Korlym

Medically induced abortion, High Blood Sugar, Cushing Syndrome + 1 more
Treatment
6 FDA approvals
20 Active Studies for Korlym

What is Korlym

MifepristoneThe Generic name of this drug
Treatment SummaryMifepristone is a hormone-blocking medication used to induce bleeding during the luteal phase and early pregnancy. It also acts as an antagonist of the glucocorticoid hormone, which is used to treat high levels of cortisol in patients with nonpituitary Cushing Syndrome. Mifepristone is available in two doses: Mifeprex® (200mg) and Korlym™ (300mg). It is currently being tested as a potential treatment for psychotic depression.
Korlymis the brand name
Korlym Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Korlym
Mifepristone
2012
3

Approved as Treatment by the FDA

Mifepristone, also called Korlym, is approved by the FDA for 6 uses including Hyperglycemia and Cushing's syndrome, Type 2 diabetes mellitus, hypercorticolism .
Hyperglycemia
Helps manage Hyperglycemia
Cushing's syndrome, Type 2 diabetes mellitus, hypercorticolism
Helps manage Cushing's syndrome, Type 2 diabetes mellitus, hypercorticolism
Medically induced abortion
Used to treat Medically induced abortion in combination with Misoprostol
High Blood Sugar
Helps manage Hyperglycemia
Therapeutic procedure
Used to treat Pregnancy termination therapy in combination with Misoprostol
Cushing Syndrome
Helps manage Cushing's syndrome, Type 2 diabetes mellitus, hypercorticolism

Effectiveness

How Korlym Affects PatientsMifepristone is a synthetic steroid prescribed to end pregnancies up to 49 days. It works by decreasing the effects of progesterone, which helps to induce contractions in the uterus. It also has weak anti-glucocorticoid and anti-androgenic effects. In rats, doses of 10-25 mg/kg have been shown to block the effects of dexamethasone. In people, doses of 4.5 mg/kg or higher increase the level of the hormones ACTH and cortisol in the body as a compensation.
How Korlym works in the bodyMifepristone works by competing with progesterone at receptor sites, blocking it from binding. This can cause pregnancy to end. Mifepristone also blocks cortisol from binding to its receptor, which helps reduce the effects of too much cortisol in the body, such as high blood sugar.

When to interrupt dosage

The measure of Korlym is dependent upon the diagnosed condition, for example Cushing Syndrome, Hyperglycemia and Medically incited premature birth. The dose fluctuates as per the technique of administration (e.g. Oral or Tablet) specified in the table below.
Condition
Dosage
Administration
Medically induced abortion
, 300.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral, Buccal; Oral
High Blood Sugar
, 300.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral, Buccal; Oral
Therapeutic procedure
, 300.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral, Buccal; Oral
Cushing Syndrome
, 300.0 mg, 200.0 mg
, Tablet, Tablet - Oral, Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral, Buccal; Oral

Warnings

Korlym has five contraindications and should not be used when presented with any of the circumstances indicated in the following table.Korlym Contraindications
Condition
Risk Level
Notes
Endometrial Hyperplasia
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
unexplained vaginal bleeding
Do Not Combine
Endometrial Hyperplasia
Do Not Combine
There are 20 known major drug interactions with Korlym.
Common Korlym Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Mifepristone.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Mifepristone.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Mifepristone.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Mifepristone.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Mifepristone.
Korlym Toxicity & Overdose RiskMost women who take mifepristone experience side effects, and many have more than one symptom. About 90% of patients also report adverse reactions after taking misoprostol, such as heavier bleeding than what is typical for a period, abdominal pain, cramping, nausea, vomiting, and diarrhea.
image of a doctor in a lab doing drug, clinical research

Korlym Novel Uses: Which Conditions Have a Clinical Trial Featuring Korlym?

33 active studies are currently being conducted to examine the potential of Korlym to provide a Therapeutic procedure, Cushing Syndrome and Medically induced abortion treatment.
Condition
Clinical Trials
Trial Phases
Medically induced abortion
0 Actively Recruiting
High Blood Sugar
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Therapeutic procedure
1 Actively Recruiting
Phase 4
Cushing Syndrome
0 Actively Recruiting

Korlym Reviews: What are patients saying about Korlym?

5Patient Review
11/9/2021
Korlym for Abortion
The only side effects I experienced were mild headaches, loss of appetite, and extreme fatigue. However, these slowly went away and the results were excellent in terms of lowering my blood sugar levels. My A1C went from 7.1 to 6.3 in just 2 1/2 months!
4.7Patient Review
2/26/2019
Korlym for Type 2 Diabetes Adjunct in Cushing's Syndrome
This treatment was very effective in reducing my symptoms and biochemical deficits. Going through cortisol withdrawal can be tough, but it's worth it in the end. This saved me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about korlym

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Korlym treat?

"Korlym is a drug that is used to control blood sugar in adults who have a condition called Cushing's syndrome and who also have type 2 diabetes or glucose intolerance. This drug is used when these patients have not been helped by surgery or are not able to have surgery."

Answered by AI

How long does it take for Korlym to work?

"About 60% of patients experienced a decrease in blood sugar levels by at least 25%. Some patients began to see improvements after just 6 weeks of treatment. By week 24 of treatment, patients' HbA1c levels had decreased by an average of 1.1%."

Answered by AI

How long do you take Korlym?

"The subjects of the study were given between 300 and 1200 milligrams of Korlym per day for a period of up to 24 weeks."

Answered by AI

Is there a generic for Korlym?

"If you're unsure about purchasing medication online, ask your healthcare provider for advice. Also check out the Generic Drug FAQ for more info."

Answered by AI

Clinical Trials for Korlym

Image of The Worship Center Cristian Church in Birmingham, United States.

Black Impact for Heart Health

18+
Male
Birmingham, AL
The goal of this clinical trial is to evaluate the implementation and effectiveness of the Black Impact program-a church-based cardiovascular health (CVH) intervention-in Black men aged 35-70 who are at risk for heart disease, diabetes, obesity, and related conditions. The main questions this study aims to answer are: * Does participation in the Black Impact program improve cardiovascular health metrics (e.g., blood pressure, cholesterol, blood sugar) and health behaviors among Black men at The Worship Center Christian Church (TWC)? * What factors influence the adoption, delivery, and sustainability of the Black Impact program in a faith-based setting? Researchers will compare an immediate-start intervention group and a delayed-start (waitlist control) group to assess both short-term health outcomes and program implementation factors. Participants will: * Attend a 90-minute weekly session for 24 weeks, including 45 minutes of physical activity led by a certified trainer and 45 minutes of health education delivered by trained coaches. * Receive one-on-one support from a community health worker to reduce barriers to care and engage with primary care. * Complete biometric health screenings and surveys at baseline, 12 weeks, and 24 weeks to assess clinical and behavioral outcomes. * Use a smartwatch, blood pressure cuff, and other tools to track progress in real time. * Participate in exit focus groups or interviews to share feedback about the intervention. * A subset of TWC leaders and interventionists (N=15) will also be interviewed to assess implementation, resource needs, and sustainability. This study uses the RE-AIM framework to assess Reach, Effectiveness, Adoption, Implementation, and Maintenance, and aims to inform scalable strategies for improving CVH among Black men in trusted community settings.
Waitlist Available
Has No Placebo
The Worship Center Cristian Church
Image of Sidney & Lois Eskenazi Hospital in Indianapolis, United States.

Composite Intervention for Metabolic Syndrome

18+
All Sexes
Indianapolis, IN
The objective of this study is to pilot a multifaceted, optimized intervention for metabolic syndrome (MetS) in emergency department patients to establish feasibility. Participants (n=20) will be randomized to intervention or control (usual care). The composite intervention will include an educational video outlining the adverse effects of MetS and the benefit of walking, a written exercise prescription with a defined goal of walking 150 minutes per week, a Fitbit accelerometer device, resources for healthy eating practices, periodic text message reminders, and an urgent referral to primary care and our health system's Healthy Me clinic for follow-up visit. Investigators hypothesize that this approach will change patient understanding and motivation to increase physical activity and healthy eating habits.
Recruiting
Has No Placebo
Sidney & Lois Eskenazi Hospital
Have you considered Korlym clinical trials? We made a collection of clinical trials featuring Korlym, we think they might fit your search criteria.Go to Trials
Image of Arizona State University 850 PBC in Phoenix, United States.

Low Glycemic Index Shake for High Blood Sugar

25 - 65
All Sexes
Phoenix, AZ
Low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies. However, there is limited information on how replacing meals with low-glycemic index shake could impact glucose regulation in free-living adults consuming their own diets. The present study aims to examine the impact of adding the SP Glucose-Assist shake to the breakfast of non-diabetic overweight and obese adults. Subjects: 40 non-diabetic adults aged 25-65 years and body mass index ranging between 25-39 . Protocol: This is going to be a three-week study that will include a one-week self-selected diet, followed by two weeks of a breakfast supplement shake (standard process glucose assist) or control cereal oat breakfast.
Recruiting
Paid Trial
Arizona State University 850 PBC
Image of University of California San Diego in San Diego, United States.

Tranexamic Acid for Bleeding

18+
Female
San Diego, CA
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality. Tranexamic acid (TXA) is used commonly in obstetrics to prevent or manage intrapartum or postpartum hemorrhage and has been associated with decreased mortality and decreased blood loss at the time of birth. Some guidelines are recommending the use of TXA for both the prevention and management of bleeding for abortion care. However, there are currently no published studies assessing the association between TXA and bleeding outcomes for abortion procedures. This study will involve a randomized, placebo-controlled trial of pregnant patients aged 18 and older desiring dilation and evacuation (D\&E) for abortion or fetal demise at 18-24 weeks gestation. The primary aim is to determine whether prophylactic TXA has an effect on the need for additional interventions to control bleeding at the time of D\&E. The secondary aim is to determine whether prophylactic TXA has an effect on the mean quantitative procedural blood loss.
Phase 4
Recruiting
University of California San Diego (+1 Sites)
Have you considered Korlym clinical trials? We made a collection of clinical trials featuring Korlym, we think they might fit your search criteria.Go to Trials
Image of One Robert Wood Johnson Place in New Brunswick, United States.

Educational Intervention for High Blood Sugar

18+
All Sexes
New Brunswick, NJ
The goal of this clinical trial is to increase Type 2 Diabetes Mellitus knowledge and awareness among patients who present to the Emergency Department with hyperglycemia. The main questions it aims to answer are: * How do patients view their risk of developing type 2 diabetes based on their demographics and behaviors? * Does giving patient education increase patient knowledge, leading to healthier behaviors? Researchers will assess if the educational intervention increases diabetes knowledge and positive health behaviors among Emergency Department hyperglycemic patients. Participants will: * Receive the educational packet (intervention) alongside standard Emergency Care. * Take pre-survey at time of Emergency Department visit and post- survey two weeks later.
Recruiting
Has No Placebo
One Robert Wood Johnson PlaceSara Heinert, PhD, MPH
Image of University of Alberta in Edmonton, Canada.

Egg White Powder for High Blood Sugar and High Blood Pressure

18 - 70
All Sexes
Edmonton, Canada
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).
Phase 1
Waitlist Available
University of AlbertaJianping Wu, PhD
Image of Children's Hospital of Pittsburgh in Pittsburgh, United States.

Smartphone App for Type 2 Diabetes

16 - 24
All Sexes
Pittsburgh, PA
This is a clinical trial that includes a run-in period, a 90 day micro-randomized trial, and a 90-day observational period. The goal of this study is to evaluate whether providing paired real time glycemic and health behavior data in a smartphone app leads to better glycemic control among adolescents and young adults with T2D. Glycemic control will be monitored using Continuous Glucose Monitors (CGM), and health behavior data will be collected via a Fitbit activity tracker and a research app (Healthmine). Participants will be prompted to view and reflect on glycemic trends and health behavior data (Fitbit data, logging of diet and medication adherence) during the 90-day micro-randomized trial period, then observed for ongoing use of the Healthmine app and engagement with CGM in the following 90-day observation period.
Waitlist Available
Has No Placebo
Children's Hospital of PittsburghMary Ellen Vajravelu, MD
Image of Nutrition Research Center, School of Public Health, Loma Linda University in Loma Linda, United States.

Mango for Prediabetes

40 - 60
All Sexes
Loma Linda, CA
The goal of this clinical trial is to test the effect of 12 weeks of 1.5 cups per day of fresh mango on glucose control, insulin resistance, lipids, inflammation, oxidation and body composition in individuals with prediabetes. The main questions it aims to answer are: * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on indicators of glycemic control including fasting glucose and HgbA1c? * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on fasting blood insulin and insulin resistance (HOMA-IR)? * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on lipids including LDL-cholesterol, total cholesterol, HDL-cholesterol and triglycerides? * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on oxidative stress including oxidized LDL-cholesterol and 8-iso-PGF2-alpha? * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on markers of inflammation including c-reactive protein, e-selectin, ICAM, VCAM, TNF-alpha and IL-beta? * What is the effect of 1.5 cups per day of fresh mango over 12 weeks on percent body fat, fat mass, and lean mass? Participants will be asked to: * Consume 1.5 cups of mango per day for 12 weeks, take a 4 to 8 week break, and then avoid consuming mangos for 12 weeks * Attend a prerandomization clinic prior to study * Attend three (3) clinics where blood will be drawn during weeks 0, and 12 of the first phase and last week of the second phase of the study * Attend eight (8) clinics where anthropometric measurements (height, weight, body composition) will be conducted and interaction with study clinicians will occur during weeks 0, 4, 8, 12 of each phase of the study * Complete questionnaires and surveys in person and remotely, including six (6) 24-hour dietary recalls. Researchers will compare the 12 weeks participants consume mango to the 12 weeks the participants are not consuming mango to see if there are differences in glycemic indicators, insulin resistance, lipids, inflammation, oxidation and body composition between the two time periods.
Waitlist Available
Has No Placebo
Nutrition Research Center, School of Public Health, Loma Linda UniversityCeline Heskey, DrPH
Have you considered Korlym clinical trials? We made a collection of clinical trials featuring Korlym, we think they might fit your search criteria.Go to Trials
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