Ketoprofen

Migraine, prophylaxis of migraine headaches, Pain + 9 more
Treatment
3 FDA approvals
20 Active Studies for Ketoprofen

What is Ketoprofen

KetoprofenThe Generic name of this drug
Treatment SummaryKetoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce fever. It belongs to a family of drugs called propionic acid derivatives.
Ketoprofenis the brand name
image of different drug pills on a surface
Ketoprofen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ketoprofen
Ketoprofen
1993
51

Approved as Treatment by the FDA

Ketoprofen, also known as Ketoprofen, is approved by the FDA for 3 uses such as Ankylosing Spondylitis and Post Partum Pain .
Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Post Partum Pain
Helps manage Post Partum Pain
Postoperative Pain
Helps manage Postoperative pain

Effectiveness

How Ketoprofen Affects PatientsKetoprofen is an over-the-counter pain reliever and fever reducer. It belongs to a class of medications called NSAIDs, which work by blocking the production of certain chemicals in the body that cause inflammation and pain. It is typically used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and other types of moderate pain.
How Ketoprofen works in the bodyKetoprofen works to reduce inflammation by blocking an enzyme called COX-2. This enzyme is responsible for producing substances that cause pain, fever, and swelling. Ketoprofen also blocks another enzyme called COX-1, which can lead to stomach issues and ulcers. Additionally, ketoprofen appears to reduce the effects of bradykinin, a chemical involved in inflammation, as well as stabilize cell membranes. Finally, it can reduce fever by increasing blood flow and allowing the body to cool off.

When to interrupt dosage

The amount of Ketoprofen is contingent upon the diagnosed situation, such as Sprains, Ankylosing Spondylitis and Pain. The quantity of dosage is contingent upon the technique of delivery (e.g. Capsule, extended release - Oral or Tablet, delayed release) featured in the table beneath.
Condition
Dosage
Administration
Postoperative Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Sprains
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Post Partum Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Rheumatoid Arthritis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Migraine
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
prophylaxis of migraine headaches
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Osteoarthritis (OA)
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Ankylosing Spondylitis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Primary Dysmenorrhoea
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Mild pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Muscle Strain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical

Warnings

Ketoprofen has two contraindications, so it should not be taken during any of the circumstances specified in the table below.Ketoprofen Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
There are 20 known major drug interactions with Ketoprofen.
Common Ketoprofen Drug Interactions
Drug Name
Risk Level
Description
Allantoin
Major
The risk or severity of adverse effects can be increased when Ketoprofen is combined with Allantoin.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ketoprofen.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Ketoprofen.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Ketoprofen.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Ketoprofen.
Ketoprofen Toxicity & Overdose RiskThe toxic dose of this drug in rats is 62.4mg/kg. Symptoms of an overdose include sleepiness, vomiting, and stomach pain. Most side effects are minor and involve the digestive system, such as feeling bloated or having an upset stomach. Other possible effects include nausea, diarrhea, stomach pain, constipation or gas.
image of a doctor in a lab doing drug, clinical research

Ketoprofen Novel Uses: Which Conditions Have a Clinical Trial Featuring Ketoprofen?

153 active studies are assessing the effectiveness of Ketoprofen in relieving Post Partum Pain, Rheumatoid Arthritis and Ankylosing Spondylitis.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Mild pain
0 Actively Recruiting
Muscle Strain
1 Actively Recruiting
Not Applicable
Ankylosing Spondylitis
2 Actively Recruiting
Phase 3, Not Applicable
Osteoarthritis (OA)
0 Actively Recruiting
prophylaxis of migraine headaches
0 Actively Recruiting
Sprains
0 Actively Recruiting
Primary Dysmenorrhoea
2 Actively Recruiting
Phase 4, Not Applicable
Pain
0 Actively Recruiting
Postoperative Pain
19 Actively Recruiting
Phase 4, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2
Post Partum Pain
0 Actively Recruiting

Ketoprofen Reviews: What are patients saying about Ketoprofen?

5Patient Review
3/10/2010
Ketoprofen for Painful Periods
This medication has successfully alleviated the pain in my hands and hips from rheumatoid arthritis. The only downside is that I feel a little bit foggy when I wake up in the morning.
5Patient Review
3/12/2013
Ketoprofen for Rheumatoid Arthritis
I've been taking this medication for years without any issues. I'm now being told by my pharmacist that they can no longer get it, which is frustrating.
5Patient Review
8/13/2013
Ketoprofen for Painful Periods
Used this for my tennis elbow and it worked great!
5Patient Review
7/9/2009
Ketoprofen for Rheumatoid Arthritis
5Patient Review
10/28/2009
Ketoprofen for Headache caused by Disorder of Cranial Blood Vessels
5Patient Review
12/26/2010
Ketoprofen for Pain
Orudis was an over-the-counter medication that worked very well for headaches. I only needed 2.5 mg for it to be effective, and it was great for the occassional headache.
5Patient Review
3/28/2015
Ketoprofen for Joint Damage causing Pain and Loss of Function
This is the only anti-inflammatory that has helped with my chronic back and leg pain. I'm really struggling now that the FDA has put a hold on this medication.
4.7Patient Review
1/3/2009
Ketoprofen for Joint Damage causing Pain and Loss of Function
4.3Patient Review
7/17/2014
Ketoprofen for Pain
Since I've started taking this medication, I've experienced the greatest relief from my chronic pain problems. It's been a game-changer for me, and although it is expensive, it is worth every penny. The only downside for me is that I bruise easily, but even that is a small price to pay for the amount of pain relief I experience on a daily basis.
3.7Patient Review
11/11/2015
Ketoprofen for Painful Periods
This treatment begins to work within half an hour, which is great. However, the effects only last for a few hours. Consequently, I have to alternate between this and other methods like using a heating pad. Ideally, one pill would provide longer-lasting relief.
3Patient Review
4/1/2010
Ketoprofen for Gout
This ketoprofen paste has been an absolute lifesaver for me. I've suffered from frontal migraines since childhood, but this treatment plan--which my doctor prescribed about a year ago--has finally given me some relief. Whenever I feel a migraine coming on, I simply put a small amount of the paste on a cotton swab and place it between my cheek and jaw. The ketoprofen reduces the inflammation of my maxillary nerve almost immediately.
2.7Patient Review
3/7/2012
Ketoprofen for Headache caused by Disorder of Cranial Blood Vessels
I've been using this medication for 16 years to help with my rheumatoid arthritis, post-polio pain, and headaches.
2.3Patient Review
2/18/2010
Ketoprofen for Rheumatoid Arthritis
I grew up with Severe Migraines and Ibuprofen or acetomenophen (sp?) has never really worked for me they more dulled the pain then helped it! THIS ONE WORKS! Tried vicoden and had withdrawal nausea and headaches even worse! Hated vicoden, try ketoprophen you won't be disappointed!
2.3Patient Review
10/21/2009
Ketoprofen for Pain
2.3Patient Review
1/7/2010
Ketoprofen for Headache caused by Disorder of Cranial Blood Vessels
1Patient Review
9/14/2010
Ketoprofen for Pain
I experienced intense abdominal pain, nausea and vomiting even when I took this medication with food.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ketoprofen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is ketoprofen stronger than ibuprofen?

"Ketoprofen is more effective than ibuprofen in managing RA pain at therapeutic doses, thus supporting its use in clinical practice."

Answered by AI

What is the drug ketoprofen used for?

"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that requires a doctor's prescription to treat pain, inflammation, swelling, stiffness, and joint pain."

Answered by AI

Can you buy ketoprofen over-the-counter?

"Is it possible to purchase ketoprofen without a prescription? It is only possible to obtain ketoprofen with a prescription. Medications that are in the same drug class and can be bought without a prescription are ibuprofen (Advil) and naproxen (Aleve)."

Answered by AI

Why is ketoprofen no longer available?

"The FDA has decided that ORUDIS KT (ketoprofen) tablets, 12.5 mg, did not need to be taken off the market for safety or effectiveness reasons. This determination means that the FDA can approve new drug applications (ANDAs) for ketoprofen tablets, 12.5 mg."

Answered by AI

Clinical Trials for Ketoprofen

Have you considered Ketoprofen clinical trials? We made a collection of clinical trials featuring Ketoprofen, we think they might fit your search criteria.
Have you considered Ketoprofen clinical trials? We made a collection of clinical trials featuring Ketoprofen, we think they might fit your search criteria.
Have you considered Ketoprofen clinical trials? We made a collection of clinical trials featuring Ketoprofen, we think they might fit your search criteria.
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