Lean Pork in Plant-Based Diet for Healthy Aging

(PRODMED2 Trial)

MD
Overseen ByMoul Dey, Ph.D.
Age: 65+
Sex: Any
Trial Phase: Academic
Sponsor: South Dakota State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how adding lean pork to a mostly plant-based diet might improve health as people age. The researchers aim to determine if this combination can help maintain muscle strength, ensure adequate nutrients, and support metabolic functions, all crucial for healthy aging. Participants will follow a diet either with lean pork or without any meat to compare the effects. Ideal candidates are those 65 and older who are generally healthy, eat meat, and are willing to consume pork as their only meat during the study. As an unphased trial, this study offers a unique opportunity to contribute to understanding dietary impacts on aging health.

Will I have to stop taking my current medications?

The trial protocol does not specify whether you need to stop taking your current medications. However, you must be willing to consume pork as the sole meat source and abstain from certain nutritional supplements, alcohol, or non-study foods during the study period.

What prior data suggests that this dietary pattern is safe for healthy aging?

In a previous study, researchers found that lean pork is generally safe compared to other meats like beef and chicken. They observed no major differences in health outcomes among people consuming these different meats, suggesting that most people can eat lean pork without problems.

Eating a diet rich in plant-based foods is also linked to good health, though some risks exist. However, a diet high in plant foods and low in heavily processed foods is associated with healthier aging. This indicates that combining lean pork with a mostly plant-based diet could be safe and beneficial for health.

Overall, evidence suggests that adding lean pork to a plant-based diet should be safe for most people. However, consulting a healthcare provider before changing one's diet is advisable, especially when considering participation in a clinical trial.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores how incorporating lean pork into a plant-based diet might benefit healthy aging. Unlike traditional plant-based diets that exclude meat entirely, this approach allows for the inclusion of minimally processed animal protein, which could provide a unique combination of nutrients. The trial aims to understand if this blend can offer the benefits of a plant-forward diet while also addressing potential protein gaps that might occur without meat. By focusing on low-ultra-processed foods, it might also highlight a dietary pattern that supports aging healthily without resorting to heavily processed alternatives.

What evidence suggests that this trial's treatments could be effective for healthy aging?

Research has shown that adding lean pork to a mostly plant-based diet can be beneficial. In one study with overweight adults, participants who included lean pork in their meals lost weight and reduced their waist size. Another study found that eating minimally processed lean pork alongside a plant-based diet improved overall health. This trial will compare two dietary patterns: one group will follow a low-ultra-processed omnivorous diet that includes lean pork, while another group will follow a low-ultra-processed plant-forward diet with no meat. While plant-based diets are known for promoting longevity and health, adding lean pork might boost nutrient intake and support muscle health. These findings suggest that lean pork can complement a plant-focused diet and may enhance health as people age.14678

Who Is on the Research Team?

MD

Moul Dey, Ph.D.

Principal Investigator

South Dakota State University

Are You a Good Fit for This Trial?

This trial is for people aged 65 or older who are generally healthy, weigh at least 110 pounds, and have a normal HbA1C level. Participants should currently follow a meat-based diet without special dietary requirements and be willing to eat meals on-site and provide samples.

Inclusion Criteria

I am 65 years or older and in good health.
Generally good health status based on one routine physical in the past 15 months, current health status
My HbA1C levels are normal and I weigh at least 110 lb.
See 1 more

Exclusion Criteria

My kidney function is not normal.
I have a history of cancer, diabetes, heart, liver, or kidney diseases.
If they were unwilling to abstain from taking nutritional supplements, alcohol, non-study foods, and beverage during the study period.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants follow a plant-forward diet with or without lean pork for 16 weeks

16 weeks

Washout

A 2-week washout period between diet phases

2 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Role of Lean-pork Within a Plant-based Dietary Pattern
Trial Overview The study tests if adding lean pork to a plant-only diet improves cognitive function, muscle fitness, and immune-metabolic functions in older adults. It's an all-food-provided study comparing two diets over 18 weeks with comprehensive health assessments.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Low-ultra-processed OmnivorousExperimental Treatment1 Intervention
Group II: Low-ultra-processed No meatExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

South Dakota State University

Lead Sponsor

Trials
21
Recruited
10,100+

Published Research Related to This Trial

In a nine-month study involving 49 overweight or obese adults, regular consumption of pork, beef, or chicken did not lead to significant differences in body mass index (BMI) or other markers of body fat.
The findings suggest that diets high in pork protein do not provide unique benefits for body composition compared to other high-protein meats like beef and chicken, indicating that the type of meat may not significantly impact adiposity in overweight individuals.
A comparison of regular consumption of fresh lean pork, beef and chicken on body composition: a randomized cross-over trial.Murphy, KJ., Parker, B., Dyer, KA., et al.[2022]
In a 6-month study involving 164 overweight adults, those who incorporated up to 1 kg of lean pork per week showed significant reductions in weight, BMI, waist circumference, and body fat compared to a control group.
The weight loss observed in the pork group was primarily due to a decrease in fat mass, with no adverse effects on lean mass or other metabolic parameters, suggesting that lean pork can be a beneficial addition to a weight loss diet.
Effects of eating fresh lean pork on cardiometabolic health parameters.Murphy, KJ., Thomson, RL., Coates, AM., et al.[2021]
In a 20-year study of 1,139 older adults, higher intake of animal protein was linked to lower all-cause and cardiovascular mortality, suggesting it may have protective health benefits for this age group.
Plant protein intake did not show a direct association with mortality outcomes, but its effects varied based on the presence of hypertension, indicating that individual health conditions may influence dietary impacts.
Animal Protein Intake Is Inversely Associated With Mortality in Older Adults: The InCHIANTI Study.Meroño, T., Zamora-Ros, R., Hidalgo-Liberona, N., et al.[2022]

Citations

Lean Pork in Plant-Based Diet for Healthy Aging · Info ...In a 6-month study involving 164 overweight adults, those who incorporated up to 1 kg of lean pork per week showed significant reductions in weight, BMI, waist ...
Perspective: Vegan Diets for Older Adults? A ...So far, we have presented data indicating that a vegan diet can lead to decreases in overall protein intake and in the intake of high-quality protein sources ...
Plant-Based Diet & Aging Trajectory in Large CohortOur study demonstrated a differential impact of plant-based foods on accelerated aging trajectory, i.e., a healthful plant-based diet was more ...
Benefits of Plant-Based Nutrition: Longevity & Quality of LifeResearch indicates that a plant-based diet is the cornerstone of life longevity and can help patients achieve a better quality of life as they age.
Effects of Minimally Processed Red Meat Within a Plant- ...This randomized controlled feeding intervention evaluated the effects of incorporating minimally processed lean pork daily within a plant- ...
Pork Meat Composition and Health: A Review of the ...There is a common belief that eating pork meat might increase the risk of cardiovascular disease due to its fat content, particularly its fatty acid composition ...
Plant-based diets and long-term health: findings from the ...Overall, the health of people following plant-based diets appears to be generally good, with advantages but also some risks, and the extent to which the risks ...
Healthy eating in midlife linked to overall healthy agingMaintaining a diet rich in plant-based foods and lower in ultra-processed foods was linked to healthier aging.
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