What is Lopid
TiclopidineThe Generic name of this drug
Treatment SummaryTiclopidine is a drug used to prevent the clumping of platelets in the blood. It works by blocking the action of the ADP receptor which is necessary for platelet aggregation. The brand name for ticlopidine is Ticlid and it is prescribed to patients who cannot take aspirin or in whom aspirin has not been successful in preventing a thrombotic stroke. Ticlopidine carries a black-box warning about potential risks including low white blood cells and platelets, so regular monitoring of white blood cells and platelets is necessary when taking this drug.
Ticlidis the brand name
Lopid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ticlid
Ticlopidine
1991
9
Approved as Treatment by the FDA
Ticlopidine, otherwise called Ticlid, is approved by the FDA for 4 uses including subacute stent thrombosis and Thrombosis .subacute stent thrombosis
Thrombosis
Stroke
Coronary Stent Implantation
Effectiveness
How Lopid Affects PatientsTiclopidine is a drug that is changed by the body into a substance that helps reduce the ability of platelets in the blood to stick together and form clots. This can lead to increased bleeding times. In its original form, ticlopidine has no effect on platelets when taken at normal doses.
How Lopid works in the bodyTiclopidine stops platelets, which are cells involved in blood clotting, from clumping together. It does this by blocking the receptor on platelets that binds to adenosine diphosphate (ADP). This prevents ADP from activating the GPIIb/IIIa complex, which is the main way platelets stick together. In turn, this stops platelets from sticking to fibrinogen and forming a clot. Ticlopidine also blocks other ways platelets can stick together, which further prevents clotting.
When to interrupt dosage
The recommended measure of Lopid is contingent upon the diagnosed disorder, for example, Stroke, Stent, gadget and antecedent strokes. The amount of dosage additionally varies as indicated by the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Stroke
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
Stent, device
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
experienced stroke precursors
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
Thrombosis
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
subacute stent thrombosis
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
previous stroke
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
Thrombotic Stroke
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
aspirin
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
Coronary Stent Implantation
, 250.0 mg
Tablet - Oral, , Tablet, Tablet, film coated - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, film coated, Oral
Warnings
Lopid has seven contraindications, so it should not be taken in coordination with the ailments indicated in the table below.Lopid ContraindicationsCondition
Risk Level
Notes
Low Platelet Count
Do Not Combine
history of aplastic anemia
Do Not Combine
Hemostatic Disorders
Do Not Combine
Thrombocytopenic purpura
Do Not Combine
Hemorrhage
Do Not Combine
Neutropenia
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Common Lopid Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Ticlopidine is combined with Abrocitinib.
Albendazole
Major
The metabolism of Albendazole can be decreased when combined with Ticlopidine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ticlopidine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ticlopidine.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Ticlopidine.
Lopid Toxicity & Overdose RiskTaking too much ticlopidine can be fatal in both rats and mice. Symptoms of an overdose include stomach bleeding, seizures, lowered body temperature, shortness of breath, loss of balance, and difficulty walking. The FDA warns that taking ticlopidine may cause a decrease in white blood cells and platelets, so patients should be monitored during treatment.
Lopid Novel Uses: Which Conditions Have a Clinical Trial Featuring Lopid?
Seventeen active clinical trials are investigating the novel use of Lopid to potentially treat subacute stent thrombosis, Coronary Stent Implantation and prior stroke.Condition
Clinical Trials
Trial Phases
subacute stent thrombosis
0 Actively Recruiting
Coronary Stent Implantation
0 Actively Recruiting
previous stroke
0 Actively Recruiting
experienced stroke precursors
0 Actively Recruiting
Stroke
17 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3
aspirin
0 Actively Recruiting
Stent, device
0 Actively Recruiting
Thrombosis
1 Actively Recruiting
Not Applicable
Thrombotic Stroke
1 Actively Recruiting
Not Applicable
Lopid Reviews: What are patients saying about Lopid?
5Patient Review
9/18/2014 Triglycerides were at an all-time high for me--1300. Lopid dropped them significantly, and now with pravachol I'm down to 150. Generic Gemfribozil has been working great for me with no side effects.
5Patient Review
8/2/2017 I found Lopid to be much more effective than Niaspan, and it was also easier to take. I only had to take it twice a day instead of the three times a day that was required for Niaspan, and I saw results within just a few months.
4.7Patient Review
5/6/2015 This medicine has been really effective in reducing my triglycerides and A1C levels.
4.3Patient Review
4/11/2012 I've been taking Lopid for a while now with no negative consequences. I find that it works best if I take it before bed and again when I wake up in the morning. My triglyceride levels have decreased and stayed manageable since starting this medication.
4.3Patient Review
7/1/2016 I've been struggling with high triglycerides for years, and finally found a medication that works for me. Lopid has helped me bring my numbers down from 400-600 to 88 in just a few months. I'm feeling very blessed to have found this treatment option.
4Patient Review
6/28/2017 My cholesterol, LDL, and HDL were all normal. My triglycerides were high at 441, but that's the only out-of-whack number.
3.7Patient Review
1/29/2013 I've been on this pill for a couple months now. I didn't initially understand the side effects, but after doing some research I realized that they were normal. Headaches, fatigue, and insomnia are all to be expected. However, this week I started experiencing body aches as well. I'm not sure if this is a result of the medication or not, but it's getting pretty annoying.
3.7Patient Review
2/1/2013 The only side effects I experienced were weight loss and mild stomach cramping.
3.3Patient Review
12/8/2012 I've been on Lopid for about a month now. When I first started, I had some stomach upset. However, I take it after breakfast with lots of water and have not had any problems since. Sometimes I feel tired, but my bowel movements are better.
3.3Patient Review
5/3/2013 I started taking this drug two weeks ago as directed (twice a day, morning and evening). I have found that if I don't take it at least 30 minutes before eating, I get headaches. This medication has also killed my sex drive and made me tired all day long.
3.3Patient Review
11/24/2013 I haven't had any issues with taking the medication. It's still early to tell if it's working or not, but so far so good.
3Patient Review
9/29/20113Patient Review
4/27/2013 I've been taking this medication for a while now and it has helped lower my cholesterol levels.
2Patient Review
6/5/2012 I experienced severe muscle pain and fatigue from this medication.
2Patient Review
4/28/2014 I've been taking this for five years now, and I can say with certainty that it has made me excessively tired, weak, and prone to headaches and stomach pain. My liver tests are right at the limit, which is worrying. Additionally, I feel like my memory has worsened since starting this medication; overall, I am quite afraid of it.
1.7Patient Review
4/26/2013 I had a really negative reaction to this drug. I developed hives all over my body and felt like I was going to die.
1.3Patient Review
8/14/2012 I had some pretty severe side effects from this medication. My muscles tightened up, I got headaches and lost my appetite. The worst part was the diarrhea; if I didn't time my meals just right, I would be stuck in the bathroom for hours.
1.3Patient Review
8/16/2013 My sister developed diabetes after only taking this medication for three days to treat her triglyceride levels. We took her to the ER and they said her blood sugar level was 1649. Has anyone else experienced something similar?
1Patient Review
5/24/2012 I am so nauseous every morning after taking this medication.
1Patient Review
12/14/2011Patient Q&A Section about lopid
Is Lopid and Lipitor the same thing?
"Lopid and Lipitor are in different drug categories, with Lopid being a lipid-regulating agent and Lipitor being an HMG-CoA reductase inhibitor (a "statin" drug). Both drugs can cause side effects such as nausea, diarrhea, headache, and muscle pain." - Anonymous Online Contributor
Unverified Answer
What is the side effect of gemfibrozil?
"This medication may cause serious side effects in a small number of users, such as gallstones and liver problems. If you experience any of the following symptoms, please notify your doctor immediately: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine." - Anonymous Online Contributor
Unverified Answer
What is Lopid used for?
"Gemfibrozil is a fibrate drug that helps to lower triglycerides and raise HDL cholesterol levels when taken with a proper diet. It may also help to lower LDL cholesterol levels. Gemfibrozil works by reducing the amount of fat produced by the liver." - Anonymous Online Contributor
Unverified Answer
What are the side effects of Lopid?
"The following are possible side effects: stomach pain, indigestion, diarrhea, numbness or tingly feeling, dizziness, drowsiness, blurred vision, muscle or joint pain, or loss of interest in sex, impotence." - Anonymous Online Contributor
Unverified Answer