Eliphos
Hyperphosphataemia, Communicable Diseases, Dialysis therapy + 4 more
Treatment
3 FDA approvals
3 Active Studies for Eliphos
Treatment for
Hyperphosphataemia
What is Eliphos
Calcium acetate
The Generic name of this drug
Treatment Summary
Calcium acetate is a compound made of calcium and acetic acid. It is also known as the acetate of lime and usually comes in the form of a monohydrate, which is very absorbent.
ProcalAmine
is the brand name
Eliphos Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
ProcalAmine
Calcium acetate
1982
77
Approved as Treatment by the FDA
Calcium acetate, otherwise known as ProcalAmine, is approved by the FDA for 3 uses which include Kidney Failure, Chronic and End-stage Renal Failure (ESRF) .
Kidney Failure, Chronic
Helps manage End-stage Renal Failure (ESRF)
End-stage Renal Failure (ESRF)
Helps manage End-stage Renal Failure (ESRF)
Hyperphosphataemia
Helps manage Hyperphosphataemia
Effectiveness
How Eliphos Affects Patients
People with advanced kidney problems (creatinine clearance less than 30 ml/min) often have too much phosphate in the body, which can lead to an increase in hormones related to bone and tissue damage. This can be managed with dietary changes and dialysis, but it is not always enough. To reduce the amount of phosphate taken in from meals, phosphate binders such as calcium acetate can be taken. This binds to dietary phosphate to make it insoluble, so it is eliminated from the body in the feces. The goal of treatment with phosphate binders is usually to keep the phosphate levels in the body below 6.0 mg/
How Eliphos works in the body
Calcium acetate binds to the phosphate in food, so it can't be absorbed by your body. Instead, it is passed out of your body without being used.
When to interrupt dosage
The measure of Eliphos is contingent upon the determined disorder, including Kidney, Hyperphosphataemia and Kidney Failure, Chronic. The amount of dosage additionally shifts as per the method of delivery (e.g. Intravenous or Topical) included in the table beneath.
Condition
Dosage
Administration
Hyperphosphataemia
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
Kidney
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
high phosphate levels
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
Astringent
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
Communicable Diseases
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
Dialysis therapy
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
Kidney Failure, Chronic
667.0 mg, , 667.0 mg/mL, 0.839 mg/mg, 0.952 mg/mg, 952.0 mg, 5.95 mg/mL, 450.0 mg, 300.0 mg, 668.0 mg, 0.26 mg/mL, 22.0 mg/mL, 6.67 mg/mg, 44.0 mg/mL
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Solution, Solution - Oral, Powder, for solution - Topical, Topical, Powder, for solution, Injection - Intravenous, Injection, Injection, solution, concentrate - Intravenous, Injection, solution, concentrate, Liquid, Solution - Intravenous, Liquid - Intravenous, Intravenous, Tablet, coated, Solution - Topical, Tablet, coated - Oral
Warnings
Eliphos has two contraindications, thus it should not be utilized for the conditions given in the accompanying table.
Eliphos Contraindications
Condition
Risk Level
Notes
Hypercalcemia
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Eliphos.
Common Eliphos Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Calcium acetate may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Dobutamine
Minor
The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium acetate.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Moderate
Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acebutolol
Moderate
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.
Acetyldigitoxin
Moderate
Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Eliphos Toxicity & Overdose Risk
The toxic dose of the drug in rats is 4280mg/kg. Mild signs of an overdose include constipation, loss of appetite, nausea, and vomiting. More severe symptoms include confusion, unconsciousness, and difficulty speaking.
Eliphos Novel Uses: Which Conditions Have a Clinical Trial Featuring Eliphos?
Currently, 5 active studies are underway to assess the effectiveness of Eliphos in managing Kidney conditions, elevated phosphate levels and Hyperphosphataemia.
Condition
Clinical Trials
Trial Phases
high phosphate levels
0 Actively Recruiting
Kidney Failure, Chronic
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Hyperphosphataemia
0 Actively Recruiting
Dialysis therapy
3 Actively Recruiting
Not Applicable, Phase 3, Phase 4
Astringent
0 Actively Recruiting
Kidney
0 Actively Recruiting
Eliphos Reviews: What are patients saying about Eliphos?
5
Patient Review
5/20/2009
Eliphos for Renal Osteodystrophy with Hyperphosphatemia
Patient Q&A Section about eliphos
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What drug class is calcium acetate?
"Calcium acetate is a medication that is used to bind phosphorus in the diet and prevent it from being absorbed into the blood stream."
Answered by AI
What is calcium acetate used for?
"Calcium acetate is a medication used to treat hyperphosphatemia (too much phosphate in the blood) in patients with end stage kidney disease who are on dialysis. Calcium acetate works by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed."
Answered by AI
What is PhosLo used for?
"Phoslo is used as a calcium supplement to control phosphate levels in the blood for patients with severe kidney disease who are on dialysis."
Answered by AI
What is Eliphos used for?
"Eliphos is a phosphate binder that is indicated to help reduce serum phosphorus levels in patients with end stage renal disease. The recommended initial dose for adult dialysis patients is 2 tablets with each meal."
Answered by AI