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What is Durezol
DifluprednateThe Generic name of this drug
Treatment SummaryDifluprednate is an ointment used to reduce inflammation and pain caused by eye surgery. It is a type of corticosteroid and contains 6(α), 9(α)-difluoroprednisolone butyrate acetate. It is used to treat a type of eye inflammation called endogenous anterior uveitis.
Durezolis the brand name
Durezol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Durezol
Difluprednate
2008
9
Effectiveness
How Durezol Affects PatientsDifluprednate is a type of steroid medicine used to reduce inflammation. It is mainly used before and after eye surgeries.
How Durezol works in the bodyCorticosteroids work by increasing the production of proteins that suppress inflammation. These proteins, called lipocortins, stop the release of arachidonic acid, which is needed to make inflammatory molecules such as prostaglandins and leukotrienes. By blocking its release, the corticosteroids reduce inflammation.
When to interrupt dosage
The recommended dosage of Durezol is contingent upon the determined affliction, including Ocular Inflammation, Eye and Anterior uveitis. The measure of dosage can be found in the table below, depending on the method of administration (e.g. Emulsion - Ophthalmic or Ophthalmic).Condition
Dosage
Administration
Anterior uveitis
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Eye
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Eye
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Ocular Inflammation
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Anterior uveitis
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Eye Pain
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
eye surgery
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Warnings
Durezol ContraindicationsCondition
Risk Level
Notes
Vaccinia
Do Not Combine
Eye
Do Not Combine
epithelial herpes simplex
Do Not Combine
Varicella
Do Not Combine
Eye Infections, Fungal
Do Not Combine
Common Durezol Drug Interactions
Drug Name
Risk Level
Description
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Difluprednate.
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Difluprednate.
Inebilizumab
Minor
The risk or severity of infection can be increased when Difluprednate is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Difluprednate.
2,4-thiazolidinedione
Moderate
The risk or severity of hyperglycemia can be increased when Difluprednate is combined with 2,4-thiazolidinedione.
Durezol Toxicity & Overdose RiskTesting has found that using difluprednate ophthalmic emulsion 0.05% four times a day does not have any toxic effects on the eyes.
Durezol Novel Uses: Which Conditions Have a Clinical Trial Featuring Durezol?
6 ongoing clinical trials are assessing the potential of Durezol to address Ocular Inflammation, Anterior Uveitis and associated conditions.Condition
Clinical Trials
Trial Phases
Eye Pain
2 Actively Recruiting
Not Applicable, Phase 4
Anterior uveitis
0 Actively Recruiting
eye surgery
0 Actively Recruiting
Eye
0 Actively Recruiting
Eye
0 Actively Recruiting
Anterior uveitis
0 Actively Recruiting
Ocular Inflammation
3 Actively Recruiting
Phase 2, Phase 4, Phase 3
Durezol Reviews: What are patients saying about Durezol?
5Patient Review
2/9/2015 This medication has helped me a lot. The pain went away for a while, but it came back recently. My doctor increased the dose, and it's been working fine since then.
5Patient Review
6/5/2016 I used this post-operatively as directed and experienced no pain. It's hard to say whether or not the drug was effective, but I did everything by the book.
4.7Patient Review
2/19/2016 This eye drop worked well to get rid of the inflammation in my eye; however, I experienced some adverse side effects including blurry vision, light sensitivity, and numbness on my face. Be sure to have your doctor check your progress often if you decide to use this medication.
4.7Patient Review
9/11/2014 I had surgery to remove cataracts a month ago and have been using this medication for the past three days. Unfortunately, the pain and dryness is unbearable. The doctor doesn't want me to stop using it but I don't think it's really helping. I wouldn't recommend it.
4Patient Review
6/24/2016 I've been using this medication for about two weeks to treat my Uveitis, and it's working much better than the generic Prednisone did. The only downside is that my vision has gotten worse since starting the medication.
4Patient Review
4/18/20132.3Patient Review
4/11/2014 I developed uveitis repeatedly during the weaning stage, so my prescription had to change to Durezol in an attempt to reduce the redness, swelling, flashes of light, and severe pain caused by light sensitivity. I was excited to change medications but after 3 weeks on Durezol and 12 weeks on a different prescription for the same symptoms, I'm hoping for better results.
2.3Patient Review
8/8/2014 I've been taking this drug for over two months now with no change in my condition. However, I have noticed that I'm able to better deal with stress, so maybe it's helping me indirectly?
2.3Patient Review
4/14/2015 I no longer have vision problems since using this treatment.
2Patient Review
7/4/2013 Unfortunately, I had a terrible allergic reaction to this medication after my second cataract surgery. Hives, swelling, and conjunctivitis made it impossible for me to continue using the treatment.
2Patient Review
7/15/2014 I had PRK surgery and my doctor prescribed Durezol. I was using it four times a day, but then tapered down to twice a day. A few days after I stopped using the medication, I started getting blisters around my eyes that were very painful. My doctor said it was peri oral dermatitis caused by the drug!
2Patient Review
7/21/2014 The itching was unbearable and my doctor didn't seem to care. I wish I had known about other options before trying this treatment.
2Patient Review
8/6/2017 These corticosteroid eye drops are based on decades-old medications, and they've jacked up the price by 10 or 20 times what it used to be. This is typical price gouging from the senior group (we are the majority of users). Doctors, pharmaceutical companies, and drug stores are legalized robbers.
1Patient Review
3/20/2019 I have experienced depression and anxiety since being prescribed durezol.I still have eye pain and discomfort. After research, I learn that not only can this drug CAUSE cataracts and retinal detachment, there were no blind studies to determine its effectiveness against patients who DID NOT use this medication. I have never suffered from depression until using durazol. I am absolutely through with this drug and possibly the eye doctors who have prescribed it.
1Patient Review
7/30/2016 Only after two drops, I developed a severe case of vertigo which lasted for six to seven hours. Additionally, I experienced prickly itching on my face, neck and arms. After taking Benedryl, my doctor changed me to another medication.
1Patient Review
6/7/2013 These drops did very little to help with my inflammation.
1Patient Review
2/19/2021 I strongly advise against this eye drop. I've been experiencing increased anxiety, nausea, and blurred vision since using it. My pressure was also up to 44 today (it's normally around 12).
Patient Q&A Section about durezol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long should you use Durezol?
"The recommended dosage for adults is one drop in the affected eye(s) four times a day for 14 days. Your doctor may adjust your dose if needed. The recommended dosage for children must be determined by your doctor."
Answered by AI
What are side effects of Durezol eye drops?
"The following are symptoms you may experience with eye inflammation: temporary blurred vision, headache, burning/stinging/itching of your eyes, dry or watery eyes, feeling like something is in your eye, or increased sensitivity of your eyes to light."
Answered by AI
Is Durezol a strong steroid?
"Durezol has been found to work as well as the very potent betamethasone in reducing inflammation after surgery, with an equal chance of a positive response to steroids."
Answered by AI