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What is Enablex
DarifenacinThe Generic name of this drug
Treatment SummaryDarifenacin (Enablex®, Novartis) is a drug used to treat urinary incontinence. It works by blocking certain receptors in the bladder muscle which can cause the urge to urinate. It should not be used in people with urinary retention. The clinical advantages of Darifenacin in treating overactive bladder syndrome are still unknown.
Enablexis the brand name
Enablex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enablex
Darifenacin
2004
39
Effectiveness
How Enablex Affects PatientsDarifenacin is a drug that blocks certain muscles in the body, specifically the M3 receptor. In studies using humans, it has been shown to block M3 receptors more than other types of muscle receptors, and is mainly used to treat issues with the urinary bladder and salivary glands. Common side effects of this drug include dry mouth, constipation and abnormal vision.
How Enablex works in the bodyDarifenacin works by blocking the action of the M3 receptor. This receptor is responsible for things like contraction of the bladder, production of saliva, and movement of the iris.
When to interrupt dosage
The volume of Enablex is contingent upon the determined condition. The amount fluctuates as per the technique of delivery (e.g. Oral or Tablet, extended release) delineated in the table beneath.Condition
Dosage
Administration
Overactive Bladder Syndrome
, 7.5 mg, 15.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral
Warnings
Enablex ContraindicationsCondition
Risk Level
Notes
uncontrolled narrow-angle glaucoma
Do Not Combine
Urinary Retention
Do Not Combine
Gastric Retention
Do Not Combine
Common Enablex Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Darifenacin is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Ipratropium.
Enablex Toxicity & Overdose RiskTaking too much of this drug can lead to serious side effects caused by blocking certain nerve signals in the brain.
Enablex Novel Uses: Which Conditions Have a Clinical Trial Featuring Enablex?
At present, there are 32 active studies assessing the potential of Enablex to effectively address Overactive Bladder Syndrome.Condition
Clinical Trials
Trial Phases
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Enablex Reviews: What are patients saying about Enablex?
5Patient Review
11/6/2012 This medication has been a total game-changer for me and my bladder control issues.
5Patient Review
9/24/2013 I'm disappointed that my insurance company won't be covering this treatment next year. I switched to them for the same reason, and now I have to find a new option.
5Patient Review
11/13/2018 I'm glad my insurance company pushed me to try this cheaper alternative to Myrbetriq. Tolterodine didn't work for me, but Enablex did the trick with no noticeable side effects. My bladder control is great now and I don't have to worry about making a bathroom stop all the time.
5Patient Review
11/15/2012 I've been using Enablex for the past five months and it's really helped me. The dry mouth and constipation are manageable side effects that come with the territory, but the benefits have been worth it. I'm able to control my urges much better now and even walk to my office without having to go immediately. Taking it at night has also helped me sleep better.
5Patient Review
7/10/2014 No issues except for dry mouth. This completely solved my problem.
4Patient Review
10/13/2013 I was on Vesicare for 18 months, but it wasn't effective enough. I started Enablex a few days ago and it's been working great in terms of frequency; however, now I'm experiencing really awful leg pains. I took some pain killers and will see if they help stabilize the situation. If not, I'll have to go back to Vesicare.
4Patient Review
2/4/2014 I was having sudden urges to urinate during the night time. I do not have them as frequently, but if I have coffee, wine or a lot to drink after 5 o'clock it is less effective.
4Patient Review
8/31/2013 The only reason this isn't a five-star medication is because it can cause constipation.
4Patient Review
3/26/2016 I've been taking Enbrel for a little while now and I feel like it's not working as well as it used to.
3.3Patient Review
10/2/2013 Good stuff, but I need a higher dosage because I'm still waking up in the middle of the night.
3Patient Review
12/28/2013 I had a lot of negative side effects while taking this medication, including dry mouth and eyes, increased acid reflux, and decreased vision. I stopped taking it after just three months.
3Patient Review
1/30/2013 Enablex did help reduce my elderly father's urinary frequency and urgency, but the side effects were just too much for him to handle. He experienced constipation, nausea, appetite/weight loss, and mental confusion that made it difficult for him to remember even basic things. The medication helped with his original problem but not worth the cost of his physical and mental deterioration.
2Patient Review
9/18/2012 The side effects were too much for me to handle, so I sought out alternative treatments. Thankfully, those worked well and I no longer have the same issues!
1Patient Review
9/10/2012 This medication gave me dry lips and mouth, an upset stomach, bowel problems, severe back pain, hot flashes, and more.
Patient Q&A Section about enablex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Who should not take Enablex?
"The maximum daily dose of Enablex should not exceed 7.5 mg for patients with moderate hepatic impairment as classified by the Child-Pugh scale."
Answered by AI
Does Enablex cause weight gain?
"Weight gain is a possible side effect of taking Enablex (darifenacin), but it does not happen very often. According to research, only 1% to 2% of people who take Enablex (darifenacin) end up gaining weight. To lower your risk of weight gain, make sure to stay active and eat healthy."
Answered by AI
What is the drug Enablex used for?
"This medication may help to reduce some urinary symptoms such as leakage, urgency, and frequency. It belongs to a class of drugs called antispasmodics."
Answered by AI
What are the side effects of taking darifenacin?
"The following are common symptoms of dehydration: dry mouth, constipation, upset stomach, stomach pain, diarrhea, weakness, and dry eyes."
Answered by AI