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What is Lopid
ClopidogrelThe Generic name of this drug
Treatment SummaryTiclopidine is a drug used to prevent the clumping of platelets in the blood. It works by blocking the action of the ADP receptor which is necessary for platelet aggregation. The brand name for ticlopidine is Ticlid and it is prescribed to patients who cannot take aspirin or in whom aspirin has not been successful in preventing a thrombotic stroke. Ticlopidine carries a black-box warning about potential risks including low white blood cells and platelets, so regular monitoring of white blood cells and platelets is necessary when taking this drug.
Plavixis the brand name
Lopid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plavix
Clopidogrel
1900
178
Approved as Treatment by the FDA
Clopidogrel, commonly known as Plavix, is approved by the FDA for 19 uses including Acute Coronary Syndrome (ACS) and atherothrombotic events .Acute Coronary Syndrome (ACS)
Used to treat Acute Coronary Syndrome (ACS) in combination with Acetylsalicylic acid
atherothrombotic events
Used to treat atherothrombotic events in combination with Acetylsalicylic acid
Atrial Fibrillation
Non ST Segment Elevation Myocardial Infarction (NSTEMI)
Stroke
Unstable Angina Pectoris
Cardiovascular Events
prophylaxis of cardiovascular event
Acute Myocardial Infarction (AMI)
Used to treat Acute Myocardial Infarction (AMI) in combination with Acetylsalicylic acid
elegible for thrombolytic therapy
Used to treat elegible for thrombolytic therapy in combination with Acetylsalicylic acid
Peripheral Arterial Disease (PAD)
ST Segment Elevation Myocardial Infarction (STEMI)
Heart Attack
Used to treat Acute Myocardial Infarction (AMI) in combination with Acetylsalicylic acid
Heart Attack
Angina, Unstable
Peripheral Arterial Disease
Myocardial Infarction
Atrial Fibrillation
Acute Chest Syndrome
Used to treat Acute Coronary Syndrome (ACS) in combination with Acetylsalicylic acid
Effectiveness
How Lopid Affects PatientsTiclopidine is a drug that is changed by the body into a substance that helps reduce the ability of platelets in the blood to stick together and form clots. This can lead to increased bleeding times. In its original form, ticlopidine has no effect on platelets when taken at normal doses.
How Lopid works in the bodyTiclopidine stops platelets, which are cells involved in blood clotting, from clumping together. It does this by blocking the receptor on platelets that binds to adenosine diphosphate (ADP). This prevents ADP from activating the GPIIb/IIIa complex, which is the main way platelets stick together. In turn, this stops platelets from sticking to fibrinogen and forming a clot. Ticlopidine also blocks other ways platelets can stick together, which further prevents clotting.
When to interrupt dosage
The recommended measure of Lopid is contingent upon the diagnosed disorder, for example, Stroke, Stent, gadget and antecedent strokes. The amount of dosage additionally varies as indicated by the technique of delivery featured in the table beneath.Condition
Dosage
Administration
Atrial Fibrillation
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Angina, Unstable
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
prophylaxis of cardiovascular event
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Peripheral Arterial Disease
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Acute Chest Syndrome
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Stroke
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Cardiovascular Events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Myocardial Infarction
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
elegible for thrombolytic therapy
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
atherothrombotic events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Warnings
Lopid has seven contraindications, so it should not be taken in coordination with the ailments indicated in the table below.Lopid ContraindicationsCondition
Risk Level
Notes
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Clopidogrel may interact with Pulse Frequency
Common Lopid Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Clopidogrel is combined with Abrocitinib.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Clopidogrel.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Clopidogrel.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Clopidogrel.
Anastrozole
Major
The metabolism of Anastrozole can be decreased when combined with Clopidogrel.
Lopid Toxicity & Overdose RiskTaking too much ticlopidine can be fatal in both rats and mice. Symptoms of an overdose include stomach bleeding, seizures, lowered body temperature, shortness of breath, loss of balance, and difficulty walking. The FDA warns that taking ticlopidine may cause a decrease in white blood cells and platelets, so patients should be monitored during treatment.
Lopid Novel Uses: Which Conditions Have a Clinical Trial Featuring Lopid?
Seventeen active clinical trials are investigating the novel use of Lopid to potentially treat subacute stent thrombosis, Coronary Stent Implantation and prior stroke.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Angina, Unstable
2 Actively Recruiting
Not Applicable
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Myocardial Infarction
3 Actively Recruiting
Not Applicable, Phase 4
elegible for thrombolytic therapy
0 Actively Recruiting
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Acute Chest Syndrome
3 Actively Recruiting
Not Applicable, Phase 2
atherothrombotic events
0 Actively Recruiting
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
prophylaxis of cardiovascular event
0 Actively Recruiting
Peripheral Arterial Disease
38 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1, Phase 4
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Lopid Reviews: What are patients saying about Lopid?
5Patient Review
9/18/2014 Triglycerides were at an all-time high for me--1300. Lopid dropped them significantly, and now with pravachol I'm down to 150. Generic Gemfribozil has been working great for me with no side effects.
5Patient Review
8/2/2017 I found Lopid to be much more effective than Niaspan, and it was also easier to take. I only had to take it twice a day instead of the three times a day that was required for Niaspan, and I saw results within just a few months.
4.7Patient Review
5/6/2015 This medicine has been really effective in reducing my triglycerides and A1C levels.
4.3Patient Review
4/11/2012 I've been taking Lopid for a while now with no negative consequences. I find that it works best if I take it before bed and again when I wake up in the morning. My triglyceride levels have decreased and stayed manageable since starting this medication.
4.3Patient Review
7/1/2016 I've been struggling with high triglycerides for years, and finally found a medication that works for me. Lopid has helped me bring my numbers down from 400-600 to 88 in just a few months. I'm feeling very blessed to have found this treatment option.
Patient Q&A Section about lopid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lopid and Lipitor the same thing?
"Lopid and Lipitor are in different drug categories, with Lopid being a lipid-regulating agent and Lipitor being an HMG-CoA reductase inhibitor (a "statin" drug). Both drugs can cause side effects such as nausea, diarrhea, headache, and muscle pain."
Answered by AI
What is the side effect of gemfibrozil?
"This medication may cause serious side effects in a small number of users, such as gallstones and liver problems. If you experience any of the following symptoms, please notify your doctor immediately: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine."
Answered by AI
What is Lopid used for?
"Gemfibrozil is a fibrate drug that helps to lower triglycerides and raise HDL cholesterol levels when taken with a proper diet. It may also help to lower LDL cholesterol levels. Gemfibrozil works by reducing the amount of fat produced by the liver."
Answered by AI
What are the side effects of Lopid?
"The following are possible side effects: stomach pain, indigestion, diarrhea, numbness or tingly feeling, dizziness, drowsiness, blurred vision, muscle or joint pain, or loss of interest in sex, impotence."
Answered by AI
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