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What is Mysoline
PrimidoneThe Generic name of this drug
Treatment SummaryPrimidone is a medication used to treat seizures, such as grand mal, psychomotor, and focal epileptic seizures, as well as essential tremors. It was first developed in 1949 and approved by the FDA in 1954.
Primidoneis the brand name
Mysoline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Primidone
Primidone
1978
73
Approved as Treatment by the FDA
Primidone, also known as Primidone, is approved by the FDA for 2 uses including Seizures and Temporal Lobe Epilepsy (TLE) .Seizures
Helps manage Partial-Onset Seizures
Temporal Lobe Epilepsy (TLE)
Helps manage Temporal Lobe Epilepsy (TLE)
Effectiveness
How Mysoline Affects PatientsPrimidone works by changing how sodium and calcium move in the body, which helps to reduce the frequency of nerve signals. This can help with seizures and tremors. It is usually taken in doses between 50-1000mg per day. It is important to tell patients that suddenly stopping primidone could cause a life-threatening medical emergency called status epilepticus.
How Mysoline works in the bodyPrimidone works to reduce seizures and essential tremor by altering the transport of sodium and calcium channels in your nerves. This reduces the number of times they fire, which can help stop convulsions. Primidone does not work directly on GABA-A receptors or chloride channels, although its byproduct, phenobarbital, does.
When to interrupt dosage
The advised measure of Mysoline relies upon the defined condition, including Tonic - clonic seizures, Seizures and Temporal Lobe Epilepsy (TLE). The quantity of dosage is contingent upon the system of delivery (e.g. Tablet or Oral) detailed in the table below.Condition
Dosage
Administration
Tremor, Essential
, 50.0 mg, 250.0 mg, 125.0 mg
, Oral, Tablet, Tablet - Oral
Seizures
, 50.0 mg, 250.0 mg, 125.0 mg
, Oral, Tablet, Tablet - Oral
Temporal Lobe Epilepsy (TLE)
, 50.0 mg, 250.0 mg, 125.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Mysoline has two contraindications and must be avoided when one of the conditions in the following table is present.Mysoline ContraindicationsCondition
Risk Level
Notes
Porphyria
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Primidone may interact with Pulse Frequency
Common Mysoline Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Primidone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Primidone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Primidone.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Primidone.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Primidone.
Mysoline Toxicity & Overdose RiskThe lowest toxic dose of primidone in rats is 1500mg/kg and 280mg/kg in mice. The symptoms of primidone overdose include confusion, unconsciousness, shallow breathing, weak reflexes, low blood pressure, and low urine output. Treatment for this kind of overdose consists of supportive care and removing any unabsorbed drug from the body.
Mysoline Novel Uses: Which Conditions Have a Clinical Trial Featuring Mysoline?
At present, 4 active trials are investigating the potential of Mysoline to mitigate Temporal Lobe Epilepsy (TLE), Tremor, Essential and Grand Mal Seizures.Condition
Clinical Trials
Trial Phases
Temporal Lobe Epilepsy (TLE)
1 Actively Recruiting
Phase 1
Seizures
2 Actively Recruiting
Phase 3
Tremor, Essential
0 Actively Recruiting
Mysoline Reviews: What are patients saying about Mysoline?
5Patient Review
6/3/2016 I've been living with epilepsy for nearly 50 years now, and Mysoline has really been the best medication I've found. It's lasted all these years without any problems. Generic brands just don't work as well, so be warned!
5Patient Review
1/20/2012 This medicine has been a lifesaver for me. I've been taking it for years and it has completely controlled my seizures. I haven't experienced any negative side effects, although in the first few weeks after starting the medication I did feel a bit drowsy.
5Patient Review
2/19/2013 This drug has been great for stopping my body cramps.
5Patient Review
4/22/2013 This treatment has worked well for me. I'm very pleased with the results.
5Patient Review
8/19/20115Patient Review
11/23/20114.7Patient Review
6/29/2014 This medication is great for helping to control tremors when used in conjunction with other drugs.
4.3Patient Review
1/25/2012 I've tried a lot of different treatments, and this is by far the best one I've found. The doctor is very knowledgeable and has helped me immensely.
4Patient Review
6/15/2013 I've been on this medication for 23 years and it's done a great job of controlling my seizures. When I started taking it, the fatigue was really bad but that eventually went away.
4Patient Review
9/5/2013 I've been taking mysoline for a while now, and it hasn't really done much. Recently, I was diagnosed with asthma by a pulmonologist.
4Patient Review
6/25/2012 I often felt dizzy and nauseous after taking this medication.
3Patient Review
2/27/2021 Every year, my condition slightly worsens. I started treatment at 64 years old and saw some improvement with 100mg for three years. However, when I added vitamin E to the mix, I saw even better results for about a year. Now, I'm considering upping my dosage to 75mg with the same amount of vitamin E. From what I've read, this combination only helps a small percentage of people; luckily, I seem to be one of them.
3Patient Review
11/30/2011 I haven't had a seizure in many years but I am concerned about the long-term effects of this medication.
3Patient Review
9/7/20112Patient Review
11/3/2013 My condition has gotten worse as I've gotten older, making it hard to write and socialize. Increasing my dosage hasn't helped at all (I'm up to 150mg now).
2Patient Review
7/27/2012 While this has helped to lessen my tremors, it unfortunately hasn't had any effect on the tremor in my voice.
1Patient Review
3/27/2012 I don't know if this interacts with doxycycline
Patient Q&A Section about mysoline
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Mysoline the same as primidone?
"The seizure medicine Mysoline is known by the generic name primidone in the United States, Canada, and many other countries."
Answered by AI
What is the drug primidone used for?
"Primidone is a medicine used to control seizures (convulsions) in the treatment of epilepsy. It is an anticonvulsant that works in the brain tissue to stop seizures. This medicine is available only with your doctor's prescription."
Answered by AI
What is the drug Mysoline used for?
"This medication controls seizures either by itself or with other seizure medications. Reducing the seizures lets you do more normal daily activities, reduces the risk of harm when you lose consciousness, and also decreases the risk for a potentially deadly condition of having multiple seizures."
Answered by AI
Is Mysoline used for tremors?
"Primidone is an anti-seizure drug that is also effective for treating essential tremor. It is most useful for people with hand tremor. Although it is not clear how it works, primidone appears to be as effective as propranolol, with significant suppression of tremor in most patients."
Answered by AI