Natrecor
Heart Failure
Treatment
1 FDA approval
6 Active Studies for Natrecor
Treatment for
Heart Failure
What is Natrecor
Nesiritide
The Generic name of this drug
Treatment Summary
Nesiritide is a drug prescribed to people with congestive heart failure who feel short of breath while resting or doing light activities, such as talking, eating, or bathing. Nesiritide is a medication made from a type of protein called B-type natriuretic peptide.
Natrecor
is the brand name
Natrecor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Natrecor
Nesiritide
2001
1
Approved as Treatment by the FDA
Nesiritide, also known as Natrecor, is approved by the FDA for 1 uses including Heart Failure .
Heart Failure
Helps manage Acute Decompensated Heart Failure (ADHF)
Effectiveness
How Natrecor Affects Patients
Nesiritide helps keep the cardiovascular system in balance by decreasing the activity of the hormones (renin-angiotensin-aldosterone system) that regulate blood pressure. This helps to widen blood vessels, decrease sodium levels, and increase urine production.
How Natrecor works in the body
Nesiritide works by binding to special receptors on the walls of blood vessels. This increases the amount of a substance called cyclic GMP, which causes the vessels to relax and let more blood flow through. In studies with people who have heart failure, nesiritide has been shown to reduce the pressure in their lungs and in their arteries. It does not seem to affect the strength of their heart contractions or alter their heart rate. We don't know yet if nesiritide affects how much fluid passes through blood vessels, like a similar peptide (ANP) does.
When to interrupt dosage
The measure of Natrecor is dependent on the established condition. The amount of dosage fluctuates, depending on the delivery system (e.g. Intravenous or Injection, powder, lyophilized, for solution - Intravenous) indicated in the table beneath.
Condition
Dosage
Administration
Heart Failure
1.5 mg/mL, , 1.5 mg
Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, lyophilized, for solution, , Powder, for solution, Powder, for solution - Intravenous
Warnings
There are 20 known major drug interactions with Natrecor.
Common Natrecor Drug Interactions
Drug Name
Risk Level
Description
Aliskiren
Minor
The risk or severity of adverse effects can be increased when Nesiritide is combined with Aliskiren.
Alprenolol
Minor
Nesiritide may increase the hypotensive activities of Alprenolol.
Ambrisentan
Minor
Nesiritide may increase the hypotensive activities of Ambrisentan.
Angiotensin 1-7
Minor
Nesiritide may increase the hypotensive activities of Angiotensin 1-7.
Arotinolol
Minor
The risk or severity of adverse effects can be increased when Nesiritide is combined with Arotinolol.
Natrecor Toxicity & Overdose Risk
If too much of this drug is taken, it could cause a dangerous drop in blood pressure. Treatment for an overdose includes stopping or reducing the drug and taking appropriate measures.
Natrecor Novel Uses: Which Conditions Have a Clinical Trial Featuring Natrecor?
11 active studies are being conducted to analyze the effectiveness of Natrecor in the management of Acute Decompensated Heart Failure (ADHF).
Condition
Clinical Trials
Trial Phases
Heart Failure
7 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Natrecor Reviews: What are patients saying about Natrecor?
5
Patient Review
8/9/2010
Natrecor for Suddenly Serious Symptoms of Heart Failure
Patient Q&A Section about natrecor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is Natrecor still on the market?
"Janssen is no longer selling Natrecor powder for injection."
Answered by AI
What kind of drug is Natrecor?
"Natrecor is a prescription medicine used to treat the symptoms of Acutely Decompensated Chronic Heart failure (CHF) with Shortness of Breath (Dyspnea) at Rest. Natrecor may be used alone or with other medications. Natrecor belongs to a class of drugs called Natriuretic Peptides. These drugs work by causing the kidneys to get rid of extra water and salt from the body."
Answered by AI
What is Natrecor indicated for?
"Natrecor is used to treat patients with congestive heart failure who have difficulty breathing, either at rest or with minimal activity. This drug can reduce pulmonary pressure and improve breathing."
Answered by AI
What is the mechanism of action of nesiritide Natrecor?
"Nesiritide works by regulating the renin-angiotensin-aldosterone system, which in turn promotes cyclic guanosine monophosphate and smooth muscle cell relaxation. This regulation leads to vasodilation, natriuresis, and diuresis."
Answered by AI