Glimepiride

Physical Activity, Type 2 Diabetes, Diet + 4 more

Treatment

8 FDA approvals

20 Active Studies for Glimepiride

Treatment for

Physical Activity

What is Glimepiride

GlimepirideThe Generic name of this drug

Treatment SummaryGlimepiride is a medication used to treat type 2 diabetes. It belongs to a class of drugs called sulfonylureas, which help lower blood sugar levels by stimulating the release of insulin from the pancreas. Glimepiride has a longer duration of action than other similar drugs and is associated with a lower risk of developing hypoglycemia and weight gain. It is effective in reducing fasting plasma glucose, postprandial glucose, and glycosylated hemoglobin levels. Glimepiride was approved by the FDA in 1995 and is typically taken once daily in pill form. It is sold under the brand

Amarylis the brand name

image of different drug pills on a surface

Glimepiride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Amaryl

Glimepiride

2000

269

Approved as Treatment by the FDA

Glimepiride, otherwise known as Amaryl, is approved by the FDA for 8 uses which include Type 2 Diabetes Mellitus and Physical Activity .

Type 2 Diabetes Mellitus

Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone

Physical Activity

Used to treat Exercise in combination with Pioglitazone

Diet

Used to treat Diet in combination with Pioglitazone

Type 2 Diabetes

Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone

inadequate response to monotherapy

Used to treat inadequate response to monotherapy in combination with Pioglitazone

Inadequate Glycaemic Control

Used in combination with Insulin glargine to help manage Inadequate Glycaemic Control

Sulfonylurea Compounds

Used to treat prior thiazolidinedione and sulfonylurea treatment in combination with Pioglitazone

Inadequate Glucose Control

Used to treat Inadequate Glucose Control in combination with Metformin

Effectiveness

How Glimepiride Affects PatientsGlimepiride helps the body respond better to insulin and use glucose from the blood. In studies, patients taking glimepiride had a lower fasting plasma glucose, post-prandial glucose, and HbA1c than those taking a placebo. The 4- and 8-mg doses of glimepiride had the most significant effects, but the 4-mg dose was the most effective.

How Glimepiride works in the bodyGlimepiride works by blocking potassium channels in the pancreas that control insulin secretion. These channels open when the cell has a low ratio of ATP to ADP, which causes the cell to release potassium and become more negative. This inhibits insulin secretion. When the cell has a high ratio of ATP to ADP, the channels close and the cell becomes more positive. This leads to the opening of calcium channels, allowing calcium to enter the cell and cause the contraction of the filaments that trigger the release of insulin from stored vesicles. Glimepiride binds to both sulfonylurea receptor-1 and sulfony

When to interrupt dosage

The prescribed dose of Glimepiride is based on the diagnosed malady, including Type 2 Diabetes, Sulfonylurea Compounds and Diet. The dosage also varies as per the method of distribution (e.g. Tablet or Oral) laid out in the table beneath.

Condition

Dosage

Administration

inadequate response to monotherapy

, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg