Intuniv

Migraine, Migraine Disorders, Tourette Syndrome + 3 more
Treatment
20 Active Studies for Intuniv

What is Intuniv

GuanfacineThe Generic name of this drug
Treatment SummaryGuanfacine is a medication used to treat high blood pressure and attention deficit hyperactivity disorder (ADHD). It was first developed in 1974 and approved by the FDA in 1986. Guanfacine works by stimulating alpha-A2 adrenergic receptors, which helps regulate blood pressure and can improve focus and attention in ADHD patients.
Tenexis the brand name
image of different drug pills on a surface
Intuniv Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tenex
Guanfacine
1986
127

Effectiveness

How Intuniv Affects PatientsGuanfacine helps manage ADHD by activating an alpha-2A adrenergic receptor. It only needs to be taken once a day and is usually considered safe, but it can cause low blood pressure, a slow heart rate, or fainting. Patients should be warned of these potential side effects.
How Intuniv works in the bodyGuanfacine helps treat Attention Deficit Hyperactivity Disorder (ADHD) by targeting the sympathetic nervous system, which controls how your heart and circulatory system work. It does this by binding to alpha-2A receptors, which decreases the activity of the sympathetic nervous system.

When to interrupt dosage

The prescribed dosage of Intuniv is contingent upon the diagnosed condition, such as monotherapy, Attention Deficit Hyperactivity Disorder and Migraine. The quantity of dosage varies, in accordance with the technique of administration laid out in the table below.
Condition
Dosage
Administration
Migraine Disorders
1.0 mg, , 2.0 mg, 3.0 mg, 4.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Kit - Oral
Tourette Syndrome
1.0 mg, , 2.0 mg, 3.0 mg, 4.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Kit - Oral
Attention Deficit Hyperactivity Disorder
1.0 mg, , 2.0 mg, 3.0 mg, 4.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Kit - Oral
Hypertensive disease
1.0 mg, , 2.0 mg, 3.0 mg, 4.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Kit - Oral
treatment as monotherapy
1.0 mg, , 2.0 mg, 3.0 mg, 4.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Kit - Oral
Migraine
1.0 mg, , 2.0 mg, 3.0 mg, 4.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Kit - Oral

Warnings

Intuniv Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Guanfacine may interact with Pulse Frequency
There are 20 known major drug interactions with Intuniv.
Common Intuniv Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Guanfacine may increase the hypotensive activities of Amifostine.
Azelastine
Major
Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Iobenguane
Major
The therapeutic efficacy of Iobenguane can be decreased when used in combination with Guanfacine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Guanfacine is combined with Oliceridine.
Thalidomide
Major
Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Intuniv Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 142mg/kg orally, and 15.3mg/kg in mice, and 114mg/kg subcutaneously in rats and 46mg/kg in mice. Those who overdose may experience low blood pressure, drowsiness, fatigue, and a slow heart rate. If someone is suspected to have overdosed on this drug, call poison control and they may need to receive saline intravenously to stabilize their blood pressure.
image of a doctor in a lab doing drug, clinical research

Intuniv Novel Uses: Which Conditions Have a Clinical Trial Featuring Intuniv?

153 active clinical trials are currently evaluating the potential of Intuniv in providing Attention Deficit Hyperactivity Disorder, Hypertensive Disease and Prophylactic Migraine Headache relief.
Condition
Clinical Trials
Trial Phases
Migraine
51 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1
Attention Deficit Hyperactivity Disorder
63 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Migraine Disorders
1 Actively Recruiting
Phase 3
Tourette Syndrome
0 Actively Recruiting
treatment as monotherapy
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Intuniv Reviews: What are patients saying about Intuniv?

5Patient Review
3/9/2015
Intuniv for Attention Deficit Disorder with Hyperactivity
My daughter has been on Intuniv for a few years. We started her on 2mg, and now she's up to 4mg. I'm not happy because she's gained about 25lbs in just 3 months. Her doctor says the meds can cause this on high doses, so we're looking for something new.
5Patient Review
7/18/2016
Intuniv for Attention Deficit Disorder with Hyperactivity
My daughter has been reaping the benefits of this medication for years now. At just 9 years old, she is able to focus much better in school thanks to the 3 mg dosage. Additionally, she doesn't have any trouble sleeping and takes the medicine first thing in the morning.
4.3Patient Review
1/25/2022
Intuniv for Attention Deficit Disorder with Hyperactivity
This medication has really helped me focus on my daily tasks. The only downside is that it makes me feel nauseous. I would still recommend it to others, though.
4Patient Review
7/6/2014
Intuniv for Attention Deficit Disorder with Hyperactivity
2.3Patient Review
12/17/2014
Intuniv for Attention Deficit Disorder with Hyperactivity
I'm not thrilled with this medication because my son has started wetting the bed since taking it. I've tried giving it to him in the morning, but that hasn't helped. Has anyone else had this problem?
2.3Patient Review
2/27/2015
Intuniv for Attention Deficit Disorder with Hyperactivity
My son was taking this in conjunction with concerta. He became a very different person; low energy, depressed, mood swings, and feelings of worthlessness characterized his demeanor. There were also anger issues at school. We weaned him off of the Concerta, Prozac and Intuniv. He now takes a small dose of generic Ritalin. He's doing great now.
2.3Patient Review
11/18/2014
Intuniv for Attention Deficit Disorder with Hyperactivity
I did not have a good experience with this treatment. I think there's potential for legal action here.
2Patient Review
7/19/2016
Intuniv for Attention Deficit Disorder with Hyperactivity
Almost immediately after taking this medication, my heart rate slowed down to a dangerous level. I felt weak and dizzy, and could barely move. I tried to keep taking it, but after the second dose, I was terrified my heart was going to stop. I called my doctor and stopped taking it.
1.7Patient Review
12/6/2016
Intuniv for Attention Deficit Disorder with Hyperactivity
I was prescribed this drug to take in addition to Lamictal 50mg and Vyvanse 50mg. I started taking this drug a few days before visiting my parents for Thanksgiving. I was overtaken by spells of obsessive thinking and was so tormented by vivid memories of childhood that I was unable to sleep. After I came off the drug, I got better within a few days. Not worth it for me.
1Patient Review
9/2/2014
Intuniv for Attention Deficit Disorder with Hyperactivity
My son's behavior changed dramatically for the worse after being put on this medication. He became angry, depressed, and had thoughts of self-harm. I am grateful that we are getting him off of this drug and hope that the effects are not permanent.
1Patient Review
8/4/2014
Intuniv for Attention Deficit Disorder with Hyperactivity
Intuniv has been a much better option for my 8-year-old son than previous stimulant medications. He's gained weight, grown taller, sleeps better, and is more social now.
1Patient Review
9/27/2016
Intuniv for Attention Deficit Disorder with Hyperactivity
DO NOT TAKE THIS DRUG. I was absolutely horrified reading the reports of children taking this drug, and then I took it as a 20 year old and had an awful experience myself. I'm generally a very active person, but after taking this medication I was unable to even get out of bed without passing out. Additionally, it gave me chest pains and really sapped my energy and personality.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about intuniv

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Intuniv do for ADHD?

"Intuniv is a blockbuster medicinethat is designed to help with emotional sensitivity, hyperarousal, rejection sensitivity, and social aggression. It is different from other stimulant medications because it acts on the central alpha2A-adrenergic receptor."

Answered by AI

Is Intuniv good for anxiety?

"Some studies have shown that guanfacine ER (Intuniv) can help treat anxiety in children and adolescents, but more studies are needed to confirm this. Currently, the medication is only FDA-approved to treat ADHD."

Answered by AI

How does Intuniv make you feel?

"If you take this medication, there is a 20% chance you will not experience any benefits and may even feel worse. Approximately 10% of people who take this medication experience irritability from the first dose. In my opinion, this irritability does not go away, so I advise patients experiencing it to stop taking the medication."

Answered by AI

Is Intuniv similar to Adderall?

"Intuniv and Adderall are both drugs that can have similar side effects, such as dizziness, dry mouth, constipation, nausea, headache, stomach pain, or irritability."

Answered by AI

Clinical Trials for Intuniv

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
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Methylphenidate for Sickle Cell Disease

8 - 17
All Sexes
Memphis, TN
The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork problems and if they have any side effects. The study will assess any thinking or attention problems participants may have both before taking this drug and after. Additionally, the study will assess the decision-making process of the caregiver that may influence using this drug or not. Primary Objective: • Assess the feasibility, acceptability, and adherence to MPH treatment in children with SCD and EF deficits. Secondary Objective: • Evaluate neurobehavioral and safety outcomes following MPH treatment. Exploratory Objective: • Evaluate decision-making and determinants influencing methylphenidate utilization among parents.
Phase 1
Recruiting
St. Jude Children's Research HospitalAndrew Heitzer, PhD
Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.
Waitlist Available
Has No Placebo
Johns Hopkins MedicineRisheng Xu, MD, PhDMedtronic
Have you considered Intuniv clinical trials? We made a collection of clinical trials featuring Intuniv, we think they might fit your search criteria.Go to Trials
Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Image of UCSF Nancy Friend Pritzker Psychiatry Building in San Francisco, United States.

Trigeminal Nerve Stimulation for ADHD in Children with Autism

7 - 14
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD). It will also learn about the efficacy and tolerability of the eTNS device. The main questions it aims to answer are: * Does eTNS reduce ADHD symptoms? * Does eTNS improve core and associated features of ASD? Participation spans 8-12 weeks and includes: * 4-5 in-person visits * 4 brief virtual check-ins * Nightly use of the eTNS device with a small sticky patch applied to child's forehead * Randomized assignment (those who start with the sham device may try the active device later)
Recruiting
Device
UCSF Nancy Friend Pritzker Psychiatry Building
Image of The University of Texas at Austin in Austin, United States.

Transcranial Photobiomodulation for ADHD

18 - 44
All Sexes
Austin, TX
The investigators have previously shown that non-invasive methods of brain stimulation such as the administration of transcranial infrared light to the prefrontal cortex (PFC) can result in improvements to cognition and emotion as well as brain oxygenation. This method is called transcranial photobiomodulation (tPBM). The investigators hypothesize that tPBM can improve cognition and brain oxygenation in adults with attention deficit hyperactivity disorder (ADHD). The investigators will investigate the effects of repeated tPBM sessions on cognitive functioning in adults with ADHD. Specifically, the investigators hypothesize that participants that receive tPBM will show improvements in response control, sustained attention, and working memory, as well as improvements in prefrontal hemodynamics and a reduction in ADHD symptoms.
Waitlist Available
Online Trial
The University of Texas at Austin
Have you considered Intuniv clinical trials? We made a collection of clinical trials featuring Intuniv, we think they might fit your search criteria.Go to Trials
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Biofeedback and Lifestyle Interventions for ADHD

7 - 18
All Sexes
Gillette, WY
The Pediatric Healing Minds II intervention includes a biofeedback component, breathing practices nutrition and exercise counseling. Biofeedback is a type of mind-body technique used to control body functions such as heart, lung and muscle responses. Biofeedback uses therapeutic techniques that aim to help study participants gain more awareness and control over certain physiological functions in their bodies. It involves the use of electronic monitoring equipment to provide real-time information about physiological processes such as heart rate, HRV, coherence and muscle tension. This information is then provided back to the study participant, allowing them to learn how to consciously regulate these processes. During the sessions parents are expected to attend and participate. Study participants and parents will have access to a video that provides instructions for placement of the Heart Math single small ear lobe or finger sensor. Breathing Practices include alternate nostril, qi gong and other breathing practices. Nutrition counseling includes nutrition supplementation to correct deficiencies, dietary education and an age-and gender-specific diet prescription based on the Mediterranean Diet. Exercise counseling includes developmentally appropriate guidelines for cardiopulmonary, strength and flexibility activities based on guidelines from the American College of Sports Medicine (ACSM) and the American Academy of Pediatrics (AAP). The objective of this research proposal is to examine the combined effects of an integrative approach including biofeedback, breathing practices, nutrition and exercise counseling intervention (Healing Minds II), on symptoms and severity of ADHD, impulsivity and attention (e.g., QB continuous performance test) in youth 7-18 years of age. The investigators hypothesize that ADHD symptoms and severity, impulsivity and attention will be significantly improved and coherence increased after participation in the 6-month intervention. The investigators also propose that ADHD severity in those patients with prescribed medication but poorly-controlled ADHD will demonstrate the greatest improvement compared to those not prescribed medication and those who have well-controlled ADHD.
Waitlist Available
Has No Placebo
Hoskinson Health and Wellness ClinicInara McMaster, MDHoskinson Health and Wellness Clinic
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Virtual Reality for ADHD

18 - 25
All Sexes
Baton Rouge, LA
The goal of this larger parallel group randomized trial is to test the impact of a virtual reality program for improving the ability of emerging adults (age 18-25) with attention deficit hyperactivity disorder (ADHD) to stay focused while completing homework and studying. This study compares the impact of using a virtual reality headset to using a virtual reality headset while also receiving feedback about levels of focus to a control group. The main question is whether participants demonstrate significantly improved concentration while completing homework and studying in virtual reality and whether they enjoy and prefer working in a virtual reality environment. Concentration is measured both through participant report and also using keyboard and mouse click data to assess work productivity objectively.
Phase 4
Waitlist Available
Louisiana State University (+1 Sites)Joshua M Langberg, PhD
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Mind-Body App + Movement Program for Chronic Pain

19 - 75
All Sexes
Chilliwack, Canada
The investigators are evaluating the effects of a mind-body mobile application, in combination with a guided movement program, on the experience of chronic pain. Participants meeting the criteria for chronic/persistent pain (confirmed via self-report) will complete an online baseline questionnaire. Eligible participants will take part in an intervention that involves use of a 6-week free trial of a mind-body focused mobile application in combination with virtual asynchronous audio-guided somatic education sessions (gentle movement). External data from a usual care control arm and a mobile-app-only arm from a previous study by the same research team, National Clinical Trials (NCT) registry number NCT05090683, will be used for comparison with the current combined intervention. All participants will complete online surveys at the start of the study and after 6 weeks to measure pain intensity and interference (primary outcomes), mental health outcomes (depression, anxiety, stress), pain-related thoughts (pain catastrophizing), quality of life, and fear of movement (secondary outcomes). From weeks 2 to 6, participants will fill out weekly surveys to track how often they engage with each: the somatic education (gentle movement) program and the mobile app. Participants will also complete a follow-up survey at 12 weeks (6 weeks post-intervention conclusion).
Waitlist Available
Has No Placebo
University of the Fraser ValleyCynthia J Thomson, PhD
Have you considered Intuniv clinical trials? We made a collection of clinical trials featuring Intuniv, we think they might fit your search criteria.Go to Trials
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