Droxia

inoperable Ovarian cancer, Thrombocythemia, Essential, Sickle Cell Anemia + 4 more
Treatment
1 FDA approval
20 Active Studies for Droxia

What is Droxia

HydroxyureaThe Generic name of this drug
Treatment SummaryMethotrexate is a medication that prevents cancer cells from growing and dividing by preventing them from making DNA.
Hydroxyureais the brand name
image of different drug pills on a surface
Droxia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Hydroxyurea
Hydroxyurea
1998
25

Approved as Treatment by the FDA

Hydroxyurea, also known as Hydroxyurea, is approved by the FDA for 1 uses which include inoperable Ovarian cancer .
inoperable Ovarian cancer

Effectiveness

How Droxia Affects PatientsHydroxyurea has been found to have a positive effect when used alongside cisplatin, a chemotherapy drug. It was especially effective when taken four hours before the cisplatin in treating human lung cancer, and was also found to work well against murine lung cancer.
How Droxia works in the bodyHydroxyurea works by stopping cells from making DNA. It does this by entering the cell and disabling a molecule called ribonucleotide reductase, which is used to make DNA. This action leads to cell death, as well as inhibiting the repair of damage to DNA caused by radiation or other chemicals. Finally, hydroxyurea increases the level of fetal hemoglobin, reducing the risk of crises in people with sickle cell anemia.

When to interrupt dosage

The recommended dosage of Droxia is contingent upon the diagnosed condition, including Myeloid Leukemia, Hypereosinophilic Syndrome (HES) and Thrombocythemia, Essential. The measure of dosage fluctuates as per the strategy of delivery featured in the table below.
Condition
Dosage
Administration
Sickle Cell Anemia
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Thrombocythemia, Essential
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Polycythemia Vera (PV)
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Sickle Cell Crisis
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Hypereosinophilic Syndrome (HES)
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
inoperable Ovarian cancer
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral
Meningiomas
500.0 mg, , 1000.0 mg, 100.0 mg, 200.0 mg, 300.0 mg, 400.0 mg, 100.0 mg/mL
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Solution, Solution - Oral

Warnings

There are 20 known major drug interactions with Droxia.
Common Droxia Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Acteoside.
Droxia Toxicity & Overdose RiskHydroxyurea is toxic to mice and rats in doses of 7330mg/kg and 5760mg/kg respectively. It may cause birth defects in experimental animals, but has not been linked to any adverse effects in humans. There have also been reports of hydroxyurea causing genetic mutations in both animals and humans.
image of a doctor in a lab doing drug, clinical research

Droxia Novel Uses: Which Conditions Have a Clinical Trial Featuring Droxia?

A total of 63 active clinical trials are examining the potential of Droxia to treat Myeloid Leukemia, Polycythemia Vera (PV) and Inoperable Ovarian Cancer.
Condition
Clinical Trials
Trial Phases
Sickle Cell Anemia
7 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
inoperable Ovarian cancer
0 Actively Recruiting
Meningiomas
1 Actively Recruiting
Phase 2
Hypereosinophilic Syndrome (HES)
0 Actively Recruiting
Sickle Cell Crisis
2 Actively Recruiting
Phase 2, Not Applicable
Polycythemia Vera (PV)
0 Actively Recruiting
Thrombocythemia, Essential
15 Actively Recruiting
Phase 1, Phase 2, Phase 3

Droxia Reviews: What are patients saying about Droxia?

5Patient Review
11/24/2013
Droxia for Sickle Cell Anemia
This treatment has been working well for me. I go months without a crisis, whereas before I would have several in the span of just a couple months. The only downside is that I have to take pills every day, which can be annoying.
5Patient Review
8/5/2010
Droxia for Sickle Cell Anemia
2Patient Review
10/12/2011
Droxia for Sickle Cell Anemia
my son has been taking this medication for a little over 3 years now, and unfortunately he's been extremely sick the entire time. Some of the issues he's experienced are severe stomach pain, paleness, fluid retention and possible infection in his left hip, as well as tingling and pain in both arms and legs. In my opinion, this pill is doing more harm than good.

Patient Q&A Section about droxia

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How do you take droxia?

"The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Droxia is taken by mouth, with or without food, once daily. The dosage is based on the patient's medical condition, response to treatment, and other medications the patient is taking. The medication guide should be read before taking Droxia, and any questions should be directed to the doctor or pharmacist. All products used by the patient, including prescription and nonprescription drugs, as well as herbal products, should be reported to the doctor or pharmacist."

Answered by AI

How much does droxia cost?

"Droxia is a medication used to treat cancer. The average retail price for Droxia is $69.71. You can save 20% on the retail price of Droxia by comparing prices at different pharmacies."

Answered by AI

What is droxia used for?

"Hydroxyurea is a medication used to reduce the frequency of painful crises and reduce the need for blood transfusions in adults and children 2 years of age and older with sickle cell anemia. Sickle cell anemia is an inherited blood disorder in which the red blood cells are abnormally shaped and cannot bring enough oxygen to the body's tissues."

Answered by AI

What is the drug Hydrea used for?

"Hydroxyurea is a medication used to prevent painful episodes and reduce the need for blood transfusions in patients with sickle cell anemia. Hydroxyurea works by making red blood cells more flexible. A prescription from a doctor is required to obtain hydroxyurea."

Answered by AI

Clinical Trials for Droxia

Have you considered Droxia clinical trials? We made a collection of clinical trials featuring Droxia, we think they might fit your search criteria.
Have you considered Droxia clinical trials? We made a collection of clinical trials featuring Droxia, we think they might fit your search criteria.
Have you considered Droxia clinical trials? We made a collection of clinical trials featuring Droxia, we think they might fit your search criteria.
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