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What is Indomethacin Sodium
IndomethacinThe Generic name of this drug
Treatment SummaryIndometacin is a type of non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation, pain, and fever. It works by blocking an enzyme called cyclooxygenase (COX) which is involved in the production of prostaglandins. It was first approved by the FDA in 1965 and is commonly used to treat rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pain, and acute gouty arthritis. It is available in oral capsules, rectal, and intravenous forms. It can also be used to close a hem
Indomethacinis the brand name
Indomethacin Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Indomethacin
Indomethacin
1984
241
Effectiveness
How Indomethacin Sodium Affects PatientsIndometacin is a type of NSAID used to treat pain, fever, and inflammation. It works by blocking substances that cause pain, fever, and inflammation. Studies have shown indometacin to be effective in reducing joint swelling, reducing pain and improving mobility. However, taking indometacin can lead to serious side effects such as heart attack, stroke and gastrointestinal problems like bleeding and ulcers. In healthy people, indometacin can reduce blood flow to the brain and potentially inhibit neural activity.
How Indomethacin Sodium works in the bodyIndometacin inhibits an enzyme called cyclo-oxygenase to reduce pain, fever, and inflammation. It works by blocking the enzyme's active site and preventing it from converting arachidonic acid into prostaglandins, which are involved in inflammation. Indometacin also stops an enzyme called phospholipase A2 from releasing arachidonic acid. It is more selective in blocking cyclo-oxygenase-1, which is responsible for gastric mucosal protection, platelet, and kidney function, compared to other nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to its anti
When to interrupt dosage
The prescribed dosage of Indomethacin Sodium is contingent upon the diagnosed condition, such as Aquaporin 2, Arthritis, Gouty and Moderate to grave ankylosing spondylitis. The measure of dosage is contingent on the mode of administration (e.g. Capsule or Injection, powder, lyophilized, for solution) as detailed in the table below.Condition
Dosage
Administration
Rheumatoid Arthritis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Aquaporin 2
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Disease
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Moderate to severe ankylosing spondylitis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Tendinopathy
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Bursitis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Arthritis, Gouty
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Arthralgia
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Pain
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Body weight between 500 and 1750 g
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Muscle Pain
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Degenerative polyarthritis
25.0 mg, , 50.0 mg, 75.0 mg, 100.0 mg, 1.0 mg, 20.0 mg, 40.0 mg, 25.0 mg/mL, 1.0 mg/mL, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Rectal, Suppository, Suppository - Rectal, Ophthalmic, Liquid; Powder, for solution, Liquid; Powder, for solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension - Oral, Suspension, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Warnings
Indomethacin Sodium has twenty-three contraindications and must not be combined with any of the conditions displayed in the table below.Indomethacin Sodium ContraindicationsCondition
Risk Level
Notes
Intracranial Hemorrhage
Do Not Combine
Congenital Heart Defect
Do Not Combine
aspirin
Do Not Combine
Asthma
Do Not Combine
Urticaria caused by NSAIDs
Do Not Combine
Hemorrhage
Do Not Combine
Congenital Heart Defect
Do Not Combine
Blood Coagulation Disorders
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Hematochezia
Do Not Combine
Pulmonary Atresia
Do Not Combine
Pulse Frequency
Do Not Combine
Ductus Arteriosus, Patent
Do Not Combine
Enterocolitis, Necrotizing
Do Not Combine
proven or suspected untreated infection
Do Not Combine
Enterocolitis, Necrotizing
Do Not Combine
history of proctitis
Do Not Combine
Low Platelet Count
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indomethacin may interact with Pulse Frequency
Common Indomethacin Sodium Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Acteoside.
Altretamine
Major
The risk or severity of adverse effects can be increased when Indomethacin is combined with Altretamine.
Indomethacin Sodium Toxicity & Overdose RiskThe highest toxic dose of indomethacin in rats has been found to be 2.42mg/kg, and 13mg/kg in mice. Signs of an overdose include nausea, vomiting, severe headaches, dizziness, confusion, reduced alertness, tingling sensations, and seizures. If an overdose occurs, the patient should be given treatment to help empty the stomach and carefully monitored for any signs of ulcers or bleeding. Taking antacids may also help.
Indomethacin Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Indomethacin Sodium?
24 active clinical trials are being conducted to evaluate the potential of Indomethacin Sodium in reducing symptoms of Joint Pain, Degenerative polyarthritis and Muscle Pain.Condition
Clinical Trials
Trial Phases
Arthritis, Gouty
0 Actively Recruiting
Muscle Pain
1 Actively Recruiting
Phase 4
Pain
0 Actively Recruiting
Arthralgia
0 Actively Recruiting
Body weight between 500 and 1750 g
0 Actively Recruiting
Bursitis
0 Actively Recruiting
Tendinopathy
0 Actively Recruiting
Aquaporin 2
2 Actively Recruiting
Phase 3, Not Applicable
Rheumatoid Arthritis
0 Actively Recruiting
Disease
0 Actively Recruiting
Moderate to severe ankylosing spondylitis
0 Actively Recruiting
Degenerative polyarthritis
0 Actively Recruiting
Indomethacin Sodium Reviews: What are patients saying about Indomethacin Sodium?
5Patient Review
5/25/2018 This is an extremely effective treatment that will start providing relief within 4-6 hours. I was completely pain free within 24 hours.
5Patient Review
11/29/2020 I've been taking this for 10 years and have found that the best way to avoid prolonged pill-taking is to take two 50mg pills at the first sign of gout. I rarely have to take more than this. The key here is catching it early.
5Patient Review
3/15/2021 Worked to take dramatically reduce severe gout pain within 2 hours of taking. Even though it upset my stomach, the pain reduction was worth it.
5Patient Review
5/29/2022 I've been using this for a couple of years now and it's helped me immensely. The first time I used it, I was able to stand on my foot with full weight after just two days. My doctor prescribed it for that episode only, but when I explained that I wanted something stronger than over-the-counter options (which didn't help me at all), they prescribe it for daily use. Now, I only use it as needed when the first signs of pain appear. Thanks to this medication, my pain level has been steady at an 8 or 9 (out of 10) instead of constantly fluctuating.
5Patient Review
8/10/2021 I took this medication when I first noticed the symptoms of a gout flareup and it provided relief within one to two hours. This was my first experience with gout, and I found this treatment to be very effective. Additionally, I've also noticed that my chronic lower back pain has subsided since taking this medication. It's possible that this is just a coincidence, but I'll know for sure in the coming weeks as I only plan to take this medication when my gout is acting up.
Patient Q&A Section about indomethacin sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is indomethacin and ibuprofen the same thing?
"Indocin can be used to relieve pain, fever, and swelling. Advil may be better for treating fever, inflammation, and pain, but does not last as long as some other NSAIDs."
Answered by AI
Is indomethacin a strong NSAID?
"This risk may be greater with indomethacin than with other NSAIDs.
Indomethacin is one of the strongest NSAIDs and is usually only used after other NSAIDs have not worked. NSAIDs (including indomethacin) have been linked to an increased chance of having a stroke or heart attack. Indomethacin might have a greater chance of causing this than other NSAIDs."
Answered by AI
What class of drugs is indomethacin?
"Aug 15, 2021 - Indomethacin is a type of medication called an NSAID, which works by stopping the body's production of a substance that causes pain, fever, and inflammation."
Answered by AI
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