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What is Droxidopa
DroxidopaThe Generic name of this drug
Treatment SummaryDroxidopa is a drug used to treat symptoms of Parkinson's disease. It is approved in Japan and is currently being tested in the U.S., Canada, Australia, and Europe. Droxidopa is also used to treat orthostatic hypotension, a sudden drop in blood pressure when standing up. Clinical trials are underway to see if it can be approved for the treatment of neurogenic orthostatic hypotension and intradialytic hypotension. Droxidopa has been given orphan drug status in the U.S. for the treatment of Parkinson's disease, pure autonomic failure, and multiple system atro
Northerais the brand name
Droxidopa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Northera
Droxidopa
2014
57
Approved as Treatment by the FDA
Droxidopa, also called Northera, is approved by the FDA for 6 uses like Shy-Drager Syndrome and Dopamine-beta-monooxygenase .Shy-Drager Syndrome
Dopamine-beta-monooxygenase
Parkinson's Disease
Symptomatic Neurogenic Orthostatic Hypotension (NOH)
Non-Diabetic Autonomic Neuropathy
Multiple System Atrophy (MSA)
Effectiveness
How Droxidopa Affects PatientsDroxidopa is a medication that helps improve symptoms of NOH (a condition which causes a lack of norepinephrine in the body) by increasing the body's supply of norepinephrine. This helps improve symptoms like dizziness, lightheadedness, blurred vision, and fainting. It also leads to an increase in heart rate and blood pressure.
How Droxidopa works in the bodyDroxidopa is a drug that enters the brain and is converted into norepinephrine. Norepinephrine works on your blood vessels, by constricting them and also on your heart, to increase its rate and make your arteries wider.
When to interrupt dosage
The endorsed dosage of Droxidopa is contingent upon the identified ailment, such as Shy-Drager Syndrome, Multiple System Atrophy (MSA) and Non-Diabetic Autonomic Neuropathy. The measure of dosage is contingent upon the method of delivery featured in the table below.Condition
Dosage
Administration
Parkinson's Disease
100.0 mg, , 200.0 mg, 300.0 mg, 0.3 mg, 0.2 mg, 0.1 mg
, Oral, Capsule, Capsule - Oral
Shy-Drager Syndrome
100.0 mg, , 200.0 mg, 300.0 mg, 0.3 mg, 0.2 mg, 0.1 mg
, Oral, Capsule, Capsule - Oral
Dopamine-beta-monooxygenase
100.0 mg, , 200.0 mg, 300.0 mg, 0.3 mg, 0.2 mg, 0.1 mg
, Oral, Capsule, Capsule - Oral
Non-Diabetic Autonomic Neuropathy
100.0 mg, , 200.0 mg, 300.0 mg, 0.3 mg, 0.2 mg, 0.1 mg
, Oral, Capsule, Capsule - Oral
Symptomatic Neurogenic Orthostatic Hypotension (NOH)
100.0 mg, , 200.0 mg, 300.0 mg, 0.3 mg, 0.2 mg, 0.1 mg
, Oral, Capsule, Capsule - Oral
Multiple System Atrophy (MSA)
100.0 mg, , 200.0 mg, 300.0 mg, 0.3 mg, 0.2 mg, 0.1 mg
, Oral, Capsule, Capsule - Oral
Warnings
There are 20 known major drug interactions with Droxidopa.Common Droxidopa Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be increased when used in combination with Droxidopa.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Droxidopa.
4-Bromo-2,5-dimethoxyamphetamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Droxidopa.
Acebutolol
Major
The therapeutic efficacy of Acebutolol can be increased when used in combination with Droxidopa.
Amphetamine
Major
The therapeutic efficacy of Amphetamine can be increased when used in combination with Droxidopa.
Droxidopa Toxicity & Overdose RiskDroxidopa has low toxicity and is unlikely to cause serious harm if taken in high doses. Minor side effects such as nausea, headache, high blood pressure, hallucinations, and lack of appetite have been reported in less than 1% of patients.
Droxidopa Novel Uses: Which Conditions Have a Clinical Trial Featuring Droxidopa?
There are 46 active clinical trials investigating the potential of Droxidopa to manage Dopamine-beta-monooxygenase Deficiency, Parkinson's Disease and Non-Diabetic Autonomic Neuropathy.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Multiple System Atrophy (MSA)
3 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Dopamine-beta-monooxygenase
0 Actively Recruiting
Symptomatic Neurogenic Orthostatic Hypotension (NOH)
1 Actively Recruiting
Phase 3
Non-Diabetic Autonomic Neuropathy
0 Actively Recruiting
Shy-Drager Syndrome
0 Actively Recruiting
Droxidopa Reviews: What are patients saying about Droxidopa?
5Patient Review
3/2/2016 Droxidopa has been an absolute game-changer for me. I used to faint within 20 seconds of standing, but now that doesn't happen anymore. It's improved my quality of life so much.
3.3Patient Review
3/26/2015 I started taking Droxidopa Oral instead of Midodrine for my severe orthostatic hypotension. As I titrated up my dose by 100 mg weekly, from 100 to 600 mg, it seemed to work as well as Midodrine, but not as well as when I took Midodrine and Adderall together. Droxidopa gives me nasty headaches that are becoming less severe as time goes on, but it also makes me very drowsy.
Patient Q&A Section about droxidopa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Droxidopa lower BP?
"Droxidopa may cause people's blood pressure to increase when they lie down, which could lead to cardiovascular problems like heart attacks and strokes."
Answered by AI
How quickly does Droxidopa work?
"Although it is not FDA-approved, a low dose of fludrocortisone (0.1-0.2 mg/day) is often used in the treatment of nOH. Although higher dosages are used, they are not as effective and have more side effects. Clinical effects are seen after 1-2 weeks of treatment."
Answered by AI
What is Droxidopa used to treat?
"Droxidopa is used to treat problems with autonomic nervous system function that can cause dizziness, fainting, and lightheadedness. These problems include Parkinson's disease, multiple system atrophy, pure autonomic failure, dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy."
Answered by AI
Does Droxidopa increase blood pressure?
"Droxidopa may increase your blood pressure when you are lying down. To help prevent high blood pressure, you may need to keep your head elevated while sleeping. Follow your doctor’s instructions about how to position your body while you are lying down or sleeping."
Answered by AI