What is Hiprex
MethenamineThe Generic name of this drug
Treatment SummaryMethenamine is an organic compound with a unique structure. In its salt form, it is used to treat urinary tract infections. One example is methenamine hippurate, which is the hippuric acid salt of methenamine.
Hiprexis the brand name
Hiprex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hiprex
Methenamine
1976
17
Approved as Treatment by the FDA
Methenamine, commonly known as Hiprex, is approved by the FDA for 2 uses such as Urinary Tract Infection and prophylaxis of urinary tract infections .Urinary Tract Infection
prophylaxis of urinary tract infections
Effectiveness
How Hiprex Affects PatientsTaking 1 gram of methenamine hippurate produces an antibacterial effect in the urine after half an hour. Taking 1 gram of this drug twice a day will keep your urine antibacterial for a longer period of time.
How Hiprex works in the bodyMethenamine is a drug that works by turning into formaldehyde when in an acidic environment. Formaldehyde is a highly effective bacteria-killer, as it damages proteins and genetic material. Some bacteria can create an alkaline environment, which stops the formaldehyde from working. The salt component of the drug helps keep the environment acidic, so the formaldehyde can do its job.
When to interrupt dosage
The proposed dosage of Hiprex is contingent upon the determined condition. The amount of dosage is contingent upon the technique of administration, featured in the table below.Condition
Dosage
Administration
prophylaxis of urinary tract infections
, 1000.0 mg, 81.6 mg, 120.0 mg, 250.0 mg, 0.3875 mg/mg, 40.8 mg, 0.25 mg/mg, 1.5 mg/mL, 118.0 mg, 0.0125 mg/mg, 0.015 mg/mg, 81.0 mg, 0.0027 mg/mg, 2.7 mg/mL, 162.0 mg, 500.0 mg, 712.8 mg/mL, 10.92 mg/mL, 10.4 mg/mL, 13.0 mg/mL, 13.5 mg/mL, 1.2 mg/mg
Tablet, , Tablet - Oral, Capsule - Oral, Topical, Oral, Liquid - Extracorporeal, Capsule, Extracorporeal, Tablet, coated, Liquid, Tablet, coated - Oral, Granule, effervescent, Liquid - Topical, Kit; Tablet, Tablet, film coated, Kit; Tablet - Oral, Tablet, sugar coated, Tablet, film coated - Oral, Tablet, sugar coated - Oral, Granule, effervescent - Oral
Urinary Tract Infection
, 1000.0 mg, 81.6 mg, 120.0 mg, 250.0 mg, 0.3875 mg/mg, 40.8 mg, 0.25 mg/mg, 1.5 mg/mL, 118.0 mg, 0.0125 mg/mg, 0.015 mg/mg, 81.0 mg, 0.0027 mg/mg, 2.7 mg/mL, 162.0 mg, 500.0 mg, 712.8 mg/mL, 10.92 mg/mL, 10.4 mg/mL, 13.0 mg/mL, 13.5 mg/mL, 1.2 mg/mg
Tablet, , Tablet - Oral, Capsule - Oral, Topical, Oral, Liquid - Extracorporeal, Capsule, Extracorporeal, Tablet, coated, Liquid, Tablet, coated - Oral, Granule, effervescent, Liquid - Topical, Kit; Tablet, Tablet, film coated, Kit; Tablet - Oral, Tablet, sugar coated, Tablet, film coated - Oral, Tablet, sugar coated - Oral, Granule, effervescent - Oral
Warnings
Hiprex possesses four contraindications, and it should not be combined with the conditions displayed in the following table.Hiprex ContraindicationsCondition
Risk Level
Notes
severe hepatic insufficiency
Do Not Combine
Toxoplasma Infections
Do Not Combine
Dehydration
Do Not Combine
Impaired Renal Function
Do Not Combine
Common Hiprex Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Methenamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Methenamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Methenamine.
Acetyl sulfisoxazole
Major
Methenamine can cause a decrease in the absorption of Acetyl sulfisoxazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amphetamine
Major
The serum concentration of Amphetamine can be decreased when it is combined with Methenamine.
Hiprex Toxicity & Overdose RiskFewer than 3.5% of individuals treated with this drug may have minor side effects, such as an upset stomach, difficulty urinating, nausea, or a rash.
Hiprex Novel Uses: Which Conditions Have a Clinical Trial Featuring Hiprex?
At present, 10 clinical trials are underway to determine the potential of Hiprex as a treatment for Urinary Tract Infections.Condition
Clinical Trials
Trial Phases
Urinary Tract Infection
10 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
prophylaxis of urinary tract infections
0 Actively Recruiting
Hiprex Reviews: What are patients saying about Hiprex?
5Patient Review
11/24/2014 I've had E Coli infections for years, but since I started taking Hiprex 4 months ago, I've only had one infection. It's been excellent so far and I'm grateful for this medication.
5Patient Review
12/9/2014 I've had chronic e coli infections that resulted in me needing regular stenting surgeries. Even after ureteral reimplanation surgery, I was still getting infected due to reflux. However, since starting this medication six months ago, I haven't had a single infection and I couldn't be more grateful.
5Patient Review
10/21/2014 I've been taking Hiprex for four months now to combat my recurring E. coli infections, and it's only happened once since then! I take it alongside vitamin C to help with bladder acidity, and would recommend doing the same if you decide to go this route.
5Patient Review
3/11/2022 Hipprex is effective, but you must take Vitamin C with it. However, after being on it for years, I now have Neuropathy (numb feet and ankles). I did some research and found a link between the two, so I think care should be taken not to use this medication over long periods of time.
5Patient Review
8/2/2022 Hiprex has been a game-changer for me, and I haven't had to take antibiotics in over eight weeks. The only downside is that I've been experiencing fatigue and severe leg cramps. If anyone else has taken this medication, have you experienced similar side effects?
5Patient Review
5/27/2016 This stuff really works! I took it as directed and saw a huge difference. This is the only thing that has ever helped me, and I hate taking antibiotics. So glad to have found this product.
5Patient Review
12/22/2020 Hiprex is a real life saver. I take it as soon as I feel a UTI coming on and it always nips it in the bud.
5Patient Review
2/8/2016 Hiprex was the only drug that worked for me in the long term. However, if you have had recurring UTIs, it may be indicative of poor gut health. In this case, you might need to give up carbohydrates, sugar, and yeast altogether. I have not had a UTI since making these changes; however, I did experience a couple after ceasing Hiprex treatment even though it was effective while I was taking it. The benefits to my health and wellbeing are worth the challenge of giving up carbs.
5Patient Review
9/8/20135Patient Review
1/31/20145Patient Review
10/18/2014 I started having difficulty urinating and feeling discomfort after using Hiprex, which is concerning because there was no warning on the bottle about these potential side effects. I've been tested for a UTI but don't have one, so now I'm just waiting to see a specialist.
4Patient Review
4/8/2018 This treatment is gentle and effective. I'm from Australia and it's definitely better than cranberry capsules.
3.7Patient Review
8/25/2017 Unfortunately, this medication caused my urine to become so acidic that it literally burned all the hair off my genital area. In addition, my labia became incredibly dry and fragile to the point where even using toilet paper would cause tearing and bleeding. I stopped taking the medication and after using various creams things have healed up quite well. However, I now have urgency and frequency issues that I never had before taking this medication. I'm wondering if it will go back to normal after I've been off it for a while.
3Patient Review
8/4/2014 I am so glad to have found something that finally helps me with my chronic UTI problem.
3Patient Review
1/21/2022 I've only been taking Hiprex for a week, but the past few days I've had an awful taste in my mouth. Has anyone else experienced this?
Patient Q&A Section about hiprex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can Hiprex damage kidneys?
"This product may include inactive ingredients that can cause allergies or other issues. For more information, talk to your pharmacist. Tell your doctor or pharmacist about your medical history, especially if you have kidney or liver problems or dehydration, before taking this medication."
Answered by AI
Is Hiprex an antibiotic?
"Hiprex is an antibacterial agent that can kill both gram-positive and gram-negative bacteria. It starts working within 30 minutes of being taken."
Answered by AI
What is the drug Hiprex used for?
"Hiprex is used to prevent chronic urinary tract infections that recur. It is intended for people who need long-term prevention and is not used to treat active infections."
Answered by AI
What type of antibiotic is Hiprex?
"Hiprex is a drug used to treat and prevent urinary tract infections. It works by killing bacteria in the urinary tract."
Answered by AI