Kenalog

Macular Edema, Stomatitis, Denture, Ophthalmia, Sympathetic + 113 more

Treatment

9 FDA approvals

20 Active Studies for Kenalog

Treatment for

Macular Edema

What is Kenalog

TriamcinoloneThe Generic name of this drug

Treatment SummaryTriamcinolone is a steroid medication used to treat inflammation in the body from allergies to multiple sclerosis. It can be used as an occasional treatment for knee pain related to arthritis, and as a topical treatment for skin conditions. Triamcinolone comes in several forms such as hexacetonide, acetonide, and diacetate. The FDA approved triamcinolone in 1957 and in 2021 it was approved as an injection to treat macular edema associated with uveitis.

Aristocortis the brand name

image of different drug pills on a surface

Kenalog Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aristocort

Triamcinolone

1961

532

Approved as Treatment by the FDA

Triamcinolone, also called Aristocort, is approved by the FDA for 9 uses which include Ganglia and Granuloma Annulare .

Ganglia

Helps manage cystic tumour of the ganglia

Granuloma Annulare

Helps manage granuloma annulare lesions

Psoriasis

Helps manage Psoriatic plaque

Keloids Scars

Helps manage Keloids Scars

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

Necrobiosis lipoidica diabeticorum

Helps manage Necrobiosis lipoidica diabeticorum

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Effectiveness

How Kenalog Affects PatientsTriamcinolone is a type of medication that helps reduce inflammation. It can be used to treat inflammation in many different areas of the body. It should not be injected into the space around the spine (epidural injection).

How Kenalog works in the bodyTriamcinolone works to reduce inflammation by weakening the signals that tell leukocytes to move to inflamed areas and by changing how cell membranes are formed. It also prevents the production of molecules that can increase inflammation, such as prostaglandins and leukotrienes. Lastly, it stops a protein called nuclear factor kappa-B from sending out signals that increase inflammation.

When to interrupt dosage

The recommended dose of Kenalog is contingent upon the identified condition, such as Mycosis Fungoides (MF), Mycoses and Alopecia Areata (AA). Dosage fluctuates as per the technique of delivery (e.g. Ointment or Injection, suspension - Intralesional; Parenteral) provided in the table below.

Condition

Dosage

Administration

oral lesions

, 40.0 mg/mL, 10.0 mg/mL, 0.055 mg, 0.001 mg/mg, 0.25 mg/mL, 1.0 mg/mL, 0.0005 mg/mg, 0.00025 mg/mg, 0.005 mg/mg, 5.0 mg/mL, 20.0 mg/mL, 0.000147 mg/mg, 0.5 mg/mL, 40.0 mg, 1.0 mg, 0.000025 mg/mg, 0.1 %, 0.025 %, 5.0 mg, 0.25 mg, 2.0 mg, 4.0 mg, 0.5 %, 15.0 mg/mL, 6.5 mg, 80.0 mg/mL, 0.075 mg, 200.0 mg/mL, 32.0 mg, 0.055 mg/dose, 0.5 mg, 0.2 mg/pump actuation, 0.1 mg/dose, 25.0 mg/mL, 0.055 mg/pump actuation, 2.0 mg/mL, 0.4 mg/mL

Injection, suspension - Intra-articular; Intramuscular, Injection, suspension, Intra-articular; Intramuscular, , Intra-articular; Intralesional, Injection, suspension - Intra-articular; Intralesional, Nasal, Spray, metered, Spray, metered - Nasal, Topical, Cream, Cream - Topical, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Intralesional; Parenteral, Injection, suspension - Intralesional; Parenteral, Intra-articular; Parenteral, Injection, suspension - Intra-articular; Parenteral, Intra-articular; Intrabursal; Intradermal; Intralesional, Injection, suspension - Intra-articular; Intrabursal; Intradermal; Intralesional, Aerosol, spray, Aerosol, spray - Topical, Paste, Paste - Topical, Kit, Injection, suspension - Intramuscular, Intramuscular, Dental, Paste - Dental, Suspension, Suspension - Intra-articular; Intramuscular, Intra-articular; Intrabursal; Intradermal; Intrasynovial, Suspension - Intra-articular; Intrabursal; Intradermal; Intrasynovial, Intra-articular; Intrabursal; Intramuscular, Suspension - Intra-articular; Intrabursal; Intramuscular, Intralesional, Suspension - Intralesional, Aerosol, metered, Aerosol, metered - Nasal, Respiratory (inhalation), Aerosol, metered - Respiratory (inhalation), Intra-articular, Suspension - Intra-articular, Oral, Tablet, Tablet - Oral, Liquid, Intra-articular; Intramuscular; Intrasynovial, Liquid - Intra-articular; Intramuscular; Intrasynovial, Syrup - Oral, Syrup, Intra-articular; Intradermal; Intramuscular, Liquid - Intra-articular; Intradermal; Intramuscular, Suspension - Intramuscular, Intra-articular; Intradermal; Intralesional; Intramuscular, Suspension - Intra-articular; Intradermal; Intralesional; Intramuscular, Spray, suspension - Nasal, Injection, solution, Injection, solution - Intra-articular; Intramuscular, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Ophthalmic, Injection, suspension - Ophthalmic, Intravitreal, Suspension - Intravitreal, Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Kit - Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Spray, Spray - Topical, Intra-articular; Intrasynovial; Periarticular, Suspension - Intra-articular; Intrasynovial; Periarticular, Kit - Intra-articular; Intramuscular, Suspension - Ophthalmic, Subcutaneous, Implant, Implant - Subcutaneous, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Intra-articular; Intramuscular; Intravitreal, Injection, suspension - Intra-articular; Intramuscular; Intravitreal, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional, Kit - Epidural; Infiltration; Intra-articular; Intralesional, Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Kit - Intra-articular, Paste, dentifrice, Paste, dentifrice - Dental, Kit - Infiltration; Soft tissue; Topical, Infiltration; Soft tissue; Topical, Ointment - Buccal, Buccal, Gel, Gel - Topical, Emulsion - Topical, Emulsion, Kit - Topical, Intra-articular; Intramuscular; Topical, Injection, suspension - Intra-articular, Infiltration; Intra-articular; Intramuscular; Topical, Kit - Infiltration; Intra-articular; Intramuscular; Topical

Macular Edema

Stomatitis, Denture

Ophthalmia, Sympathetic

Stomatitis, Aphthous

Pemphigus

Multiple Sclerosis

Inflammation

Otitis Externa

Hypercalcemia

Hives

Berylliosis

Diuresis

Polymyositis

Diaper Rash

induction of Diuresis

Serum Sickness

Neurodermatitis

Intertrigo

Pericarditis

Warnings

Kenalog Contraindications

Condition

Risk Level

Notes

Mycoses

Do Not Combine

active periocular infections

Do Not Combine

active ocular infections

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Triamcinolone may interact with Pulse Frequency

There are 20 known major drug interactions with Kenalog.

Common Kenalog Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Triamcinolone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with Abetimus.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Triamcinolone.

Kenalog Toxicity & Overdose RiskThe most toxic dose of triamcinolone acetonide when given subcutaneously to rats is 13,100µg/kg, 132mg/kg in mice, 1451mg/kg in rats when given orally and 2168mg/kg in mice when given orally. Additionally, the intraperitoneal LD<sub>50</sub> in mice is 105mg/kg. Those who overdose on this drug may develop Cushing's syndrome, which can be treated through supportive therapy and mifepristone medication.

image of a doctor in a lab doing drug, clinical research

Kenalog Novel Uses: Which Conditions Have a Clinical Trial Featuring Kenalog?

A total of 1076 active trials are currently underway to evaluate the potential of Kenalog to mitigate Lupus, Atopic Dermatitis and Brain Metastases.

Condition

Clinical Trials

Trial Phases

Sarcoidosis

0 Actively Recruiting

Vitrectomy therapy

2 Actively Recruiting

Not Applicable, Phase 4

Proteinuria

5 Actively Recruiting

Phase 2, Phase 3, Phase 4

Lupus Erythematosus

4 Actively Recruiting

Phase 4, Not Applicable, Phase 1

Mycoses

0 Actively Recruiting

Transfusion Reactions

0 Actively Recruiting

ulcerative stomatitis

0 Actively Recruiting

Serum Sickness

0 Actively Recruiting

Skin

0 Actively Recruiting

Inflammation of Mouth

0 Actively Recruiting

Osteoarthritis (OA)

0 Actively Recruiting

Secondary Immunization

0 Actively Recruiting

Epicondylitis

0 Actively Recruiting

Macular Edema

33 Actively Recruiting

Phase 1, Not Applicable, Phase 3, Phase 2, Phase 4

Hives

17 Actively Recruiting

Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1

Hypercalcemia

3 Actively Recruiting

Phase 2, Not Applicable

Necrobiosis lipoidica diabeticorum

0 Actively Recruiting

oral lesions

0 Actively Recruiting

Acne

6 Actively Recruiting

Phase 4, Early Phase 1, Not Applicable, Phase 1, Phase 2

Asthma

160 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3

Kenalog Reviews: What are patients saying about Kenalog?

5Patient Review

10/15/2014

Kenalog for Inflammation of the Nose due to an Allergy

Kenalog-40 has been a life-saver for me. After many sinus infections and surgery, I finally found a treatment that works. I get two injections per year and it really helps me to breathe normally again.

5Patient Review

4/4/2009

Kenalog for Allergic Reaction causing Serum Sickness

This drug is truly a miracle. I had allergies (sinus) for 10+ years and was living on Zyrtec daily for 5+ years when I got my first shot. It lasted almost two years, and after getting another shot, it's been 3 years with no allergies or allergy medication. I haven't observed any side effects, either.

5Patient Review

8/6/2012

Kenalog for Inflammation of the Joints due to Gout

My brother suffers from gout every six weeks and it used to debilitate him to the point where he couldn't function at all. Now that he's started these injections, though, he has his life back. I'm so grateful that we have the knowledge and technology to help people in this way.

5Patient Review

8/6/2012

Kenalog for Inflammation of the Joints due to Gout

My brother has gout and used to have a flare-up every six weeks that would render him unable to function. Since he started getting these injections, though, he's been doing much better. I'm really glad there are treatments out there like this that can help people.

5Patient Review

4/4/2009

Kenalog for Allergic Reaction causing Serum Sickness

Zyrtec was a real lifesaver for me, but this shot has been an even bigger help. I haven't had any allergies or needed to take medication in years, and I have yet to observe any negative side effects.

5Patient Review

10/15/2014

Kenalog for Inflammation of the Nose due to an Allergy

After years of sinus infections and one surgery, I was finally given kenalog-40 shots. They've been working great for me as a 81 year old woman; I have two injections a year along with saline nasal spray. This has allowed me to breathe normally and without infection.

1Patient Review

2/17/2008

Kenalog for Bronchitis

I was given this drug as a one-time injection to treat lung inflammation from bronchitis. It did little to help my problem, I eventually developed pneumonia, and I now have a large golf ball sized dent in the area it was administered. I recently found out that this is a common side effect.

1Patient Review

5/19/2017

Kenalog for Joint Disease which may include Attacks of Acute Arthritis

Since getting this shot, I haven't been able to take a deep breath. It's been three months and numerous tests later, doctors still can't figure out what's wrong. This has cost me so much money in time and medical bills. I can barely walk because I can't breathe.

1Patient Review

2/17/2008

Kenalog for Bronchitis

I was given this drug as a one-time injection to treat lung inflammation from bronchitis. Not only did it fail to help my problem, I eventually developed pneumonia. To top it all off, I now have a large golf ball sized dent in the area it was administered—which, apparently, is a common side effect.

1Patient Review

5/19/2017

Kenalog for Joint Disease which may include Attacks of Acute Arthritis

Since getting this shot, I have not been able to breathe deeply. This has caused a lot of financial stress due to medical bills and time missed from work. I can barely walk because breathing is so difficult.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about kenalog

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Kenalog a steroid?

"- Triamcinolone is a potent steroid that helps reduce inflammation in the body. Triamcinolone topical (for the skin) is used to treat the inflammation and itching caused by skin conditions that respond well to steroid medications."

Answered by AI

What are the side effects of Kenalog?

"These are some of the side effects that may occur:

-Redness or pain at the injection site -Stomach upset -Headache -Dizziness -Trouble sleeping -Weight gain

If any of these effects last or get worse, you should tell your doctor or pharmacist."

Answered by AI

Why was Kenalog taken off the market?

"The NHS no longer recommends the use of Kenalog due to the potential for serious side-effects such as high blood pressure, anaphylactic shock, and increased susceptibility to infection. The drug's licence to be used as a hay fever treatment was withdrawn in October 2019."

Answered by AI

What is Kenalog used for?

"Triamcinolone is a medication that is used to treat various skin conditions. It helps by reducing the swelling, itching and redness that is often associated with these conditions. It is a medium to strong potency corticosteroid."

Answered by AI