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What is Korlym
MifepristoneThe Generic name of this drug
Treatment SummaryMifepristone is a hormone-blocking medication used to induce bleeding during the luteal phase and early pregnancy. It also acts as an antagonist of the glucocorticoid hormone, which is used to treat high levels of cortisol in patients with nonpituitary Cushing Syndrome. Mifepristone is available in two doses: Mifeprex® (200mg) and Korlym™ (300mg). It is currently being tested as a potential treatment for psychotic depression.
Korlymis the brand name
Korlym Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Korlym
Mifepristone
2012
3
Approved as Treatment by the FDA
Mifepristone, also called Korlym, is approved by the FDA for 4 uses including Cushing Syndrome and High Blood Sugar .Cushing Syndrome
Helps manage Cushing's syndrome, Type 2 diabetes mellitus, hypercorticolism
High Blood Sugar
Helps manage Hyperglycemia
Medically induced abortion
Used to treat Medically induced abortion in combination with Misoprostol
Therapeutic procedure
Used to treat Pregnancy termination therapy in combination with Misoprostol
Effectiveness
How Korlym Affects PatientsMifepristone is a synthetic steroid prescribed to end pregnancies up to 49 days. It works by decreasing the effects of progesterone, which helps to induce contractions in the uterus. It also has weak anti-glucocorticoid and anti-androgenic effects. In rats, doses of 10-25 mg/kg have been shown to block the effects of dexamethasone. In people, doses of 4.5 mg/kg or higher increase the level of the hormones ACTH and cortisol in the body as a compensation.
How Korlym works in the bodyMifepristone works by competing with progesterone at receptor sites, blocking it from binding. This can cause pregnancy to end. Mifepristone also blocks cortisol from binding to its receptor, which helps reduce the effects of too much cortisol in the body, such as high blood sugar.
When to interrupt dosage
The measure of Korlym is dependent upon the diagnosed condition, for example Cushing Syndrome, Hyperglycemia and Medically incited premature birth. The dose fluctuates as per the technique of administration (e.g. Oral or Tablet) specified in the table below.Condition
Dosage
Administration
High Blood Sugar
, 300.0 mg, 200.0 mg
, Oral, Tablet - Oral, Tablet, Buccal; Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral
Medically induced abortion
, 300.0 mg, 200.0 mg
, Oral, Tablet - Oral, Tablet, Buccal; Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral
Cushing Syndrome
, 300.0 mg, 200.0 mg
, Oral, Tablet - Oral, Tablet, Buccal; Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral
Therapeutic procedure
, 300.0 mg, 200.0 mg
, Oral, Tablet - Oral, Tablet, Buccal; Oral, Kit; Tablet, Kit; Tablet - Buccal; Oral
Warnings
Korlym has five contraindications and should not be used when presented with any of the circumstances indicated in the following table.Korlym ContraindicationsCondition
Risk Level
Notes
Endometrial Hyperplasia
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
unexplained vaginal bleeding
Do Not Combine
Endometrial Hyperplasia
Do Not Combine
Common Korlym Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Mifepristone.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Mifepristone.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Mifepristone.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Mifepristone.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Mifepristone.
Korlym Toxicity & Overdose RiskMost women who take mifepristone experience side effects, and many have more than one symptom. About 90% of patients also report adverse reactions after taking misoprostol, such as heavier bleeding than what is typical for a period, abdominal pain, cramping, nausea, vomiting, and diarrhea.
Korlym Novel Uses: Which Conditions Have a Clinical Trial Featuring Korlym?
33 active studies are currently being conducted to examine the potential of Korlym to provide a Therapeutic procedure, Cushing Syndrome and Medically induced abortion treatment.Condition
Clinical Trials
Trial Phases
Cushing Syndrome
0 Actively Recruiting
Therapeutic procedure
1 Actively Recruiting
Phase 3
Medically induced abortion
1 Actively Recruiting
Not Applicable
High Blood Sugar
36 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Korlym Reviews: What are patients saying about Korlym?
5Patient Review
11/9/2021 The only side effects I experienced were mild headaches, loss of appetite, and extreme fatigue. However, these slowly went away and the results were excellent in terms of lowering my blood sugar levels. My A1C went from 7.1 to 6.3 in just 2 1/2 months!
4.7Patient Review
2/26/2019 This treatment was very effective in reducing my symptoms and biochemical deficits. Going through cortisol withdrawal can be tough, but it's worth it in the end. This saved me.
Patient Q&A Section about korlym
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does Korlym treat?
"Korlym is a drug that is used to control blood sugar in adults who have a condition called Cushing's syndrome and who also have type 2 diabetes or glucose intolerance. This drug is used when these patients have not been helped by surgery or are not able to have surgery."
Answered by AI
How long does it take for Korlym to work?
"About 60% of patients experienced a decrease in blood sugar levels by at least 25%. Some patients began to see improvements after just 6 weeks of treatment. By week 24 of treatment, patients' HbA1c levels had decreased by an average of 1.1%."
Answered by AI
How long do you take Korlym?
"The subjects of the study were given between 300 and 1200 milligrams of Korlym per day for a period of up to 24 weeks."
Answered by AI
Is there a generic for Korlym?
"If you're unsure about purchasing medication online, ask your healthcare provider for advice. Also check out the Generic Drug FAQ for more info."
Answered by AI