Hiprex

prophylaxis of urinary tract infections, Urinary Tract Infections
Treatment
2 FDA approvals
3 Active Studies for Hiprex

What is Hiprex

MethenamineThe Generic name of this drug
Treatment SummaryMethenamine is an organic compound with a unique structure. In its salt form, it is used to treat urinary tract infections. One example is methenamine hippurate, which is the hippuric acid salt of methenamine.
Hiprexis the brand name
image of different drug pills on a surface
Hiprex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hiprex
Methenamine
1976
17

Approved as Treatment by the FDA

Methenamine, commonly known as Hiprex, is approved by the FDA for 2 uses such as prophylaxis of urinary tract infections and Urinary Tract Infections .
prophylaxis of urinary tract infections
Urinary Tract Infections

Effectiveness

How Hiprex Affects PatientsTaking 1 gram of methenamine hippurate produces an antibacterial effect in the urine after half an hour. Taking 1 gram of this drug twice a day will keep your urine antibacterial for a longer period of time.
How Hiprex works in the bodyMethenamine is a drug that works by turning into formaldehyde when in an acidic environment. Formaldehyde is a highly effective bacteria-killer, as it damages proteins and genetic material. Some bacteria can create an alkaline environment, which stops the formaldehyde from working. The salt component of the drug helps keep the environment acidic, so the formaldehyde can do its job.

When to interrupt dosage

The proposed dosage of Hiprex is contingent upon the determined condition. The amount of dosage is contingent upon the technique of administration, featured in the table below.
Condition
Dosage
Administration
prophylaxis of urinary tract infections
1000.0 mg, , 500.0 mg, 81.0 mg, 81.6 mg, 120.0 mg, 162.0 mg, 118.0 mg, 250.0 mg, 1.2 mg/mg, 40.8 mg, 0.0125 mg/mg, 0.25 mg/mg, 0.015 mg/mg, 0.3875 mg/mg, 1.5 mg/mL, 13.5 mg/mL, 2.7 mg/mL, 0.0027 mg/mg, 10.92 mg/mL, 10.4 mg/mL, 712.8 mg/mL, 13.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Granule, effervescent, Granule, effervescent - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, sugar coated, Tablet, sugar coated - Oral, Extracorporeal, Liquid - Extracorporeal, Liquid, Topical, Liquid - Topical
Urinary Tract Infections
1000.0 mg, , 500.0 mg, 81.0 mg, 81.6 mg, 120.0 mg, 162.0 mg, 118.0 mg, 250.0 mg, 1.2 mg/mg, 40.8 mg, 0.0125 mg/mg, 0.25 mg/mg, 0.015 mg/mg, 0.3875 mg/mg, 1.5 mg/mL, 13.5 mg/mL, 2.7 mg/mL, 0.0027 mg/mg, 10.92 mg/mL, 10.4 mg/mL, 712.8 mg/mL, 13.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Granule, effervescent, Granule, effervescent - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, sugar coated, Tablet, sugar coated - Oral, Extracorporeal, Liquid - Extracorporeal, Liquid, Topical, Liquid - Topical

Warnings

Hiprex possesses four contraindications, and it should not be combined with the conditions displayed in the following table.Hiprex Contraindications
Condition
Risk Level
Notes
Liver Failure
Do Not Combine
Dehydration
Do Not Combine
Renal Insufficiency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Hiprex.
Common Hiprex Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Methenamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Methenamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Methenamine.
Acetyl sulfisoxazole
Major
Methenamine can cause a decrease in the absorption of Acetyl sulfisoxazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amphetamine
Major
The serum concentration of Amphetamine can be decreased when it is combined with Methenamine.
Hiprex Toxicity & Overdose RiskFewer than 3.5% of individuals treated with this drug may have minor side effects, such as an upset stomach, difficulty urinating, nausea, or a rash.
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Hiprex Novel Uses: Which Conditions Have a Clinical Trial Featuring Hiprex?

At present, 10 clinical trials are underway to determine the potential of Hiprex as a treatment for Urinary Tract Infections.
Condition
Clinical Trials
Trial Phases
prophylaxis of urinary tract infections
0 Actively Recruiting
Urinary Tract Infections
4 Actively Recruiting
Not Applicable, Phase 4

Hiprex Reviews: What are patients saying about Hiprex?

5Patient Review
11/24/2014
Hiprex for Urinary Tract Infection
I've had E Coli infections for years, but since I started taking Hiprex 4 months ago, I've only had one infection. It's been excellent so far and I'm grateful for this medication.
5Patient Review
12/9/2014
Hiprex for Urinary Tract Infection Prevention
I've had chronic e coli infections that resulted in me needing regular stenting surgeries. Even after ureteral reimplanation surgery, I was still getting infected due to reflux. However, since starting this medication six months ago, I haven't had a single infection and I couldn't be more grateful.
5Patient Review
10/21/2014
Hiprex for Urinary Tract Infection Prevention
I've been taking Hiprex for four months now to combat my recurring E. coli infections, and it's only happened once since then! I take it alongside vitamin C to help with bladder acidity, and would recommend doing the same if you decide to go this route.
5Patient Review
3/11/2022
Hiprex for Urinary Tract Infection Prevention
Hipprex is effective, but you must take Vitamin C with it. However, after being on it for years, I now have Neuropathy (numb feet and ankles). I did some research and found a link between the two, so I think care should be taken not to use this medication over long periods of time.
5Patient Review
8/2/2022
Hiprex for Urinary Tract Infection Prevention
Hiprex has been a game-changer for me, and I haven't had to take antibiotics in over eight weeks. The only downside is that I've been experiencing fatigue and severe leg cramps. If anyone else has taken this medication, have you experienced similar side effects?
View All Reviews
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Patient Q&A Section about hiprex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can Hiprex damage kidneys?

"This product may include inactive ingredients that can cause allergies or other issues. For more information, talk to your pharmacist. Tell your doctor or pharmacist about your medical history, especially if you have kidney or liver problems or dehydration, before taking this medication."

Answered by AI

Is Hiprex an antibiotic?

"Hiprex is an antibacterial agent that can kill both gram-positive and gram-negative bacteria. It starts working within 30 minutes of being taken."

Answered by AI

What is the drug Hiprex used for?

"Hiprex is used to prevent chronic urinary tract infections that recur. It is intended for people who need long-term prevention and is not used to treat active infections."

Answered by AI

What type of antibiotic is Hiprex?

"Hiprex is a drug used to treat and prevent urinary tract infections. It works by killing bacteria in the urinary tract."

Answered by AI

Clinical Trials for Hiprex

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