Drug Therapy for Anxiety
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests two drugs, Triazolam and Buspirone, to determine their effects on brain signals related to anxiety. The researchers aim to assess whether a new, non-invasive method can measure anxiety levels by recording signals from the ear canal. Participants will receive either one of the drugs or a placebo (a harmless pill with no active ingredients) to observe changes in the signals. This trial suits individuals who have not recently undergone psychiatric treatment and do not have certain health issues, such as heart or lung disease. As an unphased trial, it offers participants the opportunity to contribute to innovative research that could lead to new ways of understanding and measuring anxiety.
Will I have to stop taking my current medications?
Yes, you will need to stop taking any psychiatric drugs, drugs that interact with the study drugs, or those with anxiety-related effects. Also, avoid antibiotics or natural health products that affect certain enzymes.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Studies have shown that both triazolam and buspirone are generally well-tolerated by patients. Triazolam often treats short-term sleep problems but can cause side effects such as daytime anxiety, memory issues, and, in rare cases, depression. These side effects typically occur with longer use, which is uncommon in short-term studies.
Buspirone is known for having fewer side effects compared to other anxiety treatments. Some individuals might experience dizziness or sleepiness, but these effects are usually mild. Recent studies have not identified any unexpected safety concerns with buspirone, and it lacks the dependence risk associated with some other anxiety medications. Overall, both medications have well-understood safety profiles, with side effects that are usually manageable.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a novel way to understand anxiety through the measurement of the hippocampal theta rhythm from the outer ear canal. Unlike traditional anxiety treatments, such as SSRIs or benzodiazepines, this approach focuses on brain wave activity, providing a new angle for diagnosing or tailoring treatments. By examining how drugs like triazolam and buspirone affect these brain rhythms, scientists hope to gain insights into their mechanisms of action and potentially improve anxiety management. This could lead to more personalized and effective therapies for those struggling with anxiety.
What evidence suggests that this trial's treatments could be effective for anxiety?
Research shows that triazolam, one of the treatments in this trial, effectively lowers anxiety. In studies, participants taking triazolam felt less anxious compared to those on a placebo and reported greater satisfaction with their treatment. Triazolam also helped with memory problems and reduced physical stress reactions. Conversely, buspirone, another treatment option in this trial, eases anxiety symptoms with fewer side effects than other treatments. It has also improved thinking skills while reducing anxiety. Both medications work differently but have proven helpful in reducing anxiety symptoms.16789
Are You a Good Fit for This Trial?
This trial is for men and women aged 18-40 without a history of substance use disorders, neurological illnesses, major hearing loss, or severe allergies. They shouldn't be pregnant, left-handed, colorblind, have had psychological treatment or taken psychiatric drugs in the past year.Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either triazolam, buspirone, or a placebo and undergo a series of tests and experiments
Follow-up
Participants are monitored for safety and effectiveness after treatment, ensuring drug effects have worn off
What Are the Treatments Tested in This Trial?
Interventions
- Measurement of the Hippocampal Theta Rhythm From the Outer Ear Canal
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Manitoba
Lead Sponsor