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What is Loratadine
DesloratadineThe Generic name of this drug
Treatment SummaryDesloratadine is an antihistamine medication used to relieve allergy symptoms. It belongs to a group of drugs known as second-generation tricyclic antihistamines and is the active form of the drug loratidine. Desloratadine is long-lasting and does not cause drowsiness because it does not enter the brain.
Clarinexis the brand name
Loratadine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clarinex
Desloratadine
2001
35
Approved as Treatment by the FDA
Desloratadine, also known as Clarinex, is approved by the FDA for 6 uses like Nasal Congestion and non-nasal symptoms .Nasal Congestion
Used to treat Nasal Congestion in combination with Pseudoephedrine
non-nasal symptoms
Used to treat non-nasal symptoms in combination with Pseudoephedrine
Perennial Allergic Rhinitis (PAR)
Hay Fever
Chronic Urticaria
nasal symptoms
Used to treat nasal symptoms in combination with Pseudoephedrine
Effectiveness
How Loratadine Affects PatientsDesloratadine is a type of medicine that helps reduce allergy symptoms. It works by blocking one type of receptor (the H1 receptor) that histamine, a chemical released during an allergic reaction, attaches to. This prevents histamine from activating cells and producing the symptoms associated with allergies. Unlike other antihistamines, desloratadine does not enter the brain and does not cause drowsiness.
How Loratadine works in the bodyDesloratadine helps to reduce allergy symptoms by blocking the effects of histamine. It does this by competing with histamine for binding to receptors in the body, keeping histamine from activating these receptors and causing symptoms. This provides temporary relief from symptoms like nasal congestion and watery eyes.
When to interrupt dosage
The advised dose of Loratadine is contingent upon the diagnosed condition, including Hay Fever, Nasal Congestion and non-nasal manifestations. The amount of dosage alters according to the technique of conveyance (e.g. Oral or Tablet, orally disintegrating - Oral) specified in the table below.Condition
Dosage
Administration
nasal symptoms
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Chronic Urticaria
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
antihistamine
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Hay Fever
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Nasal Congestion
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Asthma
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Perennial Allergic Rhinitis (PAR)
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
non-nasal symptoms
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Catarrh
, 5.0 mg, 2.5 mg, 0.5 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical
Warnings
Loratadine ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Loratadine Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Asenapine.
Loratadine Toxicity & Overdose RiskTaking too much desloratadine can lead to drowsiness. In the case of overdose, it is recommended to remove any unabsorbed drug from the body and provide supportive treatment. Studies in rats and mice have found that doses at least 120 and 290 times higher than the recommended human dose can be fatal. In monkeys, no deaths occurred at doses of up to 810 times the recommended human dose.
Loratadine Novel Uses: Which Conditions Have a Clinical Trial Featuring Loratadine?
153 ongoing trials are probing the potential of Loratadine to alleviate Asthma, Catarrh and Hay Fever symptoms.Condition
Clinical Trials
Trial Phases
Asthma
160 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Perennial Allergic Rhinitis (PAR)
1 Actively Recruiting
Phase 3
Hay Fever
1 Actively Recruiting
Phase 3
nasal symptoms
0 Actively Recruiting
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
antihistamine
0 Actively Recruiting
Chronic Urticaria
1 Actively Recruiting
Phase 4
non-nasal symptoms
0 Actively Recruiting
Nasal Congestion
1 Actively Recruiting
Not Applicable
Loratadine Reviews: What are patients saying about Loratadine?
5Patient Review
8/4/2015 Silarx Loratadine Oral Solution unfortunately does not work as well as Claritin for my daughter's allergies. We'll be switching back to the latter medication.
5Patient Review
4/10/2020 I tried this for my tinnitus and was really surprised that the humming in my ears disappeared within just one hour!
4.7Patient Review
8/14/20143.7Patient Review
12/5/2020 I find that this medication is effective when taken daily. I have tried other allergy medications in the past, but this one seems to work the best for me.
3.3Patient Review
10/16/2015 After taking loratadine for two weeks, I started shedding hair at an alarming rate. The FDA doesn't require manufacturers to list this side effect on the packaging. Do your research before taking this drug.
3.3Patient Review
8/30/2022 This medication made me feel very restless and I had a strong urge to vomit. It was difficult to control myself.
3Patient Review
5/13/2015 Sometimes this medication doesn't stop the itching like it's supposed to. I also want to know if it contains pseudophedrine.
2.7Patient Review
8/9/2015 The recommended dosage of this medication is 10 mg once a day. However, I find that without taking at least 20 mg, I spend the whole struggling not to sneeze and my eyes are always red and itchy. Is it safe to take more than the recommended dose?
2.7Patient Review
12/8/2018 I was told to take this medicine instead of Benadryl because I also take other medications. Unfortunately, this medication caused me a lot of problems: EXTREME itchiness and welts as well as a burning sensation all over my body. I only took it for 2 days before discontinuing use; thankfully, today I am fine.
2.3Patient Review
4/27/20142.3Patient Review
6/26/2018 This definitely helped me to clear out my sinuses overnight, which was a huge relief.
2Patient Review
2/23/2019 My son was taking this medication for years before we realized it was the loratadine that was making him sick. He would constantly have stomach aches, anxiety, and vomiting episodes. While it did help his allergies somewhat, it definitely wasn't worth the amount of suffering he endured.
1.7Patient Review
8/24/2015 It helps me with the itching, and nerves.
1.7Patient Review
8/9/2015 No real problems here, though it did take a little bit of time for the sneezing and runny nose to go away. In the end, my nose was left less irritated.
Patient Q&A Section about loratadine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is a loratadine used for?
"eczema.
Loratadine is an antihistamine medication that alleviates the symptoms of allergies such as hay fever, conjunctivitis (red, itchy eyes), and eczema."
Answered by AI
Does loratadine have any side effects?
"A headache, tiredness, or a dry mouth are some of the less common side effects of loratadine. It generally doesn't cause drowsiness, but some people may be affected. So, it's advised to be careful when driving or operating machinery until you know how loratadine will affect you."
Answered by AI
Do loratadine make you sleepy?
"Loratadine may cause drowsiness in some people, so it is important to make sure your reactions are normal before driving or using tools or machines."
Answered by AI
Who should not use loratadine?
"The tablet may contain phenylalanine and could be harmful if you have phenylketonuria (PKU). A doctor should be consulted before using this medicine if the patient is pregnant or breastfeeding. This medicine should not be given to a child younger than 2 years old without medical advice."
Answered by AI