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What is Ditropan Xl
OxybutyninThe Generic name of this drug
Treatment SummaryOxybutynin, sold under the brand name Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB) such as urgency, frequency, and nocturia. It has been used since 1975 and is a safe and effective first-line treatment for OAB. Oxybutynin helps improve quality of life for people with OAB by reducing the embarrassing and inconvenient symptoms associated with the condition.
Ditropanis the brand name
Ditropan Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ditropan
Oxybutynin
1975
256
Effectiveness
How Ditropan Xl Affects PatientsOxybutynin helps to relieve the symptoms of an overactive bladder, such as frequent and urgent urination, by blocking certain receptors (muscarinic receptors). Angioedema (swelling) is a possible side effect of taking this drug and should be monitored for. Other possible side effects include hallucinations, confusion, agitation, and drowsiness. It is important to assess the response to oxybutynin before operating heavy machinery or driving. Dose adjustments may also be necessary.
How Ditropan Xl works in the bodyOxybutynin relaxes the bladder muscles by blocking the effects of acetylcholine. This increases the bladder's capacity, reducing the urge to urinate and making it easier to control when going to the bathroom. The active ingredient in oxybutynin is N-desethyloxybutynin, which works by preventing the muscarinic receptors in your bladder from being activated.
When to interrupt dosage
The prescribed dose of Ditropan Xl is contingent upon the diagnosed condition, such as Neurological Disorders, Foley Catheterization and Nocturia. The amount of dosage can be found in the table below, contingent upon the mode of delivery (e.g. Tablet, extended release or Patch).Condition
Dosage
Administration
Nocturia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Longterm Indwelling Ureteral Stent
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Overactive Bladder Syndrome
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Spina Bifida
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urgency
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urge Incontinence
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Detrusor Hyperreflexia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Bladder Spasms
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Neurological Disorders
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
increased frequency of urination
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Foley Catheterization
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Warnings
Ditropan Xl has four contraindications, thus it should not be utilized when dealing with any of the conditions noted in the following table.Ditropan Xl ContraindicationsCondition
Risk Level
Notes
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Oxybutynin may interact with Pulse Frequency
Gastric Retention
Do Not Combine
Common Ditropan Xl Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Oxybutynin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Ditropan Xl Toxicity & Overdose RiskThe most toxic dose of oxybutynin in rats is 460 mg/kg. Overdosing on this drug can lead to symptoms such as confusion, fever, rapid heartbeat, difficulty urinating, breathing problems, paralysis, and coma. If an overdose is suspected, supportive care and activated charcoal should be administered immediately. Two cases of overdose from a 100 mg dose of oxybutynin have been reported in the past, both involving simultaneous alcohol consumption. Both patients were able to recover after receiving supportive treatment.
Ditropan Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Ditropan Xl?
79 active trials are presently being conducted to assess the potential of Ditropan Xl to ameliorate Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.Condition
Clinical Trials
Trial Phases
Nocturia
6 Actively Recruiting
Phase 4, Not Applicable
Spina Bifida
15 Actively Recruiting
Not Applicable
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
increased frequency of urination
2 Actively Recruiting
Phase 4, Not Applicable
Longterm Indwelling Ureteral Stent
0 Actively Recruiting
Urinary Urge Incontinence
15 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Urinary Urgency
3 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Detrusor Hyperreflexia
0 Actively Recruiting
Foley Catheterization
0 Actively Recruiting
Bladder Spasms
1 Actively Recruiting
Phase 1
Neurological Disorders
6 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Ditropan Xl Reviews: What are patients saying about Ditropan Xl?
4.7Patient Review
11/20/2012 I find this medication really keeps me up at night.
4.7Patient Review
7/23/2013 I've been taking this medication for a while, and it's been working great. Recently, I had to up my dosage from 10mg to 15mg, but it's still doing the job.
4.7Patient Review
11/20/2012 I find that this treatment helps me stay up at night.
4.7Patient Review
7/23/2013 I've been taking this for a while now, and it's been doing great things for me. Recently had to up the dosage from 10mg to 15mg, but other than that no complaints!
4.3Patient Review
2/3/2018 I take a 5mg tablet when I don't want to use the restroom as often. It generally decreases my trips to 7 or 8 times per day, which is amazing. However, I do experience extreme fatigue and stomach pain after taking it, as well as constipation.
4.3Patient Review
5/30/2015 I've used this medication for years, and I find that the generic oxybutynin chloride ER 10 is just as effective as ditropan. I hate having to take medication, but this stuff is really necessary so I've just placed my refill order.
4.3Patient Review
5/1/2013 My husband's been taking this medication since he had a stroke, but unfortunately it hasn't helped significantly with his nocturia. We're hoping his primary doctor will have some more ideas.
4.3Patient Review
5/1/2013 My husband has had to wake up every two hours at night to urinate since his stroke. The medication prescribed to him in rehab hasn't changed anything. We'll have to bring it up with his primary doctor at his next appointment.
4.3Patient Review
2/3/2018 I find that this medication really helps to cut down on the number of times I have to go to the bathroom. However, the side effects can be pretty harsh. I get very tired and often have stomach pain and constipation. I also wet the bed once after taking it, so now I make sure not to take it before bedtime.
4.3Patient Review
5/30/2015 I've been taking this for over five years and I don't think the generic oxybutynin chloride ER 10 is any less effective. I would rather not have to take medication at all, but unfortunately it's necessary in my case.
4Patient Review
1/26/2016 I've been taking this medication for over six months. It's been working very well, but I have experienced some negative side effects like dry mouth and a decreased sense of taste.
4Patient Review
9/17/2016 I was really surprised at how much this drug helped me after just one pill. My doctor prescribed it to me to help with my bladder issues until they figure out what's going on. It takes the edge off the pain and discomfort I constantly feel. The only downside is that it's very expensive.
4Patient Review
1/15/2019 The generic oxybutynin ER has been a total game-changer for me. I can actually sleep through the night now, and don't have to worry about accidents during the day. The only downside is that it made my hair fall out, but that was with the CL ER version originally prescribed.
4Patient Review
1/26/2016 I've been taking this daily for six months and it's helped me a lot. The only downside is that I have dry mouth and decreased taste, but those are minor problems in comparison to what this medication has helped me with.
4Patient Review
9/17/2016 I was really surprised at how well this medication worked. My doctor prescribed it to me to help with my bladder issues and it has definitely taken the edge off the pain. The only downside is that it's quite expensive.
4Patient Review
1/15/2019 The generic oxybutynin ER has helped me be able to control my urination, empty my bladder completely, and only get up once at night. However, the oxybutynin CL ER originally prescribed made my hair fall out.
3.7Patient Review
11/25/20103.7Patient Review
4/30/20113.7Patient Review
8/9/2019 Overall, this works really well! The only downside is that it can cause dry mouth.
3.7Patient Review
11/25/20103.7Patient Review
4/30/20113.7Patient Review
8/9/2019 Works great, but unfortunately leaves my mouth really dry.
3.3Patient Review
6/21/20103.3Patient Review
6/21/20103Patient Review
9/24/2011 At first, this drug helped me to urinate less at night. But after a few weeks of continued use, I started experiencing dry mouth and changes to my sense of taste. Additionally, my gums and tongue became sore. So, I stopped taking the medication. Unfortunately, the nighttime urination has returned; however, I am hopeful that the other side effects will dissipate as well.
3Patient Review
8/9/2019 I've found that this treatment is slowly becoming less effective.
3Patient Review
8/9/2019 I found that this treatment was less and less effective the longer I took it.
3Patient Review
9/24/2011 After taking this for a few days, I found that I had to urinate less frequently at night. However, after a few weeks I started to experience dry mouth and changes in how food tasted. These side effects continued even after discontinuing use, so be wary before starting this medication.
2.3Patient Review
9/26/20102.3Patient Review
11/21/2012 The dry mouth is the worst experience. And a funny taste in my mouth.
2.3Patient Review
10/21/2013 My doctor prescribed this to me after surgery, because I would start leaking urine when I stood up or walked. I waited the three months they suggested, and then started taking the pills. Unfortunately, the generic extended release form hasn't helped at all. If anything, it's made things worse with side effects like drowsiness, dry mouth, and an upset stomach after eating. Not sure if I should tell my doctor or just keep going for a bit longer.
2.3Patient Review
9/26/20102.3Patient Review
11/21/2012 The dry mouth is the worst experience. And a funny taste in my mouth.
2.3Patient Review
10/21/2013 I was given this medication after bladder surgery to help with incontinence. However, even after waiting the suggested three months post-op, I saw no improvement while taking the pills. Additionally, I experienced bothersome side effects like dry mouth and drowsiness. Overall, not a great experience.
2Patient Review
7/23/20102Patient Review
7/23/20101Patient Review
9/24/2012 Though this medication did work, it took a while for the effects to be felt. I'm going to try taking it earlier in the morning from now on.
1Patient Review
9/24/2012 Though this drug does work, it takes a few hours to start seeing results. I'm going to experiment with taking it earlier in the morning.
Patient Q&A Section about ditropan xl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the best time of the day to take oxybutynin?
"You should take oxybutynin two to four times a day, usually at regular intervals. The extended-release tablet is usually taken once a day, with or without food."
Answered by AI
What are the side effects of Ditropan?
"The following side effects may occur: dry mouth, dizziness, drowsiness, blurred vision, dry eyes, nausea, vomiting, upset stomach, stomach pain, constipation, diarrhea, headache, unusual taste in mouth, dry/flushed skin, and weakness. If you experience any of these effects, notify your doctor or pharmacist."
Answered by AI
How long does it take Ditropan XL to start working?
"Oxybutynin works to relax the muscles around the bladder after 3-4 hours. However, it may take up to 4 weeks before the full effect is seen. If there is no improvement after 7 days, speak to your doctor. If symptoms worsen at any time, speak to your doctor."
Answered by AI
What is Ditropan XL used for?
"This drug is a long-acting form of oxybutynin, which is used to treat overactive bladder and urinary conditions. It relaxes the muscles in the bladder, helping to decrease urgency and frequency of urination. Oxybutynin belongs to a class of drugs called antispasmodics."
Answered by AI