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What is Irbesartan
IrbesartanThe Generic name of this drug
Treatment SummaryIrbesartan is a medication used to treat high blood pressure and kidney damage caused by diabetes. It can be taken alone or in combination with hydrochlorothiazide. Unlike some other blood pressure medications, Irbesartan does not cause a dry cough. It was approved by the FDA in 1997.
Avaprois the brand name
Irbesartan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246
Approved as Treatment by the FDA
Irbesartan, also called Avapro, is approved by the FDA for 5 uses such as not adequately controlled with monotherapy and multiple antihypertensive drugs likely required .not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Effectiveness
How Irbesartan Affects PatientsIrbesartan is a medication used to help lower blood pressure and treat kidney damage from diabetes. It is generally taken once a day and has been found to be safe at low doses (150mg daily) and even more effective at higher doses (900mg/day).
How Irbesartan works in the bodyIrbesartan blocks the hormone angiotensin II from attaching to the AT1 receptor in certain tissues. This prevents the hormone from causing your blood vessels to narrow and your body from releasing aldosterone, which would raise your blood pressure. By blocking the hormone, Irbesartan helps to lower your blood pressure.
When to interrupt dosage
The suggested dosage of Irbesartan is contingent upon the recognized condition, for example Hypertensive disease, not sufficiently managed with monotherapy and Diabetic Nephropathy. The measure of dosage is contingent upon the technique of administration outlined in the table below.Condition
Dosage
Administration
Diabetic Nephropathy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Irbesartan ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Volume depletion
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
Common Irbesartan Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Irbesartan Toxicity & Overdose RiskThe lowest toxic dose of this drug in humans is 30mg/kg per 6 weeks. Overdosing can lead to low blood pressure and an abnormal heart rate (too fast or too slow). If regular treatments for blood pressure do not work, terlipressin may be used to control the heart rate and blood pressure.
Irbesartan Novel Uses: Which Conditions Have a Clinical Trial Featuring Irbesartan?
19 active clinical trials are currently assessing the potential of Irbesartan to treat Diabetic Nephropathy, Hypertensive Disease and cases where multiple antihypertensive drugs may be necessary.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Treatment Naive
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Irbesartan Reviews: What are patients saying about Irbesartan?
5Patient Review
11/28/2014 In addition to Lovaza fish oil, this treatment has helped to keep my blood pressure down. I believe it is also helping my kidneys as they used to bleed due to high blood pressure.
5Patient Review
6/1/2019 I started taking this medication around the time of the recall. It works better than any other BP medications I have taken so I opted to continue taking it. No side effects and BP around 120/70 consistently.
5Patient Review
3/4/2017 My blood pressure was through the roof when I started this medication, but it's been really effective in bringing it down to a much healthier level.
5Patient Review
11/5/20144.3Patient Review
6/15/2015 This treatment quickly and effectively lowered my blood pressure. However, I have been experiencing severe burning sensations in my arms and chest, as well as weird feelings all over my body. I'm meeting with a specialist to see if maybe I can go off the medication entirely.
4Patient Review
2/17/2017 I'm currently taking metrprolol with ibasartan. I'll have to check with my doctor about potential interactions between the two.
3.7Patient Review
3/8/2021 I was put on ibersartan when valsartan was recalled. Shortly thereafter I developed severe heartburn and hair loss. I didnâ??t realize Ibersartan was causing it but after recently switching to another blood pressure med the heartburn and hair loss stopped.
3.7Patient Review
4/7/2015 Insomnia, body aches, fatigue, nightmares are all common complaints that this treatment addresses.
3.3Patient Review
1/4/2016 I was taking 150 mg and it was increased by 75 mg to 225 and I think my hair is falling out! Anyone else have such a problem???
3Patient Review
10/1/2022 I was on 75mg and had no side effect, but then my blood pressure went up so I was put on 150mg. Almost immediately, I started experiencing pain in my back and legs which made it difficult to walk.
3Patient Review
1/22/2016 One unfortunate side effect I experienced while taking irbesartan was hair loss. This stopped once I went back to my old medication.
2.7Patient Review
1/22/2017 I didn't experience as many side effects with this medication, however I did have to increase the dose. Now that I'm on the highest dose, my muscles are aching, eyes itch, gums hurt and hair is falling out. I'll be seeing the doctor this week to get off of this medication for good.
2.7Patient Review
10/3/2022 I was on iberstartan 75 mg, then the doctor raised it to 150 mg for the last 6 months. My blood pressure went up, and my eyesight started getting blurred. For months, my right leg was aching, and in the last month muscles in my lower back and legs were aching too. I came off of it 4 days ago and my eyesight is better now, as well as the pain.
2.7Patient Review
6/10/2016 I saw some initial benefits from this medication, but after a couple weeks my muscles became weak and painful. I now feel pain in my legs when I walk, and generally have no energy. Going to see the doctor soon to switch meds.
2.7Patient Review
8/21/2019 This medicine caused me to itch severely.
2.3Patient Review
9/22/2016 This treatment left me with an upset stomach, a bad taste in my mouth, and a cough. The bad taste stayed most of the time.
2Patient Review
3/30/2018 I have taken the highest dose of this drug and it has had zero effect on my blood pressure.
1.3Patient Review
1/5/2022 This medication caused me to lose a lot of hair.
1Patient Review
12/6/2014 I've been on this medication for two weeks and it's made it really hard to swallow.
1Patient Review
10/27/2020 I didn't experience any lowering of blood pressure after taking this medication for 10 days. In fact, I felt more tired and dizzy than usual. Headaches were also a common side effect I experienced.
Patient Q&A Section about irbesartan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug irbesartan used for?
"Irbesartan is a medicine used to treat high blood pressure. It is a type of Angiotensin II Receptor Blocker (ARB), which works by relaxing the blood vessels, allowing blood to flow more easily."
Answered by AI
Does irbesartan cause weight gain?
"If you are experiencing any of the following symptoms, you should see a doctor: swelling, rapid weight gain, confusion, loss of appetite, vomiting, pain in your side or lower back."
Answered by AI
What is the best time of day to take irbesartan?
"You should take irbesartan tablets once a day. Your doctor may suggest that you take the first dose before bedtime so you don't feel dizzy. Once you've taken the first dose, you can take it at any time. Try to take it at the same time every day."
Answered by AI
What are the possible side effects of irbesartan?
"If irbesartan makes you feel dizzy when you stand up, try getting up slowly or sit down until you feel better. ... , Headaches. Make sure you rest and drink lots of fluids. ... , Feeling nauseous ... , Being sick (vomiting) ... , Diarrhea. ... , Pain in your joints or muscles."
Answered by AI