Durezol

Eye Pain, Eye, eye surgery + 4 more

Treatment

0 Active Studies for Durezol

What is Durezol

Difluprednate

The Generic name of this drug

Treatment Summary

Difluprednate is an ointment used to reduce inflammation and pain caused by eye surgery. It is a type of corticosteroid and contains 6(α), 9(α)-difluoroprednisolone butyrate acetate. It is used to treat a type of eye inflammation called endogenous anterior uveitis.

Durezol

is the brand name

image of different drug pills on a surface

Durezol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Durezol

Difluprednate

2008

9

Effectiveness

How Durezol Affects Patients

Difluprednate is a type of steroid medicine used to reduce inflammation. It is mainly used before and after eye surgeries.

How Durezol works in the body

Corticosteroids work by increasing the production of proteins that suppress inflammation. These proteins, called lipocortins, stop the release of arachidonic acid, which is needed to make inflammatory molecules such as prostaglandins and leukotrienes. By blocking its release, the corticosteroids reduce inflammation.

When to interrupt dosage

The recommended dosage of Durezol is contingent upon the determined affliction, including Ocular Inflammation, Eye and Anterior uveitis. The measure of dosage can be found in the table below, depending on the method of administration (e.g. Emulsion - Ophthalmic or Ophthalmic).

Condition

Dosage

Administration

eye surgery

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Eye

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Eye Pain

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Eye

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Anterior uveitis

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Anterior uveitis

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Conjunctivitis

0.5 mg/mL, , 0.05 %

, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Warnings

Durezol Contraindications

Condition

Risk Level

Notes

Vaccinia

Do Not Combine

Eye

Do Not Combine

Herpes Simplex

Do Not Combine

Chickenpox

Do Not Combine

Eye Infections, Fungal

Do Not Combine

There are 20 known major drug interactions with Durezol.

Common Durezol Drug Interactions

Drug Name

Risk Level

Description

Bacillus calmette-guerin substrain russian BCG-I live antigen

Major

The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Difluprednate.

Allogeneic processed thymus tissue

Minor

The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Difluprednate.

Inebilizumab

Minor

The risk or severity of infection can be increased when Difluprednate is combined with Inebilizumab.

Vibrio cholerae CVD 103-HgR strain live antigen

Minor

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Difluprednate.

2,4-thiazolidinedione

Moderate

The risk or severity of hyperglycemia can be increased when Difluprednate is combined with 2,4-thiazolidinedione.

Durezol Toxicity & Overdose Risk

Testing has found that using difluprednate ophthalmic emulsion 0.05% four times a day does not have any toxic effects on the eyes.

image of a doctor in a lab doing drug, clinical research

Durezol Novel Uses: Which Conditions Have a Clinical Trial Featuring Durezol?

6 ongoing clinical trials are assessing the potential of Durezol to address Ocular Inflammation, Anterior Uveitis and associated conditions.

Condition

Clinical Trials

Trial Phases

Anterior uveitis

0 Actively Recruiting

eye surgery

0 Actively Recruiting

Anterior uveitis

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Eye

0 Actively Recruiting

Eye Pain

0 Actively Recruiting

Eye

0 Actively Recruiting

Durezol Reviews: What are patients saying about Durezol?

5

Patient Review

2/9/2015

Durezol for Inflammation of the Uvea of the Eye

This medication has helped me a lot. The pain went away for a while, but it came back recently. My doctor increased the dose, and it's been working fine since then.

5

Patient Review

6/5/2016

Durezol for Inflammation of the Front Portion of the Eye

I used this post-operatively as directed and experienced no pain. It's hard to say whether or not the drug was effective, but I did everything by the book.

4.7

Patient Review

2/19/2016

Durezol for Postoperative Pain in Eye

This eye drop worked well to get rid of the inflammation in my eye; however, I experienced some adverse side effects including blurry vision, light sensitivity, and numbness on my face. Be sure to have your doctor check your progress often if you decide to use this medication.

4.7

Patient Review

9/11/2014

Durezol for Inflammation of the Front Portion of the Eye

I had surgery to remove cataracts a month ago and have been using this medication for the past three days. Unfortunately, the pain and dryness is unbearable. The doctor doesn't want me to stop using it but I don't think it's really helping. I wouldn't recommend it.

4

Patient Review

6/24/2016

Durezol for Inflammation of the Uvea of the Eye

I've been using this medication for about two weeks to treat my Uveitis, and it's working much better than the generic Prednisone did. The only downside is that my vision has gotten worse since starting the medication.

4

Patient Review

4/18/2013

Durezol for Inflammation of the Uvea of the Eye

2.3

Patient Review

4/11/2014

Durezol for Inflammation of the Eye Following Surgery

I developed uveitis repeatedly during the weaning stage, so my prescription had to change to Durezol in an attempt to reduce the redness, swelling, flashes of light, and severe pain caused by light sensitivity. I was excited to change medications but after 3 weeks on Durezol and 12 weeks on a different prescription for the same symptoms, I'm hoping for better results.

2.3

Patient Review

8/8/2014

Durezol for Postoperative Pain in Eye

I've been taking this drug for over two months now with no change in my condition. However, I have noticed that I'm able to better deal with stress, so maybe it's helping me indirectly?

2.3

Patient Review

4/14/2015

Durezol for Allergic Conjunctivitis

I no longer have vision problems since using this treatment.

2

Patient Review

7/4/2013

Durezol for Postoperative Pain in Eye

Unfortunately, I had a terrible allergic reaction to this medication after my second cataract surgery. Hives, swelling, and conjunctivitis made it impossible for me to continue using the treatment.

2

Patient Review

7/15/2014

Durezol for Postoperative Pain in Eye

I had PRK surgery and my doctor prescribed Durezol. I was using it four times a day, but then tapered down to twice a day. A few days after I stopped using the medication, I started getting blisters around my eyes that were very painful. My doctor said it was peri oral dermatitis caused by the drug!

2

Patient Review

7/21/2014

Durezol for Inflammation of the Eye Following Surgery

The itching was unbearable and my doctor didn't seem to care. I wish I had known about other options before trying this treatment.

2

Patient Review

8/6/2017

Durezol for Inflammation of the Eye Following Surgery

These corticosteroid eye drops are based on decades-old medications, and they've jacked up the price by 10 or 20 times what it used to be. This is typical price gouging from the senior group (we are the majority of users). Doctors, pharmaceutical companies, and drug stores are legalized robbers.

1

Patient Review

3/20/2019

Durezol for Inflammation of the Eye Following Surgery

I have experienced depression and anxiety since being prescribed durezol.I still have eye pain and discomfort. After research, I learn that not only can this drug CAUSE cataracts and retinal detachment, there were no blind studies to determine its effectiveness against patients who DID NOT use this medication. I have never suffered from depression until using durazol. I am absolutely through with this drug and possibly the eye doctors who have prescribed it.

1

Patient Review

7/30/2016

Durezol for Inflammation of the Eye Following Surgery

Only after two drops, I developed a severe case of vertigo which lasted for six to seven hours. Additionally, I experienced prickly itching on my face, neck and arms. After taking Benedryl, my doctor changed me to another medication.

1

Patient Review

6/7/2013

Durezol for Inflammation of the Eye Following Surgery

These drops did very little to help with my inflammation.

1

Patient Review

2/19/2021

Durezol for Inflammation of the Eye Following Surgery

I strongly advise against this eye drop. I've been experiencing increased anxiety, nausea, and blurred vision since using it. My pressure was also up to 44 today (it's normally around 12).
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about durezol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long should you use Durezol?

"The recommended dosage for adults is one drop in the affected eye(s) four times a day for 14 days. Your doctor may adjust your dose if needed. The recommended dosage for children must be determined by your doctor."

Answered by AI

What are side effects of Durezol eye drops?

"The following are symptoms you may experience with eye inflammation: temporary blurred vision, headache, burning/stinging/itching of your eyes, dry or watery eyes, feeling like something is in your eye, or increased sensitivity of your eyes to light."

Answered by AI

Is Durezol a strong steroid?

"Durezol has been found to work as well as the very potent betamethasone in reducing inflammation after surgery, with an equal chance of a positive response to steroids."

Answered by AI

What is Durezol used for?

"This medication is used to treat swelling and pain after eye surgery. It may also be used to treat a certain serious eye problem (endogenous anterior uveitis). This medication belongs to a class of drugs known as corticosteroids."

Answered by AI