Latanoprost
Glaucoma, Open Angle Glaucoma, Ocular Hypertension + 2 more
Treatment
7 FDA approvals
18 Active Studies for Latanoprost
Treatment for
Glaucoma
What is Latanoprost
Latanoprost
The Generic name of this drug
Treatment Summary
Latanoprostene Bunod is a medication used to treat open-angle glaucoma and ocular hypertension. It was approved by the FDA in 2017 and is the first prostaglandin analog with one of its metabolites being nitric oxide, giving it an extra effect of relaxing tissues and cells. Latanoprostene Bunod is similar to latanoprost, but it has an NO-donating moiety instead of the isopropyl ester found in latanoprost.
Xalatan
is the brand name
Latanoprost Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xalatan
Latanoprost
1995
30
Approved as Treatment by the FDA
Latanoprost, otherwise called Xalatan, is approved by the FDA for 7 uses including Open Angle Glaucoma and Glaucoma .
Open Angle Glaucoma
Used to treat Open Angle Glaucoma (OAG) in combination with Netarsudil
Glaucoma
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Netarsudil
Glaucoma, Angle-Closure
Open Angle Glaucoma (OAG)
Used to treat Open Angle Glaucoma (OAG) in combination with Netarsudil
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Netarsudil
Increased Intra Ocular Pressure (IOP)
Effectiveness
How Latanoprost Affects Patients
Upon taking an appropriate dose of latanoprost bunod, the drug will start to lower the pressure in the eye. The maximum effect will be seen after 11 to 13 hours.
How Latanoprost works in the body
Open-angle Glaucoma (OAG) is a condition that causes vision loss. It is often caused by high eye pressure, called Occular Hypertension (OHT). To help treat OAG, medications are used to reduce and maintain the pressure. Latanoprostene bunod works by two different pathways. It increases the flow of aqueous humor out of the eye by making the pathways wider, and it also reduces resistance to the flow by changing how cells contract. Both of these effects result in lower eye pressure and help prevent vision loss.
When to interrupt dosage
The quantity of Latanoprost is contingent on the declared affliction. The amount of dosage is subject to the technique of administration featured in the table below.
Condition
Dosage
Administration
Glaucoma
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Open Angle Glaucoma
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Ocular Hypertension
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Glaucoma, Angle-Closure
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
inadequate response to other therapeutic measures
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Warnings
Latanoprost Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Latanoprost may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Latanoprost may interact with Pulse Frequency
There are 2 known major drug interactions with Latanoprost.
Common Latanoprost Drug Interactions
Drug Name
Risk Level
Description
Bimatoprost
Major
The risk or severity of intraocular pressure can be increased when Latanoprost is combined with Bimatoprost.
Baricitinib
Moderate
The serum concentration of Baricitinib can be increased when it is combined with Latanoprost.
Latanoprost Toxicity & Overdose Risk
Pregnant women should not take latanoprost bunod unless the potential benefits outweigh any risks to the unborn baby. It is also not known if latanoprost bunod is present in breast milk or if it affects milk production, so breastfeeding mothers should consult with their doctor before taking this medication. Long-term use of latanoprost bunod may cause permanent darkening of the iris and increased length, thickness and number of eyelashes, which may be reversible upon discontinuing the medication. This medication can also cause or worsen eye inflammation and macular edema, and should be used with caution in patients with existing
Latanoprost Novel Uses: Which Conditions Have a Clinical Trial Featuring Latanoprost?
Currently, zero active studies are investigating the potential of Latanoprost in treating Open Angle Glaucoma or Ocular Hypertension.
Condition
Clinical Trials
Trial Phases
Glaucoma, Angle-Closure
0 Actively Recruiting
Ocular Hypertension
12 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
inadequate response to other therapeutic measures
0 Actively Recruiting
Glaucoma
0 Actively Recruiting
Open Angle Glaucoma
12 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2
Latanoprost Reviews: What are patients saying about Latanoprost?
5
Patient Review
3/16/2019
Latanoprost for Increased Pressure in the Eye
5
Patient Review
5/4/2022
Latanoprost for Wide-Angle Glaucoma
4.3
Patient Review
5/2/2018
Latanoprost for Increased Pressure in the Eye
4.3
Patient Review
4/25/2019
Latanoprost for Increased Pressure in the Eye
4
Patient Review
12/30/2018
Latanoprost for Wide-Angle Glaucoma
3.7
Patient Review
5/14/2018
Latanoprost for Increased Pressure in the Eye
3.7
Patient Review
4/22/2021
Latanoprost for Wide-Angle Glaucoma
3.7
Patient Review
3/7/2022
Latanoprost for Wide-Angle Glaucoma
3.3
Patient Review
4/10/2019
Latanoprost for Increased Pressure in the Eye
2.7
Patient Review
6/9/2022
Latanoprost for Increased Pressure in the Eye
2.3
Patient Review
10/8/2019
Latanoprost for Wide-Angle Glaucoma
2.3
Patient Review
10/7/2019
Latanoprost for Increased Pressure in the Eye
2
Patient Review
4/30/2018
Latanoprost for Increased Pressure in the Eye
1
Patient Review
9/30/2019
Latanoprost for Wide-Angle Glaucoma
1
Patient Review
1/19/2019
Latanoprost for Increased Pressure in the Eye
Patient Q&A Section about latanoprost
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What does latanoprost do for the eye?
"Latanoprost is a medication used to treat high pressure inside the eye. This increased pressure can damage your optic nerve and cause vision loss or blindness. Your doctor may prescribe latanoprost for you if you have glaucoma or high pressure in the eye (ocular hypertension)."
Answered by AI
What are the side effects of using latanoprost eye drops?
"The following side effects may occur: changes in vision, burning/stinging/itching/redness of the eye, feeling as if something is in the eye, changes in the number/color/length/thickness of eyelashes, changes in the eyelids/skin darkening, dry eye, lid crusting/discomfort, or increased sensitivity to light."
Answered by AI
Why is latanoprost taken at night?
"Latanoprost provides greater pressure reduction 12 to 24 hours after being taken, either in the morning or at night. Konstas and associates observed this peak effect."
Answered by AI
Should latanoprost be refrigerated?
"Xalatan should be stored in the refrigerator and not frozen. The opened bottle can be stored in the refrigerator for up to six weeks or at room temperature."
Answered by AI