Enablex

Overactive Bladder Syndrome

Treatment

20 Active Studies for Enablex

Treatment for

Overactive Bladder Syndrome

What is Enablex

DarifenacinThe Generic name of this drug

Treatment SummaryDarifenacin (Enablex®, Novartis) is a drug used to treat urinary incontinence. It works by blocking certain receptors in the bladder muscle which can cause the urge to urinate. It should not be used in people with urinary retention. The clinical advantages of Darifenacin in treating overactive bladder syndrome are still unknown.

Enablexis the brand name

Enablex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Enablex

Darifenacin

2004

Effectiveness

How Enablex Affects PatientsDarifenacin is a drug that blocks certain muscles in the body, specifically the M3 receptor. In studies using humans, it has been shown to block M3 receptors more than other types of muscle receptors, and is mainly used to treat issues with the urinary bladder and salivary glands. Common side effects of this drug include dry mouth, constipation and abnormal vision.

How Enablex works in the bodyDarifenacin works by blocking the action of the M3 receptor. This receptor is responsible for things like contraction of the bladder, production of saliva, and movement of the iris.

When to interrupt dosage

The volume of Enablex is contingent upon the determined condition. The amount fluctuates as per the technique of delivery (e.g. Oral or Tablet, extended release) delineated in the table beneath.

Condition

Dosage

Administration

Overactive Bladder Syndrome

, 7.5 mg, 15.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

Enablex Contraindications

Condition

Risk Level

Notes

uncontrolled narrow-angle glaucoma

Do Not Combine

Urinary Retention

Do Not Combine

Gastric Retention

Do Not Combine

There are 20 known major drug interactions with Enablex.

Common Enablex Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Darifenacin is combined with Aclidinium.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Darifenacin is combined with Cimetropium.

Eluxadoline

Major

The risk or severity of constipation can be increased when Darifenacin is combined with Eluxadoline.

Glycopyrronium

Major

The risk or severity of adverse effects can be increased when Darifenacin is combined with Glycopyrronium.

Ipratropium

Major

The risk or severity of adverse effects can be increased when Darifenacin is combined with Ipratropium.

Enablex Toxicity & Overdose RiskTaking too much of this drug can lead to serious side effects caused by blocking certain nerve signals in the brain.

image of a doctor in a lab doing drug, clinical research

Enablex Novel Uses: Which Conditions Have a Clinical Trial Featuring Enablex?

At present, there are 32 active studies assessing the potential of Enablex to effectively address Overactive Bladder Syndrome.

Condition

Clinical Trials

Trial Phases

Overactive Bladder Syndrome

36 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2

Enablex Reviews: What are patients saying about Enablex?

5Patient Review

11/6/2012

Enablex for Needing to Urinate Immediately

This medication has been a total game-changer for me and my bladder control issues.

5Patient Review

9/24/2013

Enablex for Frequent Urination

I'm disappointed that my insurance company won't be covering this treatment next year. I switched to them for the same reason, and now I have to find a new option.

5Patient Review

11/13/2018

Enablex for Needing to Urinate Immediately

I'm glad my insurance company pushed me to try this cheaper alternative to Myrbetriq. Tolterodine didn't work for me, but Enablex did the trick with no noticeable side effects. My bladder control is great now and I don't have to worry about making a bathroom stop all the time.

5Patient Review

11/15/2012

Enablex for Needing to Urinate Immediately

I've been using Enablex for the past five months and it's really helped me. The dry mouth and constipation are manageable side effects that come with the territory, but the benefits have been worth it. I'm able to control my urges much better now and even walk to my office without having to go immediately. Taking it at night has also helped me sleep better.

5Patient Review

7/10/2014

Enablex for Urine Leakage When there is a Strong Desire to Void

No issues except for dry mouth. This completely solved my problem.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about enablex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should not take Enablex?

"The maximum daily dose of Enablex should not exceed 7.5 mg for patients with moderate hepatic impairment as classified by the Child-Pugh scale."

Answered by AI

Does Enablex cause weight gain?

"Weight gain is a possible side effect of taking Enablex (darifenacin), but it does not happen very often. According to research, only 1% to 2% of people who take Enablex (darifenacin) end up gaining weight. To lower your risk of weight gain, make sure to stay active and eat healthy."

Answered by AI

What is the drug Enablex used for?

"This medication may help to reduce some urinary symptoms such as leakage, urgency, and frequency. It belongs to a class of drugs called antispasmodics."

Answered by AI