Monistat 1 Combination Pack

Inflammation, Tinea Pedis, Dermatophytosis + 20 more

Treatment

20 Active Studies for Monistat 1 Combination Pack

What is Monistat 1 Combination Pack

Miconazole

The Generic name of this drug

Treatment Summary

Miconazole is a type of antifungal drug used to treat yeast infections. This medication works by inhibiting the production of a certain enzyme in fungus, which helps to stop the growth and spread of the infection. It can be used to treat both oral and vaginal yeast infections, and is available in the form of creams, tablets, gels, and suppositories. Miconazole was approved by the FDA in 1974 and is available both by prescription and over-the-counter. It is considered to be generally safe and has a low risk of resistance due to long-term use.

SUNMARK MICONAZOLE NITRATE antifungal

is the brand name

image of different drug pills on a surface

Monistat 1 Combination Pack Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

SUNMARK MICONAZOLE NITRATE antifungal

Miconazole

1991

255

Effectiveness

How Monistat 1 Combination Pack Affects Patients

Miconazole is an antifungal medication that interferes with the growth of fungi. It is usually applied to the skin and does not get absorbed into the body much. Common side effects are allergies and anaphylaxis. If using miconazole intravaginally, it is recommended not to use contraceptives or tampons at the same time, as they can cause the medication to be less effective.

How Monistat 1 Combination Pack works in the body

Miconazole is an antifungal medication used to treat infections caused by a fungus called _Candida_. It works in three ways. First, it interferes with the production of a part of the fungus' cell membrane, making it leaky and unable to function properly. Second, it leads to increased production of reactive oxygen species (ROS), which have a variety of effects that lead to cell death. Third, it increases levels of farnesol, which prevents the fungus from forming biofilms which are harder to treat. In addition, farnesol also stops the fungus from using certain proteins that help it

When to interrupt dosage

The suggested dose of Monistat 1 Combination Pack is based on the diagnosed condition, including Gastrointestinal candidiasis, Nail candida and Infection, Mixed. The measure of dosage is contingent upon the method of administration (e.g. Topical or Aerosol, spray - Topical) featured in the following table.

Condition

Dosage

Administration

Tinea Pedis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Inflammation

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Dermatophytosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

cutaneous candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Acne Vulgaris

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Tinea

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Dermatitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Yeast Infection

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Dermatitis, Seborrheic

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Tinea Cruris

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Ringworm

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Oropharyngeal Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Arthrodermataceae

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Onychomycosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Cellulitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Coinfection

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Hyperhidrosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Intertrigo

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Cream, Liquid, Liquid - Topical, Aerosol, spray - Topical, Aerosol, spray, Aerosol, powder, Tablet, Tablet - Buccal, Buccal, Insert, Aerosol, Aerosol - Topical, Capsule; Cream; Kit, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Topical; Vaginal, Cream; Insert, Cream; Suppository - Topical; Vaginal, Cream; Insert - Topical; Vaginal, Cream; Suppository, Aerosol, powder - Topical, Lotion, Lotion - Topical, Kit - Topical; Vaginal, Paste, Insert - Vaginal, Kit - Topical, Paste - Topical

Warnings

Monistat 1 Combination Pack has two contraindications and should not be employed when afflicted with any of the ailments specified in the following table.

Monistat 1 Combination Pack Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Miconazole may interact with Pulse Frequency

There are 20 known major drug interactions with Monistat 1 Combination Pack.

Common Monistat 1 Combination Pack Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Miconazole.

Abrocitinib

Major

The metabolism of Abrocitinib can be decreased when combined with Miconazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Miconazole.

Acetylsalicylic acid

Major

The metabolism of Acetylsalicylic acid can be decreased when combined with Miconazole.

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Miconazole.

Monistat 1 Combination Pack Toxicity & Overdose Risk

Although there have been no reports of overdosing on miconazole, those who do are at risk for experiencing severe side effects such as headaches, skin irritation, diarrhea, nausea, vomiting, abdominal pain, and an altered sense of taste. Treatments for an overdose focus on managing the symptoms and providing supportive care. Tests on rats have found that the lowest toxic dose of miconazole is 500mg/kg.

image of a doctor in a lab doing drug, clinical research

Monistat 1 Combination Pack Novel Uses: Which Conditions Have a Clinical Trial Featuring Monistat 1 Combination Pack?

203 active trials are presently assessing the potential of Monistat 1 Combination Pack in alleviating Dermatophytosis, Inflammation, Excessive Perspiration and Body Odor.

Condition

Clinical Trials

Trial Phases

Inflammation

54 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3, Phase 4

Yeast Infection

0 Actively Recruiting

Onychomycosis

0 Actively Recruiting

Acne Vulgaris

3 Actively Recruiting

Phase 1, Phase 2, Early Phase 1, Phase 4

Candidiasis

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Dermatophytosis

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Cellulitis

0 Actively Recruiting

Tinea Versicolor

0 Actively Recruiting

Skin candida

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Arthrodermataceae

0 Actively Recruiting

Kerion Celsi

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Tinea Cruris

0 Actively Recruiting

Tinea

0 Actively Recruiting

Intertrigo

0 Actively Recruiting

Oropharyngeal Candidiasis

0 Actively Recruiting

Ringworm

0 Actively Recruiting

Monistat 1 Combination Pack Reviews: What are patients saying about Monistat 1 Combination Pack?

3.7

Patient Review

10/4/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

The medicine didn't quite work for me as intended. I woke up in the middle of the night in more pain than when I started. However, smoking ???? did help to alleviate the pain temporarily.

3.7

Patient Review

10/4/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

The burning sensation lasted more than 30 minutes, which was really unpleasant. I think it might have been caused by me scratching/rubbing/patting the area, which made things worse.

3.7

Patient Review

11/9/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

As a type one diabetic, I get yeast infections often. The Day 1 treatment has always been effective for me. Even though it burns and itches when I apply the gel, it's worth it because the infection always goes away.

3.3

Patient Review

10/4/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

I didn't find this to be as effective as I would have liked. In fact, the burning and itching was worse than the original yeast infection.

3.3

Patient Review

10/21/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

I tried the 1200mg dose and found it to be slightly irritating. If you've been scratch the area a lot, it'll probably burn more.

3.3

Patient Review

11/4/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

I chose the one day treatment and I'm really regretting it. This medicine is incredibly strong and not for the faint of heart. My vagina is on fire and I'm considering sticking it in the freezer to cool down.

3

Patient Review

11/1/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

One of Dante's Circles of Hell is probably made out of this stuff. I've never experienced such burning before. I had to lay in bed with my legs up and a fan pointed at me. And it did clear up the infection, so that's something.

2.3

Patient Review

10/18/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

I took Monistat 1 day and it was honestly the worst experience of my life. I felt like there was a literal fire in my vagina. It woke me up from sleep and I could still feel the sensation hours later. This product needs to be removed from the market immediately.

2.3

Patient Review

10/30/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

Unfortunately, you probably didn't see these reviews until it was too late. I can only offer some comfort in knowing that the burning and itching only lasted for a few hours after taking this medication. It was incredibly sore afterwards, but fortunately it's much more tolerable today. Good luck!

1

Patient Review

10/22/2022

Monistat 1 Combination Pack for Yeast Infection of Vagina and Vulva

The burning was unbearable. I don't think I could've slept if I wanted to. This product is terrible and should not be sold.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about monistat 1 combination pack

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does MONISTAT Combination Pack work?

"Based on the 355 reviews of Monistat 1 Combination Pack for the treatment of vaginal yeast infection, the average rating is 3.5 out of 10. 24% of reviewers reported a positive experience, while 67% reported a negative experience."

Answered by AI

Does MONISTAT 1 cure yeast infections in one day?

"The complete cure of a yeast infection with MONISTAT products can take up to seven days."

Answered by AI

How long do you have to keep MONISTAT 1 in?

"- Save up to $3.00

The cream is designed to stay within the vagina to work without having to reapply every day for seven days. You can save up to $3.00 on this product."

Answered by AI

How do you use MONISTAT 1 Combination?

"To use the medicine, insert the tablet or applicator into the vagina as far as it is comfortable. Slowly press the plunger of the applicator to release the tablet. If you experience itching or burning around the outside of the vagina (vulva), apply the skin cream to that area usually two times a day for no more than seven days."

Answered by AI

Clinical Trials for Monistat 1 Combination Pack

Image of Montana State University in Bozeman, United States.

Haskap Berries for Exercise Performance Recovery

18 - 35
All Sexes
Bozeman, MT

The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following: * Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults? * Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults? * The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses. Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance. * Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet * Participants will perform an intense resistance workout * Participants will have their blood drawn before and after the workout * Performance will be analyzed at 24, 48 and 72 hours after the workout

Recruiting
Paid Trial

Montana State University

Mary P Miles

Image of University of New Brunswick in Fredericton, Canada.

Mediterranean Diet for Toddler Health

24 - 36
All Sexes
Fredericton, Canada

Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health. This study will test whether a MED diet can improve dietary inflammation, gut health, and body composition in toddlers and whether a tailored nutrition education program for parents can help families maintain healthy eating patterns. In this study, toddlers will be randomly assigned to a 3-week MED diet or their usual diet. Families in the MED diet group will receive free meal boxes for the 3 weeks, plus guidance from a nutrition researcher through a structured education program. The standard diet group will continue their regular diet with general nutrition advice. Researchers will collect dietary information, body composition assessments, and stool samples to measure gut microbiome composition and metabolites. This first study of a controlled diet intervention in toddlers, combining behavioral support, high-quality food provision, and advanced gut microbiome analysis, will help understand how early diet shapes lifelong eating habits and health, guiding public health strategies and precision nutrition approaches to prevent chronic disease from early life.

Waitlist Available
Has No Placebo

University of New Brunswick

Dr. Maryam Kebbe, PhD, CLC

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Image of Department of Nutritional Sciences in Storrs, United States.

Freeze-dried Grape Powder for Healthy Aging

50 - 75
All Sexes
Storrs, CT

The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and immune health. However, the effects of grapes on altering immune profiles within the context of aging is not well understood. Therefore, this study will explore how daily grape consumption impacts certain markers of immunity in healthy middle- and older-aged adults. The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.

Recruiting
Paid Trial

Department of Nutritional Sciences

Image of Abcentra Investigational Site in Los Angeles, United States.

Orticumab for Heart Attack

18+
All Sexes
Los Angeles, CA

The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA. The main question it aims to answer is: Clinical effects of orticumab treatment on inflammation of the coronary artery parameters measured with CCTA Researchers will compare the effects with placebo group after 6 months of treatment Participants will Keep the planned study visit appointments Provide complete information about medical and medical history Speak to the study doctor before changing any of non-study treatments, including starting new medications, receiving any vaccinations, or setting out to join any other clinical studies

Phase 2
Recruiting

Abcentra Investigational Site (+6 Sites)

Abcentra

Image of School of Public Health in Bloomington, United States.

High Salt Intake for High Blood Pressure

60 - 85
All Sexes
Bloomington, IN

Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. Salt is particularly deleterious in older adults who are more likely to exhibit salt-sensitive hypertension. However, salt consumption remains high in the United States. Thus, there is a critical need for strategies to counteract the effects of high dietary salt as consumption is likely not going to decrease. One promising option is ketones, metabolites that are produced in the liver during prolonged exercise and very low-calorie diets. While exercise and low-calorie diets are beneficial, not many people engage in these activities. Limited evidence indicates that ketone supplements improve cardiovascular health in humans. Additionally, published rodent data indicates that ketone supplements prevent high salt-induced increases in blood pressure, blood vessel dysfunction, and kidney injury. Our human pilot data also indicates that high dietary salt reduces intrinsic ketone production, but it is unclear whether ketone supplementation confers humans' protection against high salt similar to rodents. Therefore, the investigators seek to conduct a short-term high-dietary salt study to determine whether ketone supplementation prevents high dietary salt from eliciting increased blood pressure, blood vessel dysfunction, and kidney injury/impaired blood flow. The investigators will also measure inflammatory markers in blood samples and isolate immune cells that control inflammation. Lastly, the investigators will also measure blood ketone concentration and other circulating metabolites that may be altered by high salt, which could facilitate novel therapeutic targets to combat high salt.

Recruiting
Has No Placebo

School of Public Health

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Image of Goldring Center for High Performance Sport in Toronto, Canada.

Physical Activity for Delayed Onset Muscle Soreness

18 - 35
All Sexes
Toronto, Canada

After completing novel activity or exercise we may experience exercise-induced muscle damage (EIMD), resulting in a period of reduced muscle function and delayed onset muscle soreness (DOMS). DOMS is characterized by muscle pain and tenderness that typically resolves within a week. While the precise cause of DOMS is unknown, there is growing evidence implicating damage to the connective tissue that surrounds our muscle fibers and is related to a small amount of inflammation. This inflammation is a normal part of our body's ability to recovery from injuries and may be visualized through the use of ultrasound technology. A variety of recovery techniques have been proposed that may help with the recovery of DOMS such as massage and electrical muscle stimulation, but these are not always accessible. Therefore, we are interested in investigating whether the number of daily steps can affect how you experience DOMS.

Waitlist Available
Has No Placebo

Goldring Center for High Performance Sport

Image of UCSF in San Francisco, United States.

Moisturizers for Aging

65+
All Sexes
San Francisco, CA

This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which measures of serum inflammation, skin barrier function, and the skin microbiome change in response to moisturizers. Participants will be asked to apply one of two topical moisturizers that are widely available over the counter in the US (Vaseline® 100% pure petroleum jelly or CeraVe® moisturizing cream) once daily for 4 weeks to the front of the torso, buttocks, arms, and legs. Subjects will act as their own control (i.e. they will be asked to apply the study moisturizer they are randomized to for one intervention period (4 weeks) and not to apply topical moisturizers for the other 4- week intervention period). Participants will be randomized in a 1:1:1:1 ratio to one of 4 treatment groups: i. no intervention then CeraVe; ii. CeraVe then no intervention; iii. no intervention then Vaseline; iv. Vaseline then no intervention. At each visit (baseline, week 4, and week 8), participants will undergo skin barrier testing, skin microbiome sampling, and phlebotomy to measure serum inflammatory markers.

Phase 4
Recruiting

UCSF

Katrina Abuabara, MD

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