Irbesartan

Diabetic Nephropathies, Hypertensive disease, Treatment Naive + 2 more
Treatment
6 FDA approvals
20 Active Studies for Irbesartan

What is Irbesartan

IrbesartanThe Generic name of this drug
Treatment SummaryIrbesartan is a medication used to treat high blood pressure and kidney damage caused by diabetes. It can be taken alone or in combination with hydrochlorothiazide. Unlike some other blood pressure medications, Irbesartan does not cause a dry cough. It was approved by the FDA in 1997.
Avaprois the brand name
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Irbesartan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246

Approved as Treatment by the FDA

Irbesartan, also called Avapro, is approved by the FDA for 6 uses such as Diabetic Nephropathies and Diabetic Nephropathy .
Diabetic Nephropathies
Helps manage Diabetic Nephropathy
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide

Effectiveness

How Irbesartan Affects PatientsIrbesartan is a medication used to help lower blood pressure and treat kidney damage from diabetes. It is generally taken once a day and has been found to be safe at low doses (150mg daily) and even more effective at higher doses (900mg/day).
How Irbesartan works in the bodyIrbesartan blocks the hormone angiotensin II from attaching to the AT1 receptor in certain tissues. This prevents the hormone from causing your blood vessels to narrow and your body from releasing aldosterone, which would raise your blood pressure. By blocking the hormone, Irbesartan helps to lower your blood pressure.

When to interrupt dosage

The suggested dosage of Irbesartan is contingent upon the recognized condition, for example Hypertensive disease, not sufficiently managed with monotherapy and Diabetic Nephropathy. The measure of dosage is contingent upon the technique of administration outlined in the table below.
Condition
Dosage
Administration
Diabetic Nephropathies
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Irbesartan Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Dehydration
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
There are 20 known major drug interactions with Irbesartan.
Common Irbesartan Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Irbesartan Toxicity & Overdose RiskThe lowest toxic dose of this drug in humans is 30mg/kg per 6 weeks. Overdosing can lead to low blood pressure and an abnormal heart rate (too fast or too slow). If regular treatments for blood pressure do not work, terlipressin may be used to control the heart rate and blood pressure.
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Irbesartan Novel Uses: Which Conditions Have a Clinical Trial Featuring Irbesartan?

19 active clinical trials are currently assessing the potential of Irbesartan to treat Diabetic Nephropathy, Hypertensive Disease and cases where multiple antihypertensive drugs may be necessary.
Condition
Clinical Trials
Trial Phases
not adequately controlled with monotherapy
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Irbesartan Reviews: What are patients saying about Irbesartan?

5Patient Review
11/28/2014
Irbesartan for High Blood Pressure
In addition to Lovaza fish oil, this treatment has helped to keep my blood pressure down. I believe it is also helping my kidneys as they used to bleed due to high blood pressure.
5Patient Review
6/1/2019
Irbesartan for High Blood Pressure
I started taking this medication around the time of the recall. It works better than any other BP medications I have taken so I opted to continue taking it. No side effects and BP around 120/70 consistently.
5Patient Review
3/4/2017
Irbesartan for High Blood Pressure
My blood pressure was through the roof when I started this medication, but it's been really effective in bringing it down to a much healthier level.
5Patient Review
11/5/2014
Irbesartan for High Blood Pressure
4.3Patient Review
6/15/2015
Irbesartan for High Blood Pressure
This treatment quickly and effectively lowered my blood pressure. However, I have been experiencing severe burning sensations in my arms and chest, as well as weird feelings all over my body. I'm meeting with a specialist to see if maybe I can go off the medication entirely.
View All Reviews
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Patient Q&A Section about irbesartan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug irbesartan used for?

"Irbesartan is a medicine used to treat high blood pressure. It is a type of Angiotensin II Receptor Blocker (ARB), which works by relaxing the blood vessels, allowing blood to flow more easily."

Answered by AI

Does irbesartan cause weight gain?

"If you are experiencing any of the following symptoms, you should see a doctor: swelling, rapid weight gain, confusion, loss of appetite, vomiting, pain in your side or lower back."

Answered by AI

What is the best time of day to take irbesartan?

"You should take irbesartan tablets once a day. Your doctor may suggest that you take the first dose before bedtime so you don't feel dizzy. Once you've taken the first dose, you can take it at any time. Try to take it at the same time every day."

Answered by AI

What are the possible side effects of irbesartan?

"If irbesartan makes you feel dizzy when you stand up, try getting up slowly or sit down until you feel better. ... , Headaches. Make sure you rest and drink lots of fluids. ... , Feeling nauseous ... , Being sick (vomiting) ... , Diarrhea. ... , Pain in your joints or muscles."

Answered by AI

Clinical Trials for Irbesartan

Have you considered Irbesartan clinical trials? We made a collection of clinical trials featuring Irbesartan, we think they might fit your search criteria.
Have you considered Irbesartan clinical trials? We made a collection of clinical trials featuring Irbesartan, we think they might fit your search criteria.
Have you considered Irbesartan clinical trials? We made a collection of clinical trials featuring Irbesartan, we think they might fit your search criteria.
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