused by certain types of bacteria, such as Enterobacter, Escherichia coli, Morganella Morganii, Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. This drug is effective against most urinary pH levels and kills the bacteria it targets. In some cases, bacteria can become resistant to nalidixic acid, but this resistance cannot be passed on.

How Neggram works in the bodyNalidixic acid works by attaching itself to DNA. This blocks the production of RNA and proteins, which stops bacteria from growing and multiplying.

When to interrupt dosage

The prescribed dosage of Neggram is contingent upon the diagnosed condition. The dosage likewise fluctuates based on the method of delivery (e.g. Tablet - Oral or Oral) featured in the table beneath.

Condition

Dosage

Administration

Urinary Tract Infections

500.0 mg,

, Oral, Tablet - Oral, Tablet

Warnings

Neggram has four contraindications and should not be taken when suffering from any of the disorders detailed in the following table.Neggram Contraindications

Condition

Risk Level

Notes

Porphyrias

Do Not Combine

Seizures

Do Not Combine

known hypersensitivity to the drug or any of the ingredients

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Neggram.

Common Neggram Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Amiodarone.

Amitriptyline

Major

Nalidixic acid may increase the QTc-prolonging activities of Amitriptyline.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Artemether.

Neggram Toxicity & Overdose RiskThe toxic dose of this drug for rats is 1160 mg/kg, and for mice it is 572 mg/kg. Taking too much of this drug may cause mental confusion, seizures, increased brain pressure, and an acid buildup in the body. People may also experience vomiting, nausea, and extreme tiredness.

Neggram Novel Uses: Which Conditions Have a Clinical Trial Featuring Neggram?

There are currently 10 active trials assessing the potential of Neggram to manage Urinary Tract Infection.

Condition

Clinical Trials

Trial Phases

Urinary Tract Infections

4 Actively Recruiting

Not Applicable, Phase 4

Neggram Reviews: What are patients saying about Neggram?

1Patient Review

9/26/2009

Neggram for Urinary Tract Infection

I had an incredibly severe allergic reaction to this medication when I was 10 years old. I spent over a month hospitalized and my joints were so swollen it was excruciating to even move. In my opinion, this drug should be taken off the market entirely.

Patient Q&A Section about neggram

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of nalidixic acid?

"blurred vision

The person experiences drowsiness, weakness, headache, dizziness, a spinning sensation, abdominal pain, nausea, vomiting, and blurred vision."

Answered by AI

What is negram used for?

"Nalidixic acid (Negram - Bayer) is a new antibacterial drug that can be used to treat acute and chronic urinary tract infections. The recommended dose is 1 gram taken six hours apart. The drug is a naphthyridine derivative and is chemically unrelated to any of the established antibacterial substances."

Answered by AI

What does nalidixic acid do to bacteria?

"In 1963, nalidixic acid, the first quinolone antibiotic, was approved. Later derivatives of quinolones, such as fluoroquinolones, block DNA replication and repair by inhibiting DNA gyrase. They are active against both Gram-positive and Gram-negative pathogens."

Answered by AI

What is nalidixic acid used for?

"Nalidixic acid is a drug that is only effective against a small number of types of enteric bacteria. It is used to treat uncomplicated urinary tract infections."

Answered by AI