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What is Jentadueto
LinagliptinThe Generic name of this drug
Treatment SummaryLinagliptin is a medication used to treat type 2 diabetes. It works by blocking an enzyme called DPP-4, which helps control blood sugar levels. Unlike other DPP-4 inhibitors, linagliptin does not need to be cleared by the kidneys, and its effects depend on the concentration in the body. It was approved by the FDA in 2011.
Tradjentais the brand name
Jentadueto Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tradjenta
Linagliptin
2011
17
Approved as Treatment by the FDA
Linagliptin, also known as Tradjenta, is approved by the FDA for 3 uses like Physical Activity and Type 2 Diabetes .Physical Activity
Used to treat Exercise in combination with Empagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin
Diet
Used to treat Diet in combination with Empagliflozin
Effectiveness
How Jentadueto Affects PatientsTaking 5mg of linagliptin by mouth stops the enzyme dipeptidyl peptidase 4 (DPP-4) from working for at least 24 hours. This increase in GLP-1 (glucagon-like peptide 1) lowers the amount of sugar in blood and helps control blood sugar levels.
How Jentadueto works in the bodyLinagliptin works by blocking an enzyme called DPP-4. This prevents the body from breaking down two hormones - GLP-1 and GIP - that help to increase insulin in the body. This lowers the amount of glucose broken down in the liver, which helps to reduce blood sugar levels.
When to interrupt dosage
The proposed measure of Jentadueto is contingent upon the established condition, like Physical Activity, Diet and Type 2 Diabetes. The dosage also fluctuates as per the method of delivery (e.g. Tablet - Oral or Tablet) as described in the table below.Condition
Dosage
Administration
Type 2 Diabetes
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diet
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Physical Activity
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Jentadueto ContraindicationsCondition
Risk Level
Notes
Acute Coryza
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Metabolic acidosis
Do Not Combine
Dialysis therapy
Do Not Combine
Kidney Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Linagliptin may interact with Pulse Frequency
Common Jentadueto Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Linagliptin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Linagliptin.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Linagliptin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Linagliptin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Linagliptin.
Jentadueto Toxicity & Overdose RiskThe dosage of linagliptin does not need to be adjusted for factors like age, weight, sex, kidney or liver function. Clinical trials have shown the drug to be safe for use in children ages 10 to 18. Animal studies have revealed a risk of lymphoma in female rats at a very high dose. However, linagliptin has not been found to be harmful to fertility or cause mutations or chromosome damage.
Jentadueto Novel Uses: Which Conditions Have a Clinical Trial Featuring Jentadueto?
196 active clinical trials are currently underway to assess the potential of Jentadueto to improve Physical Activity, Type 2 Diabetes and Dietary Outcomes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diet
5 Actively Recruiting
Not Applicable
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Jentadueto Reviews: What are patients saying about Jentadueto?
5Patient Review
8/22/20125Patient Review
10/29/2014 This medication has been a godsend.
5Patient Review
1/31/2016 So far, I've been really pleased with this pill. There have been no side effects that I can tell, and my cravings for sugary foods have stopped. My blood sugar readings have been consistent between 80 and 100, which is great.
5Patient Review
7/29/2016 I've been taking this pill for a while now, and it's really great. My sugar levels have lowered and I think I've even lost some weight! No negative side effects that I can tell, either.
5Patient Review
11/4/2013 So far, I've seen a decrease in my sugar levels after only five days of using this treatment! I'll write another review in two weeks to update my progress.
5Patient Review
9/5/2012 I've only been taking this medication for two weeks, but I've already seen a significant difference in my blood sugar levels. My doctor is going to refill my prescription as soon as possible. So far, this drug has worked well for me with no problems.
5Patient Review
5/22/2013 I saw a decrease in my morning sugar levels within the first two weeks of taking this medication. The downside is that I've been getting headaches more frequently, and my stomach has bloated and become painful on the left side.
5Patient Review
1/8/2014 For over a year now, I've been taking this medication and it's helped me lose 30lbs. My blood sugar is more stable now, between 110-90. And my AIC has improved to 5.6-5.7
4.7Patient Review
3/13/2015 Though I found this drug to be very effective, I unfortunately experienced some odd side-effects in the form of chest pains. My doctor and I initially thought it might be unrelated, but we realized that every time I stopped taking the medication, the chest pains went away, and whenever I started again they came back. It's a real shame because it did such a great job of controlling my blood sugar levels.
3.7Patient Review
5/17/2013 I've been on this for a month now and I'm getting some weird aches in my legs. They feel weak, like I've been running for a while. Not sure if it's a side effect of the medication or not.
3Patient Review
4/15/2013 I didn't experience any difference after taking this medication.
3Patient Review
6/12/2014 Jentadueto was successful in keeping my sugar levels low, but I experienced some negative side effects like chills, weakness, and fatigue.
2.3Patient Review
5/19/2014 I took this medicine for three months. My blood sugar lowered, but I started having extreme belching attacks and then diarrhea daily. An endoscopic exam and biopsies of my small intestines were negative. When I stopped taking the medication, all my problems went away, so it didn't work for me personally.
1Patient Review
12/20/2012 My A1C levels stayed at 5.7 while taking this medication with no negative side effects.
Patient Q&A Section about jentadueto
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should you take Jentadueto?
"You should take JENTADUETO twice a day, with meals. If you forget a dose, you can take it with a meal when you remember, or skip it until your next scheduled dose."
Answered by AI
Is Jentadueto the same as metformin?
"What are the effects of Jentadueto?
Jentadueto can help control blood sugar levels by decreasing glucose production in the liver and decreasing absorption of glucose by the intestines. This can help you manage your diabetes and avoid potential complications."
Answered by AI
What is the drug Jentadueto used for?
"JENTADUETO and JENTADUETO XR are prescription medicines that contain 2 diabetes medicines, linagliptin and metformin hydrochloride. JENTADUETO and JENTADUETO XR can be used along with diet and exercise to lower blood sugar in adults with type 2 diabetes."
Answered by AI