Methocarbamol

Discomfort, Lockjaw, Chronic Pain + 9 more
Treatment
8 FDA approvals
20 Active Studies for Methocarbamol

What is Methocarbamol

MethocarbamolThe Generic name of this drug
Treatment SummaryMethocarbamol is a prescription medicine used to relieve muscle spasticity and associated pain. It is available in tablet form and can be injected directly into the muscle. In the United States, it is used in combination with rest, physical therapy, and other treatments for musculoskeletal conditions. In Canada, methocarbamol can be sold as an over-the-counter oral medicine in combination with acetaminophen or ibuprofen. A combination product with aspirin and codeine is available in Canada by prescription. The drug was approved by the FDA in 1957.
Robaxinis the brand name
image of different drug pills on a surface
Methocarbamol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Robaxin
Methocarbamol
1959
395

Approved as Treatment by the FDA

Methocarbamol, commonly known as Robaxin, is approved by the FDA for 8 uses including Musculoskeletal Disorders and Muscle Spasms .
Musculoskeletal Disorders
Muscle Spasms
Used to treat Muscle Spasms in combination with Acetaminophen
Pain
Used to treat moderate to severe pain in combination with Acetaminophen
Discomfort
Tetanus
Spasm
Used to treat Muscle Spasms in combination with Acetaminophen
Musculoskeletal Diseases
Lockjaw

Effectiveness

How Methocarbamol Affects PatientsMethacarbamol is a drug used to help relax muscles. How it works is not yet known. Studies have shown that it can block certain nerve signals, reduce nerve transmission, and lengthen the amount of time it takes for a muscle to recover after a contraction. It does not work as a numbing agent when injected and has been found to prevent seizures in animals when shocked with electricity.
How Methocarbamol works in the bodyMethocarbamol works by calming the nervous system, which reduces nerve activity. It does this by blocking reflexes and slowing down the way messages are sent between the brain and spinal cord. It does not, however, have any effect on muscle fibers or motor end plates.

When to interrupt dosage

The advocated dosage of Methocarbamol is contingent upon the determined affliction, including Physical Therapy, Gouty Arthritis and Muscle Spasms. The measure of dosage also fluctuates in regard to the method of delivery (e.g. Tablet - Oral or Tablet) as illustrated in the table beneath.
Condition
Dosage
Administration
Physical Therapy
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Lockjaw
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Discomfort
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Chronic Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Muscle Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Rheumatism
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Arthritis, Gouty
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Rest
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Spasm
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Musculoskeletal Diseases
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Inflammation
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral

Warnings

Methocarbamol has one contraindication and should not be consumed together with the issues specified in the following table.Methocarbamol Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Methocarbamol may interact with Pulse Frequency
There are 20 known major drug interactions with Methocarbamol.
Common Methocarbamol Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Methocarbamol is combined with Oliceridine.
Thalidomide
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Methocarbamol is combined with Daridorexant.
Methocarbamol Toxicity & Overdose RiskOverdosing on methocarbamol can cause nausea, drowsiness, blurred vision, low blood pressure, seizures, and even a coma. Treatment usually involves making sure the patient can breathe, monitoring vital signs, and providing intravenous fluids if necessary. The toxic dose in rats is 3576.2mg/kg. The FDA has not determined the safety of methocarbamol during pregnancy or while breastfeeding, but fetal and congenital abnormalities have been reported in some cases. There is also not enough research to know if it causes cancer, mutations, or affects fertility. Caution should be taken when taking
image of a doctor in a lab doing drug, clinical research

Methocarbamol Novel Uses: Which Conditions Have a Clinical Trial Featuring Methocarbamol?

356 clinical trials are currently underway to assess the potential of Methocarbamol in providing relief from Gouty Arthritis, Rest and Musculoskeletal Diseases.
Condition
Clinical Trials
Trial Phases
Physical Therapy
6 Actively Recruiting
Not Applicable
Musculoskeletal Diseases
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Chronic Pain
129 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1
Inflammation
0 Actively Recruiting
Lockjaw
0 Actively Recruiting
Rheumatism
0 Actively Recruiting
Rest
0 Actively Recruiting
Spasm
0 Actively Recruiting
Discomfort
0 Actively Recruiting
Arthritis, Gouty
0 Actively Recruiting
Pain
0 Actively Recruiting
Muscle Pain
3 Actively Recruiting
Phase 4, Not Applicable, Phase 2

Methocarbamol Reviews: What are patients saying about Methocarbamol?

4Patient Review
9/26/2021
Methocarbamol for Muscle Spasm
After my car accident, this medication was prescribed to me by my doctor. I experienced some intense twitching after a week of taking it, so he switched me to another medication. The only other side effect I experienced with this was blurred vision.
4Patient Review
7/14/2022
Methocarbamol for Muscle Spasm
I've been struggling with lower lumbar arthritis pain for a while now, and this treatment really helps. It's a big relief to finally find something that dulls the pain for 4-6 hours.
3.7Patient Review
11/27/2021
Methocarbamol for Muscle Spasm
This treatment provides temporary pain relief for about two hours. However, the effects wear off pretty quickly and I have to wait a while before taking another dose. Additionally, I started feeling more aggressive after taking this medication for a few days. Overall, it wasn't a good fit for me.
3.7Patient Review
7/18/2021
Methocarbamol for Muscle Spasm
I was taking flexiril for months with no results, but this treatment seems to be better.
3.7Patient Review
2/11/2021
Methocarbamol for Muscle Spasm
This medication was very effective in reducing the frequency and intensity of my leg spasms. I also found that it helped with hand cramping due to dystonia. However, I experienced most of the listed side effects except for convulsions.
3.3Patient Review
3/21/2022
Methocarbamol for Muscle Spasm
I take this medication for muscle spasms caused by severe stenosis in the lumbar spine. I tried it at bedtime, but found that it had the opposite effect of what I was hoping for - it took a long time to get to sleep and my sleep was short and restless. Taking a combination of methocarbamol and acetaminophen in the morning and again 6 hours before bedtime seems to help during the day and then I use a different muscle relaxant at night.
2.3Patient Review
5/6/2022
Methocarbamol for Muscle Spasm
I haven't experienced any benefits from this treatment after a week of use. The only change I've noticed is that I'm much more gassy.
2Patient Review
7/2/2022
Methocarbamol for Muscle Spasm
I've tried other muscle relaxers in the past that have been more effective, but this one didn't make me drowsy.
2Patient Review
6/16/2021
Methocarbamol for Muscle Spasm
This unfortunately did not work at all for my back spasms. I've heard from others that it works better for them, but I can't in good faith recommend this product.
2Patient Review
11/2/2022
Methocarbamol for Muscle Spasm
I have a lot of issues with my back. I broke it in 1993 at L6, 7, and 8. I also have lumbar problems and am supposed to get surgery on my neck but haven't yet because no medication has really helped me. The best muscle relaxer out there is Soma; it's the only spasm medication that actually works for me.
2Patient Review
6/18/2021
Methocarbamol for Muscle Spasm
This treatment was totally ineffective.
2Patient Review
5/28/2022
Methocarbamol for Muscle Spasm
I took the recommended dose but only experienced gut pain when I woke up. Unfortunately, I didn't really see any benefits from this treatment. Tylenol and Advil worked much better for me.
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Patient Q&A Section about methocarbamol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of methocarbamol?

"If you experience any of the following side effects, call your doctor immediately: drowsiness, dizziness, upset stomach, blurred vision, fever, or black, blue, or green discoloration of urine."

Answered by AI

Does methocarbamol 750 mg make you sleepy?

"The active ingredient in methocarbamol can cause drowsiness and affect your concentration and focus. This is more likely to happen if you are over 65 or take other medications that cause drowsiness. Do not drink alcohol while taking this medication."

Answered by AI

What is methocarbamol prescribed for?

"Methocarbamol is a medicine used to relieve discomfort caused by acute, painful muscle or bone conditions. However, this medicine should not be used in place of rest, exercise, physical therapy, or other treatment that your doctor may recommend for your medical problem."

Answered by AI

How long does it take methocarbamol to kick in?

"Methocarbamol starts working within 30 minutes, with full effects appearing within 2 hours. As it is relatively short acting, it needs to be taken 3-4 times a day as directed by a doctor."

Answered by AI

Clinical Trials for Methocarbamol

Image of Vanderbilt University Medical Center in Nashville, United States.

Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Image of Baylor College of Medicine/Texas Children's Hospital in Austin, United States.

Guided Imagery Therapy for Abdominal Pain

7 - 12
All Sexes
Austin, TX
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet. Participants will complete a baseline abdominal pain and stooling diary to determine eligibility, as well as other surveys. Eligible participants will be given access to the guided imagery therapy mobile application. This intervention asks participants to listen to a 10- to 15-minute GIT session 5 out of 7 days per week for 8 weeks, in addition to their usual care for their abdominal pain. Then, participants will complete another abdominal pain and stooling diary, along with other psychometric surveys, at the end of this intervention period. Participants will also collect another diary and surveys 3 months post-treatment.
Waitlist Available
Has No Placebo
Baylor College of Medicine/Texas Children's Hospital (+1 Sites)
Have you considered Methocarbamol clinical trials? We made a collection of clinical trials featuring Methocarbamol, we think they might fit your search criteria.Go to Trials
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Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
Image of Walter Reed National Military Medical Center in Bethesda, United States.

Corticosteroid Injections for Osteoarthritis

18+
All Sexes
Bethesda, MD
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function
Phase 2 & 3
Waitlist Available
Walter Reed National Military Medical CenterJohn P Cody, MD
Have you considered Methocarbamol clinical trials? We made a collection of clinical trials featuring Methocarbamol, we think they might fit your search criteria.Go to Trials
Image of Rutgers School of Dental Medicine in Newark, United States.

Temporo-masseteric Nerve Block for Postoperative Pain

18+
All Sexes
Newark, NJ
The proposed design is a triple-blind, placebo-controlled randomized prospective phase II trial to assess the feasibility of employing the Temporo-masseteric Nerve Block (TMNB) injection to decrease jaw muscle pain, overall pain, improve mouth opening and minimize pain medication consumption. 80 participants undergoing lower third molar removal under sedation will be enrolled. Those who develop significant jaw muscle pain on the following day will be randomized to receive either the TMNB injection or a placebo. Daily ecological momentary assessments (EMAs) will be collected reflecting elements of patient experience for all participants. On Day 8, participants return for an end-of-study evaluation and return their unused pain medications. Up to 40 participants who are randomized to receive TMNB/placebo will be recruited to participate in a qualitative interview regarding their experience.
Phase 2
Waitlist Available
Rutgers School of Dental Medicine
Image of BC Children's Hospital in Vancouver, Canada.

Digital Media for Anxiety in Children

5 - 23
All Sexes
Vancouver, Canada
The goal of this clinical trial is to learn whether different forms of media (2D, 360, or 360 in virtual reality) have different impacts on pre-procedural anxiety and post-procedural pain in children. The main questions it aims to answer are: Does one type (and richness) of media reduce pre-procedural anxiety and post-procedural pain more than another type of media? For example, will learning about an upcoming procedure by watching a 360 video in virtual reality reduce pre-procedural anxiety more than learning about the same upcoming procedure by watching it in a 2D video or 360 video? The second question is whether watching a 360 video in VR about an upcoming procedure more effective in reducing pre-procedural anxiety and post-procedural pain compared to the 2D video or the 360 video without VR groups for specific procedures? For example, is watching an explanation of a procedure in VR always more effective in reducing pre-procedural anxiety and post-procedural pain, or is it procedure specific (i.e., watching a video about surgery preparation is more effective in VR, but for cast removal it doesn't matter whether participants learn about their procedure viewed through VR, 360 video, or 2D)?
Recruiting
Has No Placebo
BC Children's Hospital
Have you considered Methocarbamol clinical trials? We made a collection of clinical trials featuring Methocarbamol, we think they might fit your search criteria.Go to Trials
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