Nascobal

Anemia, Pernicious, Convalescence, Folic Acid Deficiency + 28 more

Treatment

18 FDA approvals

20 Active Studies for Nascobal

Treatment for

Anemia, Pernicious

What is Nascobal

Cyanocobalamin

The Generic name of this drug

Treatment Summary

Cyanocobalamin, also known as Vitamin B12, is an important vitamin that helps the body produce DNA and energy. It occurs naturally in bacteria and comes in several forms, including cyano-, methyl-, deoxyadenosyl- and hydroxy-cobalamin. Vitamin B12 is available in tablet, injection, and nasal spray forms and was first approved by the FDA in 1942.

O-Cal FA multivitamin

is the brand name

Nascobal Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

O-Cal FA multivitamin

Cyanocobalamin

1970

Approved as Treatment by the FDA

Cyanocobalamin, also known as O-Cal FA multivitamin, is approved by the FDA for 18 uses like Pancreatic Neoplasms and Anemia, Pernicious .

Pancreatic Neoplasms

Anemia, Pernicious

Gastrointestinal Problems

folic acid

prophylaxis of Vitamin B12 deficiency

Vitamin B12 Deficiency

Gastrointestinal Surgery

Gastrointestinal Dysfunction

Neoplasms, Pancreatic

Malignant Neoplasm of Colon

Small Intestinal Bacterial Overgrowth Syndrome (SIBO)

Gluten-Sensitive Enteropathy

Total or Partial Gastrectomy

Cestode Infections

Vitamin B 12 Deficiency

Celiac Disease

Colon Cancer

Anemia, Pernicious

Effectiveness

How Nascobal Affects Patients

Cyanocobalamin, or vitamin B12, is used to treat a deficiency of this vitamin, which can cause various symptoms such as anemia, gastrointestinal issues, and neurological damage. It helps with cell growth, reproduction, and metabolism of fat, carbohydrates, and proteins. Parenteral administration of vitamin B12 quickly and completely reverses the symptoms of deficiency. Intranasal doses given daily for 8 weeks have been shown to restore levels of vitamin B12 to the target therapeutic range.

How Nascobal works in the body

Vitamin B12 is essential for the body's ability to create new cells, proteins, and hormones. It helps convert homocysteine into methionine, which donates methyl groups to other molecules. Without vitamin B12, your body can't regenerate folic acid, leading to anemia. Vitamin B12 also helps create succinyl-CoA, which is needed for fat and protein metabolism. A deficiency of vitamin B12 can lead to neurological symptoms, as well as megaloblastic anemia.

When to interrupt dosage

The proposed measure of Nascobal is contingent upon the diagnosed condition, including Gastrointestinal Dysfunction, Vitamin B 12 Deficiency and Nutritional supplementation. The amount of dosage is contingent upon the method of delivery, as indicated in the table below.

Condition

Dosage

Administration

Gastrointestinal Dysfunction

, 0.025 mg, 0.012 mg, 1.0 mg/mL, 0.005 mg, 2.0 mg, 0.01 mg, 0.00405 mg/mL, 1.0 mg, 0.5 mg, 0.05 mg, 0.015 mg, 0.006 mg, 25.0 mg, 10.0 mg, 0.12 mg, 0.1 mg, 0.25 mg, 0.004 mg, 0.024 mg, 0.0225 mg, 0.035 mg, 0.002 mg, 0.001 mg, 0.125 mg, 0.0333 mg, 0.008 mg, 0.003 mg, 0.3 mg, 0.0045 mg, 0.075 mg, 0.0007 mg, 0.0125 mg, 0.02 mg, 0.027 mg, 0.033 mg, 0.016 mg, 0.00375 mg, 1.2 mg, 0.002 mg/mL, 0.017 mg, 0.115 mg, 0.013 mg, 125.0 mg, 0.0667 mg/mL, 2.5 mg, 6.0 mg, 1.5 mg, 3.0 mg, 0.000133 mg/mL, 0.2 mg, 5.0 mg, 5.0 mg/mL, 3.0 mg/mL, 0.005 mg/mg, 0.6 mg, 0.4 mg, 1.3 mg, 0.014 mg, 0.0025 mg, 0.0023 mg, 0.0168 mg, 0.009 mg, 0.00667 mg, 0.001 mg/mL, 0.06 mg, 0.0005 mg/mL, 12.0 mg, 0.003 mg/mL, 12.0 [iU], 0.03 mg, 0.005 mg/mL, 0.0009 mg/mL, 0.0002 mg/mL, 0.25 mg/mL, 0.00733 mg, 0.0002 mg, 0.00175 mg, 0.03333 mg, 0.055 mg, 0.00024 mg, 0.15 mg, 0.0166 mg, 0.052 mg, 0.08334 mg, 0.00076 mg, 0.00167 mg, 0.00625 mg, 0.00833 mg, 0.045 mg, 0.065 mg, 0.0035 mg, 0.0375 mg, 1.05 mg, 0.06666 mg, 0.018 mg, 0.04 mg, 0.00054 mg, 0.0012 mg, 0.07 mg, 0.05 mg/mg, 0.01667 mg, 0.2666 mg, 0.007 mg, 0.06667 mg, 5.0 mg/mg, 0.000075 mg, 0.1 mg/mL, 52.0 mg, 0.0014 mg, 0.0045 mg/mL, 0.0000018 mg/mg, 0.000007 mg/mL, 0.0025 mg/mL, 0.0014 mg/mL, 0.00045 mg/mL, 0.004 mg/mL, 0.00003 mg/mL, 0.00002 mg/mL, 0.01 mg/mL, 0.0000364 mg/mg, 0.00007 mg/mL, 0.0006 mg/mL, 0.00000008 mg/mg, 0.0001 mg/mL, 0.0052 mg/mL, 0.00000021 mg/mg, 0.000006 mg/mg, 0.05 mg/mL, 0.0000003 mg/mg, 0.006 mg/mL, 0.0000006 mg/mg, 0.000000024 mg/mg, 0.00011 mg/mL, 0.0033 mg/mL, 0.00012 mg/mg, 0.0004 mg/mL, 0.00017 mg/mL, 0.000002 mg/mg, 0.0000007 mg/mg, 0.0011 mg/mL, 0.00005 mg/mL, 0.0003 mg/mL, 0.0000002 mg/mg, 0.000005 mg/mg, 0.000311 mg/mL, 0.5 mg/mL

Tablet - Oral, Tablet, , Tablet, film coated - Oral, Oral, Tablet, film coated, Injection, solution, Injection, solution - Intramuscular, Tablet, coated - Oral, Tablet, coated, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Liquid, Liquid - Oral, Nasal, Spray, Spray - Nasal, Injection, solution - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous, Capsule, liquid filled - Oral, Capsule, liquid filled, Injection, Injection - Intramuscular; Subcutaneous, Liquid - Intramuscular; Subcutaneous, Solution, Liquid - Intramuscular, Syrup - Oral, Syrup, Tablet, extended release - Oral, Intramuscular, Kit - Intramuscular; Subcutaneous, Kit, Lozenge - Oral, Solution - Intramuscular; Subcutaneous, Tablet, extended release, Lozenge, Liquid - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder - Oral, Powder, Liquid; Tablet - Oral, Liquid; Tablet, Solution / drops, Tablet, chewable - Oral, Tablet, chewable, Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Liquid - Intravenous, Solution - Oral, Solution / drops - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, orally disintegrating - Oral, Tablet - Sublingual, Tablet, orally disintegrating, Tablet, Delayed Release - Oral, Sublingual, Solution - Parenteral, Gel - Nasal, Elixir - Oral, Injection, solution - Intravenous, Tablet, effervescent, Tablet, effervescent - Oral, Parenteral, Tablet, Delayed Release, Elixir, Kit - Oral, Injection, powder, lyophilized, for solution, Wafer - Oral, Wafer, Kit - Intramuscular; Subcutaneous; Topical, Intramuscular; Subcutaneous; Topical, Spray, metered, Spray, metered - Nasal, Liquid - Intramuscular; Intravenous, Intramuscular; Intravenous, Capsule; Liquid - Oral, Capsule; Liquid, Solution - Intravenous, Capsule, coated - Oral, Injection - Intramuscular, Patch, Patch - Transdermal, Capsule, coated, Transdermal, Strip - Oral, Strip, Tablet, delayed release, Tablet, delayed release - Oral, Topical, Lotion, Lotion - Topical, Injection - Intravenous, Intramuscular; Topical, Powder, for solution, Powder, for solution - Oral

Gastrointestinal Problems

Avitaminosis

Malignant Neoplasms

Celiac Disease

Nervous system structure

Total or Partial Gastrectomy

Beriberi

Vitamin supplementation

Iron Deficiency Anemia

Diabetic Neuropathy

Vitamin B 12 Deficiency

Colon Cancer

Vitamin supplementation therapy

Gastrointestinal Surgery

Vitamin B 12 Deficiency

Convalescence

Folic Acid Deficiency

Beriberi

Neuritis

Warnings

Nascobal Contraindications

Condition

Risk Level

Notes

cobalt

Do Not Combine

Congestive Heart Failure

Do Not Combine

There are 20 known major drug interactions with Nascobal.

Common Nascobal Drug Interactions

Drug Name

Risk Level

Description

Abacavir

Minor

Cyanocobalamin may decrease the excretion rate of Abacavir which could result in a higher serum level.

Aclidinium

Minor

Cyanocobalamin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Cyanocobalamin may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Cyanocobalamin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Allopurinol

Minor

Cyanocobalamin may decrease the excretion rate of Allopurinol which could result in a higher serum level.

Nascobal Toxicity & Overdose Risk

Vitamin B12 is generally safe, even in high doses. In some cases, people have experienced mild diarrhea, itchy skin, swelling, breathing difficulties, and even death. It is not known to cause cancer. No negative effects have been reported in pregnant or breastfeeding women when taking the normal daily requirement of Vitamin B12. For pregnant women using the nasal spray form of Vitamin B12, it is not yet known if it can cause harm or affect the baby.

image of a doctor in a lab doing drug, clinical research

Nascobal Novel Uses: Which Conditions Have a Clinical Trial Featuring Nascobal?

At present, 42 clinical trials are being conducted to assess the potential of Nascobal to address Tapeworm infestation, Folate and Vitamin Deficiencies.

Condition

Clinical Trials

Trial Phases

Iron Deficiency Anemia

21 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4

Colon Cancer

44 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Folic Acid Deficiency

0 Actively Recruiting

Gastrointestinal Surgery

1 Actively Recruiting

Not Applicable

Vitamin B 12 Deficiency

0 Actively Recruiting

Anemia, Pernicious

0 Actively Recruiting

Vitamin B 6 Deficiency

0 Actively Recruiting

Malignant Neoplasms

0 Actively Recruiting

Vitamin supplementation

0 Actively Recruiting

Vitamin B 12 Deficiency

0 Actively Recruiting

Vitamin B 12 Deficiency

0 Actively Recruiting

Convalescence

0 Actively Recruiting

Gastrointestinal Problems

0 Actively Recruiting

vitamin B12

0 Actively Recruiting

Nutritional supplementation

1 Actively Recruiting

Early Phase 1

Pancreatic Neoplasms

8 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3

Celiac Disease

0 Actively Recruiting

folic acid

0 Actively Recruiting

Small Intestinal Bacterial Overgrowth Syndrome (SIBO)

3 Actively Recruiting

Phase 1, Not Applicable

Nervous system structure

0 Actively Recruiting

Nascobal Reviews: What are patients saying about Nascobal?

4.7

Patient Review

6/20/2010

Nascobal for Prevention of Vitamin B12 Deficiency

I had gastric bypass surgery six months ago. My doctor prescribed this medication to me to prevent B-12 deficiency, and I took it for two months before deciding that I didn't think it was doing anything extraordinary for me so I stopped taking it. However, I continued taking my complete regiment of bariatric vitamins. Shortly after, I believe as a result of not taking the medication, I became fatigued, had poor short term memory, confusion and anxiety. So don't make the same mistake I did - follow the dosing instructions carefully.

4.7

Patient Review

7/8/2013

Nascobal for Prevention of Vitamin B12 Deficiency

I've been using this medication for three months now, and it definitely seems to help. I haven't experienced any negative side effects yet, which is great.

2.7

Patient Review

5/5/2012

Nascobal for Anemia caused by Vitamin B12 Deficiency-Pernicious Anemia

I was prescribed nascobal 500mcg spray 2.3 ml (8-week dose) for Pernicious anemia. I refilled the prescription but was given 1.3 ml (4-week dose) for the same price (after insurance). When I asked the pharmacist about it I was told that the manufacturer had changed the amount sold from 2.3 to 1.3 and the insurance company paid out the same no matter the amount. So, now I have to pay double for what I need.

Patient Q&A Section about nascobal

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there a generic for Nascobal?

"The prescription drug Nascobal is manufactured by Endo Pharmaceuticals. There is no generic version of Nascobal available at this time."

Answered by AI

What is Nascobal Nasal Spray used for?

"NASCOBAL® Nasal Spray is a prescription medicine used to treat vitamin B12 deficiency caused by malabsorption that is not related to pernicious anemia."

Answered by AI

How often do you take Nascobal?

"Use this medication in the nose once weekly. Avoid hot food or drinks for 1 hour before or after using this medication, as they may produce mucus that can wash away the medication."

Answered by AI

What does vitamin b112 do?

"Vitamin B-12 is involved in many essential body functions, including red blood cell formation, cell metabolism, nerve function, and DNA production. It can be found in poultry, meat, fish, and dairy products."

Answered by AI