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What is Flucytosine
FlucytosineThe Generic name of this drug
Treatment SummaryFlucytosine is a medication used to treat fungal infections. It is a type of cytosine analog, which is a synthetic molecule that is similar to the natural cytosine molecule found in cells.
Ancobonis the brand name
Flucytosine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ancobon
Flucytosine
1971
38
Approved as Treatment by the FDA
Flucytosine, also called Ancobon, is approved by the FDA for 8 uses which include Septicemia and Urinary tract infection .Septicemia
Urinary tract infection
Yeast Infection
Endocarditis
Cryptococcosis
Meningitis, Fungal
Candidiasis, Systemic
Used to treat Candidiasis, Systemic in combination with Amphotericin B
disseminated Cryptococcosis
Used to treat disseminated Cryptococcosis in combination with Amphotericin B
Effectiveness
How Flucytosine Affects PatientsFlucytosine is a medicine used to treat fungal infections caused by Candida or Cryptococcus. It works by entering fungal cells and disrupting the production of DNA and RNA, leading to the death of the fungus. It is often used in combination with another antifungal medication called amphotericin B, which has been shown to increase the effectiveness of Flucytosine.
How Flucytosine works in the bodyFlucytosine works against fungal infections in two ways. First, it prevents fungal organisms from absorbing necessary compounds like purines and pyrimidines. Second, it converts to 5-fluorouracil inside the fungal cell, which disrupts the cell's ability to create DNA and RNA. This leads to an unbalanced growth that eventually kills the fungal organism. It is also thought to inhibit an enzyme in fungi called thymidylate synthase.
When to interrupt dosage
The recommended dosage of Flucytosine is contingent upon the indicated condition, such as Urinary tract infection, Cryptococcosis and Infections, Fungal. The quantity of dosage is contingent upon the method of administration recorded in the table below.Condition
Dosage
Administration
Yeast Infection
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
disseminated Cryptococcosis
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Septicemia
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Candidiasis, Systemic
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Meningitis, Fungal
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Cryptococcosis
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Urinary tract infection
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Endocarditis
, 500.0 mg, 250.0 mg
, Capsule, Capsule - Oral, Oral, Tablet - Oral, Tablet
Warnings
There are 20 known major drug interactions with Flucytosine.Common Flucytosine Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Flucytosine is combined with Acteoside.
Flucytosine Toxicity & Overdose RiskThe lowest lethal dose of the drug for rats is greater than 15 grams per kilogram.
Flucytosine Novel Uses: Which Conditions Have a Clinical Trial Featuring Flucytosine?
There are currently 7 active trials examining the potential of Flucytosine to treat Endocarditis, Meningitis, Fungal and Yeast Infections.Condition
Clinical Trials
Trial Phases
Septicemia
1 Actively Recruiting
Not Applicable
Candidiasis, Systemic
0 Actively Recruiting
Cryptococcosis
0 Actively Recruiting
disseminated Cryptococcosis
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Endocarditis
0 Actively Recruiting
Yeast Infection
6 Actively Recruiting
Phase 1, Phase 2, Phase 3, Early Phase 1, Not Applicable
Meningitis, Fungal
0 Actively Recruiting
Patient Q&A Section about flucytosine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is another name for flucytosine?
"Ancobon is an antifungal medication used to treat serious fungal infections of the blood, lungs, heart, central nervous system, and urinary tract. Ancobon is available as a generic medication."
Answered by AI
What are the side effects of flucytosine?
"The side effects of the medication include nausea, vomiting, loss of appetite, diarrhea, headache, dizziness, numbness, tingling, or burning pain in your hands or feet, dry mouth, or skin rash."
Answered by AI
What is flucytosine used for?
"Flucytosine is a medication used in treating systemic and severe candida and cryptococcus infections. It works by inhibiting the growth of fungi."
Answered by AI
What kind of antifungal is flucytosine?
"Flucytosine acts as an antifungal agent against Candida species and C. neoformans, but not against other commonly encountered fungi. However, resistance to Flucytosine develops quickly when it is used as monotherapy, limiting its use to combination therapy."
Answered by AI