Loratadine

Q: What is a loratadine used for?

<p><a href="https://www.withpower.com/clinical-trials/eczema">eczema</a>.</p> <p>Loratadine is an antihistamine medication that alleviates the symptoms of allergies such as hay fever, conjunctivitis (red, itchy eyes), and eczema.</p>

Catarrh, Asthma, nasal symptoms + 6 more

Treatment

9 FDA approvals

20 Active Studies for Loratadine

Treatment for

Catarrh

What is Loratadine

DesloratadineThe Generic name of this drug

Treatment SummaryDesloratadine is an antihistamine medication used to relieve allergy symptoms. It belongs to a group of drugs known as second-generation tricyclic antihistamines and is the active form of the drug loratidine. Desloratadine is long-lasting and does not cause drowsiness because it does not enter the brain.

Clarinexis the brand name

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Loratadine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Clarinex

Desloratadine

2001

Approved as Treatment by the FDA

Desloratadine, also known as Clarinex, is approved by the FDA for 9 uses like Seasonal Allergic Rhinitis and Chronic Idiopathic Urticaria .

Seasonal Allergic Rhinitis

Chronic Idiopathic Urticaria

nasal symptoms

Used to treat nasal symptoms in combination with Pseudoephedrine

non-nasal symptoms

Used to treat non-nasal symptoms in combination with Pseudoephedrine

Perennial Allergic Rhinitis (PAR)

Nasal Congestion

Used to treat Nasal Congestion in combination with Pseudoephedrine

Hay Fever

Chronic Urticaria

Rhinitis, Allergic

Effectiveness

How Loratadine Affects PatientsDesloratadine is a type of medicine that helps reduce allergy symptoms. It works by blocking one type of receptor (the H1 receptor) that histamine, a chemical released during an allergic reaction, attaches to. This prevents histamine from activating cells and producing the symptoms associated with allergies. Unlike other antihistamines, desloratadine does not enter the brain and does not cause drowsiness.

How Loratadine works in the bodyDesloratadine helps to reduce allergy symptoms by blocking the effects of histamine. It does this by competing with histamine for binding to receptors in the body, keeping histamine from activating these receptors and causing symptoms. This provides temporary relief from symptoms like nasal congestion and watery eyes.

When to interrupt dosage

The advised dose of Loratadine is contingent upon the diagnosed condition, including Hay Fever, Nasal Congestion and non-nasal manifestations. The amount of dosage alters according to the technique of conveyance (e.g. Oral or Tablet, orally disintegrating - Oral) specified in the table below.

Condition

Dosage

Administration

Catarrh

, 5.0 mg, 2.5 mg, 0.5 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical

Chronic Urticaria

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Asthma

, 5.0 mg, 2.5 mg, 0.5 mg/mL

nasal symptoms

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Hay Fever

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Nasal Congestion

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Rhinitis, Allergic

, 5.0 mg, 2.5 mg, 0.5 mg/mL

non-nasal symptoms

, 5.0 mg, 2.5 mg, 0.5 mg/mL

antihistamine

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Warnings

Loratadine Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Loratadine.

Common Loratadine Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Amiodarone.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Artemether.

Asenapine

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Asenapine.

Loratadine Toxicity & Overdose RiskTaking too much desloratadine can lead to drowsiness. In the case of overdose, it is recommended to remove any unabsorbed drug from the body and provide supportive treatment. Studies in rats and mice have found that doses at least 120 and 290 times higher than the recommended human dose can be fatal. In monkeys, no deaths occurred at doses of up to 810 times the recommended human dose.

image of a doctor in a lab doing drug, clinical research

Loratadine Novel Uses: Which Conditions Have a Clinical Trial Featuring Loratadine?

153 ongoing trials are probing the potential of Loratadine to alleviate Asthma, Catarrh and Hay Fever symptoms.

Condition

Clinical Trials

Trial Phases

Asthma

88 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

antihistamine

0 Actively Recruiting

Catarrh

0 Actively Recruiting

nasal symptoms

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Hay Fever

0 Actively Recruiting

Chronic Urticaria

1 Actively Recruiting

Phase 2

non-nasal symptoms

0 Actively Recruiting

Rhinitis, Allergic

0 Actively Recruiting

Loratadine Reviews: What are patients saying about Loratadine?

5Patient Review

8/4/2015

Loratadine for Itching

Silarx Loratadine Oral Solution unfortunately does not work as well as Claritin for my daughter's allergies. We'll be switching back to the latter medication.

5Patient Review

4/10/2020

Loratadine for Allergic Conjunctivitis

I tried this for my tinnitus and was really surprised that the humming in my ears disappeared within just one hour!

4.7Patient Review

8/14/2014

Loratadine for Inflammation of the Nose due to an Allergy

3.7Patient Review

12/5/2020

Loratadine for Stuffy Nose

I find that this medication is effective when taken daily. I have tried other allergy medications in the past, but this one seems to work the best for me.

3.3Patient Review

10/16/2015

Loratadine for Sneezing

After taking loratadine for two weeks, I started shedding hair at an alarming rate. The FDA doesn't require manufacturers to list this side effect on the packaging. Do your research before taking this drug.

View All Reviews

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Patient Q&A Section about loratadine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is a loratadine used for?

"eczema.

Loratadine is an antihistamine medication that alleviates the symptoms of allergies such as hay fever, conjunctivitis (red, itchy eyes), and eczema."

Answered by AI

Does loratadine have any side effects?

"A headache, tiredness, or a dry mouth are some of the less common side effects of loratadine. It generally doesn't cause drowsiness, but some people may be affected. So, it's advised to be careful when driving or operating machinery until you know how loratadine will affect you."

Answered by AI

Do loratadine make you sleepy?

"Loratadine may cause drowsiness in some people, so it is important to make sure your reactions are normal before driving or using tools or machines."

Answered by AI

Who should not use loratadine?

"The tablet may contain phenylalanine and could be harmful if you have phenylketonuria (PKU). A doctor should be consulted before using this medicine if the patient is pregnant or breastfeeding. This medicine should not be given to a child younger than 2 years old without medical advice."

Answered by AI

Clinical Trials for Loratadine

Have you considered Loratadine clinical trials? We made a collection of clinical trials featuring Loratadine, we think they might fit your search criteria.

Have you considered Loratadine clinical trials? We made a collection of clinical trials featuring Loratadine, we think they might fit your search criteria.