Enulose

Constipation, Hepatic Encephalopathy, Hepatic Encephalopathy

Treatment

6 FDA approvals

16 Active Studies for Enulose

Treatment for

Constipation

What is Enulose

LactuloseThe Generic name of this drug

Treatment SummaryLactulose is a sugar-based medication that is used to treat constipation and to help manage portal-systemic encephalopathy (PSE). It was first developed in 1929, but it wasn't until the 1960s that its use as a laxative was studied. Lactulose was approved by the FDA in 1977 and is now available in both generic and brand-name forms. It is listed on the World Health Organization’s List of Essential Medicines, but its effectiveness in treating constipation and PSE is still unclear. Lactulose is usually prescribed after other lifestyle or dietary modifications have failed,

Lactuloseis the brand name

image of different drug pills on a surface

Enulose Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lactulose

1966

Approved as Treatment by the FDA

Lactulose, also known as Lactulose, is approved by the FDA for 6 uses which include Hepatic Encephalopathy (HE) and Constipation .

Hepatic Encephalopathy (HE)

Constipation

prophylaxis of Hepatic encephalopathy

Constipation

Hepatic Encephalopathy

Effectiveness

How Enulose Affects PatientsLactulose is most often taken by mouth or through the rectum, and does not get absorbed into the body. It works by increasing the amount of stool and making it softer. This can lead to an increase in bowel sounds, bloating, belching, flatulence, and diarrhea.

How Enulose works in the bodyLactulose is a sugar that helps to soften stool and increase the frequency of bowel movements. It also helps to rid the body of ammonia, which is a waste product of the body's metabolism. Lactulose is broken down by bacteria in the colon, which releases acids that create an acidic environment. This acidic environment helps to trap the ammonia in the colon, where it cannot be reabsorbed into the bloodstream. The bacteria also use the ammonia in the colon to make proteins. All of these actions help to reduce the amount of ammonia in the body and treat portal-systemic encephalopathy (PSE).

When to interrupt dosage

The proposed dosage of Enulose is contingent upon the identified illness, including Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy. The measure of dosage hinges on the method of administration (e.g. Oral or Solution) enumerated in the following table.

Condition

Dosage

Administration

Constipation

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal

Hepatic Encephalopathy

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

Hepatic Encephalopathy

, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg

Warnings

Enulose has two contraindications and should not be taken simultaneously with the conditions listed in the following table.Enulose Contraindications

Condition

Risk Level

Notes

low galactose diet

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Enulose.

Common Enulose Drug Interactions

Drug Name

Risk Level

Description

Alloin

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Alloin.

Bisacodyl

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Bisacodyl.

Bisoxatin

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Bisoxatin.

Calcium polycarbophil

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Calcium polycarbophil.

Carboxymethylcellulose

Minor

The risk or severity of adverse effects can be increased when Lactulose is combined with Carboxymethylcellulose.

Enulose Toxicity & Overdose RiskThe lethal dose of lactulose in mice is 48.8mL/kg and more than 30mL/kg in rats. Overdosing on lactulose can cause abdominal cramps and diarrhea, and should be treated with fluids and electrolytes. There is not enough information to know if lactulose is safe to use during pregnancy or while nursing, so it should only be used when necessary. Studies in animals have not shown any negative effects on fertility. There is limited information about the safety of using lactulose in children, and no information about its potential for causing mutations or cancer in humans.

Enulose Novel Uses: Which Conditions Have a Clinical Trial Featuring Enulose?

25 active clinical trials are currently investigating the potential of Enulose to manage Hepatic Encephalopathy, Chronic Constipation and other Hepatic Encephalopathy-related conditions.

Condition

Clinical Trials

Trial Phases

Hepatic Encephalopathy

0 Actively Recruiting

Constipation

16 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3

Hepatic Encephalopathy

0 Actively Recruiting

Enulose Reviews: What are patients saying about Enulose?

5Patient Review

4/27/2009

Enulose for High Amount of Ammonium in the Blood

I had no issue with giving my daughter this medication, and it worked relatively quickly to help regulate her bowels. If you're struggling with constipation, I would recommend asking your health care provider about this treatment option.

5Patient Review

3/20/2009

Enulose for Impaired Brain Function due to Liver Disease

I can always count on this treatment to help me. It's easy to take, which is great.

4.7Patient Review

9/23/2008

Enulose for High Amount of Ammonium in the Blood

I had no issues with bowel movements while taking a low dose of this medication. However, I cannot speak to its efficacy in regards to brain function or liver disease.

4.3Patient Review

5/13/2008

Enulose for Incomplete or Infrequent Bowel Movements

4.3Patient Review

3/23/2009

Enulose for Incomplete or Infrequent Bowel Movements

This medication works great for me, except it makes my diahrea worse.

View All Reviews

Patient Q&A Section about enulose

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Enulose used for?

"This drug is used to treat or prevent complications of liver disease by decreasing the amount of ammonia in the blood."

Answered by AI

What is Enulose made of?

"Lactulose is a colonic acidifier for the treatment and prevention of portal-systemic encephalopathy. It is a solution that contains 15 mL of lactulose, 10 g of galactose, less than 1.2 g of lactose, and 0.1 g or less of fructose."

Answered by AI

Is lactulose and Enulose the same thing?

"Lactulose is a medication used to treat constipation. It is available in generic form and under the brand names Enulose, Kristalose, Constulose, and Generlac."

Answered by AI

Is Enulose good for constipation?

"It is a lactose derivative with a neutral taste.

Lactulose is a medication used to treat constipation and liver disease. It is a synthetic disaccharide, usually in solution form, that is taken orally or rectally. It is a lactose derivative, meaning it is derived from milk, and has a neutral taste. Some common side effects of lactulose include abdominal cramps, bloating, diarrhea, and flatulence."

Answered by AI