Metoclopramide

Gastroparesis, Aerophagy, Migraine + 23 more

Treatment

4 FDA approvals

20 Active Studies for Metoclopramide

What is Metoclopramide

Metoclopramide

The Generic name of this drug

Treatment Summary

Metoclopramide is a medication used to treat nausea, vomiting, and other symptoms caused by diabetic gastroparesis. It is also used to treat nausea and vomiting caused by chemotherapy or certain medical procedures. Unlike some other medications, metoclopramide does not increase stomach acid production. It comes in tablet and liquid form and can also be given intravenously. Metoclopramide was first approved by the FDA in 1980.

Metoclopramide

is the brand name

image of different drug pills on a surface

Metoclopramide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Metoclopramide

Metoclopramide

1985

199

Approved as Treatment by the FDA

Metoclopramide, commonly known as Metoclopramide, is approved by the FDA for 4 uses including Gastroesophageal reflux disease and Gastroesophageal Reflux Disease (GERD) .

Gastroesophageal reflux disease

Gastroesophageal Reflux Disease (GERD)

Failed conventional therapy

Gastroparesis

Effectiveness

How Metoclopramide Affects Patients

Metoclopramide helps food pass through your digestive system by reducing the pressure of the lower esophageal sphincter. It also helps prevent and reduce symptoms of nausea and vomiting. It increases digestive activity without increasing the amount of acid produced in the stomach, bile, or pancreas. However, it should not be taken for longer than 12 weeks since it can cause tardive dyskinesia (TD), dystonia, and akathisia.

How Metoclopramide works in the body

Metoclopramide works to prevent nausea and vomiting by blocking dopamine and serotonin receptors in the brain. It also increases the amount of acetylcholine released, which helps to speed up digestion and reduce stomach discomfort. Metoclopramide also works by blocking dopamine receptors, which can help to relax the gastrointestinal tract.

When to interrupt dosage

The prescribed measure of Metoclopramide is reliant upon the identified illness, including Nausea, Intubation (process) and Gastroesophageal Reflux Disease (GERD). The dosage may differ, as indicated by the administration technique (e.g. Spray or Tablet, orally disintegrating) listed in the table beneath.

Condition

Dosage

Administration

Nausea

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

gastric emptying for radiologic procedures

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Therapeutic procedure

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Gastric Motility Disorder

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

prophylaxis of Hiccups

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

meteorism

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Nausea

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Failed conventional therapy

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Acute Coryza

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Nausea

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Hyperacidity

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

radiation therapy induced nausea and vomiting

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Aerophagy

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Flatulence

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Indigestion

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Gastrointestinal distress

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Hiccup

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Nausea

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Pharmacotherapy

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Intubation (procedure)

10.0 mg, , 5.0 mg, 5.0 mg/mL, 10.0 mg/mL, 1.0 mg/mL, 1.0 mg, 9.0 mg/mL, 1500.0 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous, Liquid - Intramuscular; Intravenous, Liquid, Syrup, Syrup - Oral, Liquid - Oral, Liquid - Intravenous, Injection, solution - Intravenous, Kit - Oral; Topical, Kit, Oral; Topical, Nasal, Spray, Spray - Nasal, Solution - Intramuscular; Intravenous

Warnings

Metoclopramide Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Metoclopramide may interact with Pulse Frequency

Mechanical Intestinal Obstruction

Do Not Combine

Gastrointestinal Hemorrhage

Do Not Combine

Gastrointestinal Perforation

Do Not Combine

Paraganglioma

Do Not Combine

Tardive Dyskinesia

Do Not Combine

Pharmaceutical Preparations

Do Not Combine

Pheochromocytoma

Do Not Combine

Parkinson's Disease

Do Not Combine

Depression

Do Not Combine

Epilepsy

Do Not Combine

Gastrectomy

Do Not Combine

Dystonia

Do Not Combine

Feeling suicidal (finding)

Do Not Combine

There are 20 known major drug interactions with Metoclopramide.

Common Metoclopramide Drug Interactions

Drug Name

Risk Level

Description

Acepromazine

Major

The risk or severity of adverse effects can be increased when Metoclopramide is combined with Acepromazine.

Aceprometazine

Major

The risk or severity of adverse effects can be increased when Metoclopramide is combined with Aceprometazine.

Acetophenazine

Major

The risk or severity of adverse effects can be increased when Metoclopramide is combined with Acetophenazine.

Alimemazine

Major

The risk or severity of adverse effects can be increased when Metoclopramide is combined with Alimemazine.

Amisulpride

Major

The risk or severity of adverse effects can be increased when Metoclopramide is combined with Amisulpride.

Metoclopramide Toxicity & Overdose Risk

Metoclopramide has a toxic dose of 750mg/kg in rats. An overdose on metoclopramide can cause drowsiness, confusion, and muscle control problems. To treat these symptoms, drugs used for Parkinson's disease or antihistamines with anticholinergic properties may be used. In some cases, these symptoms may last up to 24 hours. Unintentional overdose in infants can lead to seizures, muscle control issues, and a weak state. Additionally, methemoglobinemia (a rare blood disorder) can occur after an overdose. To treat this, methylene blue may be administered. However

image of a doctor in a lab doing drug, clinical research

Metoclopramide Novel Uses: Which Conditions Have a Clinical Trial Featuring Metoclopramide?

113 active clinical trials are presently evaluating the potential of Metoclopramide to alleviate Migraine, Nausea and as an adjunct in Pharmacotherapy.

Condition

Clinical Trials

Trial Phases

Gastroparesis

15 Actively Recruiting

Phase 3, Not Applicable, Phase 1, Early Phase 1

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Gastric Acid

0 Actively Recruiting

Gastroesophageal Reflux Disease (GERD)

9 Actively Recruiting

Not Applicable, Phase 2

Flatulence

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Pharmacotherapy

0 Actively Recruiting

Indigestion

6 Actively Recruiting

Phase 3, Not Applicable, Phase 2

radiation therapy induced nausea and vomiting

0 Actively Recruiting

Nausea

0 Actively Recruiting

Gastrointestinal distress

9 Actively Recruiting

Phase 2, Early Phase 1, Phase 1, Phase 3, Not Applicable, Phase 4

Hiccup

0 Actively Recruiting

Failed conventional therapy

0 Actively Recruiting

meteorism

0 Actively Recruiting

Nausea

0 Actively Recruiting

Gastric Motility Disorder

0 Actively Recruiting

Aerophagy

0 Actively Recruiting

Intubation (procedure)

0 Actively Recruiting

gastric emptying for radiologic procedures

0 Actively Recruiting

prophylaxis of Hiccups

0 Actively Recruiting

Metoclopramide Reviews: What are patients saying about Metoclopramide?

5

Patient Review

6/13/2017

Metoclopramide for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking this medication for nearly a decade, and have only just now realized that it has caused my breasts to grow larger and my sex drive to dwindle. As a man, this was never explained to me by the doctor prescribing the drug, and I feel like it amounts to criminal negligence.

4.7

Patient Review

1/19/2017

Metoclopramide for Condition in which Stomach Acid is Pushed Into the Esophagus

I had great results for the three weeks I took this medication. It stopped my acid reflux and helped slow my diarrhea, but now the pharmacy says I can't renew it.

4

Patient Review

12/4/2019

Metoclopramide for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been on this medication for a while now and it seems to be helping, though I am concerned about how long I've been taking it. From what I can tell, it's supposed to be temporary.

3

Patient Review

2/2/2019

Metoclopramide for Nausea and Vomiting

I was prescribed this to help with pregnancy-related nausea and vomiting. It worked for two days, at which point I stopped taking it due to the deep all-day migraine it caused, as well as toothache pain.

2.7

Patient Review

10/21/2021

Metoclopramide for Condition in which Stomach Acid is Pushed Into the Esophagus

I felt incredibly drowsy after taking this drug, to the point where I couldn't speak properly. My stomach also felt empty and I was overall quite tired.

2.3

Patient Review

3/21/2021

Metoclopramide for Condition in which Stomach Acid is Pushed Into the Esophagus

One significant downside to this medication is that it made me quite drowsy to the point where I was nodding off even while walking. It became difficult to stick to my usual routine. After a few days, I had to stop taking it.

2.3

Patient Review

10/21/2021

Metoclopramide for Condition in which Stomach Acid is Pushed Into the Esophagus

I am taking the medication three times a day as prescribed. I have noticed increased drowsiness, difficulty speaking due to fatigue in my jaw, and a general feeling of emptiness in my stomach.

2.3

Patient Review

6/7/2018

Metoclopramide for Nausea and Vomiting

Though it did stop my vomiting, I experienced an incredibly painful panic attack less than an hour later. This was the first and only time I've ever had a panic attack in my life.

2

Patient Review

5/25/2022

Metoclopramide for Nausea and Vomiting

I had a really bad experience with this medication, to the point where it was affecting my vision. I would never take it again.

1.3

Patient Review

7/4/2017

Metoclopramide for Stomach Muscle Paralysis and Decreased Function

I found that this treatment caused me a lot of trouble sleeping, agitation, and even thoughts of suicide. I was also very confused and felt quite depressed while taking it.

1

Patient Review

7/21/2020

Metoclopramide for Nausea and Vomiting

I would not recommend this medication to anyone. I tried it and had an incredibly negative reaction. Within a day, I started feeling uncomfortable and by the end of the day, was hyperventilating, uncontrollably moving, and panicking. Do not take this drug.

1

Patient Review

9/17/2019

Metoclopramide for Nausea and Vomiting

This drug had an unfortunate side effect of making me feel perpetually nauseous. It was prescribed to help with morning sickness during pregnancy, but all it did was make me more sick.

1

Patient Review

7/2/2020

Metoclopramide for Nausea and Vomiting

I took this for nausea and it gave me incredibly bad anxiety, uncontrollable muscle movements, and made it impossible to sit still. Please be careful with this drug-- the side effects could become permanent if you take it for too long.

1

Patient Review

8/13/2017

Metoclopramide for Nausea and Vomiting

The patient I was treating with this saw severe side effects after just two days of use. They are now dealing with Parkinson's-like symptoms and we haven't found any way to reverse the damage done.

1

Patient Review

3/16/2017

Metoclopramide for Heartburn

The Restless Leg Syndrome got so bad that I couldn't sleep!

1

Patient Review

11/7/2022

Metoclopramide for Stomach Muscle Paralysis and Decreased Function

I had terrible diarrhea and lost four pounds in the week that I took this medication. Additionally, it made everything outside look too bright and my vision felt different. As soon as I stopped taking the medication, these symptoms subsided.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about metoclopramide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is metoclopramide used for?

"Metoclopramide can help with nausea and vomiting caused by cancer treatment, migraines, or other conditions."

Answered by AI

Is metoclopramide the same as Zofran?

"The brand names for ondansetron are Zofran, Zofran ODT, and Zuplenz. The brand names for metoclopramide are Reglan and Metozolv ODT. Ondansetron and metoclopramide are in different drug classes. Ondansetron is an anti-nausea medication and metoclopramide is a "prokinetic" drug."

Answered by AI

What class of drugs is metoclopramide?

"Oct 15, 2018Metoclopramide belongs to a class of medications called prokinetic agents. It works by speeding up the movement of food through the stomach and intestines."

Answered by AI

What are the side effects of metoclopramide?

"The following effects may occur: drowsiness, dizziness, tiredness, trouble sleeping, agitation, headache, and diarrhea. If you experience any of these effects for an extended period of time, or if they get worse, tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Metoclopramide

Image of Arizona State University in Phoenix, United States.

App-based Breathing Program for Migraine

18+
All Sexes
Phoenix, AZ

Migraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.

Waitlist Available
Online Trial

Arizona State University

Have you considered Metoclopramide clinical trials?

We made a collection of clinical trials featuring Metoclopramide, we think they might fit your search criteria.
Go to Trials
Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD

This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.

Waitlist Available
Has No Placebo

Johns Hopkins Medicine

Risheng Xu, MD, PhD

Medtronic

Image of Endeavor Health in Evanston, United States.

Autonomic Neural Blockade for Postoperative Symptoms in Bariatric Surgery

18 - 90
All Sexes
Evanston, IL

The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72 hours after sleeve gastrectomy or gastric bypass surgery. Participants will be randomly assigned either to the standard of care or the ANB group before surgery. As part of standard of care, in both groups, laparoscopic bariatric surgery will be initiated with local anesthetic injected into the abdominal wall. In the ANB group, participants will be given an additional injection of local anesthetic medication to block nerves on and around the stomach.

Waitlist Available
Has No Placebo

Endeavor Health

Herbert Hedberg, MD

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Image of University of Minnesota in Minneapolis, United States.

Visual Adaptation for Visual Snow

18 - 60
All Sexes
Minneapolis, MN

The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: * Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * How does brain activity contribute to VSS? Participants will: 1. Undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function. 2. Make visual judgements based on images presented to them both inside and outside a magnetic resonance imaging (MRI) machine. 3. Undergo scanning of their brain while inside of an MRI machine.

Recruiting
Paid Trial

University of Minnesota

Michael-Paul Schallmo, Ph.D.

Image of Mayo Clinic in Rochester in Rochester, United States.

High Resolution Gastric Mapping and Gastroduodenal Manometry for Indigestion

18 - 80
All Sexes
Rochester, MN

Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation. Therapeutic options manage symptoms, and there is no FDA approved medical therapy for dyspepsia. There is a need for better objective understanding of sensorimotor dysfunction in dyspepsia, as well as noninvasive, efficacious, safe, and inexpensive treatments for dyspepsia. The purpose of this research is to identify disturbances and characterize phenotypes in patients with functional dyspepsia, and to assess the correlations between symptoms (during the manometry and in daily life), gastric emptying, electrical activity (BSGM), and pressure activity (manometry).

Recruiting
Has No Placebo

Mayo Clinic in Rochester

Nicholas R Oblizajek, MD

Image of HCA Florida north florida Hospital in Gainesville, United States.

Bupivacaine Injection for Headache

18+
All Sexes
Gainesville, FL

Headache is a frequent chief complaint among patients presenting to the Emergency Department (ED), accounting for 2.1 million visits annually in the United States. Often, individuals resort to ED care only after over-the-counter or home remedies have failed, leading to the predominant use of intravenous (IV) medications in the ED, including NSAIDs, triptans, neuroleptics, antiepileptics, and dopaminergic antagonists. Unfortunately, these pharmacologic treatments frequently induce side effects such as cognitive impairment, extrapyramidal reactions, and the potential for medication dependency. In the ED, patients frequently require concurrent administration of multiple systemic medications to achieve satisfactory pain relief, thereby elevating the risk associated with medication use. Despite these medication regimens, a significant portion of patients continue to experience inadequate pain relief. Consequently, the search for an optimal headache therapy-characterized by rapid and effective pain relief, long lasting results, minimal side effects, and allows for rapid ED patient turnover-continues to be a popular area of research in emergency medicine. The investigators plan to evaluate the use of 0.5% bupivacaine cervical IM injection at the c6-7 location for the treatment of non traumatic headaches using a non-inferiority design, randomized, prospective, open-label, controlled trial comparing it to physicians choice of intravenous medications in treatment of headache in the Emergency Department at North Florida Hospital.

Phase 3
Waitlist Available

HCA Florida north florida Hospital

Robyn Hoelle, MD

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