Lopid

Atrial Fibrillation, Unstable Angina Pectoris, Heart Attack + 9 more
Treatment
12 FDA approvals
20 Active Studies for Lopid

What is Lopid

ClopidogrelThe Generic name of this drug
Treatment SummaryTiclopidine is a drug used to prevent the clumping of platelets in the blood. It works by blocking the action of the ADP receptor which is necessary for platelet aggregation. The brand name for ticlopidine is Ticlid and it is prescribed to patients who cannot take aspirin or in whom aspirin has not been successful in preventing a thrombotic stroke. Ticlopidine carries a black-box warning about potential risks including low white blood cells and platelets, so regular monitoring of white blood cells and platelets is necessary when taking this drug.
Plavixis the brand name
image of different drug pills on a surface
Lopid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plavix
Clopidogrel
1900
178

Approved as Treatment by the FDA

Clopidogrel, commonly known as Plavix, is approved by the FDA for 12 uses including Myocardial Infarction and elegible for thrombolytic therapy .
Myocardial Infarction
elegible for thrombolytic therapy
Used to treat elegible for thrombolytic therapy in combination with Acetylsalicylic acid
Peripheral Arterial Disease
Cardiovascular Events
Stroke
prophylaxis of cardiovascular event
Heart Attack
Heart Attack
Used to treat Acute Myocardial Infarction (AMI) in combination with Acetylsalicylic acid
Atrial Fibrillation
Acute Chest Syndrome
Used to treat Acute Coronary Syndrome (ACS) in combination with Acetylsalicylic acid
Unstable Angina Pectoris
atherothrombotic events
Used to treat atherothrombotic events in combination with Acetylsalicylic acid

Effectiveness

How Lopid Affects PatientsTiclopidine is a drug that is changed by the body into a substance that helps reduce the ability of platelets in the blood to stick together and form clots. This can lead to increased bleeding times. In its original form, ticlopidine has no effect on platelets when taken at normal doses.
How Lopid works in the bodyTiclopidine stops platelets, which are cells involved in blood clotting, from clumping together. It does this by blocking the receptor on platelets that binds to adenosine diphosphate (ADP). This prevents ADP from activating the GPIIb/IIIa complex, which is the main way platelets stick together. In turn, this stops platelets from sticking to fibrinogen and forming a clot. Ticlopidine also blocks other ways platelets can stick together, which further prevents clotting.

When to interrupt dosage

The recommended measure of Lopid is contingent upon the diagnosed disorder, for example, Stroke, Stent, gadget and antecedent strokes. The amount of dosage additionally varies as indicated by the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
Atrial Fibrillation
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Unstable Angina Pectoris
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
prophylaxis of cardiovascular event
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Peripheral Arterial Disease
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Acute Chest Syndrome
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Stroke
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Cardiovascular Events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Myocardial Infarction
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
elegible for thrombolytic therapy
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
atherothrombotic events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit

Warnings

Lopid has seven contraindications, so it should not be taken in coordination with the ailments indicated in the table below.Lopid Contraindications
Condition
Risk Level
Notes
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Clopidogrel may interact with Pulse Frequency
There are 20 known major drug interactions with Lopid.
Common Lopid Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Clopidogrel is combined with Abrocitinib.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Clopidogrel.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Clopidogrel.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Clopidogrel.
Anastrozole
Major
The metabolism of Anastrozole can be decreased when combined with Clopidogrel.
Lopid Toxicity & Overdose RiskTaking too much ticlopidine can be fatal in both rats and mice. Symptoms of an overdose include stomach bleeding, seizures, lowered body temperature, shortness of breath, loss of balance, and difficulty walking. The FDA warns that taking ticlopidine may cause a decrease in white blood cells and platelets, so patients should be monitored during treatment.
image of a doctor in a lab doing drug, clinical research

Lopid Novel Uses: Which Conditions Have a Clinical Trial Featuring Lopid?

Seventeen active clinical trials are investigating the novel use of Lopid to potentially treat subacute stent thrombosis, Coronary Stent Implantation and prior stroke.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
140 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1
Unstable Angina Pectoris
2 Actively Recruiting
Not Applicable
Acute Chest Syndrome
1 Actively Recruiting
Not Applicable
Stroke
10 Actively Recruiting
Not Applicable, Phase 1
Peripheral Arterial Disease
38 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Phase 2, Early Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Heart Attack
9 Actively Recruiting
Not Applicable, Phase 2, Phase 3
prophylaxis of cardiovascular event
0 Actively Recruiting
elegible for thrombolytic therapy
0 Actively Recruiting
Myocardial Infarction
4 Actively Recruiting
Not Applicable, Phase 4
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
atherothrombotic events
0 Actively Recruiting

Lopid Reviews: What are patients saying about Lopid?

5Patient Review
9/18/2014
Lopid for High Amount of Triglyceride in the Blood
Triglycerides were at an all-time high for me--1300. Lopid dropped them significantly, and now with pravachol I'm down to 150. Generic Gemfribozil has been working great for me with no side effects.
5Patient Review
8/2/2017
Lopid for High Amount of Triglyceride in the Blood
I found Lopid to be much more effective than Niaspan, and it was also easier to take. I only had to take it twice a day instead of the three times a day that was required for Niaspan, and I saw results within just a few months.
4.7Patient Review
5/6/2015
Lopid for High Amount of Triglyceride in the Blood
This medicine has been really effective in reducing my triglycerides and A1C levels.
4.3Patient Review
4/11/2012
Lopid for High Amount of Triglyceride in the Blood
I've been taking Lopid for a while now with no negative consequences. I find that it works best if I take it before bed and again when I wake up in the morning. My triglyceride levels have decreased and stayed manageable since starting this medication.
4.3Patient Review
7/1/2016
Lopid for High Amount of Triglyceride in the Blood
I've been struggling with high triglycerides for years, and finally found a medication that works for me. Lopid has helped me bring my numbers down from 400-600 to 88 in just a few months. I'm feeling very blessed to have found this treatment option.
4Patient Review
6/28/2017
Lopid for High Amount of Triglyceride in the Blood
My cholesterol, LDL, and HDL were all normal. My triglycerides were high at 441, but that's the only out-of-whack number.
3.7Patient Review
1/29/2013
Lopid for High Amount of Triglyceride in the Blood
I've been on this pill for a couple months now. I didn't initially understand the side effects, but after doing some research I realized that they were normal. Headaches, fatigue, and insomnia are all to be expected. However, this week I started experiencing body aches as well. I'm not sure if this is a result of the medication or not, but it's getting pretty annoying.
3.7Patient Review
2/1/2013
Lopid for High Amount of Triglyceride in the Blood
The only side effects I experienced were weight loss and mild stomach cramping.
3.3Patient Review
12/8/2012
Lopid for High Amount of Triglyceride in the Blood
I've been on Lopid for about a month now. When I first started, I had some stomach upset. However, I take it after breakfast with lots of water and have not had any problems since. Sometimes I feel tired, but my bowel movements are better.
3.3Patient Review
5/3/2013
Lopid for High Amount of Triglyceride in the Blood
I started taking this drug two weeks ago as directed (twice a day, morning and evening). I have found that if I don't take it at least 30 minutes before eating, I get headaches. This medication has also killed my sex drive and made me tired all day long.
3.3Patient Review
11/24/2013
Lopid for High Amount of Triglyceride in the Blood
I haven't had any issues with taking the medication. It's still early to tell if it's working or not, but so far so good.
3Patient Review
9/29/2011
Lopid for High Amount of Fats in the Blood
3Patient Review
4/27/2013
Lopid for Low HDL Cholesterol
I've been taking this medication for a while now and it has helped lower my cholesterol levels.
2Patient Review
6/5/2012
Lopid for Primary Prevention of Heart Attack
I experienced severe muscle pain and fatigue from this medication.
2Patient Review
4/28/2014
Lopid for High Amount of Triglyceride in the Blood
I've been taking this for five years now, and I can say with certainty that it has made me excessively tired, weak, and prone to headaches and stomach pain. My liver tests are right at the limit, which is worrying. Additionally, I feel like my memory has worsened since starting this medication; overall, I am quite afraid of it.
1.7Patient Review
4/26/2013
Lopid for High Amount of Triglyceride in the Blood
I had a really negative reaction to this drug. I developed hives all over my body and felt like I was going to die.
1.3Patient Review
8/14/2012
Lopid for High Amount of Triglyceride in the Blood
I had some pretty severe side effects from this medication. My muscles tightened up, I got headaches and lost my appetite. The worst part was the diarrhea; if I didn't time my meals just right, I would be stuck in the bathroom for hours.
1.3Patient Review
8/16/2013
Lopid for High Amount of Triglyceride in the Blood
My sister developed diabetes after only taking this medication for three days to treat her triglyceride levels. We took her to the ER and they said her blood sugar level was 1649. Has anyone else experienced something similar?
1Patient Review
5/24/2012
Lopid for High Amount of Triglyceride in the Blood
I am so nauseous every morning after taking this medication.
1Patient Review
12/14/2011
Lopid for High Amount of Triglyceride in the Blood
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lopid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lopid and Lipitor the same thing?

"Lopid and Lipitor are in different drug categories, with Lopid being a lipid-regulating agent and Lipitor being an HMG-CoA reductase inhibitor (a "statin" drug). Both drugs can cause side effects such as nausea, diarrhea, headache, and muscle pain."

Answered by AI

What is the side effect of gemfibrozil?

"This medication may cause serious side effects in a small number of users, such as gallstones and liver problems. If you experience any of the following symptoms, please notify your doctor immediately: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine."

Answered by AI

What is Lopid used for?

"Gemfibrozil is a fibrate drug that helps to lower triglycerides and raise HDL cholesterol levels when taken with a proper diet. It may also help to lower LDL cholesterol levels. Gemfibrozil works by reducing the amount of fat produced by the liver."

Answered by AI

What are the side effects of Lopid?

"The following are possible side effects: stomach pain, indigestion, diarrhea, numbness or tingly feeling, dizziness, drowsiness, blurred vision, muscle or joint pain, or loss of interest in sex, impotence."

Answered by AI

Clinical Trials for Lopid

Have you considered Lopid clinical trials? We made a collection of clinical trials featuring Lopid, we think they might fit your search criteria.
Have you considered Lopid clinical trials? We made a collection of clinical trials featuring Lopid, we think they might fit your search criteria.
Have you considered Lopid clinical trials? We made a collection of clinical trials featuring Lopid, we think they might fit your search criteria.