Mysoline

Seizures, Essential Tremor, Epilepsy, Temporal Lobe

Treatment

5 FDA approvals

20 Active Studies for Mysoline

Treatment for

Seizures

What is Mysoline

PrimidoneThe Generic name of this drug

Treatment SummaryPrimidone is a medication used to treat seizures, such as grand mal, psychomotor, and focal epileptic seizures, as well as essential tremors. It was first developed in 1949 and approved by the FDA in 1954.

Primidoneis the brand name

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Mysoline Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Primidone

1978

Approved as Treatment by the FDA

Primidone, also known as Primidone, is approved by the FDA for 5 uses including Seizures and Temporal Lobe Epilepsy (TLE) .

Seizures

Helps manage Partial-Onset Seizures

Temporal Lobe Epilepsy (TLE)

Helps manage Temporal Lobe Epilepsy (TLE)

Generalized Tonic-Clonic Seizures

Helps manage Generalized Tonic-Clonic Seizures

Epilepsy, Temporal Lobe

Helps manage Temporal Lobe Epilepsy (TLE)

Partial-Onset Seizures

Helps manage Partial-Onset Seizures

Effectiveness

How Mysoline Affects PatientsPrimidone works by changing how sodium and calcium move in the body, which helps to reduce the frequency of nerve signals. This can help with seizures and tremors. It is usually taken in doses between 50-1000mg per day. It is important to tell patients that suddenly stopping primidone could cause a life-threatening medical emergency called status epilepticus.

How Mysoline works in the bodyPrimidone works to reduce seizures and essential tremor by altering the transport of sodium and calcium channels in your nerves. This reduces the number of times they fire, which can help stop convulsions. Primidone does not work directly on GABA-A receptors or chloride channels, although its byproduct, phenobarbital, does.

When to interrupt dosage

The advised measure of Mysoline relies upon the defined condition, including Tonic - clonic seizures, Seizures and Temporal Lobe Epilepsy (TLE). The quantity of dosage is contingent upon the system of delivery (e.g. Tablet or Oral) detailed in the table below.

Condition

Dosage

Administration

Seizures

, 50.0 mg, 250.0 mg, 125.0 mg

, Oral, Tablet, Tablet - Oral

Essential Tremor

, 50.0 mg, 250.0 mg, 125.0 mg

, Oral, Tablet, Tablet - Oral

Epilepsy, Temporal Lobe

, 50.0 mg, 250.0 mg, 125.0 mg

, Oral, Tablet, Tablet - Oral

Warnings

Mysoline has two contraindications and must be avoided when one of the conditions in the following table is present.Mysoline Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Primidone may interact with Pulse Frequency

Porphyrias

Do Not Combine

There are 20 known major drug interactions with Mysoline.

Common Mysoline Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Primidone.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Primidone.

5-androstenedione

Major

The metabolism of 5-androstenedione can be increased when combined with Primidone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Primidone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Primidone.

Mysoline Toxicity & Overdose RiskThe lowest toxic dose of primidone in rats is 1500mg/kg and 280mg/kg in mice. The symptoms of primidone overdose include confusion, unconsciousness, shallow breathing, weak reflexes, low blood pressure, and low urine output. Treatment for this kind of overdose consists of supportive care and removing any unabsorbed drug from the body.

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Mysoline Novel Uses: Which Conditions Have a Clinical Trial Featuring Mysoline?

At present, 4 active trials are investigating the potential of Mysoline to mitigate Temporal Lobe Epilepsy (TLE), Tremor, Essential and Grand Mal Seizures.

Condition

Clinical Trials

Trial Phases

Essential Tremor

26 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 1

Seizures

4 Actively Recruiting

Phase 3, Phase 2

Epilepsy, Temporal Lobe

0 Actively Recruiting

Mysoline Reviews: What are patients saying about Mysoline?

5Patient Review

6/3/2016

Mysoline for Convulsive Seizures

I've been living with epilepsy for nearly 50 years now, and Mysoline has really been the best medication I've found. It's lasted all these years without any problems. Generic brands just don't work as well, so be warned!

5Patient Review

1/20/2012

Mysoline for Epileptic Seizure

This medicine has been a lifesaver for me. I've been taking it for years and it has completely controlled my seizures. I haven't experienced any negative side effects, although in the first few weeks after starting the medication I did feel a bit drowsy.

5Patient Review

2/19/2013

Mysoline for Epileptic Seizure

This drug has been great for stopping my body cramps.

5Patient Review

4/22/2013

Mysoline for Convulsive Seizures

This treatment has worked well for me. I'm very pleased with the results.

5Patient Review

8/19/2011

Mysoline for Epileptic Seizure

View All Reviews

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Patient Q&A Section about mysoline

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Mysoline the same as primidone?

"The seizure medicine Mysoline is known by the generic name primidone in the United States, Canada, and many other countries."

Answered by AI

What is the drug primidone used for?

"Primidone is a medicine used to control seizures (convulsions) in the treatment of epilepsy. It is an anticonvulsant that works in the brain tissue to stop seizures. This medicine is available only with your doctor's prescription."

Answered by AI

What is the drug Mysoline used for?

"This medication controls seizures either by itself or with other seizure medications. Reducing the seizures lets you do more normal daily activities, reduces the risk of harm when you lose consciousness, and also decreases the risk for a potentially deadly condition of having multiple seizures."

Answered by AI

Is Mysoline used for tremors?

"Primidone is an anti-seizure drug that is also effective for treating essential tremor. It is most useful for people with hand tremor. Although it is not clear how it works, primidone appears to be as effective as propranolol, with significant suppression of tremor in most patients."

Answered by AI

Clinical Trials for Mysoline

Have you considered Mysoline clinical trials? We made a collection of clinical trials featuring Mysoline, we think they might fit your search criteria.

Have you considered Mysoline clinical trials? We made a collection of clinical trials featuring Mysoline, we think they might fit your search criteria.