Hiprex

prophylaxis of urinary tract infections, Urinary Tract Infections
Treatment
2 FDA approvals
6 Active Studies for Hiprex

What is Hiprex

MethenamineThe Generic name of this drug
Treatment SummaryMethenamine is an organic compound with a unique structure. In its salt form, it is used to treat urinary tract infections. One example is methenamine hippurate, which is the hippuric acid salt of methenamine.
Hiprexis the brand name
image of different drug pills on a surface
Hiprex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hiprex
Methenamine
1976
17

Approved as Treatment by the FDA

Methenamine, commonly known as Hiprex, is approved by the FDA for 2 uses such as prophylaxis of urinary tract infections and Urinary Tract Infections .
prophylaxis of urinary tract infections
Urinary Tract Infections

Effectiveness

How Hiprex Affects PatientsTaking 1 gram of methenamine hippurate produces an antibacterial effect in the urine after half an hour. Taking 1 gram of this drug twice a day will keep your urine antibacterial for a longer period of time.
How Hiprex works in the bodyMethenamine is a drug that works by turning into formaldehyde when in an acidic environment. Formaldehyde is a highly effective bacteria-killer, as it damages proteins and genetic material. Some bacteria can create an alkaline environment, which stops the formaldehyde from working. The salt component of the drug helps keep the environment acidic, so the formaldehyde can do its job.

When to interrupt dosage

The proposed dosage of Hiprex is contingent upon the determined condition. The amount of dosage is contingent upon the technique of administration, featured in the table below.
Condition
Dosage
Administration
prophylaxis of urinary tract infections
1000.0 mg, , 500.0 mg, 81.0 mg, 81.6 mg, 120.0 mg, 162.0 mg, 118.0 mg, 250.0 mg, 1.2 mg/mg, 40.8 mg, 0.0125 mg/mg, 0.25 mg/mg, 0.015 mg/mg, 0.3875 mg/mg, 1.5 mg/mL, 13.5 mg/mL, 2.7 mg/mL, 0.0027 mg/mg, 10.92 mg/mL, 10.4 mg/mL, 712.8 mg/mL, 13.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Granule, effervescent, Granule, effervescent - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, sugar coated, Tablet, sugar coated - Oral, Extracorporeal, Liquid - Extracorporeal, Liquid, Topical, Liquid - Topical
Urinary Tract Infections
1000.0 mg, , 500.0 mg, 81.0 mg, 81.6 mg, 120.0 mg, 162.0 mg, 118.0 mg, 250.0 mg, 1.2 mg/mg, 40.8 mg, 0.0125 mg/mg, 0.25 mg/mg, 0.015 mg/mg, 0.3875 mg/mg, 1.5 mg/mL, 13.5 mg/mL, 2.7 mg/mL, 0.0027 mg/mg, 10.92 mg/mL, 10.4 mg/mL, 712.8 mg/mL, 13.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Granule, effervescent, Granule, effervescent - Oral, Tablet, coated - Oral, Tablet, coated, Tablet, sugar coated, Tablet, sugar coated - Oral, Extracorporeal, Liquid - Extracorporeal, Liquid, Topical, Liquid - Topical

Warnings

Hiprex possesses four contraindications, and it should not be combined with the conditions displayed in the following table.Hiprex Contraindications
Condition
Risk Level
Notes
Liver Failure
Do Not Combine
Dehydration
Do Not Combine
Renal Insufficiency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Hiprex.
Common Hiprex Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Methenamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Methenamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Methenamine.
Acetyl sulfisoxazole
Major
Methenamine can cause a decrease in the absorption of Acetyl sulfisoxazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amphetamine/Dextroamphetamine
Major
The serum concentration of Amphetamine can be decreased when it is combined with Methenamine.
Hiprex Toxicity & Overdose RiskFewer than 3.5% of individuals treated with this drug may have minor side effects, such as an upset stomach, difficulty urinating, nausea, or a rash.
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Hiprex Novel Uses: Which Conditions Have a Clinical Trial Featuring Hiprex?

At present, 10 clinical trials are underway to determine the potential of Hiprex as a treatment for Urinary Tract Infections.
Condition
Clinical Trials
Trial Phases
prophylaxis of urinary tract infections
0 Actively Recruiting
Urinary Tract Infections
7 Actively Recruiting
Not Applicable, Phase 4

Hiprex Reviews: What are patients saying about Hiprex?

5Patient Review
11/24/2014
Hiprex for Urinary Tract Infection
I've had E Coli infections for years, but since I started taking Hiprex 4 months ago, I've only had one infection. It's been excellent so far and I'm grateful for this medication.
5Patient Review
12/9/2014
Hiprex for Urinary Tract Infection Prevention
I've had chronic e coli infections that resulted in me needing regular stenting surgeries. Even after ureteral reimplanation surgery, I was still getting infected due to reflux. However, since starting this medication six months ago, I haven't had a single infection and I couldn't be more grateful.
5Patient Review
10/21/2014
Hiprex for Urinary Tract Infection Prevention
I've been taking Hiprex for four months now to combat my recurring E. coli infections, and it's only happened once since then! I take it alongside vitamin C to help with bladder acidity, and would recommend doing the same if you decide to go this route.
5Patient Review
3/11/2022
Hiprex for Urinary Tract Infection Prevention
Hipprex is effective, but you must take Vitamin C with it. However, after being on it for years, I now have Neuropathy (numb feet and ankles). I did some research and found a link between the two, so I think care should be taken not to use this medication over long periods of time.
5Patient Review
8/2/2022
Hiprex for Urinary Tract Infection Prevention
Hiprex has been a game-changer for me, and I haven't had to take antibiotics in over eight weeks. The only downside is that I've been experiencing fatigue and severe leg cramps. If anyone else has taken this medication, have you experienced similar side effects?
5Patient Review
5/27/2016
Hiprex for Urinary Tract Infection
This stuff really works! I took it as directed and saw a huge difference. This is the only thing that has ever helped me, and I hate taking antibiotics. So glad to have found this product.
5Patient Review
12/22/2020
Hiprex for Urinary Tract Infection
Hiprex is a real life saver. I take it as soon as I feel a UTI coming on and it always nips it in the bud.
5Patient Review
2/8/2016
Hiprex for Urinary Tract Infection
Hiprex was the only drug that worked for me in the long term. However, if you have had recurring UTIs, it may be indicative of poor gut health. In this case, you might need to give up carbohydrates, sugar, and yeast altogether. I have not had a UTI since making these changes; however, I did experience a couple after ceasing Hiprex treatment even though it was effective while I was taking it. The benefits to my health and wellbeing are worth the challenge of giving up carbs.
5Patient Review
9/8/2013
Hiprex for Urinary Tract Infection Prevention
5Patient Review
1/31/2014
Hiprex for Urinary Tract Infection Prevention
5Patient Review
10/18/2014
Hiprex for Urinary Tract Infection Prevention
I started having difficulty urinating and feeling discomfort after using Hiprex, which is concerning because there was no warning on the bottle about these potential side effects. I've been tested for a UTI but don't have one, so now I'm just waiting to see a specialist.
4Patient Review
4/8/2018
Hiprex for Urinary Tract Infection
This treatment is gentle and effective. I'm from Australia and it's definitely better than cranberry capsules.
3.7Patient Review
8/25/2017
Hiprex for Urinary Tract Infection Prevention
Unfortunately, this medication caused my urine to become so acidic that it literally burned all the hair off my genital area. In addition, my labia became incredibly dry and fragile to the point where even using toilet paper would cause tearing and bleeding. I stopped taking the medication and after using various creams things have healed up quite well. However, I now have urgency and frequency issues that I never had before taking this medication. I'm wondering if it will go back to normal after I've been off it for a while.
3Patient Review
8/4/2014
Hiprex for Urinary Tract Infection
I am so glad to have found something that finally helps me with my chronic UTI problem.
3Patient Review
1/21/2022
Hiprex for Urinary Tract Infection
I've only been taking Hiprex for a week, but the past few days I've had an awful taste in my mouth. Has anyone else experienced this?
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about hiprex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can Hiprex damage kidneys?

"This product may include inactive ingredients that can cause allergies or other issues. For more information, talk to your pharmacist. Tell your doctor or pharmacist about your medical history, especially if you have kidney or liver problems or dehydration, before taking this medication."

Answered by AI

Is Hiprex an antibiotic?

"Hiprex is an antibacterial agent that can kill both gram-positive and gram-negative bacteria. It starts working within 30 minutes of being taken."

Answered by AI

What is the drug Hiprex used for?

"Hiprex is used to prevent chronic urinary tract infections that recur. It is intended for people who need long-term prevention and is not used to treat active infections."

Answered by AI

What type of antibiotic is Hiprex?

"Hiprex is a drug used to treat and prevent urinary tract infections. It works by killing bacteria in the urinary tract."

Answered by AI

Clinical Trials for Hiprex

Image of UPMC Magee-Womens Hospital in Pittsburgh, United States.

Catheterization Methods for Postpartum Urinary Problems

18+
All Sexes
Pittsburgh, PA
At least ten percent of patients have postpartum urinary retention or difficulty urinating after birth, which can cause incontinence and other urinary problems long-term. After getting an epidural placed, patients should be numb in their pelvic region. This numbness makes it difficult to feel the need to urinate, so patients need a urinary catheter placed to empty the bladder. Some patients have one catheter placed throughout their labor and others have a catheter placed to empty the bladder then removed every few hours. The investigators are studying whether placing a catheter once or catheterizing multiple times affects the rate of postpartum urinary problems and infection.
Waitlist Available
Has No Placebo
UPMC Magee-Womens HospitalAnna Binstock, MD
Image of University of California, San Francisco in San Francisco, United States.

Trimethoprim-Sulfamethoxazole for Urinary Tract Infections

13 - 29
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant. Most people take TMP-SMX for about 6 months after getting a kidney transplant. In this study, researchers want to see what happens if people keep taking it for 6 more months. The main questions this study is asking are: * Does TMP-SMX lower the number of UTIs in the first year after transplant? * What side effects or problems do participants have while taking TMP-SMX? Researchers will compare TMP-SMX to a placebo (a look-alike pill that does not contain any medication) to see if TMP-SMX works to prevent UTIs. Participants will: * Take either TMP-SMX or a placebo pill by mouth every day for 6 months * Have three visits to touch base with the study team about any issues * Complete short monthly online surveys about any symptoms or side effects * Share blood and urine test results from their regular transplant clinic visits
Phase 4
Waitlist Available
University of California, San FranciscoAlexandra Bicki, MD
Have you considered Hiprex clinical trials? We made a collection of clinical trials featuring Hiprex, we think they might fit your search criteria.Go to Trials
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Antibiotic Usage for Overactive Bladder

18+
All Sexes
Seattle, WA
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is FDA approved as a treatment for overactive bladder. Intradetrusor of onabotulinumtoxinA is currently standard of care of patients with OAB who have persistent OAB symptoms despite behavioral therapies and oral medication treatments for OAB. As one of the main adverse events associated with intradetrusor injection of onabotulinumtoxinA is UTI, and published guidelines for cystoscopic procedures with manipulation recommend the use of prophylactic antibiotics, a single dose of prophylactic antibiotic is administered prior to this procedure. However, these recommendations are primarily based on data from randomized controlled trials (RCTs) involving antimicrobial prophylaxis during transurethral resection of the prostate. A previously published prospective study demonstrated that the rate of post-procedural UTI did not differ amongst patients with neurogenic bladder who did not receive prophylactic antibiotics and were asymptomatic for UTI, regardless of whether they had sterile urine cultures or asymptomatic bacteriuria, suggesting that patients who are not symptomatic for UTI may not require antibiotic prophylaxis prior to intradetrusor onabotulinumtoxinA injection. Studies have reported that up to 50% of antibiotic usage is inappropriate, leading to unnecessary exposure of patients to potential complications of antibiotic therapy, including Clostridium difficile infection which can cause recurrent diarrhea that may progress to sepsis and death, increasing antibiotic resistances, as well as dermal/allergic and gastro-intestinal manifestations. Therefore, in an effort to optimize antibiotic use, the investigators propose a prospective, randomized study to formally evaluate the differences in UTI frequency in subjects who have a negative urinalysis and are not symptomatic for UTI and receive prophylactic antibiotics at the time of intradetrusor onabotulinumtoxinA injection compared to those who do not receive prophylactic antibiotics at the time of injection. The proposed study seeks to evaluate the current practice standard of antibiotic prophylaxis prior to intradetrusor onabotulinumtoxin injection.
Recruiting
Has No Placebo
Vriginia Mason Medical Center (+1 Sites)Justina Tam, MD
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