Durezol

Eye Pain, Eye, eye surgery + 4 more
Treatment
0 Active Studies for Durezol

What is Durezol

DifluprednateThe Generic name of this drug
Treatment SummaryDifluprednate is an ointment used to reduce inflammation and pain caused by eye surgery. It is a type of corticosteroid and contains 6(α), 9(α)-difluoroprednisolone butyrate acetate. It is used to treat a type of eye inflammation called endogenous anterior uveitis.
Durezolis the brand name
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Durezol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Durezol
Difluprednate
2008
9

Effectiveness

How Durezol Affects PatientsDifluprednate is a type of steroid medicine used to reduce inflammation. It is mainly used before and after eye surgeries.
How Durezol works in the bodyCorticosteroids work by increasing the production of proteins that suppress inflammation. These proteins, called lipocortins, stop the release of arachidonic acid, which is needed to make inflammatory molecules such as prostaglandins and leukotrienes. By blocking its release, the corticosteroids reduce inflammation.

When to interrupt dosage

The recommended dosage of Durezol is contingent upon the determined affliction, including Ocular Inflammation, Eye and Anterior uveitis. The measure of dosage can be found in the table below, depending on the method of administration (e.g. Emulsion - Ophthalmic or Ophthalmic).
Condition
Dosage
Administration
Eye
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Eye
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Anterior uveitis
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Eye Pain
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
eye surgery
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Anterior uveitis
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic
Conjunctivitis
0.5 mg/mL, , 0.05 %
, Ophthalmic, Emulsion, Emulsion - Ophthalmic

Warnings

Durezol Contraindications
Condition
Risk Level
Notes
Vaccinia
Do Not Combine
Eye
Do Not Combine
Herpes Simplex
Do Not Combine
Chickenpox
Do Not Combine
Eye Infections, Fungal
Do Not Combine
There are 20 known major drug interactions with Durezol.
Common Durezol Drug Interactions
Drug Name
Risk Level
Description
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Difluprednate.
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Difluprednate.
Inebilizumab
Minor
The risk or severity of infection can be increased when Difluprednate is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Difluprednate.
2,4-thiazolidinedione
Moderate
The risk or severity of hyperglycemia can be increased when Difluprednate is combined with 2,4-thiazolidinedione.
Durezol Toxicity & Overdose RiskTesting has found that using difluprednate ophthalmic emulsion 0.05% four times a day does not have any toxic effects on the eyes.
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Durezol Novel Uses: Which Conditions Have a Clinical Trial Featuring Durezol?

6 ongoing clinical trials are assessing the potential of Durezol to address Ocular Inflammation, Anterior Uveitis and associated conditions.
Condition
Clinical Trials
Trial Phases
Anterior uveitis
0 Actively Recruiting
eye surgery
0 Actively Recruiting
Anterior uveitis
0 Actively Recruiting
Conjunctivitis
0 Actively Recruiting
Eye
0 Actively Recruiting
Eye Pain
1 Actively Recruiting
Phase 1
Eye
0 Actively Recruiting

Durezol Reviews: What are patients saying about Durezol?

5Patient Review
2/9/2015
Durezol for Inflammation of the Uvea of the Eye
This medication has helped me a lot. The pain went away for a while, but it came back recently. My doctor increased the dose, and it's been working fine since then.
5Patient Review
6/5/2016
Durezol for Inflammation of the Front Portion of the Eye
I used this post-operatively as directed and experienced no pain. It's hard to say whether or not the drug was effective, but I did everything by the book.
4.7Patient Review
2/19/2016
Durezol for Postoperative Pain in Eye
This eye drop worked well to get rid of the inflammation in my eye; however, I experienced some adverse side effects including blurry vision, light sensitivity, and numbness on my face. Be sure to have your doctor check your progress often if you decide to use this medication.
4.7Patient Review
9/11/2014
Durezol for Inflammation of the Front Portion of the Eye
I had surgery to remove cataracts a month ago and have been using this medication for the past three days. Unfortunately, the pain and dryness is unbearable. The doctor doesn't want me to stop using it but I don't think it's really helping. I wouldn't recommend it.
4Patient Review
6/24/2016
Durezol for Inflammation of the Uvea of the Eye
I've been using this medication for about two weeks to treat my Uveitis, and it's working much better than the generic Prednisone did. The only downside is that my vision has gotten worse since starting the medication.
View All Reviews
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Patient Q&A Section about durezol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long should you use Durezol?

"The recommended dosage for adults is one drop in the affected eye(s) four times a day for 14 days. Your doctor may adjust your dose if needed. The recommended dosage for children must be determined by your doctor."

Answered by AI

What are side effects of Durezol eye drops?

"The following are symptoms you may experience with eye inflammation: temporary blurred vision, headache, burning/stinging/itching of your eyes, dry or watery eyes, feeling like something is in your eye, or increased sensitivity of your eyes to light."

Answered by AI

Is Durezol a strong steroid?

"Durezol has been found to work as well as the very potent betamethasone in reducing inflammation after surgery, with an equal chance of a positive response to steroids."

Answered by AI

What is Durezol used for?

"This medication is used to treat swelling and pain after eye surgery. It may also be used to treat a certain serious eye problem (endogenous anterior uveitis). This medication belongs to a class of drugs known as corticosteroids."

Answered by AI
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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