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What is Doribax
DoripenemThe Generic name of this drug
Treatment SummaryDoripenem is an antibiotic used to treat complicated urinary tract and abdominal infections. It was approved by the FDA in 2007 under the brand name Doribax. In 2014, the FDA revised the label for Doripenem to include a warning against its use in ventilator-associated pneumonia due to an increased risk of death and lower clinical cure rates. Doripenem is safe and effective for its approved indications.
Doribaxis the brand name
Doribax Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Doribax
Doripenem
2007
7
Approved as Treatment by the FDA
Doripenem, also known as Doribax, is approved by the FDA for 4 uses like Abdominal Infection and Pyelonephritis .Abdominal Infection
Pyelonephritis
Urinary Tract Infection (UTI)
Urinary tract infection
Effectiveness
How Doribax Affects PatientsDoripenem is an antibiotic that works similarly to other beta-lactam antibiotics. Studies show that the most effective way for it to fight infection is to have a certain amount of unbound drug in the blood for a certain amount of time.
How Doribax works in the bodyDoripenem is a type of antibiotic that works to kill bacteria. It works by targeting certain enzymes, called penicillin-binding proteins, that are responsible for forming the bacterial cell wall. By blocking these proteins, doripenem is able to cause the bacteria to break apart, killing it. Doripenem is better at this task than other antibiotics due to its 1-beta-methyl side chain, which makes it resistant to dehydration, and its trans-alpha-1-hydroxyethyl group at position 6, which provides extra protection from beta-lactamase enzymes.
When to interrupt dosage
The amount of Doribax is contingent upon the determined malady, including Urinary tract infection, Pyelonephritis and Urinary Tract Infection (UTI). The dose can be found in the table below, reliant upon the technique of application.Condition
Dosage
Administration
Abdominal Infection
500.0 mg, , 250.0 mg, 25.0 mg/mL, 50.0 mg/mL
Intravenous, , Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Pyelonephritis
500.0 mg, , 250.0 mg, 25.0 mg/mL, 50.0 mg/mL
Intravenous, , Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
catheter device
500.0 mg, , 250.0 mg, 25.0 mg/mL, 50.0 mg/mL
Intravenous, , Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Urinary Tract Infection (UTI)
500.0 mg, , 250.0 mg, 25.0 mg/mL, 50.0 mg/mL
Intravenous, , Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Urinary tract infection
500.0 mg, , 250.0 mg, 25.0 mg/mL, 50.0 mg/mL
Intravenous, , Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Warnings
Doribax ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Doribax Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Doripenem.
Aclidinium
Minor
Doripenem may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Doripenem may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Doripenem may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Doripenem may decrease the excretion rate of Almasilate which could result in a higher serum level.
Doribax Toxicity & Overdose RiskDue to decreased kidney function, doripenem dosage may need to be adjusted in patients with moderate or severe renal impairment. In a clinical trial, those who received doripenem for ventilator-associated bacterial pneumonia had higher death rates and lower clinical response rates than those who received imipenem. Seizures have been reported with the drug, especially in people with pre-existing conditions of the central nervous system, compromised renal function, or those taking doses greater than 500mg every 8 hours. Doripenem may reduce the effectiveness of valproic acid in patients taking it for seizure disorders. The drug
Doribax Novel Uses: Which Conditions Have a Clinical Trial Featuring Doribax?
31 active studies are currently in progress to assess the potential of Doribax in providing relief from Pyelonephritis, Abdominal Infections and catheter-related issues.Condition
Clinical Trials
Trial Phases
Abdominal Infection
0 Actively Recruiting
Urinary tract infection
2 Actively Recruiting
Phase 2, Phase 3
Pyelonephritis
4 Actively Recruiting
Not Applicable, Phase 3
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable
catheter device
0 Actively Recruiting
Patient Q&A Section about doribax
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was Doribax discontinued?
"Doribax was discontinued because of adverse drug reactions in a very small percentage of patients. The adverse drug reactions that led to Doribax discontinuation were nausea, diarrhoea, itching, vulvomycotic infection, increased liver enzymes, and rash."
Answered by AI
Is doripenem FDA approved?
"The FDA approved the drug doripenem in October 2007. This drug is the most recent addition to the carbapenem class."
Answered by AI
What is Doribax used for?
"Doribax is a prescription medication used to treat the symptoms of complicated intra-abdominal infection and to complicate urinary tract infection (UTI). Doribax may be used alone or with other medications. Doribax belongs to a class of drugs called carbapenems."
Answered by AI
How do you give doripenem?
"Doripenem injection is a liquid that is injected into a vein. It is usually given every 8 hours. The length of treatment depends on the type of infection being treated."
Answered by AI