Ketoprofen

Migraine, Migraine Disorders, Pain + 9 more
Treatment
5 FDA approvals
20 Active Studies for Ketoprofen

What is Ketoprofen

KetoprofenThe Generic name of this drug
Treatment SummaryKetoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce fever. It belongs to a family of drugs called propionic acid derivatives.
Ketoprofenis the brand name
image of different drug pills on a surface
Ketoprofen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ketoprofen
Ketoprofen
1993
51

Approved as Treatment by the FDA

Ketoprofen, also known as Ketoprofen, is approved by the FDA for 5 uses such as Postoperative Pain and Postoperative pain .
Postoperative Pain
Helps manage Postoperative pain
Postoperative pain
Helps manage Postoperative pain
Post Partum Pain
Helps manage Post Partum Pain
Ankylosing Spondylitis (AS)
Helps manage Ankylosing Spondylitis (AS)
Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)

Effectiveness

How Ketoprofen Affects PatientsKetoprofen is an over-the-counter pain reliever and fever reducer. It belongs to a class of medications called NSAIDs, which work by blocking the production of certain chemicals in the body that cause inflammation and pain. It is typically used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and other types of moderate pain.
How Ketoprofen works in the bodyKetoprofen works to reduce inflammation by blocking an enzyme called COX-2. This enzyme is responsible for producing substances that cause pain, fever, and swelling. Ketoprofen also blocks another enzyme called COX-1, which can lead to stomach issues and ulcers. Additionally, ketoprofen appears to reduce the effects of bradykinin, a chemical involved in inflammation, as well as stabilize cell membranes. Finally, it can reduce fever by increasing blood flow and allowing the body to cool off.

When to interrupt dosage

The amount of Ketoprofen is contingent upon the diagnosed situation, such as Sprains, Ankylosing Spondylitis and Pain. The quantity of dosage is contingent upon the technique of delivery (e.g. Capsule, extended release - Oral or Tablet, delayed release) featured in the table beneath.
Condition
Dosage
Administration
Rheumatoid Arthritis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Ankylosing Spondylitis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Osteoarthritis
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Sprains and Strains
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Muscle Strain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Mild pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Migraine
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Migraine Disorders
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Postoperative Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Primary Dysmenorrhoea
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical
Post Partum Pain
, 50.0 mg, 75.0 mg, 200.0 mg, 100.0 mg, 150.0 mg, 0.05 mg/mg, 25.0 mg, 3.35 mg/mg, 0.5525 mg/mg
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Kit, Tablet - Oral, Tablet, Tablet, delayed release, Tablet, delayed release - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Powder - Topical, Topical

Warnings

Ketoprofen has two contraindications, so it should not be taken during any of the circumstances specified in the table below.Ketoprofen Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
There are 20 known major drug interactions with Ketoprofen.
Common Ketoprofen Drug Interactions
Drug Name
Risk Level
Description
Allantoin
Major
The risk or severity of adverse effects can be increased when Ketoprofen is combined with Allantoin.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Ketoprofen.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Ketoprofen.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Ketoprofen.
Dabrafenib
Major
The metabolism of Dabrafenib can be decreased when combined with Ketoprofen.
Ketoprofen Toxicity & Overdose RiskThe toxic dose of this drug in rats is 62.4mg/kg. Symptoms of an overdose include sleepiness, vomiting, and stomach pain. Most side effects are minor and involve the digestive system, such as feeling bloated or having an upset stomach. Other possible effects include nausea, diarrhea, stomach pain, constipation or gas.
image of a doctor in a lab doing drug, clinical research

Ketoprofen Novel Uses: Which Conditions Have a Clinical Trial Featuring Ketoprofen?

153 active studies are assessing the effectiveness of Ketoprofen in relieving Post Partum Pain, Rheumatoid Arthritis and Ankylosing Spondylitis.
Condition
Clinical Trials
Trial Phases
Postoperative Pain
19 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 3
Rheumatoid Arthritis
53 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Migraine
54 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Migraine Disorders
1 Actively Recruiting
Phase 3
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Mild pain
0 Actively Recruiting
Primary Dysmenorrhoea
1 Actively Recruiting
Not Applicable
Muscle Strain
0 Actively Recruiting
Sprains and Strains
0 Actively Recruiting
Pain
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Post Partum Pain
0 Actively Recruiting

Ketoprofen Reviews: What are patients saying about Ketoprofen?

5Patient Review
3/10/2010
Ketoprofen for Painful Periods
This medication has successfully alleviated the pain in my hands and hips from rheumatoid arthritis. The only downside is that I feel a little bit foggy when I wake up in the morning.
5Patient Review
3/12/2013
Ketoprofen for Rheumatoid Arthritis
I've been taking this medication for years without any issues. I'm now being told by my pharmacist that they can no longer get it, which is frustrating.
5Patient Review
8/13/2013
Ketoprofen for Painful Periods
Used this for my tennis elbow and it worked great!
5Patient Review
7/9/2009
Ketoprofen for Rheumatoid Arthritis
5Patient Review
10/28/2009
Ketoprofen for Headache caused by Disorder of Cranial Blood Vessels
View All Reviews
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Patient Q&A Section about ketoprofen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is ketoprofen stronger than ibuprofen?

"Ketoprofen is more effective than ibuprofen in managing RA pain at therapeutic doses, thus supporting its use in clinical practice."

Answered by AI

What is the drug ketoprofen used for?

"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that requires a doctor's prescription to treat pain, inflammation, swelling, stiffness, and joint pain."

Answered by AI

Can you buy ketoprofen over-the-counter?

"Is it possible to purchase ketoprofen without a prescription? It is only possible to obtain ketoprofen with a prescription. Medications that are in the same drug class and can be bought without a prescription are ibuprofen (Advil) and naproxen (Aleve)."

Answered by AI

Why is ketoprofen no longer available?

"The FDA has decided that ORUDIS KT (ketoprofen) tablets, 12.5 mg, did not need to be taken off the market for safety or effectiveness reasons. This determination means that the FDA can approve new drug applications (ANDAs) for ketoprofen tablets, 12.5 mg."

Answered by AI

Clinical Trials for Ketoprofen

Have you considered Ketoprofen clinical trials? We made a collection of clinical trials featuring Ketoprofen, we think they might fit your search criteria.
Have you considered Ketoprofen clinical trials? We made a collection of clinical trials featuring Ketoprofen, we think they might fit your search criteria.
Have you considered Ketoprofen clinical trials? We made a collection of clinical trials featuring Ketoprofen, we think they might fit your search criteria.
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