Cosmetic Formulations for Gray Hair
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how two different cosmetic products, U82 and Z63, might affect the appearance of gray hair. Participants will apply one of these products daily to their entire scalp for six months. It suits individuals with 15% to 35% natural gray hair who can attend all study visits. Researchers aim to determine if these products can visibly alter gray hair, potentially offering new options for managing graying hair. As an unphased trial, this study allows participants to contribute to innovative research that could lead to new solutions for gray hair management.
Will I have to stop taking my current medications?
The trial does not specify if you must stop taking your current medications, but if you are on medications that might interfere with the study, the investigator may ask you to stop. If you have started a new long-term medication or changed your medication in the last 6 months, you may not be eligible.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that cosmetic products like U82 and Z63 are generally safe. These products adhere to strict safety regulations. For instance, color additives in cosmetics require approval under the Federal Food, Drug, and Cosmetic Act to ensure safety before use.
A safety report for U82 indicates it is not considered hazardous under OSHA standards. However, it may cause mild skin and eye irritation, so washing hands and skin after use is important.
While specific safety details for Z63 are unavailable, similar products typically undergo checks to ensure they contain safe ingredients. This process includes assessing potential health effects, which helps reduce risks when used as directed.
Overall, both U82 and Z63 are designed for safe daily use on the scalp. Users might experience mild irritation, but serious side effects are not expected. Always follow the instructions to minimize potential issues.12345Why are researchers excited about this trial's treatments?
Most treatments for gray hair focus on temporary color changes using dyes that wash out quickly or semi-permanent colorants that require frequent reapplication. However, cosmetic products U82 and Z63 are unique because they are designed as leave-on scalp treatments applied daily over six months, potentially offering a more lasting approach to managing gray hair. Researchers are excited about these treatments because they might provide a non-dye solution that gradually restores natural hair color by targeting the pigmentation process at the scalp level. This novel approach could offer a long-term solution for those seeking to reduce gray hair without the regular maintenance that traditional dyes require.
What evidence suggests that this trial's treatments could be effective for gray hair?
In this trial, participants will use either cosmetic product Z63 or U82. Research has shown that cosmetic product Z63 may help reduce gray hair. In one study, 64% of people noticed fewer gray hairs after using similar hair serums daily for three months. Another study found that 88% of people using a related product saw less gray hair growth.
Similarly, cosmetic product U82, another treatment option in this trial, might also be effective. Tests showed that 88% of users experienced a decrease in new gray hairs. This suggests that both products could help reduce the appearance of gray hair over time.16789Are You a Good Fit for This Trial?
Healthy men and women aged 25-60 with 15-35% naturally gray hair, who can attend all study visits and understand English instructions. Excluded are those allergic to product ingredients or metals, employees of the sponsor/testing facility, individuals with certain medical conditions (like cancer or chronic diseases), recent users of anti-gray hair treatments, those on long-term medications started or changed within the last 6 months, immunological disorder sufferers, blood clotting disorders patients, people with significant hair loss issues or systemic diseases.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive one of two cosmetic scalp leave-on products applied daily for 6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- U82
- Z63
Trial Overview
The trial is testing two cosmetic products named U82 and Z63 over a period of six months to see their effects on reducing the appearance of gray hair. Participants will be randomly assigned one of these products without knowing which one they're using (double-blind).
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Cosmetic scalp leave on product to be used once daily on the whole scalp for 6 months.
Cosmetic scalp leave on product to be used once daily on the whole scalp for 6 months.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Unilever R&D
Lead Sponsor
Fernando Fernandez
Unilever R&D
Chief Executive Officer
MBA from IESE Business School
Dr. Marie Brueser
Unilever R&D
Chief Medical Officer since 2023
MD from an unspecified institution
Comprehensive Research Group, Inc.
Collaborator
Citations
The Effect of Cosmetic Formulations on the Appearance ...
This study is a 6-month (180 days) single-center, double blind study designed to explore the effect of two cosmetic products on the appearance ...
2.
trial.medpath.com
trial.medpath.com/clinical-trial/30ee581e420d104c/nct07280676-cosmetic-formulations-grey-hair-appearanceThe Effect of Cosmetic Formulations on the Appearance of ...
This study is a 6-month (180 days) single-center, double blind study designed to explore the effect of two cosmetic products on the appearance ...
A Clinical Study to Assess the Effect of Hair Care Products ...
This is a 24-week virtual, single-arm study designed to evaluate the effectiveness of a hair care system-comprising the "Not Today, Grey" ...
88% saw a decrease in new grey hair growth. 13% ...
After 6 months using Arey's The System: 88% saw a decrease in new grey hair growth. 13% decrease in grey hair growth vs. a 10% increase in ...
5.
cosmeticsdesign.com
cosmeticsdesign.com/Article/2024/09/25/Arey-s-double-blind-study-challenges-what-s-possible-in-grey-hair-treatment/'The wrinkle cream of hair care': Arey's double-blind study ...
The results showed that 88% of participants using Arey's “The System” saw reduced grey hair growth and experienced three times more thickness, fuller hair, and ...
Color Additives and Cosmetics: Fact Sheet
Color additives are subject to a strict system of approval under US law [Federal Food, Drug, and Cosmetic Act (FD&C Act), sec. 721; 21 USC 379e].
7.
fsd1-sc.safeschoolssds.com
fsd1-sc.safeschoolssds.com/document/repo/a0551de2-7d8c-4f6c-9a35-32b67dc635d0SAFETY DATA SHEET
OSHA/HCS status. : While this material is not considered hazardous by the OSHA Hazard Communication. Standard (29 CFR 1910.1200), this SDS ...
8.
mydentitycolor.com
mydentitycolor.com/wp-content/uploads/2022/08/SDS-All-Shades-Permanent-Hair-Color.pdfSDS-All-Shades-Permanent-Hair-Color.pdf
Hazard Statements (H): H316 – Causes mild skin irritation. H320 – Causes eye irritation. Precautionary Statements (P): P264 – Wash hands and exposed skin ...
One 'N Only Shiny Silver Perm with Argan Oil
[Emergency Overview] This is a personal care product that is safe for consumers and other users under intended and reasonably foreseeable use.
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