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What is Diflunisal
DiflunisalThe Generic name of this drug
Treatment SummaryDiflunisal is a type of nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It works by blocking the production of substances that cause inflammation in the body. Diflunisal is commonly used to reduce pain and swelling associated with rheumatoid arthritis and osteoarthritis.
Diflunisalis the brand name
Diflunisal Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diflunisal
Diflunisal
1992
17
Approved as Treatment by the FDA
Diflunisal, also known as Diflunisal, is approved by the FDA for 4 uses which include Pain and Mild pain .Pain
Mild pain
Rheumatoid Arthritis
Osteoarthritis (OA)
Effectiveness
How Diflunisal Affects PatientsDiflunisal is a non-narcotic painkiller, anti-inflammatory, and fever reducer. It is not known to cause addiction or tolerance. The chemical makeup of diflunisal is different from aspirin, as it has two fluorine atoms in the difluorophenyl ring structure instead of an acetyl group. It does not break down into salicylic acid, so it works differently than aspirin.
How Diflunisal works in the bodyWe don't know exactly how diflunisal works, but it likely reduces the amount of pain-causing chemicals in the body. These chemicals, called prostaglandins, can increase sensitivity to pain and inflammation. By reducing their amount in the body, diflunisal helps to reduce pain and inflammation.
When to interrupt dosage
The endorsed dosage of Diflunisal is contingent upon the diagnosed condition, including Rheumatoid Arthritis, Mild Pain and Pain. The measure of dosage varies as per the approach of application (e.g. Tablet - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
Rheumatoid Arthritis
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Osteoarthritis (OA)
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pain
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Mild pain
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Diflunisal.Common Diflunisal Drug Interactions
Drug Name
Risk Level
Description
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Diflunisal.
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Diflunisal.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Diflunisal.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Diflunisal.
Mycophenolic acid
Major
The metabolism of Mycophenolic acid can be decreased when combined with Diflunisal.
Diflunisal Toxicity & Overdose RiskThe toxic dose of diflunisal in rats, mice, and rabbits is 392mg/kg, 439mg/kg, and 603mg/kg respectively. Symptoms of an overdose include drowsiness, nausea, vomiting, diarrhea, rapid breathing, rapid heartbeat, sweating, ringing in the ears, confusion, stupor, and coma. Taking 15 grams of diflunisal at one time has been linked to death. There is a risk of cardiovascular events such as heart attack and stroke, especially with long-term use. Short-term use may increase the risk of gastrointestinal problems, kidney damage, liver
Diflunisal Novel Uses: Which Conditions Have a Clinical Trial Featuring Diflunisal?
75 active trials are currently underway to determine the potential of Diflunisal to alleviate Osteoarthritis (OA), Mild Pain and Rheumatoid Arthritis.Condition
Clinical Trials
Trial Phases
Osteoarthritis (OA)
0 Actively Recruiting
Pain
0 Actively Recruiting
Mild pain
0 Actively Recruiting
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Diflunisal Reviews: What are patients saying about Diflunisal?
5Patient Review
11/22/2008 This drug was prescribed a week ago for an abcessed tooth and associated swelling. It worked very quickly to eliminate the pain overnight. The script was for 20 pills, but I'll stop taking it today. The associated benefits were relief from arthritis and fibromyalgia pain.
5Patient Review
4/23/2011 Within a week, I had experienced several complications including rectal bleeding, intense stomach pain, and crippling headaches. Almost all of the potential side effects listed on the medication's website applied to me.
5Patient Review
11/22/2008 Unfortunately, this medication didn't do much for me in terms of pain relief or reducing inflammation. I found that a couple ibuprofren did a better job.
5Patient Review
9/30/2013 This has been a life-saver for me. I'm unable to take hydrocodone, and this stops the pain just as effectively.
4.7Patient Review
8/28/2013 Diflunisal has been a game-changer for me. I was diagnosed with Fibromyalgia & Chronic Myofascial Pain in 2002 and have been taking Tramadol & Cymbalta since then. The meds stopped working and I felt "radiating" pain all over my body. Diflunisal 500mg 3 x a day has helped to diminish the "radiating" pain and I am able to do more now.
4.3Patient Review
9/14/2009 I have fibromyalgia, rheumatoid arthritis, polymyalgia, chronic mylemonocytic leukemia, incontinence and pain all over. Diflunisal works well for me in combination with Robaxin (a muscle relaxer). I see a significant difference in as little as 30 minutes. This is great because I also experience severe muscle spasms in my lower back. Additionally, it doesn't seem to bother my stomach like some other treatments do.
4.3Patient Review
6/20/2013 I've been taking this for a while now with excellent results and no side effects.
4Patient Review
5/30/2013 I've only just started taking this medication for my chronic neck pain, so it's hard to give a thorough review. So far, though, I'm cautiously optimistic.
3.7Patient Review
12/27/2012 I've tried a lot of different medications for my arthritis, and this one is by far the most effective. It takes a few days to really kick in, but it's worth the wait.
3.3Patient Review
8/23/2011 Nausea, vomiting, headaches, and fatigue have been my experience with this medication. So far it hasn't done anything to help ease the pain of my arthritis. I'm going to give it a few more days, but if things don't improve I'll be looking for something else.
3.3Patient Review
11/3/2012 Overall, this was working great for me and I was able to walk normally again. However, it took a few days to realize that the worst outbreak of canker sores I ever had was a side effect. The same thing happened with the replacement pain killer!
3.3Patient Review
6/8/20082.7Patient Review
1/29/2011 I've been using this treatment for my arthritis for about three months now, and it's done a pretty good job of alleviating the symptoms.
1Patient Review
3/12/2018 This medicine made me nauseous, even when I took it with food.
1Patient Review
11/4/2009 I would not recommend this medication because it causes unexpected bleeding.
1Patient Review
12/9/2008 Diflunisal is effective for treating my tendonitis and the inflammation in my hip. I don't experience any stomach upset because I take it after eating.
Patient Q&A Section about diflunisal
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are diflunisal used for?
"Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) that can be used to treat mild to moderate pain, and provides relief from arthritis symptoms (e.g. osteoarthritis and rheumatoid arthritis), including inflammation, swelling, stiffness, and joint pain."
Answered by AI
What class drug is diflunisal?
"Diflunisal is an NSAID, a medication that works by stopping the body's production of a substance that causes pain, fever, and inflammation."
Answered by AI
How long does it take for diflunisal to work?
"If you have an ongoing condition such as arthritis, keep taking the medication as prescribed by your doctor. Talk to your doctor or pharmacist about the risks and benefits of taking this drug. It may take a few weeks of regular use before you feel the full effects of the medication if you have a condition such as arthritis."
Answered by AI