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What is Nalidixic Acid
Nalidixic acidThe Generic name of this drug
Treatment SummaryNalidixic acid is a synthetic drug used to kill bacteria. It works by preventing the bacteria’s DNA from being able to replicate, which stops the bacteria from growing and spreading. This drug is only effective against a limited number of bacteria.
NegGramis the brand name
Nalidixic Acid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
NegGram
Nalidixic acid
1964
1
Effectiveness
How Nalidixic Acid Affects PatientsNalidixic acid is a type of antibiotic taken orally to treat infections caused by certain bacteria. It is especially effective against gram-negative bacteria such as Enterobacter, E. coli, Morganella Morganii, Proteus Mirabilis, Proteus vulgaris, and Providencia rettgeri. Pseudomonas species are usually resistant to this drug. Nalidixic acid is able to fight bacteria in any pH range in the urinary tract. In rare cases, resistance to nalidixic acid can develop within 2-14% of patients taking it in full dosage, but this resistance cannot be
How Nalidixic Acid works in the bodyNalidixic acid works by attaching to DNA in cells and blocking the production of RNA and proteins. This stops the cell from working properly.
When to interrupt dosage
The recommended measure of Nalidixic Acid is contingent upon the determined condition. The amount of dosage fluctuates, in regard to the technique of delivery (e.g. Tablet - Oral or Oral) as depicted in the table beneath.Condition
Dosage
Administration
Urinary Tract Infection
500.0 mg,
, Oral, Tablet - Oral, Tablet
Warnings
Nalidixic Acid ContraindicationsCondition
Risk Level
Notes
Porphyria
Do Not Combine
Convulsions
Do Not Combine
known hypersensitivity to the drug or any of the ingredients
Do Not Combine
Pulse Frequency
Do Not Combine
Common Nalidixic Acid Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Amiodarone.
Amitriptyline
Major
Nalidixic acid may increase the QTc-prolonging activities of Amitriptyline.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nalidixic acid is combined with Artemether.
Nalidixic Acid Toxicity & Overdose RiskThe lethal dose for rats is 1160mg/kg and for mice is 572mg/kg. Taking too much of this drug can cause mental confusion, seizures, increased pressure in the skull, or too much acid in the body. Overdosing can also lead to vomiting, nausea, and tiredness.
Nalidixic Acid Novel Uses: Which Conditions Have a Clinical Trial Featuring Nalidixic Acid?
10 active trials are currently assessing the efficacy of Nalidixic Acid in the treatment of Urinary Tract Infections.Condition
Clinical Trials
Trial Phases
Urinary Tract Infection
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Nalidixic Acid Reviews: What are patients saying about Nalidixic Acid?
3Patient Review
10/15/2011 This medication quickly and effectively took care of my UTI symptoms. Paired with the antibiotic, it cleared up the infection entirely.
Patient Q&A Section about nalidixic acid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is nalidixic acid still used?
"This medication was historically used to treat urinary tract infections that were caused by different types of bacteria. Now, there are other medications that are less toxic and more effective, so this drug is no longer used for that purpose in the USA."
Answered by AI
What does nalidixic acid prevent?
"Nalidixic acid was the first quinolone antibiotic to be approved, in 1963. Later quinolone antibiotics (and their derivative, fluoroquinolones) work by inhibiting DNA replication and repair. They do this by targeting DNA gyrase, an enzyme essential for these processes. These antibiotics are effective against both Gram-positive and Gram-negative bacteria."
Answered by AI
What class of drug is nalidixic acid?
"NegGram is a drug in the quinolone antibiotics class. It is not known if it is safe and effective in children."
Answered by AI