What is Evamist
EstradiolThe Generic name of this drug
Treatment SummaryEstradiol is a hormone naturally found in females. It is used in hormone therapy to treat conditions caused by a lack of estrogen, such as hot flashes and vaginal dryness. It can be taken orally as a tablet or injection, or it can be used as a vaginal ring, patch, spray, gel, or cream. Ethinyl estradiol is a synthetic form of estradiol that is usually used in combination oral contraceptive pills because it is more bioavailable and resistant to metabolism.
Estradermis the brand name
Evamist Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Estraderm
Estradiol
1986
356
Approved as Treatment by the FDA
Estradiol, also known as Estraderm, is approved by the FDA for 4 uses like Palliative Treatment and Breast Cancer .Palliative Treatment
Breast Cancer
Birth Control
Used to treat Contraception in combination with Levonorgestrel
Hormonal Contraception
Used to treat Hormonal Contraception therapy in combination with Levonorgestrel
Effectiveness
How Evamist Affects PatientsEstradiol is used to reduce hot flashes, vaginal dryness, and pain during sex. It can also help improve bone density and lower cholesterol levels in the blood. The hormone also increases levels of proteins such as sex hormone binding globulin and thyroid-binding globulin, and it suppresses the formation of follicle-stimulating hormone. However, estradiol use should be avoided for those at risk of cardiovascular disease, deep vein thrombosis, and stroke as it can cause an increased risk of these conditions. It also triggers a hyper-coagulable state and can raise blood pressure by causing sodium
How Evamist works in the bodyEstrogen is a hormone found in many parts of the body, including the breast, uterus, ovaries, skin, prostate, bone, fat, and brain. In women, most estrogen is produced by the ovaries before menopause. After menopause, most estrogen comes from the adrenal glands. Estrogen binds to receptors in the body and triggers changes in the body that can cause symptoms like hot flashes, chills, vaginal dryness, mood swings, irregular menstruation, and sleep problems. Estrogen works by binding two types of receptor: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ).
When to interrupt dosage
The proposed dosage of Evamist is contingent upon the declared condition, such as Premature Menopause, Pharmaceutical Preparations and Postmenopause. The amount of dosage relies upon the technique of delivery as mentioned in the following table.Condition
Dosage
Administration
Therapeutic procedure
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
estradiol
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Birth Control
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Prostate Cancer
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
female castration
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hypogonadism
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
moderate to severe symptoms
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Postmenopause
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Breast
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Palliation
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Low Testosterone
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hot flashes
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Vasomotor Symptoms Associated With Menopause
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Hormonal Contraception
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Atrophic
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
hypoestrogenism
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Metastatic Breast Cancer
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Kraurosis Vulvae
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
advanced androgen dependent Prostate cancer
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
no menstrual period in previous 6 months
0.005 mg/hour, 4.0 mg, 0.0025 mg/mg, , 0.5 mg, 1.0 mg, 0.0075 mg/mg, 0.0025 mg/hour, 0.01 mg/hour, 0.00375 mg/hour, 0.0075 mg/hour, 0.0005 mg/mg, 0.001 mg/mg, 0.00025 mg/mg, 25.0 mg, 8.0 mg, 0.00075 mg/mg, 0.005 mg/mg, 2.0 mg, 0.00125 mg/mg, 0.004 mg, 0.01 mg, 0.06 %, 1.5 mg, 1.53 mg, 0.006 mg/hour, 0.00052 mg/mg, 0.0006 mg/mg, 0.0001 mg/mg, 0.00005 mg/mg, 40.0 mg/mL, 0.0014 mg/hour, 0.097 mg/[USP'U], 0.146 mg/[USP'U], 0.194 mg/[USP'U], 4.4 mg, 0.01 mg/[USP'U], 5.0 mg/mL, 15.0 mg, 6.0 mg, 12.5 mg, 10.0 mg, 18.0 mg, 20.0 mg, 22.0 mg, 0.1 %, 4.33 mg, 3.28 mg, 6.56 mg, 8.66 mg, 5.0 mg, 0.025 mg, 0.62 mg, 0.0045 mg/hour, 0.0052 mg/mg, 0.05 mg, 20.0 mg/mL, 10.0 mg/mL, 2.17 mg, 0.51 mg, 0.45 mg, 6.57 mg, 2.5 mg/mL, 1.8 mg, 0.9 mg, 4.84 mg, 14.0 mg, 4.95 mg, 50.0 mg
Transdermal, , Tablet, film coated, Insert - Vaginal, Tablet - Oral, Patch, extended release - Transdermal, Patch - Transdermal, Patch, Oral, Oral; Transdermal, Capsule; Kit, Vaginal, Patch, extended release, Tablet, Kit; Tablet - Oral, Insert, Gel - Transdermal, Topical, Spray, Cream - Vaginal, Capsule, Gel, Capsule; Spray, metered, Capsule; Kit - Oral, Tablet, film coated - Oral, Kit; Tablet, Film, extended release, Gel - Topical, Gel, metered, Ring - Vaginal, Spray - Transdermal, Tablet - Vaginal, Emulsion - Topical, Cream, Pellet - Oral, Pellet, Film, extended release - Transdermal, Capsule; Spray, metered - Oral; Transdermal, Emulsion, Lotion - Topical, Capsule - Oral, Gel, metered - Topical, Tablet, film coated - Vaginal, Spray, metered, Spray, metered - Transdermal, Ring, Gel, metered - Transdermal, Injection - Intramuscular, Intramuscular, Cream - Transdermal, Pellet, implantable - Subcutaneous, Injection, solution - Intramuscular, Pellet, implantable
Warnings
Evamist has eighteen contraindications, and it should not be joined with the conditions in the following table.Evamist ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Estradiol may interact with Toxoplasma Infections
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Thromboembolism
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Liver Dysfunction
Do Not Combine
Thrombophilia
Do Not Combine
Breast
Do Not Combine
Breast
Do Not Combine
Angioedema
Do Not Combine
Breast Cancer
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulmonary Embolism
Do Not Combine
Angioedema
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
suspected pregnancy
Do Not Combine
Common Evamist Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Estradiol.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Estradiol.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Estradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Estradiol.
Evamist Toxicity & Overdose RiskThe highest safe dose of estradiol in rats after 90 days was 0.003mg/kg/day. The highest toxic dose for women was 21mg/kg/21D and the toxic dose for rats was 960mg/kg. An overdose on estradiol may cause side effects such as nausea, vomiting, abdominal pain, breast tenderness, blood clots, and vaginal bleeding. It is recommended to stop taking estradiol and get supportive care if an overdose occurs.
Evamist Novel Uses: Which Conditions Have a Clinical Trial Featuring Evamist?
867 active clinical trials are presently investigating the potential of Evamist to remediate Osteoporosis, Amenorrhea (absence of menstrual period in previous 6 months) and Urogenital Atrophy.Condition
Clinical Trials
Trial Phases
Hot flashes
19 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Osteoporosis
43 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3
Metastatic Breast Cancer
82 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4
Hormone Replacement Therapy
0 Actively Recruiting
Hypogonadism
0 Actively Recruiting
Birth Control
35 Actively Recruiting
Phase 4, Not Applicable, Phase 3, Phase 2, Early Phase 1
Vasomotor Symptoms Associated With Menopause
9 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Postmenopausal Osteoporosis
4 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Low Testosterone
18 Actively Recruiting
Phase 1, Phase 2, Phase 4
Hormonal Contraception
0 Actively Recruiting
Hysterectomy
1 Actively Recruiting
Phase 4
Postmenopause
6 Actively Recruiting
Phase 2, Not Applicable, Phase 3
moderate to severe symptoms
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 4, Phase 2, Not Applicable, Early Phase 1
no menstrual period in previous 6 months
0 Actively Recruiting
Urogenital atrophy
0 Actively Recruiting
Kraurosis Vulvae
0 Actively Recruiting
Breast Cancer
718 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Premature Menopause
0 Actively Recruiting
Breast
0 Actively Recruiting
Evamist Reviews: What are patients saying about Evamist?
5Patient Review
9/2/2010 I had post-menopausal symptoms for 18 years before using Evamist. No other estrogen delivery method was successful because of all the meds I take for migraines. Evamist is a delight to use and provides nearly all the relief I need. If I skip a dose, the absence can increase my tendencies for migraines.
5Patient Review
8/31/2013 I repeatedly brought up to my family doctor how terrible my hot flashes were and how they interrupted my sleep. She brushed me off for years, until finally referring me to an OB/GYN. Within days of taking the prescribed medication, I noticed a significant decrease in hot flashes and improved mental clarity. The only side effect I experienced was feeling more aggressive (but this went away after continued use).
5Patient Review
3/2/2013 I've been using Evamist for three years and it has really helped me. I had an unplanned hysterectomy which resulted in hot flashes, night sweats, and depression. This medication completely eliminated those symptoms for me and I would recommend it to anyone experiencing similar issues.
5Patient Review
12/13/2016 This is the best way to take this drug. The dosage is perfect, and the spray is both fast-acting and contained. I couldn't be more pleased.
5Patient Review
12/12/2013 I had been using estrogen patches for three years; they got gunky around the edges, some came off, and my skin got irritated. After a while they simply didn't work. I've been on evamist for several weeks and all my menopause symptoms are gone. My head is clear, my joints aren't as sore, no more hot flashes or night sweats, I'm not as emotional, I just feel so much better!
4.7Patient Review
11/22/2011 I started taking evamist because my migraine symptoms were getting worse and I wondered if stabilizing my hormonal levels would help. It did! Not only that, but it also relieved a number of menopause symptoms I had been ignoring. For example, yay for having a libido again! The process is very easy to use; however, the only drawback is I am never sure if I am getting the exact same dose each day depending on how hard I press the pump or how I position it.
4.7Patient Review
1/29/2012 Evamist, in combination with Prometrium, was the only drug that effectively managed my menopausal symptoms. It completely changed my quality of life for the better. However, I have recently started experiencing joint pain and didn't initially make the connection to this medication. If anyone else has had a similar reaction, please let me know.
4.7Patient Review
6/4/2012 I no longer experience hot flashes and I feel great!
4.7Patient Review
4/8/2014 After years of being on patches, they stopped working and all the nightmares of anxiety,brain fog,crying,joint aches,insomnia,hot flashes,fatigue came roaring back. I started on Evamist 3 sprays once a day and after only a few days the hot flashes stopped! And I could sleep longer throughout the night. My mood is much better, and no more crying and anxiety is becoming much less.
3.3Patient Review
7/8/2012 I'm 65 and I've been taking Evamist for a little over three weeks to help with my night sweats. The medication isn't really doing much, unfortunately, and now my nipples are sore and tender. Has anyone else had this reaction?
3.3Patient Review
10/11/2016 I've been using this treatment for a little over a year now, and I'm starting to notice some negative side effects, like dark circles around my eyes. I'd love to try something different, like birth control pills, that might help balance out my hormones better.
1.7Patient Review
6/19/2012 I have developed extreme numbness and tingling in both hands since starting on Evamist. It is progressing slowly but surely. Has anyone else experienced these side effects?
Patient Q&A Section about evamist
Is Evamist discontinued?
"There is no version of Evamist available in the United States that is therapeutically equivalent. Note: There are online pharmacies that may attempt to sell a generic version of Evamist that is not approved. These medications may be counterfeit and potentially unsafe." - Anonymous Online Contributor
Unverified Answer
Is Evamist a bioidentical hormone?
"Evamist is a bioidentical estradiol spray." - Anonymous Online Contributor
Unverified Answer
Does Evamist cause weight gain?
"Is weight gain a common side effect of Evamist (estradiol)?
No, weight gain is not a common side effect of Evamist (estradiol). However, if you do notice any unusual weight gain after starting this medication, contact your healthcare provider right away." - Anonymous Online Contributor
Unverified Answer
What is Evamist spray used for?
"Evamist is a prescription estradiol-based spray that has been clinically shown to help reduce moderate to severe hot flashes caused by menopause. In fact, research has demonstrated that Evamist can help lower the frequency and intensity of hot flashes." - Anonymous Online Contributor
Unverified Answer