Lipofen

Hypertriglyceridemia, Hypertriglyceridemia, Primary Hypercholesterolemia + 2 more
Treatment
8 FDA approvals
19 Active Studies for Lipofen

What is Lipofen

FenofibrateThe Generic name of this drug
Treatment SummaryFenofibrate is a medication used to treat high cholesterol, an abnormal mix of fats in the blood, and very high levels of triglycerides. It belongs to a class of drugs called fibric acid derivatives and was approved by the FDA in 1993.
Tricoris the brand name
Lipofen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tricor
Fenofibrate
2002
421

Approved as Treatment by the FDA

Fenofibrate, also known as Tricor, is approved by the FDA for 8 uses which include Hypertriglyceridemia and Primary Hypercholesterolemia .
Hypertriglyceridemia
Primary Hypercholesterolemia
Severe Hypertriglyceridemia (sHTG)
severe Fredrickson Type V Hypertriglyceridemia
Hypertriglyceridemia
Hypertriglyceridemia
severe Fredrickson Type IV Hypertriglyceridemia
Dyslipidemias

Effectiveness

How Lipofen Affects PatientsFenofibrate is a type of drug used to help control cholesterol levels and treat certain types of fatty acid problems. It is taken once a day, and its effects last for 19-27 hours. The recommended dose is 50-150mg per day, so it is safe to take in different doses. Taking fenofibrate can cause muscle problems, including rhabdomyolysis, myopathy, and cholelithiasis, so patients should be made aware of the risks.
How Lipofen works in the bodyFenofibrate helps to break down fatty molecules in the body. It does this by activating a special protein called PPARα. This protein signals the body to produce substances that help break down fat. In rare cases, this increased activity can put too much stress on the liver, leading to cirrhosis or chronic hepatitis.

When to interrupt dosage

The advised dosage of Lipofen is contingent upon the diagnosed condition, including extreme Fredrickson Type V Hypertriglyceridemia, Dyslipidemias and Hypertriglyceridemia. The degree of dosage is influenced by the technique of delivery (e.g. Oral or Tablet, film coated) as detailed in the table beneath.
Condition
Dosage
Administration
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Primary Hypercholesterolemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Dyslipidemias
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral
Hypertriglyceridemia
145.0 mg, 48.0 mg, , 160.0 mg, 54.0 mg, 43.0 mg, 130.0 mg, 67.0 mg, 200.0 mg, 134.0 mg, 1.45 mg, 1.6 mg, 40.0 mg, 120.0 mg, 150.0 mg, 50.0 mg, 100.0 mg, 30.0 mg, 90.0 mg, 87.0 mg
Oral, Tablet, , Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Lipofen Contraindications
Condition
Risk Level
Notes
Liver Diseases
Do Not Combine
Gallbladder Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fenofibrate may interact with Pulse Frequency
There are 20 known major drug interactions with Lipofen.
Common Lipofen Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fenofibrate.
Aluminium clofibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Aluminium clofibrate.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fenofibrate.
Bezafibrate
Major
The risk or severity of adverse effects can be increased when Fenofibrate is combined with Bezafibrate.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Fenofibrate.
Lipofen Toxicity & Overdose RiskThe lowest toxic dose of fenofibrate in rats is over 2g/kg and in mice is 1600mg/kg. If a patient has recently overdosed, they should be monitored closely and treated with vomiting or stomach pumping. Because fenofibrate binds to proteins in the bloodstream, dialysis is not expected to be effective in removing the drug.

Lipofen Novel Uses: Which Conditions Have a Clinical Trial Featuring Lipofen?

15 active clinical trials are examining the possible benefits of Lipofen in the management of severe Fredrickson Type V Hypertriglyceridemia, Hypertriglyceridemia and Dyslipidemias.
Condition
Clinical Trials
Trial Phases
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hypertriglyceridemia
8 Actively Recruiting
Phase 3, Phase 2
Hypertriglyceridemia
0 Actively Recruiting
Hypertriglyceridemia
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2

Lipofen Reviews: What are patients saying about Lipofen?

5Patient Review
1/21/2009
Lipofen for High Amount of Triglyceride in the Blood
Pravastatin made me feel really bad, so I started Lipofen and it's been amazing. I haven't had my blood tests yet, but I'll update this review when I do.
5Patient Review
3/2/2010
Lipofen for High Amount of Triglyceride in the Blood
I've been having trouble with my triglycerides for over 10 years now, and this is the first medication that has really helped. I do miss being able to go to the tanning beds, but it's a small price to pay for finally getting my cholesterol under control.
5Patient Review
10/29/2010
Lipofen for High Amount of Triglyceride in the Blood
I was really pleased with how well this worked. My trigliceride levels went from 357 to 120 in just three months, without any adverse effects that I could tell.
5Patient Review
1/16/2009
Lipofen for Combined High Blood Cholesterol and Triglyceride Level
I was really pleased with how much cheaper Lipofen was in comparison to other options on the market. I even got a coupon which made it the same price as generic medications!
4.7Patient Review
7/30/2010
Lipofen for Combined High Blood Cholesterol and Triglyceride Level
I had a terrible experience with this medication. My lower back on each side hurt terribly and I felt nauseous the entire time. I was only on the medication for two days before discontinuing use.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lipofen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is fenofibrate used for?

"Fenofibrate is a medication used to reduce high cholesterol and triglyceride levels in the blood, which may help prevent pancreatitis."

Answered by AI

What are the side effects of atorvastatin?

"The following are some tips for what to do when you are feeling sick: Stick to simple meals and do not eat rich or spicy food. If you have a headache, make sure you rest and drink plenty of fluids. If you have a nosebleed, try to tilt your head forward slightly and breathe through your mouth. If you have a sore throat, try gargling with salt water. If you have cold-like symptoms, such as a runny nose, blocked nose or sneezing, try to stay warm and dry. If you are constipated or farting (flatulence), try to eat more fibre-rich foods. If you have diarrhoea, make sure you drink plenty of fluids to replace what is lost."

Answered by AI

What is lipofen used for?

"Fenofibrate is used to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood."

Answered by AI

Clinical Trials for Lipofen

Have you considered Lipofen clinical trials? We made a collection of clinical trials featuring Lipofen, we think they might fit your search criteria.
Have you considered Lipofen clinical trials? We made a collection of clinical trials featuring Lipofen, we think they might fit your search criteria.
Have you considered Lipofen clinical trials? We made a collection of clinical trials featuring Lipofen, we think they might fit your search criteria.
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