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What is Glipizide
GlipizideThe Generic name of this drug
Treatment SummaryGlipizide is a drug used to treat type 2 diabetes. It was first introduced in 1984 and approved by the FDA in 1994. Glipizide belongs to a class of drugs called sulfonylureas which lower blood sugar levels. It is generally preferred for early-stage type 2 diabetes as it requires functional pancreatic beta cells for effectiveness. Compared to other sulfonylureas, glipizide has a shorter half-life and duration of action, reducing the risk of hypoglycemia. Glipizide is available as both a single-drug tablet (Glucotrol®) and in combination
Glipizideis the brand name
Glipizide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Glipizide
Glipizide
1984
471
Approved as Treatment by the FDA
Glipizide, also called Glipizide, is approved by the FDA for 1 uses such as Type 2 Diabetes .Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Effectiveness
How Glipizide Affects PatientsGlipizide is a drug used to lower blood sugar levels. It usually starts working about 30 minutes after taking it and can last up to 24 hours. Glipizide works by stimulating the pancreas to release insulin, as well as other hormones that regulate metabolism. However, long-term use of glipizide can lead to hypoglycemia and weight gain. Glipizide also works in other parts of the body, such as the muscles, fat, and liver cells. It helps to increase glucose uptake, inhibit lipolysis in the liver and fat cells, and reduce hepatic glucose output. Studies
How Glipizide works in the bodyType 2 Diabetes is a metabolic disorder caused by the body's inability to process blood glucose normally. Insulin is a hormone that helps the body handle glucose, but when it's not working correctly, glucose can build up in the bloodstream. Glipizide is a medication that helps the body better use insulin by stimulating the pancreas to produce more. It does this by binding to a receptor on the cell surface and allowing potassium and calcium to enter the cell, which triggers the release of insulin. Glipizide also helps the body to use glucose more efficiently by increasing the number and sensitivity of insulin receptors.
When to interrupt dosage
The amount of Glipizide is contingent upon the diagnosed affliction. The dosage may also differ according to the delivery approach (e.g. Tablet - Oral or Tablet, film coated - Oral) featured in the table beneath.Condition
Dosage
Administration
Type 2 Diabetes
2.5 mg, , 5.0 mg, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Glipizide has seven contraindications, and so should not be taken when suffering from any of the ailments outlined in the following table.Glipizide ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Acute Coryza
Do Not Combine
Metabolic acidosis
Do Not Combine
Comatose
Do Not Combine
Comatose
Do Not Combine
Diabetic ketoacidosis with coma
Do Not Combine
Comatose
Do Not Combine
Common Glipizide Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Glipizide may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Glipizide may increase the anticoagulant activities of (S)-Warfarin.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Glipizide.
Aclidinium
Minor
Glipizide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Glipizide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Glipizide Toxicity & Overdose RiskIn rats, the lowest amount of glipizide that is toxic when taken orally is greater than 4000 mg/kg and when injected directly into the body is 1200 mg/kg. The smallest amount that has been known to cause toxicity in children is 379 μg/kg. Symptoms of glipizide overdose can include coma, seizures, or other neurological issues due to severe hypoglycemia. Treatment involves giving the patient glucagon or intravenous glucose and monitoring them for at least 24-48 hours as hypoglycemia may recur even after the symptoms have gone away. Milder hypoglycemic symptoms can be treated with oral
Glipizide Novel Uses: Which Conditions Have a Clinical Trial Featuring Glipizide?
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Glipizide Reviews: What are patients saying about Glipizide?
5Patient Review
12/12/2017 This treatment has been amazing for my Type 2 diabetes. My A1C was 15.8 when I was diagnosed, but after just a month and a half of taking this medication, it's down to the 85-150 range. I'm also eating better now, though I did have some issues with diarrhea at first. Overall, highly recommend!
4Patient Review
5/14/2020 This treatment works well in conjunction with metformin, but I'm struggling with continuing to gain weight. Can't wait to discuss this development with my doctor.
4Patient Review
8/31/2018 I was on metformin for 10 years and had a recent blood test that showed high creatin levels. As a result, I was put on glipizide temporarily. So far, there have been no problems or side effects.
3.7Patient Review
12/14/2015 While this medication does help to keep my blood sugar levels in check, I have found that it comes with the very unwelcome side effect of weight gain.
3Patient Review
5/8/2015 Even at a reduced dosage, I'm still experiencing hypoglycemia within four hours of taking the pill. Whether I've eaten a large meal or not doesn't seem to matter. I don't think I need it if my alcohol consumption is less than 7 units, but I can't get my doctor to see things my way. For now, I'll discontinue use for three months and monitor my alcohol intake. If it's still below 7 units, then we can reassess.
3Patient Review
6/20/2016 I frequently experience blood sugar crashes while taking this medication, which makes me very hesitant to continue using it. The crash comes on quickly and causes dizziness, sweating, shaking, and trembling. I have to take something with sugar and rest for 15-20 minutes for it to subside.
3Patient Review
9/19/2017 While this medication has helped to lower my blood sugar levels, I've unfortunately also gained 20 pounds in a few short weeks due to being on a 1,500 calorie diet.
3Patient Review
10/12/2021 Unfortunately, this medication led to me contracting yeast infections frequently. I had to discontinue use as a result.
2.3Patient Review
7/12/2016 Though this lowered my levels, it didn't bring them down to where they need to be.
2.3Patient Review
4/1/2022 At first, this seemed to work well. However, after a little while it didn't seem to be any more effective than diet control.
2Patient Review
1/28/2020 I had hypoglycemia attacks while taking this medication alongside Atenolol. Additionally, this medicine would frequently spike my blood sugar levels. I no longer take it as a result.
2Patient Review
5/23/2017 This medication caused me to gain a lot of weight.
1.3Patient Review
6/27/2015 Despite my best efforts, this medication has not helped me get my blood sugar under control. I'll be trying a different drug.
1Patient Review
4/2/2016 Glipizide was a huge disappointment after using Glyburide for so many years. It doesn't work for me at all, and my sugars were through the roof without Metformin to help balance things out. Now we're back to square one trying to find something that will actually work and that my insurance will cover.
Patient Q&A Section about glipizide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the best time of day to take glipizide?
"It's generally recommended that you take glipizide about 30 minutes before a meal for optimal results. Some people find that taking the medication twice a day works better for them, though. If you have an illness or other condition that causes your blood sugar to become uncontrolled, talk to your doctor about what to do. This can include things like fevers, injuries, infections, or surgery."
Answered by AI
What are the side effects of taking glipizide?
"If you experience any of the following symptoms, you may be experiencing an allergic reaction: diarrhea, gas, feeling jittery, dizziness, uncontrollable shaking of a part of the body, red or itchy skin, rash, hives."
Answered by AI
Does glipizide lower blood sugar immediately?
"It takes 30 minutes for glipizide IR tablets to start lowering your blood sugar, and the drug reaches its full effects 1 to 3 hours after each dose."
Answered by AI
Is metformin and glipizide the same thing?
"Glipizide and metformin are not interchangeable. Glipizide is a sulfonylurea that is indicated for the treatment of Type 2 diabetes in adults. Metformin is a biguanide that is indicated for the treatment of Type 2 diabetes in adults and children who are 10 years of age and older. Glipizide and metformin have different mechanisms of action and different dosage recommendations."
Answered by AI