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What is Epzicom
LamivudineThe Generic name of this drug
Treatment SummaryAbacavir (ABC) is a medication used to treat HIV and AIDS. It is a type of drug called a nucleoside analog reverse transcriptase inhibitor (NRTI) that works by stopping the virus from replicating. It is a synthetic carbocyclic nucleoside with an 1S, 4R absolute configuration on the cyclopentene ring. In the body, it dissociates into its active form, abacavir.
Epiviris the brand name
Epzicom Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Epivir
Lamivudine
1995
178
Approved as Treatment by the FDA
Lamivudine, otherwise called Epivir, is approved by the FDA for 3 uses which include Chronic Hepatitis B Infection and HIV .Chronic Hepatitis B Infection
HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Abacavir
HIV
Effectiveness
How Epzicom Affects PatientsAbacavir is a drug used to treat HIV-1 infections. It works by blocking the virus from making copies of itself. Tests have shown that Abacavir can reduce the amount of virus in the body by 50% in concentrations ranging from 0.28 mcg/mL to 5.8 mcg/mL. Abacavir can also be used in combination with other drugs such as zidovudine, nevirapine and amprenavir to increase its effectiveness. When used together with the drugs didanosine, emtricitabine, lamivudine, stavudine
How Epzicom works in the bodyAbacavir is a drug used to treat HIV. It works by blocking a protein called reverse transcriptase, which is responsible for replicating the virus. Inside the body, abacavir is changed into an active form that competes with the natural DNA building block dGTP. When abacavir is used instead, it prevents the virus from making new copies of itself.
When to interrupt dosage
The quantity of Epzicom is contingent upon the determined medical condition. The amount likewise fluctuates as per the technique of delivery (e.g. Oral or Tablet, film coated - Oral) featured in the table beneath.Condition
Dosage
Administration
HIV
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Chronic Hepatitis B Infection
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Anti-Retroviral Agents
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
treatment failure
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
HIV
150.0 mg, 100.0 mg, , 5.0 mg/mL, 300.0 mg, 10.0 mg/mL, 30.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Epzicom has three contraindications and it should not be administered in cases of the following conditions in the table.There are 20 known major drug interactions with Epzicom.Common Epzicom Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
Lamivudine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Lamivudine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Lamivudine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Allylestrenol
Minor
Lamivudine may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Almasilate
Minor
Lamivudine may decrease the excretion rate of Almasilate which could result in a higher serum level.
Epzicom Toxicity & Overdose RiskAt least 10% of adults in HIV-1 clinical trials have reported feeling moderate levels of nausea, headaches, tiredness, vomiting, and disordered sleep. Abacavir is known to cause serious allergic reactions in some people with the HLA-B*57:01 gene. Testing for this gene is recommended by the FDA before beginning treatment. Research has also found that rats and mice who take abacavir may experience heart damage.
Epzicom Novel Uses: Which Conditions Have a Clinical Trial Featuring Epzicom?
A total of 43 active studies are being conducted to assess the efficacy of Epzicom in managing HIV (Human Immunodeficiency Virus).Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Chronic Hepatitis B Infection
7 Actively Recruiting
Phase 3, Phase 2, Phase 1
Treatment Naive
0 Actively Recruiting
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Epzicom Reviews: What are patients saying about Epzicom?
4.7Patient Review
4/17/2008 Epzicom, in conjunction with Sustiva, has been my go-to treatment since it became available. I've had undetectable viral load, high CD4 counts and good CD4/CD8 ratio while on this regimen. The only downside is the price; it's becoming more and more expensive.
4.7Patient Review
10/14/2008 I am taking this medication as part of my HIV treatment and it is going great! I love how easy it is to take, and it is just one of three medications I'm on. The side effects weren't bad for me either. Some levels were adjusted after a couple days and that was it. Now the only problem is that I'm always hot. Sleeping has been a challenge because of it, especially for my husband!
3Patient Review
3/23/2008 I started taking this medication two days ago and have experienced some side effects. I'm not sure what to do at the moment.
1Patient Review
10/18/2009 I had a lot of negative side effects from this medication, so I would not recommend it to others.
Patient Q&A Section about epzicom
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of drug is Epzicom?
"Epzicom contains a combination of abacavir and lamivudine. These antiviral medicines work to prevent human immunodeficiency virus (HIV) from multiplying in your body. Epzicom is a combination medicine used to treat HIV, the virus that can cause the acquired immunodeficiency syndrome (AIDS)."
Answered by AI
How much does Epzicom cost?
"The cost for Epzicom oral tablet (600 mg-300 mg) is around $1,370 for a supply of 30 tablets. Prices may vary depending on the pharmacy you visit. This price is for cash paying customers only and does not apply to customers with insurance plans."
Answered by AI
What is Epzicom used for?
"This product contains a combination of two drugs, abacavir and lamivudine, which are used in conjunction with other HIV medications to help control the progression of HIV infection by reducing the amount of the virus in the patient's body, allowing the immune system to function more effectively."
Answered by AI
Is Epzicom generic?
"The generic version of Epzicom may be significantly cheaper compared to the brand version."
Answered by AI