Natrecor

Heart Failure

Treatment

1 FDA approval

7 Active Studies for Natrecor

Treatment for

Heart Failure

What is Natrecor

NesiritideThe Generic name of this drug

Treatment SummaryNesiritide is a drug prescribed to people with congestive heart failure who feel short of breath while resting or doing light activities, such as talking, eating, or bathing. Nesiritide is a medication made from a type of protein called B-type natriuretic peptide.

Natrecoris the brand name

Natrecor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Natrecor

Nesiritide

2001

Approved as Treatment by the FDA

Nesiritide, also known as Natrecor, is approved by the FDA for 1 uses including Heart Failure .

Heart Failure

Helps manage Acute Decompensated Heart Failure (ADHF)

Effectiveness

How Natrecor Affects PatientsNesiritide helps keep the cardiovascular system in balance by decreasing the activity of the hormones (renin-angiotensin-aldosterone system) that regulate blood pressure. This helps to widen blood vessels, decrease sodium levels, and increase urine production.

How Natrecor works in the bodyNesiritide works by binding to special receptors on the walls of blood vessels. This increases the amount of a substance called cyclic GMP, which causes the vessels to relax and let more blood flow through. In studies with people who have heart failure, nesiritide has been shown to reduce the pressure in their lungs and in their arteries. It does not seem to affect the strength of their heart contractions or alter their heart rate. We don't know yet if nesiritide affects how much fluid passes through blood vessels, like a similar peptide (ANP) does.

When to interrupt dosage

The measure of Natrecor is dependent on the established condition. The amount of dosage fluctuates, depending on the delivery system (e.g. Intravenous or Injection, powder, lyophilized, for solution - Intravenous) indicated in the table beneath.

Condition

Dosage

Administration

Heart Failure

1.5 mg/mL, , 1.5 mg

, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous

Warnings

There are 20 known major drug interactions with Natrecor.

Common Natrecor Drug Interactions

Drug Name

Risk Level

Description

Aliskiren

Minor

The risk or severity of adverse effects can be increased when Nesiritide is combined with Aliskiren.

Alprenolol

Minor

Nesiritide may increase the hypotensive activities of Alprenolol.

Ambrisentan

Minor

Nesiritide may increase the hypotensive activities of Ambrisentan.

Angiotensin 1-7

Minor

Nesiritide may increase the hypotensive activities of Angiotensin 1-7.

Arotinolol

Minor

The risk or severity of adverse effects can be increased when Nesiritide is combined with Arotinolol.

Natrecor Toxicity & Overdose RiskIf too much of this drug is taken, it could cause a dangerous drop in blood pressure. Treatment for an overdose includes stopping or reducing the drug and taking appropriate measures.

Natrecor Novel Uses: Which Conditions Have a Clinical Trial Featuring Natrecor?

11 active studies are being conducted to analyze the effectiveness of Natrecor in the management of Acute Decompensated Heart Failure (ADHF).

Condition

Clinical Trials

Trial Phases

Heart Failure

7 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3

Natrecor Reviews: What are patients saying about Natrecor?

5Patient Review

8/9/2010

Natrecor for Suddenly Serious Symptoms of Heart Failure

The only downside I experienced to this treatment was some serious cramping in my calf muscles.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about natrecor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Natrecor still on the market?

"Janssen is no longer selling Natrecor powder for injection."

Answered by AI

What kind of drug is Natrecor?

"Natrecor is a prescription medicine used to treat the symptoms of Acutely Decompensated Chronic Heart failure (CHF) with Shortness of Breath (Dyspnea) at Rest. Natrecor may be used alone or with other medications. Natrecor belongs to a class of drugs called Natriuretic Peptides. These drugs work by causing the kidneys to get rid of extra water and salt from the body."

Answered by AI

What is Natrecor indicated for?

"Natrecor is used to treat patients with congestive heart failure who have difficulty breathing, either at rest or with minimal activity. This drug can reduce pulmonary pressure and improve breathing."

Answered by AI

What is the mechanism of action of nesiritide Natrecor?

"Nesiritide works by regulating the renin-angiotensin-aldosterone system, which in turn promotes cyclic guanosine monophosphate and smooth muscle cell relaxation. This regulation leads to vasodilation, natriuresis, and diuresis."

Answered by AI

Clinical Trials for Natrecor

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