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What is Diclegis
DoxylamineThe Generic name of this drug
Treatment SummaryDoxylamine is a drug used to treat allergies and coughs. It has a sedative effect and can also be used to treat nausea and insomnia. Doxylamine has previously been used to treat Parkinson's disease, and is still used in veterinary medicine.
Unisom SleepTabsis the brand name
Diclegis Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Unisom SleepTabs
Doxylamine
1978
82
Approved as Treatment by the FDA
Doxylamine, also known as Unisom SleepTabs, is approved by the FDA for 4 uses like Gastrointestinal distress and Catarrh .Gastrointestinal distress
Used to treat Nausea in combination with Pyridoxine
Catarrh
Used in combination with Doxylamine for Common Cold
Nausea and Vomiting
Used to treat Vomiting in combination with Pyridoxine
Symptoms Flu
Used in combination with Doxylamine for Symptoms Flu
Effectiveness
How Diclegis Affects PatientsDoxylamine is an antihistamine used to treat allergies, hives, and hay fever. It is also used as a sleep aid and is much more powerful than other over-the-counter sleep aids. This drug is even more powerful than many prescription sedatives. It also has strong anticholinergic properties.
How Diclegis works in the bodyDoxylamine is an antihistamine that blocks histamine from binding to cells, reducing allergic reactions and providing a sedative effect. It also has anticholinergic effects, which can help to reduce symptoms of allergies.
When to interrupt dosage
The recommended dosage of Diclegis is dependent upon the specified ailment, including Symptoms Flu, Nausea and Nausea and Vomiting. The amount of dosage fluctuates depending on the administration approach outlined in the table below.Condition
Dosage
Administration
Nausea and Vomiting
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Insomnia
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Symptoms Flu
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Catarrh
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Gastrointestinal distress
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Mild Allergic Rhinitis
, 1.25 mg/mL, 6.25 mg, 25.0 mg, 0.625 mg/mL, 12.5 mg, 7.5 mg, 6.25 mg/mL, 3.125 mg/mL, 9.75 mg/mL, 5.0 mg, 10.0 mg, 0.0125 mg/mg, 12.5 mg/mL, 1.0 mg/mL, 20.0 mg, 0.75 mg/mL, 135.0 mg/mL, 10.5 mg, 9.78 mg/mL, 0.4167 mg/mL, 6.5 mg, 7.5 mg/mL, 1.2 mg/mL, 6.0 mg/mL
, Oral, Liquid, Liquid - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, effervescent, Tablet, effervescent - Oral, Powder, for solution, Powder, for solution - Oral, Kit, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Syrup - Oral, Syrup, Kit - Oral, Kit; Tablet, Kit; Tablet - Oral, Capsule; Kit, Capsule; Kit - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, chewable, Tablet, chewable - Oral, Powder - Oral, Powder
Warnings
There are 20 known major drug interactions with Diclegis.Common Diclegis Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxylamine is combined with Aclidinium.
Azelastine
Major
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Doxylamine is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Doxylamine is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Doxylamine is combined with Glycopyrronium.
Diclegis Toxicity & Overdose RiskSigns of an overdose on Montelukast include wheezing, chest tightness, fever, itching, a severe cough, skin discoloration, seizures, and swelling of the face, lips, tongue, or throat.
Diclegis Novel Uses: Which Conditions Have a Clinical Trial Featuring Diclegis?
Condition
Clinical Trials
Trial Phases
Insomnia
89 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Symptoms Flu
0 Actively Recruiting
Mild Allergic Rhinitis
0 Actively Recruiting
Gastrointestinal distress
21 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Nausea and Vomiting
24 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
Diclegis Reviews: What are patients saying about Diclegis?
5Patient Review
10/25/2017 I had a great experience with this drug, and would recommend it to anyone. The only downside is the cost, which can be prohibitive for some people.
5Patient Review
7/21/2015 Diclegis has been an absolute lifesaver for me. I was so sick starting at 4 weeks, and when I went to the doctor at 6 weeks she prescribed this medication. It's really helped me a lot; I only take two pills before bed and I feel fine all day long.
5Patient Review
8/27/2015 I was really struggling with my MS, to the point where I considered abortion. But then I took this pill and it completely changed everything. I'm so thankful for it.
5Patient Review
10/1/2015 Diclegis was a life-saver for me during my third pregnancy. I had morning sickness all day long, and this medication really helped me get some relief and get back to my normal self.
5Patient Review
10/12/2016 This drug is wonderful! I was feeling so sick during my first trimester, but after just one dose of this medicine, I felt great. It made such a big difference in how I was feeling that I could tell if I forgot to take a dose.
5Patient Review
8/24/2019 I'm on my third pregnancy, and as anyone who's been pregnant before knows, nausea is unfortunately a common symptom. I tried other treatments but found them to be ineffective. Diclegis has really helped me out and made it much easier to handle the nausea.
5Patient Review
8/27/2015 This treatment is fantastic. I feel great and have more energy. It's a nice reminder that pregnancy isn't always 9 months of feeling terrible.
5Patient Review
10/22/2015 I was struggling with nausea during my first pregnancy, to the point where I could only eat one meal a day. Once I started taking diclegis, I felt so much better! My friend who was on zofran had similar results; she found relief within hours of taking it.
5Patient Review
7/26/2016 This was prescribed for morning sickness and the sleeping part was a bonus. It kicked in really fast and has stopped my morning sickness completely. I'm only taking one instead of two like prescribed though because it knocks me out on just one.
3.3Patient Review
5/10/2015 The drowsiness this medication caused was really debilitating. I couldn't function at all while taking it, and it wasn't even safe for me to be driving or taking care of my child.
2.7Patient Review
4/10/2016 I was given this medication for nausea, and it did help with that. However, I felt incredibly exhausted after taking the first dose. To the point where I fell asleep while my toddler was playing (very unsafe). This continued even after a few more days of taking the medication, so I've decided to get rid of it.
2.3Patient Review
10/8/2015 I'm on my second pregnancy and was prescribed this medication for severe nausea and vomiting. It worked great the first day, but I've slowly been getting worse over the past two weeks. I still vomit at least once a day and my nausea is all day long. I'm tired all the time and can barely find energy to play with my 2 year old.
2.3Patient Review
9/23/2015 I would not recommend this medicine to anyone. I've been experiencing extreme mood swings and other unpleasant side effects for the last six hours, and it's supposed to last up to 12 hours.
Patient Q&A Section about diclegis
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was Diclegis taken off the market?
"The company Duchesnay applied to start selling the same two active ingredients, under the name Diclegis, that were voluntarily withdrawn from the American market in 1983. This was due to falling sales and rising legal costs."
Answered by AI
Is Diclegis just Unisom and B6?
"Diclegis is a combination of vitamin B6 and doxylamine, which is an antihistamine, sold for around $6 per pill. It is for women who might need to take up to four tablets a day."
Answered by AI
What does Diclegis do?
"Doxylamine with pyridoxine is a combination medication that is used to help relieve nausea and vomiting during pregnancy. This can improve your health and nutrition during pregnancy."
Answered by AI
Is Zofran better than Diclegis?
"Pregnant women who were given ondansetron reported greater reduction in both nausea and vomiting than those who received doxylamine-pyridoxine."
Answered by AI