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What is Lipofen
FenofibrateThe Generic name of this drug
Treatment SummaryFenofibrate is a medication used to treat high cholesterol, an abnormal mix of fats in the blood, and very high levels of triglycerides. It belongs to a class of drugs called fibric acid derivatives and was approved by the FDA in 1993.
Tricoris the brand name
Lipofen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tricor
Fenofibrate
2002
421
Approved as Treatment by the FDA
Fenofibrate, also known as Tricor, is approved by the FDA for 5 uses which include Hypertriglyceridemia and Primary Hypercholesterolemia .Hypertriglyceridemia
Primary Hypercholesterolemia
Dyslipidemias
Hypertriglyceridemia
severe Fredrickson Type V Hypertriglyceridemia
Effectiveness
How Lipofen Affects PatientsFenofibrate is a type of drug used to help control cholesterol levels and treat certain types of fatty acid problems. It is taken once a day, and its effects last for 19-27 hours. The recommended dose is 50-150mg per day, so it is safe to take in different doses. Taking fenofibrate can cause muscle problems, including rhabdomyolysis, myopathy, and cholelithiasis, so patients should be made aware of the risks.
How Lipofen works in the bodyFenofibrate helps to break down fatty molecules in the body. It does this by activating a special protein called PPARα. This protein signals the body to produce substances that help break down fat. In rare cases, this increased activity can put too much stress on the liver, leading to cirrhosis or chronic hepatitis.
When to interrupt dosage
The advised dosage of Lipofen is contingent upon the diagnosed condition, including extreme Fredrickson Type V Hypertriglyceridemia, Dyslipidemias and Hypertriglyceridemia. The degree of dosage is influenced by the technique of delivery (e.g. Oral or Tablet, film coated) as detailed in the table beneath.Condition
Dosage
Administration
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Primary Hypercholesterolemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Dyslipidemias
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
severe Fredrickson Type V Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Lipofen ContraindicationsCondition
Risk Level
Notes
active liver disease
Do Not Combine
Gall Bladder Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibrate may interact with Pulse Frequency
Common Lipofen Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fenofibrate.
Aluminium clofibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Aluminium clofibrate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fenofibrate.
Bezafibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Bezafibrate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fenofibrate.
Lipofen Toxicity & Overdose RiskThe lowest toxic dose of fenofibrate in rats is over 2g/kg and in mice is 1600mg/kg. If a patient has recently overdosed, they should be monitored closely and treated with vomiting or stomach pumping. Because fenofibrate binds to proteins in the bloodstream, dialysis is not expected to be effective in removing the drug.
Lipofen Novel Uses: Which Conditions Have a Clinical Trial Featuring Lipofen?
15 active clinical trials are examining the possible benefits of Lipofen in the management of severe Fredrickson Type V Hypertriglyceridemia, Hypertriglyceridemia and Dyslipidemias.Condition
Clinical Trials
Trial Phases
Dyslipidemias
1 Actively Recruiting
Phase 2
severe Fredrickson Type V Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
4 Actively Recruiting
Phase 3
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Lipofen Reviews: What are patients saying about Lipofen?
5Patient Review
1/21/2009 Pravastatin made me feel really bad, so I started Lipofen and it's been amazing. I haven't had my blood tests yet, but I'll update this review when I do.
5Patient Review
3/2/2010 I've been having trouble with my triglycerides for over 10 years now, and this is the first medication that has really helped. I do miss being able to go to the tanning beds, but it's a small price to pay for finally getting my cholesterol under control.
5Patient Review
10/29/2010 I was really pleased with how well this worked. My trigliceride levels went from 357 to 120 in just three months, without any adverse effects that I could tell.
5Patient Review
1/16/2009 I was really pleased with how much cheaper Lipofen was in comparison to other options on the market. I even got a coupon which made it the same price as generic medications!
4.7Patient Review
7/30/2010 I had a terrible experience with this medication. My lower back on each side hurt terribly and I felt nauseous the entire time. I was only on the medication for two days before discontinuing use.
4.3Patient Review
10/1/2008 So, this is the first medication I've been prescribed. I imagine I'll be off it soon given that they're also testing me for liver damage. No side effects that I can see, but the price tag was pretty shocking. $80 for 30 pills!
4Patient Review
1/12/2010 I have difficulty swallowing pills, so I'm not sure if it's okay that I break open the capsule and sprinkle it on food or dissolve it in water. I don't want to cause myself problems though.
3Patient Review
12/9/20072.7Patient Review
8/18/2010 I was prescribed lipofen for my high triglycerides. However, I had to stop taking the medication before we could test its efficacy because I started feeling very ill--shortness of breath and muscle pain, among other symptoms. Once I ran out of CoQ10 and these effects worsened, I decided to discontinue the treatment.
2.3Patient Review
9/23/2009 I was pleased to see that my blood test results improved after taking Lipofen for three months. My triglicerides, HDL, LDL, and cholesterol levels were all better than they had been when I was taking Pravastatin. And with no side effects!
2.3Patient Review
3/15/2010 This drug was amazing at reducing my triglycerides, and I never had any problems with side effects. I would highly recommend it to anyone looking to improve their cholesterol or triglyceride levels.
1.3Patient Review
10/28/2009 I experienced pain in my lower back and down my leg after taking Lipofen for 18 days. Once I stopped the medication, the pain started to go away within 9 days.
1Patient Review
9/19/2010 Unfortunately, this drug has caused me a lot of pain and problems with my bowels. I thought maybe taking it every other day would help, but even on the days I didn't take it I still experienced the same symptoms.
Patient Q&A Section about lipofen
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is fenofibrate used for?
"Fenofibrate is a medication used to reduce high cholesterol and triglyceride levels in the blood, which may help prevent pancreatitis."
Answered by AI
What are the side effects of atorvastatin?
"The following are some tips for what to do when you are feeling sick: Stick to simple meals and do not eat rich or spicy food. If you have a headache, make sure you rest and drink plenty of fluids. If you have a nosebleed, try to tilt your head forward slightly and breathe through your mouth. If you have a sore throat, try gargling with salt water. If you have cold-like symptoms, such as a runny nose, blocked nose or sneezing, try to stay warm and dry. If you are constipated or farting (flatulence), try to eat more fibre-rich foods. If you have diarrhoea, make sure you drink plenty of fluids to replace what is lost."
Answered by AI
What is lipofen used for?
"Fenofibrate is used to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood."
Answered by AI