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LY3457263 + Tirzepatide for Obesity

Phase 1
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up predose on day 1 up to 43 days postdose
Awards & highlights

Study Summary

This trial will assess the safety and tolerability of a new drug combo in overweight/obese participants, and measure how much of the drug gets into their bloodstream. It will last 11 weeks.

Eligible Conditions
  • Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~predose on day 1 up to 43 days postdose
This trial's timeline: 3 weeks for screening, Varies for treatment, and predose on day 1 up to 43 days postdose for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Therapeutic procedure
Secondary outcome measures
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of LY3457263

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3457263 + TirzepatideExperimental Treatment2 Interventions
LY3457263 administered subcutaneously (SC) in combination with tirzepatide given SC.
Group II: Placebo + TirzepatidePlacebo Group2 Interventions
Placebo administered SC in combination with tirzepatide given SC.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tirzepatide
2019
Completed Phase 3
~7590
LY3457263
2022
Completed Phase 1
~200

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,615 Previous Clinical Trials
3,201,020 Total Patients Enrolled
53 Trials studying Obesity
40,790 Patients Enrolled for Obesity
Study DirectorEli Lilly and Company
1,344 Previous Clinical Trials
405,214 Total Patients Enrolled
36 Trials studying Obesity
20,509 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is participation in this research open to me?

"In order to be considered for this study, individuals must demonstrate obesity and fall within the 20-70 year old age bracket. There are 45 spots available in total."

Answered by AI

Are there still openings for people to join this clinical trial?

"Affirmative. Clinicaltrials.gov presents evidence that this clinical research project, which was initially posted on November 11th 2022, is presently seeking enrollees. Approximately 45 patients need to be enrolled across a single medical centre."

Answered by AI

Has the combination of LY3457263 and Tirzepatide obtained regulatory approval?

"As LY3457263 + Tirzepatide is still undergoing its initial trial, there are only a few data points that can serve as evidence of the drug's safety and efficacy. Thus, our team at Power rates it a 1 on their scale from 1 to 3."

Answered by AI

Does this experimental study recruit individuals over the age of 40?

"Qualified participants of this experiment must span the ages 20 to 70 inclusive. There are 223 studies open for individuals below the age of majority, and 697 trials available for those over 65 years old."

Answered by AI

How many patients are enrolled in this research trial at its current capacity?

"Affirmative. The information available on clinicaltrials.gov confirms that the trial commenced recruitment on November 11th 2022 and is still ongoing, requiring 45 participants from one location."

Answered by AI

Who else is applying?

What state do they live in?
Florida
New York
Texas
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
What site did they apply to?
LabCorp CRU, Inc.
How many prior treatments have patients received?
3+
2

What questions have other patients asked about this trial?

How long does the screening take? Will I be able to do this study living in a different state?
PatientReceived 2+ prior treatments

Why did patients apply to this trial?

I have tried Ozempic in the past and it helped me lose weight but i have plateaued at 206.
PatientReceived 1 prior treatment
I've tried 3 different weight loss programs. They were not effective, I'm hoping the clinical trials will help me to loss weight.
PatientReceived 2+ prior treatments
I have tried various weight loss programs and diets. My insurance does not cover this medication and I can not afford it on my own.
PatientReceived no prior treatments
I have been thin until the age of 40. Once I turned 40, everything all of a sudden changed. I am 52 now and still have not been able to get this weight off of me; I went from 130 to 270 pounds. I am miserable. My legs stopped working, and I need knee replacements now because of the weight gain. I cannot wear the things I used to wear, and I don't have any energy to do anything. I sit around feeling down and sad. I wouldn't say I like anything about the way I look. I barely eat, yet I cannot get this weight off. I try to exercise as much as possible but can't do much with my knee issues. I can't have my knee replacement surgery until I lose weight, but it is hard to lose weight when I can hardly walk.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
A Study of LY3457263 in Obese Participants
2022. "A Study of LY3457263 in Obese Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05582096.
~16 spots leftby Apr 2025
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