Lipofen

Hypertriglyceridemia, Hypertriglyceridemia, Primary Hypercholesterolemia + 2 more
Treatment
8 FDA approvals
14 Active Studies for Lipofen

What is Lipofen

FenofibrateThe Generic name of this drug
Treatment SummaryFenofibrate is a medication used to treat high cholesterol, an abnormal mix of fats in the blood, and very high levels of triglycerides. It belongs to a class of drugs called fibric acid derivatives and was approved by the FDA in 1993.
Tricoris the brand name
Lipofen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tricor
Fenofibrate
2002
421

Approved as Treatment by the FDA

Fenofibrate, also known as Tricor, is approved by the FDA for 8 uses which include Primary Hypercholesterolemia and Severe Hypertriglyceridemia (sHTG) .
Primary Hypercholesterolemia
Severe Hypertriglyceridemia (sHTG)
Hypertriglyceridemia
Hypertriglyceridemia
Hypertriglyceridemia
severe Fredrickson Type V Hypertriglyceridemia
severe Fredrickson Type IV Hypertriglyceridemia
Dyslipidemias

Effectiveness

How Lipofen Affects PatientsFenofibrate is a type of drug used to help control cholesterol levels and treat certain types of fatty acid problems. It is taken once a day, and its effects last for 19-27 hours. The recommended dose is 50-150mg per day, so it is safe to take in different doses. Taking fenofibrate can cause muscle problems, including rhabdomyolysis, myopathy, and cholelithiasis, so patients should be made aware of the risks.
How Lipofen works in the bodyFenofibrate helps to break down fatty molecules in the body. It does this by activating a special protein called PPARα. This protein signals the body to produce substances that help break down fat. In rare cases, this increased activity can put too much stress on the liver, leading to cirrhosis or chronic hepatitis.

When to interrupt dosage

The advised dosage of Lipofen is contingent upon the diagnosed condition, including extreme Fredrickson Type V Hypertriglyceridemia, Dyslipidemias and Hypertriglyceridemia. The degree of dosage is influenced by the technique of delivery (e.g. Oral or Tablet, film coated) as detailed in the table beneath.
Condition
Dosage
Administration
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Primary Hypercholesterolemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Dyslipidemias
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Lipofen Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Gallbladder Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibrate may interact with Pulse Frequency
There are 20 known major drug interactions with Lipofen.
Common Lipofen Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fenofibrate.
Aluminium clofibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Aluminium clofibrate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fenofibrate.
Bezafibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Bezafibrate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fenofibrate.
Lipofen Toxicity & Overdose RiskThe lowest toxic dose of fenofibrate in rats is over 2g/kg and in mice is 1600mg/kg. If a patient has recently overdosed, they should be monitored closely and treated with vomiting or stomach pumping. Because fenofibrate binds to proteins in the bloodstream, dialysis is not expected to be effective in removing the drug.

Lipofen Novel Uses: Which Conditions Have a Clinical Trial Featuring Lipofen?

15 active clinical trials are examining the possible benefits of Lipofen in the management of severe Fredrickson Type V Hypertriglyceridemia, Hypertriglyceridemia and Dyslipidemias.
Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
8 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hypertriglyceridemia
5 Actively Recruiting
Phase 3
Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2

Lipofen Reviews: What are patients saying about Lipofen?

5Patient Review
1/21/2009
Lipofen for High Amount of Triglyceride in the Blood
Pravastatin made me feel really bad, so I started Lipofen and it's been amazing. I haven't had my blood tests yet, but I'll update this review when I do.
5Patient Review
3/2/2010
Lipofen for High Amount of Triglyceride in the Blood
I've been having trouble with my triglycerides for over 10 years now, and this is the first medication that has really helped. I do miss being able to go to the tanning beds, but it's a small price to pay for finally getting my cholesterol under control.
5Patient Review
10/29/2010
Lipofen for High Amount of Triglyceride in the Blood
I was really pleased with how well this worked. My trigliceride levels went from 357 to 120 in just three months, without any adverse effects that I could tell.
5Patient Review
1/16/2009
Lipofen for Combined High Blood Cholesterol and Triglyceride Level
I was really pleased with how much cheaper Lipofen was in comparison to other options on the market. I even got a coupon which made it the same price as generic medications!
4.7Patient Review
7/30/2010
Lipofen for Combined High Blood Cholesterol and Triglyceride Level
I had a terrible experience with this medication. My lower back on each side hurt terribly and I felt nauseous the entire time. I was only on the medication for two days before discontinuing use.
4.3Patient Review
10/1/2008
Lipofen for High Amount of Triglyceride in the Blood
So, this is the first medication I've been prescribed. I imagine I'll be off it soon given that they're also testing me for liver damage. No side effects that I can see, but the price tag was pretty shocking. $80 for 30 pills!
4Patient Review
1/12/2010
Lipofen for High Amount of Triglyceride in the Blood
I have difficulty swallowing pills, so I'm not sure if it's okay that I break open the capsule and sprinkle it on food or dissolve it in water. I don't want to cause myself problems though.
3Patient Review
12/9/2007
Lipofen for High Amount of Triglyceride in the Blood
2.7Patient Review
8/18/2010
Lipofen for High Amount of Triglyceride in the Blood
I was prescribed lipofen for my high triglycerides. However, I had to stop taking the medication before we could test its efficacy because I started feeling very ill--shortness of breath and muscle pain, among other symptoms. Once I ran out of CoQ10 and these effects worsened, I decided to discontinue the treatment.
2.3Patient Review
9/23/2009
Lipofen for High Amount of Triglyceride in the Blood
I was pleased to see that my blood test results improved after taking Lipofen for three months. My triglicerides, HDL, LDL, and cholesterol levels were all better than they had been when I was taking Pravastatin. And with no side effects!
2.3Patient Review
3/15/2010
Lipofen for High Cholesterol
This drug was amazing at reducing my triglycerides, and I never had any problems with side effects. I would highly recommend it to anyone looking to improve their cholesterol or triglyceride levels.
1.3Patient Review
10/28/2009
Lipofen for High Amount of Triglyceride in the Blood
I experienced pain in my lower back and down my leg after taking Lipofen for 18 days. Once I stopped the medication, the pain started to go away within 9 days.
1Patient Review
9/19/2010
Lipofen for High Amount of Triglyceride in the Blood
Unfortunately, this drug has caused me a lot of pain and problems with my bowels. I thought maybe taking it every other day would help, but even on the days I didn't take it I still experienced the same symptoms.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lipofen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is fenofibrate used for?

"Fenofibrate is a medication used to reduce high cholesterol and triglyceride levels in the blood, which may help prevent pancreatitis."

Answered by AI

What are the side effects of atorvastatin?

"The following are some tips for what to do when you are feeling sick: Stick to simple meals and do not eat rich or spicy food. If you have a headache, make sure you rest and drink plenty of fluids. If you have a nosebleed, try to tilt your head forward slightly and breathe through your mouth. If you have a sore throat, try gargling with salt water. If you have cold-like symptoms, such as a runny nose, blocked nose or sneezing, try to stay warm and dry. If you are constipated or farting (flatulence), try to eat more fibre-rich foods. If you have diarrhoea, make sure you drink plenty of fluids to replace what is lost."

Answered by AI

What is lipofen used for?

"Fenofibrate is used to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood."

Answered by AI

Clinical Trials for Lipofen

Image of Clinical Research Site 4 in Santa Clarita, United States.

Plozasiran for Hypertriglyceridemia

18+
All Sexes
Santa Clarita, CA
This study will evaluate the efficacy and safety of plozasiran in approximately 288 adult participants with severe hypertriglyceridemia (SHTG) and history of at least two prior acute pancreatitis (AP) events not attributed to other etiologies, with at least one occurring within the last 12 months prior to screening. Eligible participants will be randomly assigned in a double-blind manner to either receive plozasiran 25 mg by subcutaneous (SC) injection every three months (Q3M) or matching placebo. Enrolled participants will be counseled to remain on the specified low-fat diet and background medications throughout the study. Following completion of the double-blind treatment period, or if the participant has a positively adjudicated AP event (whichever occurs first), participants will transition to the 12-month Open-Label Extension (OLE) treatment period receiving plozasiran 25 mg by SC injection Q3M.
Phase 3
Recruiting
Clinical Research Site 4 (+9 Sites)Arrowhead Pharmaceuticals
Image of Atlantic Medical Group in Clark, United States.

Supportive Care for High Cholesterol

18 - 120
All Sexes
Clark, NJ
Hypercholesterolemia is recognized as the major driver for cardiovascular morbidity and mortality. To help address this in our community, Atlantic Medical Group (AMG) formed a lipid workgroup chaired by Robert D. Fishberg, MD, and Jeffrey N. Feldman, MD. The overarching goal of the lipid workgroup is to enhance the treatment of lipid disorders in those patients with abnormal lipid levels by improving access to resources at the primary care practice level and specialty level. We aim to develop a model for primary and secondary prevention that integrates guidelines for treatment at the practice level. Our primary objective is to identify high-risk patients by utilizing the electronic health record and partnering with patients' primary care providers to provide comprehensive medical management.
Recruiting
Has No Placebo
Atlantic Medical Group (+1 Sites)Robert D Fishberg, MDRegeneron Pharmaceuticals
Have you considered Lipofen clinical trials? We made a collection of clinical trials featuring Lipofen, we think they might fit your search criteria.Go to Trials
Image of University of Pennsylvania, Perelman School of Medicine in Philadelphia, United States.

Cascade Screening for High Cholesterol

18+
All Sexes
Philadelphia, PA
The goal of this clinical trial is to test two implementation strategies (automated health system \[Penn Medicine\]-mediated strategy vs. Family Heart Foundation-mediated strategy using a patient navigator) versus usual care to promote family cascade screening for familial hypercholesterolemia (FH) in Penn Medicine patients diagnosed with FH ("probands"). The main questions this study aims to answer are: (1) evaluating the effect of the three approaches on reach (proportion of probands who have at least one family member who completes screening), number of family members screened, number of family members diagnosed with FH, and proband LDL-C levels; and (2) identifying implementation strategy mechanisms focusing on health equity using mixed methods and oversampling populations that experience disparities. Participants (probands) in the active arms (health system \[Penn Medicine\]-mediated, Family Heart Foundation-mediated) will receive messaging that provides education about FH and provides instructions for participating in family cascade screening. A subset of probands will be invited to complete a qualitative interview about their experience receiving the implementation strategy. The research team will compare the active arms to Penn Medicine usual care for cascade screening to evaluate whether the active arms are more effective at promoting cascade screening than usual care.
Waitlist Available
Has No Placebo
University of Pennsylvania, Perelman School of Medicine
Have you considered Lipofen clinical trials? We made a collection of clinical trials featuring Lipofen, we think they might fit your search criteria.Go to Trials
Image of University of Maryland Amish Research Clinic in Lancaster, United States.

Direct Contact Genetic Screening for High Cholesterol

18+
All Sexes
Lancaster, PA
An important aspect of successful genomic medicine implementation is developing effective approaches for screening at-risk family members after probands are identified, also known as cascade screening. Most cascade screening studies conducted to date have been conducted outside the US, and very few studies have used a rigorous approach involving a comparator group or randomized controlled design. A major question in the field is how to most effectively implement cascade screening, given commonly cited communication barriers, while respecting privacy among probands and family members. This study will conduct a randomized controlled trial to assess direct contact of relatives by study team members vs indirect, or proband-initiated, contact. We will assess efficacy of the cascade screening intervention, patient-centered outcomes regarding mental, physical, and psychosocial outcomes in probands and family members, and implementation evaluation outcomes. Individuals who are known to carry the KCNQ1 Met224Thr or APOB Arg3527Gln variant will be eligible to participate. After providing consent and being deemed eligible, individuals will be randomized in a 1:1 manner into the direct or indirect contact of family members arm of the study. The randomization will be stratified by variant to ensure equal representation of each variant in the study arms. Individuals in the indirect arm will be instructed to contact their first-degree family members about the opportunity to be screened. They will be provided with a disease-specific pamphlet and a family letter explaining the cascade screening. In the direct arm, probands will be advised that the study staff will be contacting their family members. They will be instructed to also contact their family members prior to the study team contacting them. Approximately two weeks after this meeting with the proband, the study staff will mail letters to eligible first-degree family members of the probands. If we do not hear back from individual family members, we will follow-up with another letter, telephone call, or home visit. The information contained in the letters will be the same information for both the direct and indirect arms of the study. All interested family members will receive pre-test counseling and free, in-home, saliva-based genetic testing, and post-test counseling.
Recruiting
Has No Placebo
University of Maryland Amish Research Clinic
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