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What is Methocarbamol
MethocarbamolThe Generic name of this drug
Treatment SummaryMethocarbamol is a prescription medicine used to relieve muscle spasticity and associated pain. It is available in tablet form and can be injected directly into the muscle. In the United States, it is used in combination with rest, physical therapy, and other treatments for musculoskeletal conditions. In Canada, methocarbamol can be sold as an over-the-counter oral medicine in combination with acetaminophen or ibuprofen. A combination product with aspirin and codeine is available in Canada by prescription. The drug was approved by the FDA in 1957.
Robaxinis the brand name
Methocarbamol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Robaxin
Methocarbamol
1959
395
Approved as Treatment by the FDA
Methocarbamol, commonly known as Robaxin, is approved by the FDA for 5 uses including Muscle Spasms and Pain .Muscle Spasms
Used to treat Muscle Spasms in combination with Acetaminophen
Pain
Used to treat moderate to severe pain in combination with Acetaminophen
Discomfort
Musculoskeletal Diseases
Lockjaw
Effectiveness
How Methocarbamol Affects PatientsMethacarbamol is a drug used to help relax muscles. How it works is not yet known. Studies have shown that it can block certain nerve signals, reduce nerve transmission, and lengthen the amount of time it takes for a muscle to recover after a contraction. It does not work as a numbing agent when injected and has been found to prevent seizures in animals when shocked with electricity.
How Methocarbamol works in the bodyMethocarbamol works by calming the nervous system, which reduces nerve activity. It does this by blocking reflexes and slowing down the way messages are sent between the brain and spinal cord. It does not, however, have any effect on muscle fibers or motor end plates.
When to interrupt dosage
The advocated dosage of Methocarbamol is contingent upon the determined affliction, including Physical Therapy, Gouty Arthritis and Muscle Spasms. The measure of dosage also fluctuates in regard to the method of delivery (e.g. Tablet - Oral or Tablet) as illustrated in the table beneath.Condition
Dosage
Administration
Discomfort
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Lockjaw
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Physical Therapy
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Chronic Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Muscle Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Rheumatism
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Gouty Arthritis
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Rest
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Muscle Spasms
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Musculoskeletal Diseases
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Inflammation
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Pain
750.0 mg, , 500.0 mg, 100.0 mg/mL, 400.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Injection, solution, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Tablet, coated, Tablet, coated - Oral, Kit, Parenteral, Injection - Parenteral, Kit - Oral
Warnings
Methocarbamol has one contraindication and should not be consumed together with the issues specified in the following table.Methocarbamol ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Methocarbamol may interact with Pulse Frequency
Common Methocarbamol Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Methocarbamol is combined with Oliceridine.
Thalidomide
Major
Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Methocarbamol is combined with Daridorexant.
Methocarbamol Toxicity & Overdose RiskOverdosing on methocarbamol can cause nausea, drowsiness, blurred vision, low blood pressure, seizures, and even a coma. Treatment usually involves making sure the patient can breathe, monitoring vital signs, and providing intravenous fluids if necessary. The toxic dose in rats is 3576.2mg/kg. The FDA has not determined the safety of methocarbamol during pregnancy or while breastfeeding, but fetal and congenital abnormalities have been reported in some cases. There is also not enough research to know if it causes cancer, mutations, or affects fertility. Caution should be taken when taking
Methocarbamol Novel Uses: Which Conditions Have a Clinical Trial Featuring Methocarbamol?
356 clinical trials are currently underway to assess the potential of Methocarbamol in providing relief from Gouty Arthritis, Rest and Musculoskeletal Diseases.Condition
Clinical Trials
Trial Phases
Chronic Pain
173 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Inflammation
0 Actively Recruiting
Lockjaw
2 Actively Recruiting
Phase 2
Rheumatism
0 Actively Recruiting
Rest
0 Actively Recruiting
Muscle Spasms
0 Actively Recruiting
Physical Therapy
7 Actively Recruiting
Not Applicable
Discomfort
0 Actively Recruiting
Musculoskeletal Diseases
4 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Gouty Arthritis
1 Actively Recruiting
Phase 2, Phase 3
Pain
0 Actively Recruiting
Muscle Pain
8 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Early Phase 1
Methocarbamol Reviews: What are patients saying about Methocarbamol?
4Patient Review
9/26/2021 After my car accident, this medication was prescribed to me by my doctor. I experienced some intense twitching after a week of taking it, so he switched me to another medication. The only other side effect I experienced with this was blurred vision.
4Patient Review
7/14/2022 I've been struggling with lower lumbar arthritis pain for a while now, and this treatment really helps. It's a big relief to finally find something that dulls the pain for 4-6 hours.
3.7Patient Review
11/27/2021 This treatment provides temporary pain relief for about two hours. However, the effects wear off pretty quickly and I have to wait a while before taking another dose. Additionally, I started feeling more aggressive after taking this medication for a few days. Overall, it wasn't a good fit for me.
3.7Patient Review
7/18/2021 I was taking flexiril for months with no results, but this treatment seems to be better.
3.7Patient Review
2/11/2021 This medication was very effective in reducing the frequency and intensity of my leg spasms. I also found that it helped with hand cramping due to dystonia. However, I experienced most of the listed side effects except for convulsions.
3.3Patient Review
3/21/2022 I take this medication for muscle spasms caused by severe stenosis in the lumbar spine. I tried it at bedtime, but found that it had the opposite effect of what I was hoping for - it took a long time to get to sleep and my sleep was short and restless. Taking a combination of methocarbamol and acetaminophen in the morning and again 6 hours before bedtime seems to help during the day and then I use a different muscle relaxant at night.
2.3Patient Review
5/6/2022 I haven't experienced any benefits from this treatment after a week of use. The only change I've noticed is that I'm much more gassy.
2Patient Review
7/2/2022 I've tried other muscle relaxers in the past that have been more effective, but this one didn't make me drowsy.
2Patient Review
6/16/2021 This unfortunately did not work at all for my back spasms. I've heard from others that it works better for them, but I can't in good faith recommend this product.
2Patient Review
11/2/2022 I have a lot of issues with my back. I broke it in 1993 at L6, 7, and 8. I also have lumbar problems and am supposed to get surgery on my neck but haven't yet because no medication has really helped me. The best muscle relaxer out there is Soma; it's the only spasm medication that actually works for me.
2Patient Review
6/18/2021 This treatment was totally ineffective.
2Patient Review
5/28/2022 I took the recommended dose but only experienced gut pain when I woke up. Unfortunately, I didn't really see any benefits from this treatment. Tylenol and Advil worked much better for me.
Patient Q&A Section about methocarbamol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of methocarbamol?
"If you experience any of the following side effects, call your doctor immediately: drowsiness, dizziness, upset stomach, blurred vision, fever, or black, blue, or green discoloration of urine."
Answered by AI
Does methocarbamol 750 mg make you sleepy?
"The active ingredient in methocarbamol can cause drowsiness and affect your concentration and focus. This is more likely to happen if you are over 65 or take other medications that cause drowsiness. Do not drink alcohol while taking this medication."
Answered by AI
What is methocarbamol prescribed for?
"Methocarbamol is a medicine used to relieve discomfort caused by acute, painful muscle or bone conditions. However, this medicine should not be used in place of rest, exercise, physical therapy, or other treatment that your doctor may recommend for your medical problem."
Answered by AI
How long does it take methocarbamol to kick in?
"Methocarbamol starts working within 30 minutes, with full effects appearing within 2 hours. As it is relatively short acting, it needs to be taken 3-4 times a day as directed by a doctor."
Answered by AI