Ditropan Xl

Nocturia, Urinary Bladder, Overactive, Neurological Disorders + 8 more
Treatment
20 Active Studies for Ditropan Xl

What is Ditropan Xl

OxybutyninThe Generic name of this drug
Treatment SummaryOxybutynin, sold under the brand name Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB) such as urgency, frequency, and nocturia. It has been used since 1975 and is a safe and effective first-line treatment for OAB. Oxybutynin helps improve quality of life for people with OAB by reducing the embarrassing and inconvenient symptoms associated with the condition.
Ditropanis the brand name
image of different drug pills on a surface
Ditropan Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ditropan
Oxybutynin
1975
256

Effectiveness

How Ditropan Xl Affects PatientsOxybutynin helps to relieve the symptoms of an overactive bladder, such as frequent and urgent urination, by blocking certain receptors (muscarinic receptors). Angioedema (swelling) is a possible side effect of taking this drug and should be monitored for. Other possible side effects include hallucinations, confusion, agitation, and drowsiness. It is important to assess the response to oxybutynin before operating heavy machinery or driving. Dose adjustments may also be necessary.
How Ditropan Xl works in the bodyOxybutynin relaxes the bladder muscles by blocking the effects of acetylcholine. This increases the bladder's capacity, reducing the urge to urinate and making it easier to control when going to the bathroom. The active ingredient in oxybutynin is N-desethyloxybutynin, which works by preventing the muscarinic receptors in your bladder from being activated.

When to interrupt dosage

The prescribed dose of Ditropan Xl is contingent upon the diagnosed condition, such as Neurological Disorders, Foley Catheterization and Nocturia. The amount of dosage can be found in the table below, contingent upon the mode of delivery (e.g. Tablet, extended release or Patch).
Condition
Dosage
Administration
Urinary Bladder, Overactive
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Neurological Disorders
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Spinal Dysraphism
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
increased frequency of urination
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Foley Catheterization
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Longterm Indwelling Ureteral Stent
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Nocturia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Bladder Spasms
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urgency
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Incontinence, Urge
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Overactive Bladder Syndrome
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered

Warnings

Ditropan Xl has four contraindications, thus it should not be utilized when dealing with any of the conditions noted in the following table.Ditropan Xl Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Oxybutynin may interact with Pulse Frequency
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Gastric Retention
Do Not Combine
There are 20 known major drug interactions with Ditropan Xl.
Common Ditropan Xl Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Oxybutynin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Ditropan Xl Toxicity & Overdose RiskThe most toxic dose of oxybutynin in rats is 460 mg/kg. Overdosing on this drug can lead to symptoms such as confusion, fever, rapid heartbeat, difficulty urinating, breathing problems, paralysis, and coma. If an overdose is suspected, supportive care and activated charcoal should be administered immediately. Two cases of overdose from a 100 mg dose of oxybutynin have been reported in the past, both involving simultaneous alcohol consumption. Both patients were able to recover after receiving supportive treatment.
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Ditropan Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Ditropan Xl?

79 active trials are presently being conducted to assess the potential of Ditropan Xl to ameliorate Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.
Condition
Clinical Trials
Trial Phases
Nocturia
4 Actively Recruiting
Not Applicable, Phase 4
Bladder Spasms
1 Actively Recruiting
Phase 2
Spinal Dysraphism
0 Actively Recruiting
Urinary Incontinence, Urge
17 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Foley Catheterization
1 Actively Recruiting
Not Applicable
Urinary Urgency
4 Actively Recruiting
Not Applicable, Phase 4
Urinary Bladder, Overactive
0 Actively Recruiting
Overactive Bladder Syndrome
36 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Longterm Indwelling Ureteral Stent
0 Actively Recruiting
Neurological Disorders
7 Actively Recruiting
Not Applicable, Phase 3, Phase 2
increased frequency of urination
3 Actively Recruiting
Not Applicable, Phase 4

Ditropan Xl Reviews: What are patients saying about Ditropan Xl?

4.7Patient Review
11/20/2012
Ditropan Xl for Needing to Urinate Immediately
I find this medication really keeps me up at night.
4.7Patient Review
7/23/2013
Ditropan Xl for Problems with Bladder Control
I've been taking this medication for a while, and it's been working great. Recently, I had to up my dosage from 10mg to 15mg, but it's still doing the job.
4.7Patient Review
11/20/2012
Ditropan Xl for Needing to Urinate Immediately
I find that this treatment helps me stay up at night.
4.7Patient Review
7/23/2013
Ditropan Xl for Problems with Bladder Control
I've been taking this for a while now, and it's been doing great things for me. Recently had to up the dosage from 10mg to 15mg, but other than that no complaints!
4.3Patient Review
2/3/2018
Ditropan Xl for Problems with Bladder Control
I take a 5mg tablet when I don't want to use the restroom as often. It generally decreases my trips to 7 or 8 times per day, which is amazing. However, I do experience extreme fatigue and stomach pain after taking it, as well as constipation.
View All Reviews
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Patient Q&A Section about ditropan xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the best time of the day to take oxybutynin?

"You should take oxybutynin two to four times a day, usually at regular intervals. The extended-release tablet is usually taken once a day, with or without food."

Answered by AI

What are the side effects of Ditropan?

"The following side effects may occur: dry mouth, dizziness, drowsiness, blurred vision, dry eyes, nausea, vomiting, upset stomach, stomach pain, constipation, diarrhea, headache, unusual taste in mouth, dry/flushed skin, and weakness. If you experience any of these effects, notify your doctor or pharmacist."

Answered by AI

How long does it take Ditropan XL to start working?

"Oxybutynin works to relax the muscles around the bladder after 3-4 hours. However, it may take up to 4 weeks before the full effect is seen. If there is no improvement after 7 days, speak to your doctor. If symptoms worsen at any time, speak to your doctor."

Answered by AI

What is Ditropan XL used for?

"This drug is a long-acting form of oxybutynin, which is used to treat overactive bladder and urinary conditions. It relaxes the muscles in the bladder, helping to decrease urgency and frequency of urination. Oxybutynin belongs to a class of drugs called antispasmodics."

Answered by AI

Clinical Trials for Ditropan Xl

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