Motrin

Insomnia, Catarrh, Chronic Pain + 33 more

Treatment

13 FDA approvals

20 Active Studies for Motrin

Treatment for

Insomnia

What is Motrin

Ibuprofen

The Generic name of this drug

Treatment Summary

Ibuprofen is a common pain reliever that was first developed in 1960 as a safer alternative to aspirin. It was officially patented in 1961 and became available for use in the UK in 1969 and the US in 1974. Ibuprofen is a type of non-steroidal anti-inflammatory drug (NSAID) and is usually sold as a racemic mixture. The S-enantiomer of ibuprofen is believed to be more effective at reducing pain than the R-enantiomer.

Motrin

is the brand name

image of different drug pills on a surface

Motrin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Motrin

Ibuprofen

1974

2460

Approved as Treatment by the FDA

Ibuprofen, also called Motrin, is approved by the FDA for 13 uses including Acute Pain and Dysmenorrhea .

Acute Pain

Used to treat Pain, Acute in combination with Oxycodone

Dysmenorrhea

Mild pain

Gastric Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Famotidine

Stomach Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Pain, Acute

Used to treat Pain, Acute in combination with Oxycodone

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Famotidine

Migraine

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Famotidine

Fever

Headache

Menstrual Distress (Dysmenorrhea)

Effectiveness

How Motrin Affects Patients

Ibuprofen is used to reduce pain, fever and inflammation. It works by blocking the substances that cause these issues (prostanoids) from being produced by the COX-1 and COX-2 enzymes. It also helps to reduce swelling, and has been found to increase beta-endorphin levels in the blood. Ibuprofen is commonly used to treat dysmenorrhea, migraines, and joint pain, and has been found to reduce neurodegeneration when taken in low doses over a long period of time. It has also been linked to a decrease in the rate of breast cancer by 50

How Motrin works in the body

Ibuprofen works by blocking an enzyme called cyclooxygenase, which is involved in making substances that cause pain and fever. Ibuprofen is a non-selective inhibitor, meaning it blocks both COX-1 and COX-2. Blocking COX-2 reduces the production of prostaglandins that cause inflammation, pain, fever, and swelling. Blocking COX-1 can cause side effects like stomach ulcers.

When to interrupt dosage

The advocated dosage of Motrin is contingent upon the indicated condition, such as smooth muscle relaxation prior to radiological procedures, Catarrh and Pain relief. The amount of dosage is contingent upon the mode of delivery (e.g. Kit - Oral; Topical or Tablet) listed in the table hereunder.

Condition

Dosage

Administration

Migraine

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Liquid, Capsule, Capsule - Oral, Capsule, coated, Capsule, coated - Oral, Intravenous, Solution - Intravenous, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Injection, solution - Intravenous, Injection, solution, Tablet, extended release, Tablet, extended release - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Oral; Topical, Kit - Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Cream, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops

Migraine Disorders

Stomach Ulcer

Arthritis, Gouty

Dysmenorrhea

Premature Birth

Muscle Relaxation

Acute Pain

Chronic Pain

Analgesics

Muscle Spasticity

Cystic Fibrosis

Spasm

Mild pain

Primary Dysmenorrhoea

Pain

Opioids

Nasal Congestion

Juvenile arthritis

Warnings

Motrin Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Motrin.

Common Motrin Drug Interactions

Drug Name

Risk Level

Description

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Ibuprofen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Ibuprofen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Ibuprofen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Ibuprofen.

Fluorouracil

Major

The metabolism of Fluorouracil can be decreased when combined with Ibuprofen.

Motrin Toxicity & Overdose Risk

Taking too much ibuprofen can result in abdominal pain, nausea, vomiting, fatigue, dizziness, vertigo, drowsiness, insomnia, headaches, loss of consciousness, ringing in the ears, depression of the central nervous system, seizures, and difficulty breathing. In rare cases, it may lead to a metabolic acidosis, abnormal liver function, high levels of potassium in the blood, kidney failure, and coma. The lethal dose of ibuprofen has been recorded as 636mg/kg in rats, 740mg/kg in mice, and 495mg/kg in guinea pigs.

image of a doctor in a lab doing drug, clinical research

Motrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Motrin?

Currently, 531 active clinical trials are examining the potential of Motrin to provide relief for Rheumatoid Arthritis, Chronic Pain and Migraine symptoms.

Condition

Clinical Trials

Trial Phases

Premature Birth

25 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1

Rheumatoid Arthritis

56 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Influenza

0 Actively Recruiting

Pain

0 Actively Recruiting

Aquaporin 2

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Chronic Pain

116 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Migraine

44 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Muscle Relaxation

0 Actively Recruiting

Juvenile arthritis

6 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Migraine

15 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Acute Pain

2 Actively Recruiting

Not Applicable, Phase 1

Primary Dysmenorrhoea

2 Actively Recruiting

Not Applicable

Nasal Congestion

0 Actively Recruiting

Catarrh

0 Actively Recruiting

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Arthritis, Gouty

0 Actively Recruiting

Insomnia

0 Actively Recruiting

Pain

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Pain

0 Actively Recruiting

Motrin Reviews: What are patients saying about Motrin?

Patient Review

1/14/2020

Motrin for Minor Musculoskeletal Injury

I was surprised at how quickly Motrin took effect. I only needed to take one gel capsule and, 12 hours later, I'm still feeling a bit groggy but that's a small price to pay for its efficacy.

Patient Review

11/19/2010

Motrin for Pain

I have to take 800mg three or four times a day, which can be tough. I also take Tramadol though.

Patient Review

6/7/2013

Motrin for Joint Damage causing Pain and Loss of Function

I had a knee replacement and was worried about the pain. This treatment really helped me though, and I didn't have to worry about it at all.

Patient Review

5/21/2012

Motrin for Pain

I have nerve damage in my right arm and hand. The nerves are healing, but in the meantime I experience pulses of pain, pins and needles, as well as a burning sensation.

4.7

Patient Review

6/27/2010

Motrin for Pain

4.3

Patient Review

5/26/2011

Motrin for Joint Damage causing Pain and Loss of Function

I find this to be an effective treatment for pain with no unpleasant side effects.

4.3

Patient Review

12/25/2013

Motrin for Gout

I was worried about potential side effects but this treatment really helped me. Not sure what else to do besides take it and hope for the best.

Patient Review

11/1/2011

Motrin for Pain

Arthritis is a tough battle, but this medication has helped me immensely.

Patient Review

4/19/2010

Motrin for Pain

Patient Review

7/7/2010

Motrin for Rheumatoid Arthritis

3.3

Patient Review

12/3/2011

Motrin for Pain

This medication caused my hands to swell.

Patient Review

7/12/2012

Motrin for Pain

Motrin 600mg is the medication I am currently taking for my back pain. I originally got it from the ER after pulling a muscle, but it's not as effective as I'd hoped.

2.7

Patient Review

1/25/2014

Motrin for Pain

I found that this drug really helped me push through my workout. I could easily go another two hours on the treadmill after taking it. However, I much prefer to inject steroids directly into my calves at this point.

Patient Review

7/27/2010

Motrin for Joint Damage causing Pain and Loss of Function

Patient Review

2/17/2011

Motrin for Pain

This medication effectively reduced the swelling in my ear caused by an infection.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about motrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Motrin the same as ibuprofen or Tylenol?

"Tylenol, Advil, and Aleve are all pain relievers that can be found on drugstore shelves. The active ingredient in Tylenol is acetaminophen, while the active ingredient in both Advil and Motrin is ibuprofen. The active ingredient in Aleve is naproxen."

Answered by AI

Is Motrin & Tylenol the same?

"The two drugs have different active ingredients and thus belong to different drug classes. Tylenol is an analgesic that relieves pain, and it is also an antipyretic, which means it reduces fever. Motrin, on the other hand, is an NSAID, or nonsteroidal anti-inflammatory drug. Both drugs can cause nausea, stomach pain, skin itching or rash, and headache, among other side effects."

Answered by AI

What is a Motrin used for?

"MOTRIN® is a non-steroidal anti-inflammatory drug (NSAID), and contains ibuprofen. Ibuprofen is used to relieve pain and reduce fever. Adult MOTRIN® IB products contain 200 milligrams of ibuprofen and are available as tablets or Liquid Gels (liquid-filled capsules)."

Answered by AI

Is ibuprofen and Motrin the same thing?

"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is also known as Advil or Motrin. Other members of this drug class include aspirin and naproxen (Aleve)."

Answered by AI

Clinical Trials for Motrin

Image of UCI Health Susan Samueli Integrative Health Institute in Irvine, United States.

Biofield Therapy for Cancer

18+

All Sexes

Irvine, CA

Cancer treatment with immunotherapy is often associated with symptoms such as fatigue, pain, and emotional distress, which may affect patients' daily functioning and quality of life. Additional supportive care approaches are being studied to better understand their potential role in supporting these symptoms. The purpose of this study is to learn whether a biofield therapy, called Reiki may help to support adults with cancer who are receiving immunotherapy and currently struggling with fatigue. Reiki is a non-invasive complementary therapy delivered by a trained practitioner who places their hands lightly near the body. It is intended to promote relaxation and support general well-being. Reiki is used as a supportive practice and is not considered a medical treatment or replacement for standard care. The secondary goal of this study is to evaluate the feasibility of delivering Reiki in this clinical setting. This includes examining recruitment, retention, adherence to study procedures, and overall participant engagement. Lastly, the third aim is to explore participants' experiences with Reiki through guided interviews. Participants enrolled in this study will first be asked to participate in a one-hour, one-on-one interview about their experiences with cancer treatment, their symptoms, and their thoughts about integrative care practices such as Reiki. After the interview, they will be randomly assigned to one of two groups: Immediate Reiki Group: If participants are assigned to this group, they will receive six weekly, in-person 30-minute Usui Reiki sessions from a Reiki master at the Susan Samueli Integrative Health Institute. Before and after each session, participants will complete questionnaires about fatigue, pain, and stress. At the first and final sessions, a small blood sample will be collected to measure inflammatory biomarkers, and Electroencephalogram (EEG) hyperscanning will be conducted to measure brain activity and connectivity between the participant and the practitioner. Four weeks after the final session, they will complete the questionnaires again, followed by a short satisfaction survey about their experience. Waitlist Group: If they are assigned to the waitlist group, they will first complete a 6-week observation period that includes brief weekly fatigue questionnaires and two in-person 30-minute sessions with EEG measurements at Week 1 and Week 6. This will be followed by a 4-week period with no sessions, after which they will complete questionnaires about fatigue, pain, and psychological distress. Participants will then begin the same six weekly, in-person 30-minute sessions described above. As with the Immediate Group, they will complete questionnaires before and after each session. At the first and final sessions, a small blood sample will be collected and EEG hyperscanning will be conducted. At the end of the study, participants will also complete a short satisfaction survey about their experience. The investigators hypothesize that participants receiving Reiki will report improvements in symptoms and well-being compared to those not yet receiving Reiki, and that the intervention will be feasible to implement and acceptable to participants.

Recruiting

Has No Placebo

UCI Health Susan Samueli Integrative Health Institute (+1 Sites)

Image of Alberta Children's Hospital in Calgary, Canada.

Therapeutic Cuddling for Pain in Critically Ill Children

< 65

All Sexes

Calgary, Canada

2.1 CONTEXT Pain and agitation are common comorbidities of pediatric critical illness due to both underlying disease processes and ICU related therapies. These are associated with both short and long term negative sequelae including increased mortality, length of stay, rates of ICU delirium, worse sleep, increased anxiety, depression, and chronic pain. The current standard of care to manage PICU associated pain and agitation is the use of analgosedation (e.g. opioids and benzodiazepines) these too are associated with increased time on the ventilator, length of stay, ICU delirium, and long term mental health and negative neuro-cognitive outcomes. Despite recommendations for increased use of non-pharmacologic therapies in the prevention and management of PICU associated pain, agitation, delirium, and analgosedation exposure, there are currently know therapies with clear evidence of efficacy. Therapeutic cuddling (e.g. kangaroo care, clothed cuddling, comfort holding, etc.) has been shown to decrease pain and anxiety in critically ill neonates, and healthy children and adults. Positive affective touch and hugging has known physiologic benefits and has been associated with decreased pain, improved immunity, and decreased mortality. Despite the potential for this intervention to aid in the prevention and management of PICU associated pain, agitation, delirium and analgosedation exposure, little data exists on efficacy of therapeutic cuddling in critically ill children. 2.2 OBJECTIVES 2.2.1 Primary Determine the feasibility of screening, consent, randomization, and retention of participants in a pragmatic RCT of therapeutic cuddling versus standard of care in the Alberta Children's Hospital Pediatric Intensive Care Unit. 2.2.2 Secondary 1. Determine treatment fidelity of participants randomized to the intervention arm. 2. Determine the prevalence of the therapeutic cuddling intervention in those randomized to the standard of care arm. 3. Determine the feasibility of measurement of key outcomes and co-variates (i.e., pain, agitation, sedation, delirium, analgosedation exposure, parental presence). 4. Describe the experience of patients, caregivers, and healthcare professionals in delivering/receiving the therapeutic cuddling intervention. 2.3 STUDY DESIGN Pilot feasibility randomized controlled trial of a structured co-designed therapeutic cuddling intervention as compared to the standard of care in a single tertiary care PICU. 2.4 DURATION 6 months to 1 year 2.5 LOCATION, DEPARTMENTS, AND FACILITY WHERE RESEARCH WILL BE UNDERTAKEN The pediatric intensive care unit at the Alberta Children's Hospital 2.6 SAMPLE SIZE A total sample size of 112 participants (56 per arm)

Recruiting

Has No Placebo

Alberta Children's Hospital